Abstract
The rheological properties of brushes of different length on the surface of human epithelial cancerous cells are studied here by means of coarse – grained numerical simulations, where the surface of the cell is subjected to an external oscillatory force acting on the plane of the cell’s surface. We model explicitly the tip of an atomic force microscope and the cancerous cell as a surface covered by brushes of different length, and take into account the interactions of the brush chains with the tip and with each other, leading to complex rheological behavior as displayed by the profiles of viscosity and the friction coefficient of this complex system. We comment briefly on how these findings can help in the experimental effort to understand the nature of the cancer growth in human epithelial cells.
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Acknowledgments
AGG would like to thank S.J. Alas, S. Hernández, J.L. Menchaca and I. Sokolov for helpful discussions. JDHV and AGG acknowledge also the hospitality of E. Pérez and the Polymer Group at the Instituto de Física (UASLP), where this work was conceived.
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Hernández Velázquez, J.D., Mejía-Rosales, S., Gama Goicochea, A. (2016). Rheological Properties of Brushes on Cancerous Epithelial Cells Under the Influence of an External Oscillatory Force. In: Gitler, I., Klapp, J. (eds) High Performance Computer Applications. ISUM 2015. Communications in Computer and Information Science, vol 595. Springer, Cham. https://doi.org/10.1007/978-3-319-32243-8_30
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DOI: https://doi.org/10.1007/978-3-319-32243-8_30
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