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Neuropsychological Impairment of Patients with Depression

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Cardiovascular Diseases and Depression

Abstract

Neuropsychological impairment is one of the most common and persistent symptoms of depressive disorders. Studies indicate impairment in the domains of executive functions, attention, and memory. However, a definite profile of these impairments has yet not been identified possibly due to the fact that the neuropsychological performance is influenced by several clinical and demographic factors, e.g., depression subtype, rumination, and age. Depression also further deteriorates cognitive performance of brain-damaged patients. Impairments improve with remission of the disorder but do often not reverse completely. In addition, they have an important clinical impact and are positively related to suicidality, poor treatment response, and reduced everyday functioning. Therefore, effective treatment is needed. First results raised hope that neuropsychological impairment in depression is successfully treatable with neuropsychological therapy, training of mindfulness, specific antidepressants, and new neurobiological treatments such as transcranial magnet stimulation.

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References

  • Alexopoulos GS, Meyers BS, Young RC et al (1997) ‘Vascular depression’ hypothesis. Arch Gen Psychiatry 54:915–922

    Article  CAS  PubMed  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, (DSM-5), 5th edn. American Psychiatric Association, Washington, DC

    Google Scholar 

  • Andersen G, Vestergaard K, Ingemann-Nielsen M et al (1995) Risk factors for post-stroke depression. Acta Psychiatr Scand 92:193–198

    Article  CAS  PubMed  Google Scholar 

  • Austin MP, Ross M, Murray C et al (1992) Cognitive function in major depression. J Affect Disord 25:21–29

    Article  CAS  PubMed  Google Scholar 

  • Avila R, Moscoso MA, Ribeiz S et al (2009) Influence of education and depressive symptoms on cognitive function in the elderly. Int Psychogeriatr 21:560–567

    Article  PubMed  Google Scholar 

  • Barrett SL, Kelly C, Bell R et al (2008) Gender influences the detection of spatial working memory deficits in bipolar disorder. Bipolar Disord 10:647–654

    Article  PubMed  Google Scholar 

  • Baune BT, Miller R, Mcafoose J et al (2010) The role of cognitive impairment in general functioning in major depression. Psychiatry Res 176:183–189

    Article  PubMed  Google Scholar 

  • Baune BT, Fuhr M, Air T et al (2014) Neuropsychological functioning in adolescents and young adults with major depressive disorder – a review. Psychiatry Res 218:261–271

    Article  PubMed  Google Scholar 

  • Beats BC, Sahakian BJ, Levy R (1996) Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med 26:591–603

    Article  CAS  PubMed  Google Scholar 

  • Beblo T, Herrmann M (2000) Neuropsychologische Defizite bei depressiven Störungen. Fortschr Neurol Psychiatr 68:1–11

    Article  CAS  PubMed  Google Scholar 

  • Beblo T, Lautenbacher S (2006) Neuropsychologie der Depression. Hogrefe, Göttingen

    Google Scholar 

  • Beblo T, Baumann B, Bogerts B et al (1999) Neuropsychological correlates of major depression: a short term follow-up. Cogn Neuropsychiatr 4:333–341

    Article  Google Scholar 

  • Beblo T, Lahr D, Hartje W (2005) The impact of neuropsychological testing on the emotional state of patients with major depression. Z Neuropsychol 16:15–22

    Article  Google Scholar 

  • Beblo T, Mensebach C, Wingenfeld K et al (2010) The impact of neutral and emotionally negative distraction on memory performance and its relation to memory complaints in major depression. Psychiatry Res 178:106–111

    Article  PubMed  Google Scholar 

  • Beblo T, Sinnamon G, Baune BT (2011) Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychol Rev 21:337–359

    Google Scholar 

  • Beck AT (1967) Depression: clinical, experimental and theoretical aspects. Harper and Row, New York

    Google Scholar 

  • Beck AT, Clark DA, Alford BA (1999) Scientific foundations of cognitive theory and therapy of depression. Wiley, New York

    Google Scholar 

  • Beckwe M, Deroost N, Koster EH et al (2014) Worrying and rumination are both associated with reduced cognitive control. Psychological Research 78:651–660

    Article  PubMed  Google Scholar 

  • Belcher J, Kangas M (2014) Reduced goal specificity is associated with reduced memory specificity in depressed adults. Cogn Emot 28:163–171

    Article  PubMed  Google Scholar 

  • Benitez A, Horner MD, Bachman D (2011) Intact cognition in depressed elderly veterans providing adequate effort. Arch Clin Neuropsychol: Off J Natl Acad Neuropsychol 26:184–193

    Article  Google Scholar 

  • Bowie CR, Gupta M, Holshausen K (2013) Cognitive remediation therapy for mood disorders: rationale, early evidence, and future directions. Can J Psychiatry 58:319–325

    PubMed  Google Scholar 

  • Brissos S, Dias VV, Carita AI et al (2008) Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates. Psychiatry Res 160:55–62

    Article  PubMed  Google Scholar 

  • Brodaty H, Luscombe G, Parker G et al (2001) Early and late onset depression in old age: different aetiologies, same phenomenology. J Affect Disord 66:225–236

    Article  CAS  PubMed  Google Scholar 

  • Brunoni AR, Vanderhasselt MA (2014) Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: a systematic review and meta-analysis. Brain Cogn 86:1–9

    Article  PubMed  Google Scholar 

  • Burt T, Prudic J, Peyser S et al (2000) Learning and memory in bipolar and unipolar major depression: effects of aging. Neuropsychiatr Neuropsychol Behav Neurol 13:246–253

    CAS  Google Scholar 

  • Cella M, Dymond S, Cooper A (2010) Impaired flexible decision-making in major depressive disorder. J Affect Disord 124:207–210

    Google Scholar 

  • Chiesa A, Calati R, Serretti A (2011) Does mindfulness training improve cognitive abilities? A systematic review of neuropsychological findings. Clin Psychol Rev 31:449–464

    Article  PubMed  Google Scholar 

  • Christensen H, Griffiths K, Mackinnon A et al (1997) A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc 3:631–651

    CAS  PubMed  Google Scholar 

  • Conradi HJ, Ormel J, De Jonge P (2011) Presence of individual (residual) symptoms during depressive episodes and periods of remission: a 3-year prospective study. Psychol Med 41:1165–1174

    Article  CAS  PubMed  Google Scholar 

  • Crane C, Barnhofer T, Visser C et al (2007) The effects of analytical and experiential rumination on autobiographical memory specificity in individuals with a history of major depression. Behav Res Ther 45:3077–3087

    Article  PubMed  PubMed Central  Google Scholar 

  • Deckersbach T, Nierenberg AA, Kessler R et al (2010) RESEARCH: cognitive rehabilitation for bipolar disorder: an open trial for employed patients with residual depressive symptoms. CNS Neurosci Ther 16:298–307

    Article  PubMed  PubMed Central  Google Scholar 

  • Deckersbach T, Holzel BK, Eisner LR et al (2012) Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorder. CNS Neurosci Ther 18:133–141

    Article  PubMed  Google Scholar 

  • Delaloye C, Moy G, De Bilbao F et al (2010) Neuroanatomical and neuropsychological features of elderly euthymic depressed patients with early- and late-onset. J Neurol Sci 299:19–23

    Article  PubMed  Google Scholar 

  • Dombrovski AY, Butters MA, Reynolds CF 3rd et al (2008) Cognitive performance in suicidal depressed elderly: preliminary report. Am J Geriatr Psychiatry 16:109–115

    Article  PubMed  PubMed Central  Google Scholar 

  • Donaldson C, Lam D (2004) Rumination, mood and social problem-solving in major depression. Psychol Med 34:1309–1318

    Article  CAS  PubMed  Google Scholar 

  • Douglas KM, Porter RJ, Frampton CM et al (2009) Abnormal response to failure in unmedicated major depression. J Affect Disord 119:92–99

    Article  PubMed  Google Scholar 

  • Drevets WC, Price JL, Furey ML (2008) Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 213:93–118

    Article  PubMed  PubMed Central  Google Scholar 

  • Drysdale E, Knight HM, Mcintosh AM et al (2013) Cognitive endophenotypes in a family with bipolar disorder with a risk locus on chromosome 4. Bipolar Disord 15:215–222

    Article  PubMed  Google Scholar 

  • Elgamal S, Mckinnon MC, Ramakrishnan K et al (2007) Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study. Psychol Med 37:1229–1238

    Article  PubMed  Google Scholar 

  • Elliott R, Sahakian BJ, Mckay AP et al (1996) Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med 26:975–989

    Article  CAS  PubMed  Google Scholar 

  • Elliott R, Sahakian BJ, Herrod JJ et al (1997) Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment. J Neurol Neurosurg Psychiatry 63:74–82

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ellwart T, Rinck M, Becker ES (2003) Selective memory and memory deficits in depressed inpatients. Depress Anxiety 17:197–206

    Article  PubMed  Google Scholar 

  • Escolano C, Navarro-Gil M, Garcia-Campayo J et al (2014) A controlled study on the cognitive effect of alpha neurofeedback training in patients with major depressive disorder. Front Behav Neurosci 8:296

    Article  PubMed  PubMed Central  Google Scholar 

  • Everaert J, Koster EH, Derakshan N (2012) The combined cognitive bias hypothesis in depression. Clin Psychol Rev 32:413–424

    Article  PubMed  Google Scholar 

  • Flaster M, Sharma A, Rao M (2013) Poststroke depression: a review emphasizing the role of prophylactic treatment and synergy with treatment for motor recovery. Top Stroke Rehabil 20:139–150

    Article  PubMed  Google Scholar 

  • Fleming SK, Blasey C, Schatzberg AF (2004) Neuropsychological correlates of psychotic features in major depressive disorders: a review and meta-analysis. J Psychiatr Res 38:27–35

    Article  PubMed  Google Scholar 

  • Gabaldon L, Fuentes B, Frank-Garcia A et al (2007) Poststroke depression: importance of its detection and treatment. Cerebrovasc Dis 24(Suppl 1):181–188

    Article  PubMed  Google Scholar 

  • Gorwood P, Corruble E, Falissard B et al (2008) Toxic effects of depression on brain function: impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients. Am J Psychiatry 165:731–739

    Article  PubMed  Google Scholar 

  • Gotlib IH, Joormann J (2010) Cognition and depression: current status and future directions. Annu Rev Clin Psychol 6:285–312

    Article  PubMed  PubMed Central  Google Scholar 

  • Gualtieri CT, Morgan DW (2008) The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: an unaccounted source of variance in clinical trials. J Clin Psychiatr 69:1122–1130

    Article  Google Scholar 

  • Hadidi N, Treat-Jacobson DJ, Lindquist R (2009) Poststroke depression and functional outcome: a critical review of literature. Heart Lung: J Crit Care 38:151–162

    Article  Google Scholar 

  • Hasher L, Zacks RT (1979) Automatic and effortful processing in memory. J Exp Psychol Gen 108:356–388

    Article  Google Scholar 

  • Hasler G, Drevets WC, Manji HK et al (2004) Discovering endophenotypes for major depression. Neuropsychopharmacology 29:1765–1781

    Article  CAS  PubMed  Google Scholar 

  • Hasselbalch B, Knorr U, Hasselbalch S et al (2013) The cumulative load of depressive illness is associated with cognitive function in the remitted state of unipolar depressive disorder. Eur Psychiatry 28:349–355

    Article  CAS  PubMed  Google Scholar 

  • Henry J, Crawford JR (2005) A meta-analytic review of verbal fluency deficits in depression. J Clin Exp Neuropsychol 27:78–101

    Article  PubMed  Google Scholar 

  • Herrera-Guzman I, Gudayol-Ferre E, Herrera-Guzman D et al (2009) Effects of selective serotonin reuptake and dual serotonergic-noradrenergic reuptake treatments on memory and mental processing speed in patients with major depressive disorder. J Psychiatr Res 43:855–863

    Article  PubMed  Google Scholar 

  • Hsiao YL, Wu YS, Wu JY et al (2009) Neuropsychological functions in patients with bipolar I and bipolar II disorder. Bipolar Disord 11:547–554

    Article  PubMed  Google Scholar 

  • Ives-Deliperi VL, Howells F, Stein DJ et al (2013) The effects of mindfulness-based cognitive therapy in patients with bipolar disorder: a controlled functional MRI investigation. J Affect Disord 150:1152–1157

    Article  PubMed  Google Scholar 

  • Joormann J, Gotlib IH (2008) Updating the contents of working memory in depression: interference from irrelevant negative material. J Abnorm Psychol 117:182–192

    Article  PubMed  Google Scholar 

  • Kabat-Zinn J (1990) Full catastrophe living: using the wisdom of your body and mind to face stress, pain, and illness. Delta Trade Paperbacks, New York

    Google Scholar 

  • Keefe RS (1995) The contribution of neuropsychology to psychiatry. Am J Psychiatr 152:6–15

    Article  CAS  PubMed  Google Scholar 

  • Keefe RS, Mcclintock SM, Roth RM et al (2014) Cognitive effects of pharmacotherapy for major depressive disorder: a systematic review. J Clin Psychiatry 75:864–876

    Article  PubMed  Google Scholar 

  • Keilp J, Gorlyn M, Russell M et al (2013) Neuropsychological function and suicidal behavior: attention control, memory and executive dysfunction in suicide attempt. Psychol Med 43:539–551

    Article  CAS  PubMed  Google Scholar 

  • Kircanski K, Joormann J, Gotlib IH (2012) Cognitive aspects of depression. Wiley Interdiscip Rev Cogn Sci 3:301–313

    Article  PubMed  PubMed Central  Google Scholar 

  • Korten N, Penninx BW, Kok RM et al (2014) Heterogeneity of late-life depression: relationship with cognitive functioning. Int Psychogeriatr 26:953–963

    Article  PubMed  Google Scholar 

  • Koster EH, De Raedt R, Leyman L et al (2010) Mood-congruent attention and memory bias in dysphoria: exploring the coherence among information-processing biases. Behav Res Ther 48:219–225

    Article  PubMed  Google Scholar 

  • Lahr D, Beblo T, Hartje W (2007) Cognitive performance and subjective complaints before and after remission of major depression. Cogn Neuropsychiatry 12:25–45

    Article  PubMed  Google Scholar 

  • Laks J, Engelhardt E (2010) Peculiarities of geriatric psychiatry: a focus on aging and depression. CNS Neurosci Ther 16:374–379

    Article  PubMed  Google Scholar 

  • Leppanen JM (2006) Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 19:34–39

    Article  PubMed  Google Scholar 

  • Mackin RS, Nelson JC, Delucchi KL et al (2014) Association of age at depression onset with cognitive functioning in individuals with late-life depression and executive dysfunction. Am J Geriatr Psychiatry 22:1633–1641

    Article  PubMed  PubMed Central  Google Scholar 

  • Maeshima H, Baba H, Nakano Y et al (2013) Time course for memory dysfunction in early-life and late-life major depression: a longitudinal study from the Juntendo university mood disorder project. J Affect Disord 151:66–70

    Article  PubMed  Google Scholar 

  • Marano CM, Workman CI, Lyman CH et al (2015) Structural imaging in late life depression: association with mood and cognitive responses to antidepressant treatment. Am J Geriatr Psychiatr 23:6–12

    Google Scholar 

  • Martinez-Aran A, Scott J, Colom F et al (2009) Treatment nonadherence and neurocognitive impairment in bipolar disorder. J Clin Psychiatry 70:1017–1023

    Article  PubMed  Google Scholar 

  • Martinez-Aran A, Torrent C, Sole B et al (2011) Functional remediation for bipolar disorder. Clin Pract Epidemiol Ment Health: CP EMH 7:112–116

    Article  PubMed  PubMed Central  Google Scholar 

  • Mckinnon MC, Yucel K, Nazarov A et al (2009) A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci 34:41–54

    PubMed  PubMed Central  Google Scholar 

  • Merikanto I, Lahti T, Castaneda AE et al (2012) Influence of seasonal variation in mood and behavior on cognitive test performance among young adults. Nord J Psychiatry 66:303–310

    Article  PubMed  Google Scholar 

  • Mesholam-Gately RI, Giuliano AJ, Zillmer EA et al (2012) Verbal learning and memory in older adults with minor and major depression. Arch Clin Neuropsychol: Off J Natl Acad Neuropsychol 27:196–207

    Article  Google Scholar 

  • Mettenburg JM, Benzinger TL, Shimony JS et al (2012) Diminished performance on neuropsychological testing in late life depression is correlated with microstructural white matter abnormalities. NeuroImage 60:2182–2190

    Article  PubMed  PubMed Central  Google Scholar 

  • Michopoulos I, Zervas IM, Pantelis C et al (2008) Neuropsychological and hypothalamic-pituitary-axis function in female patients with melancholic and non-melancholic depression. Eur Arch Psychiatry Clin Neurosci 258:217–225

    Article  PubMed  Google Scholar 

  • Mirochnic S, Wolf S, Staufenbiel M et al (2009) Age effects on the regulation of adult hippocampal neurogenesis by physical activity and environmental enrichment in the APP23 mouse model of Alzheimer disease. Hippocampus 19:1008–1018

    Article  CAS  PubMed  Google Scholar 

  • Moffoot AP, O’carroll RE, Bennie J et al (1994) Diurnal variation of mood and neuropsychological function in major depression with melancholia. J Affect Disord 32:257–269

    Article  CAS  PubMed  Google Scholar 

  • Murphy FC, Michael A, Robbins TW et al (2003) Neuropsychological impairment in patients with major depressive disorder: the effects of feedback on task performance. Psychol Med 33:455–467

    Article  CAS  PubMed  Google Scholar 

  • Nadeau SE, Bowers D, Jones TL et al (2014) Cognitive effects of treatment of depression with repetitive transcranial magnetic stimulation. Cogn Behav Neurol 27:77–87

    Article  PubMed  Google Scholar 

  • Naismith SL, Redoblado-Hodge MA, Lewis SJ et al (2010) Cognitive training in affective disorders improves memory: a preliminary study using the NEAR approach. J Affect Disord 121:258–262

    Article  PubMed  Google Scholar 

  • Newberg AR, Davydow DS, Lee HB (2006) Cerebrovascular disease basis of depression: post-stroke depression and vascular depression. Int Rev Psychiatry 18:433–441

    Article  PubMed  Google Scholar 

  • Paizanis E, Hamon M, Lanfumey L (2007) Hippocampal neurogenesis, depressive disorders, and antidepressant therapy. Neural Plast 2007:73754

    PubMed  PubMed Central  Google Scholar 

  • Pálsson S, Johansson B, Berg S et al (2000) A population study on the influence of depression on neuropsychological functioning in 85-year-olds. Acta Psychiatr Scand 101:185–193

    Article  PubMed  Google Scholar 

  • Papakostas GI (2014) Cognitive symptoms in patients with major depressive disorder and their implications for clinical practice. J Clin Psychiatry 75:8–14

    Article  PubMed  Google Scholar 

  • Pehrson AL, Leiser SC, Gulinello M et al (2015) Treatment of cognitive dysfunction in major depressive disorder-a review of the preclinical evidence for efficacy of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors and the multimodal-acting antidepressant vortioxetine. Eur J Pharmacol 753:19–31

    Google Scholar 

  • Peretti S, Judge R, Hindmarch I (2000) Safety and tolerability considerations: tricyclic antidepressants vs. selective serotonin reuptake inhibitors. Acta Psychiatr Scand Suppl 403:17–25

    Article  CAS  PubMed  Google Scholar 

  • Philippot P, Brutoux F (2008) Induced rumination dampens executive processes in dysphoric young adults. J Behav Ther Exp Psychiatry 39:219–227

    Article  PubMed  Google Scholar 

  • Porter RJ, Bourke C, Gallagher P (2007) Neuropsychological impairment in major depression: its nature, origin and clinical significance. Aust N Z J Psychiatry 41:115–128

    Article  PubMed  Google Scholar 

  • Porterfield T, Cook M, Deary IJ et al (1997) Neuropsychological function and diurnal variation in depression. J Clin Exp Neuropsychol 19:906–913

    Article  CAS  PubMed  Google Scholar 

  • Post RM (1992) Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am J Psychiatry 149:999–1010

    Article  CAS  PubMed  Google Scholar 

  • Potter GG, Mcquoid DR, Steffens DC (2015) Appetite loss and neurocognitive deficits in late‐life depression. Int J Geriatr Psychiatry 30:647–654

    Google Scholar 

  • Preiss M, Shatil E, Čermáková R et al (2013) Personalized cognitive training in unipolar and bipolar disorder: a study of cognitive functioning. Front Hum Neurosci 7:108

    Article  PubMed  PubMed Central  Google Scholar 

  • Quinn C, Harris A, Kemp A (2012) The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. J Int Neuropsychol Soc 18:361–369

    Article  PubMed  Google Scholar 

  • Ramel W, Goldin PR, Carmona PE et al (2004) The effects of mindfulness meditation on cognitive processes and affect in patients with past depression. Cogn Ther Res 28:435–455

    Google Scholar 

  • Richard-Devantoy S, Jollant F, Kefi Z et al (2012) Deficit of cognitive inhibition in depressed elderly: a neurocognitive marker of suicidal risk. J Affect Disord 140:193–199

    Article  CAS  PubMed  Google Scholar 

  • Richards PM, Ruff RM (1989) Motivational effects on neuropsychological functioning: comparison of depressed versus nondepressed individuals. J Consult Clin Psychol 57:396–402

    Article  CAS  PubMed  Google Scholar 

  • Robinson RG, Spalletta G (2010) Poststroke depression: a review. Can J Psychiatry 55:341–349

    PubMed  PubMed Central  Google Scholar 

  • Robinson RG, Kubos KL, Starr LB et al (1984) Mood disorders in stroke patients: importance of location of lesion. Brain 107:81–93

    Article  PubMed  Google Scholar 

  • Roiser JP, Sahakian BJ (2013) Hot and cold cognition in depression. CNS Spectr 18:139–149

    Article  PubMed  Google Scholar 

  • Ros L, Aguilar MJ, Serrano JP et al (2013) Depression affects specifically executive functioning: new evidence from older population. Int J Geriatr Psychiatry 28:327–328

    Article  PubMed  Google Scholar 

  • Sarapas C, Shankman SA, Harrow M et al (2012) Parsing trait and state effects of depression severity on neurocognition: evidence from a 26-year longitudinal study. J Abnorm Psychol 121:830–837

    Article  PubMed  PubMed Central  Google Scholar 

  • Scheurich A, Fellgiebel A, Schermuly I et al (2008) Experimental evidence for a motivational origin of cognitive impairment in major depression. Psychol Med 38:237–246

    Article  CAS  PubMed  Google Scholar 

  • Shamay-Tsoory S, Harari H, Szepsenwol O et al (2009) Neuropsychological evidence of impaired cognitive empathy in euthymic bipolar disorder. J Neuropsychiatry Clin Neurosci 21:59–67

    Article  PubMed  Google Scholar 

  • Snyder HR (2013) Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol Bull 139:81–132

    Article  PubMed  Google Scholar 

  • Sotiropoulos I, Cerqueira JJ, Catania C et al (2008) Stress and glucocorticoid footprints in the brain-the path from depression to Alzheimer’s disease. Neurosci Biobehav Rev 32:1161–1173

    Article  CAS  PubMed  Google Scholar 

  • Steffens DC, Krishnan KR (1998) Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions. Biol Psychiatry 43:705–712

    Article  CAS  PubMed  Google Scholar 

  • Taylor Tavares JV, Clark L, Cannon DM et al (2007) Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression. Biol Psychiatry 62:917–924

    Article  PubMed  Google Scholar 

  • Thomas AJ, Gallagher P, Robinson LJ et al (2009) A comparison of neurocognitive impairment in younger and older adults with major depression. Psychol Med 39:725–733

    Article  CAS  PubMed  Google Scholar 

  • Torrent C, Martinez-Aran A, Daban C et al (2006) Cognitive impairment in bipolar II disorder. Br J Psychiatry 189:254–259

    Article  PubMed  Google Scholar 

  • Torrent C, Bonnin Cdel M, Martinez-Aran A et al (2013) Efficacy of functional remediation in bipolar disorder: a multicenter randomized controlled study. Am J Psychiatry 170:852–859

    Article  PubMed  Google Scholar 

  • Trebo E, Holzner B, Pircher M et al (2007) The effects of a computer assisted cognitive training on neuropsychological parameters, mood and dysfunctional cognitions in depressive patients. Neuropsychiatr: Klin Diagn Ther Rehabil: Organ Ges Osterreichischer Nervenarzte Psychiater 21:207–215

    Google Scholar 

  • Van Den Heuvel N, Smits CH, Deeg DJ et al (1996) Personality: a moderator of the relation between cognitive functioning and depression in adults aged 55–85? J Affect Disord 41:229–240

    Article  PubMed  Google Scholar 

  • Volkert J, Kopf J, Kazmaier J et al (2015) Evidence for cognitive subgroups in bipolar disorder and the influence of subclinical depression and sleep disturbances. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol 25:192–202

    Google Scholar 

  • Watkins E, Brown RG (2002) Rumination and executive function in depression: an experimental study. J Neurol Neurosurg Psychiatry 72:400–402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Westheide J, Quednow BB, Kuhn KU et al (2008) Executive performance of depressed suicide attempters: the role of suicidal ideation. Eur Arch Psychiatry Clin Neurosci 258:414–421

    Article  PubMed  Google Scholar 

  • Who (1991) ICD-10 Classification of mental and behavioral disorders with glossary and diagnostic criteria for research ICD-10: DCR-10. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Williams JM, Scott J (1988) Autobiographical memory in depression. Psychol Med 18:689–695

    Article  CAS  PubMed  Google Scholar 

  • Withall A, Harris LM, Cumming SR (2010) A longitudinal study of cognitive function in melancholic and non-melancholic subtypes of major depressive disorder. J Affect Disord 123:150–157

    Article  PubMed  Google Scholar 

  • Wolkenstein L, Plewnia C (2013) Amelioration of cognitive control in depression by transcranial direct current stimulation. Biol Psychiatry 73:646–651

    Article  PubMed  Google Scholar 

  • Yaffe K, Falvey CM, Hoang T (2014) Connections between sleep and cognition in older adults. Lancet Neurol 13:1017–1028

    Article  PubMed  Google Scholar 

  • Yoon KL, Lemoult J, Joormann J (2014) Updating emotional content in working memory: a depression-specific deficit? J Behav Ther Exp Psychiatry 45:368–374

    Article  PubMed  Google Scholar 

  • Young KD, Erickson K, Drevets WC (2012) Differential effects of emotionally versus neutrally cued autobiographical memories on performance of a subsequent cognitive task: effects of task difficulty. Front Psychol 3:299

    Article  PubMed  PubMed Central  Google Scholar 

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Beblo, T. (2016). Neuropsychological Impairment of Patients with Depression. In: Baune, B., Tully, P. (eds) Cardiovascular Diseases and Depression. Springer, Cham. https://doi.org/10.1007/978-3-319-32480-7_9

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