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Vitamin D and Anemia in Chronic Kidney Disease

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Vitamin D in Chronic Kidney Disease

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Abstract

A considerable proportion of patients with chronic kidney disease develop anemia. Several factors are known to contribute to this renal anemia, like EPO deficiency, EPO hyporesponsiveness and functional iron deficiency due to increasing concentrations of hepcidin. Recent studies showing an association in abnormalities of the vitamin D system with low hemoglobin (Hb) levels and erythropoietin stimulating agent (ESA) resistance suggest cross-talk between the vitamin D system and erythropoiesis. The administration of either inactive or active vitamin D has been associated with an improvement of anemia and reduction in EPO hyporesponsiveness. Potential links between the vitamin D system and erythropoiesis are described in this chapter.

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Author information

Authors and Affiliations

  1. Department of Nephrology and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands

    Fenna van Breda MD, MSc

  2. Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet MD, PhD, FERA

Authors
  1. Fenna van Breda MD, MSc
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  2. Marc G. Vervloet MD, PhD, FERA
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Corresponding author

Correspondence to Marc G. Vervloet MD, PhD, FERA .

Editor information

Editors and Affiliations

  1. Ramsay-Générale de Santé, Clinique du Landy, Saint Ouen, France

    Pablo A. Ureña Torres

  2. San Paolo Hospital, DiSS University of Milan, Milan, Italy

    Mario Cozzolino

  3. VU University Medical Center, Amsterdam, The Netherlands

    Marc G. Vervloet

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© 2016 Springer International Publishing Switzerland

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van Breda, F., Vervloet, M.G. (2016). Vitamin D and Anemia in Chronic Kidney Disease. In: Ureña Torres, P., Cozzolino, M., Vervloet, M. (eds) Vitamin D in Chronic Kidney Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-32507-1_23

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  • DOI: https://doi.org/10.1007/978-3-319-32507-1_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32505-7

  • Online ISBN: 978-3-319-32507-1

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