Abstract
The removal of infectious biofilms from tissues or implanted devices and their transmission through fluid transport systems depends in part of the mechanical properties of their polymeric matrix. Linking the various physical and chemical microscopic interactions to macroscopic deformation and failure modes promises to unveil design principles for novel therapeutic strategies targeting biofilm eradication, and provide a predictive capability to accelerate the development of devices, water lines, etc, that minimise microbial dispersal. Here, our current understanding of biofilm mechanics is appraised from the perspective of biophysics , with an emphasis on constitutive modelling that has been highly successful in soft matter. Fitting rheometric data to viscoelastic models has quantified linear and nonlinear stress relaxation mechanisms, how they vary between species and environments, and how candidate chemical treatments alter the mechanical response. The rich interplay between growth, mechanics and hydrodynamics is just becoming amenable to computational modelling and promises to provide unprecedented characterisation of infectious biofilms in their native state.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2008) Molecular biology of the cell, 5th edn. Garland
Alpkvist E, Klapper I (2007) Water Sci Tech 55:265
Alpkvist E, Picioreanu C, van Loosdrecht MCM, Heyden A (2006) Biotech Bioeng 94:961
Aggarwal S, Hozalski RM (2012) Langmuir 28:2812
Aggarwal S, Poppele EH, Hozalski RM (2010) Biotech Bioeng 105:924
Aravas N, Laspidou CS (2008) Biotech Bioeng 101:196
Balaban N (ed) (2008) Control of biofilm infections by signal manipulation. Springer, Berlin
Barnes HA, Hutton JF, Walters K (1989) An introduction to rheology. Elsevier
Basu A, Wen Q, Mao X, Lubensky TC, Janmey PA, Yodh AG (2011) Macromolecules 44:1671
Ben Amar M, Wu M (2014) Europhys Lett 108:38003
Blanco LP, Evans ML, Smith DR, Badtke MP, Chapman MR (2012) Trends Microbiol 20:66
Böl M, Möhle RB, Heasner M, Neu TR, Horn H, Krull R (2009) Biotech Bioeng 103:177
Brady RF, Singer IL (2000) Biofouling 15:73–81
Brindle ER, Miller DA, Stewart PS (2011) Biotech Bioeng 108:2968
Broedersz CP, MacKintosh FC (2014) Rev Mod Phys 86:995
Busscher HJ, van der Mei HC (2006) Clin Microbiol Rev 19:127–141
Chambless JD, Stewart PS (2007) Biotech Bioeng 97:1573
Chang HT, Rittmann BE, Amar D, Heim R, Ehlinger O, Lesty Y (1991) Biotech Bioeng 38:499
Chang S-W, Buehler MJ (2014) Mater Today 17:70
Cogan NG (2011) Int J Numer Meth Biomed Eng 27:1982
Coroneo M, Yoshihara L, Wall WA (2014) Biotech Bioeng 111:1385
Costerton JW (2007) The Biofilm Primer. Springer, Berlin
Davies DG (2011) Biofilm Highlights In: Flemming H-C, Wingender J, Szewzyk U (eds). Springer, Berlin
Dexter SC (1979) J Coll Int Sci 70:346–353
Doi M, Edwards S (1986) The theory of polymer dynamics. Oxford
Duddu R, Chopp DL, Moran B (2009) Biotech Bioeng 103:92
Dupin HJ, Kitanidis PK, McCarty PL (2001) Wat Res Res 37:2965
Eberl HJ, Sudarsan R (2008) J Theor Biol 253:788
Ehret AE, Böl M (2012) J Roy Soc Int 10:20120676
Espeso DR, Carpio A, Einarsson B (2015) Phys Rev E 91:022710
Evans RML, Tassieri M, Auhl D, Waigh TA (2009) Phys Rev E 80:012501
Fielding SM, Sollich P, Cates ME (2000) J Rheol 44:323
Flemming H-C, Wingender J (2010) Nat Rev Microbiol 8:623
Flemming H-C, Sriyutha Murthy P, Venkatesan R, Cooksey KE (eds) (2009) Marine and industrial biofouling. Springer, Berlin
Fu J, Wang Y-K, Yang MT, Desai RA, Yu X, Liu Z, Chen CC (2011) Nat Meth 7:733–736
Fux CA, Wilson S, Stoodley P (2004) J Bacteriol 186:4486
Galy O, Latour-Lambert P, Zrelli K, Ghigo J-M, Beloin C, Henry N (2012) Biophys J 103:1400
Gilkeson CA, Camargo-Valero MA, Pickin LE, Noakes CJ (2013) Build Env 65:35–48
Guélon T, Mathias J-D, Stoodley P (2011) Biofilm highlights In: Flemming H-C, Wingender J, Szewzyk U (eds). Springer, Berlin
Hall-Stoodley L, Costerton JW, Stoodley P (2004) Nat Rev Microbiol 2:95
He Y, Peterson BW, Jongsma MA, Ren Y, Sharma PK, Busscher HJ, can der Mei HC (2013) PLoS ONE 8:e63750
Hödl I, Mari L, Bertuzzo E, Suweis S, Besemer K, Rinaldo A, Battin TJ (2014) Env Microbiol 16:802
Hohne DN, Younger JG, Solomon MJ (2009) Langmuir 25:7743
Hogg S (2005) Essential microbiology. Wiley, Chichester
Houry A, Gohar M, Deschamps J, Tischenko E, Aymerich S, Gruss A, Briandet R (2012) Proc Nat Acad Sci 109:13088
Howlin RP, Fabbri S, Offin DG, Symonds N, Kiang KS, Knee RJ, Yoganantham DC, Webb JS, Birkin PR, Leighton TG, Stoodley P (2015) J Dent Res 94:1303
Huang Z, McLamore ES, Chuang HS, Zhang W, Werely S, Leon JLC, Banks MK (2013) Biotech Bioeng 110:525
Hwang G, Marsh G, Gao L, Waugh R, Koo H (2015) J Dent Res 94:1310
Katsikogianni MG, Missirlis YF (2010) Acta Biomater 6:1107–1118
Kim MK, Drescher K, Pak OS, Bassler BL, Stone HA (2014) New J Phys 16:065024
Klapper I, Dockery J (2006) Phys Rev E 74:031902
Knutson CE, Werth CJ, Valocchi AJ (2005) Wat Res Res 41:W07007
Landau LD, Lifshitz EM (1986) Theory of elasticity, 3rd edn. Butterworth-Heinemann
Lau PCY, Dutcher JR, Beveridge TJ, Lam JS (2009) Biophys J 96:2935
Lieleg O, Caldara M, Baumgärtel R, Ribbeck K (2011) Soft Matter 7:3307
Lin Y-C, Yao NY, Broedersz CP, Herrmann H, MacKintosh FC, Weitz DA (2010) Phys Rev Lett 104:058101
Marchetti MC, Joanny JF, Ramaswamy S, Liverpool TB, Prost J, Rao M, Simha RA (2013) Rev Mod Phys 85:1143
Marsh PD (1994) Adv Dent Res 8:263
Marsh PD, Martin MV (2009) Oral microbiology, 5th edn. Churchill-Livingstone
Marsh PD, Moter A, Devine D (2011) Perio 2000 55:16
Mason TG (2000) Rheol Acta 39:371
Mason TG, Weitz DA (1995) Phys Rev Lett 74:1250
McDougald D, Rice SA, Barraud N, Steinberg PD, Kjelleberg S (2012) Nat Rev Microbiol 10:39
Mizuno D, Head DA, MacKintosh FC, Schmidt CF (2008) Macromolecules 41:7194
Morse DC (1998) Macromolecules 31:7044
Ochoa J-O, Coufort C, Escudié R, Liné A, Paul E (2007) Chem Eng Sci 62:3672
Ogden RW (1984) Non-linear elastic deformations. Dover, New York
Paramonova E, de Jong ED, Krom BP, van der Mei HC, Busscher HJ, Sharma PK (2007) App Env Microbiol 73:7023
Pavlovsky L, Sturtevant RA, Younger JG, Solomon MJ (2015) Langmuir 31:2036
Pavlovsky L, Younger JG, Solomon MJ (2012) Soft Matter 9:122
Peterson BW, van der Mei HC, Sjollema J, Busscher HJ, Sharma PK (2013) mBio 4:e00497–13
Picioreanu C, van Loosdrecht MCM, Heijnen JJ (2001) Biotech. Bioeng. 72:205
Pritchard RH, Huang YYS, Terentjev EM (2014) Soft Matter 10:1864
Roberts D, Rochas C, Saiani A, Miller AF (2012) Langmuir 28:16196
Rodriguez D, Einarsson B, Carpio A (2012) Phys Rev E 86:061914
Rogers SS, van der Walle C, Waigh TA (2008) Langmuir 24:13549
Rombouts WH, Colomb-Delsuc M, Werten MWT, Otto S, de Wolf FA, van der Gucht J (2013) Soft Matter 9:6936
Rubinstein M, Colby RH (2003) Polymer physics. Oxford
Rupp CJ, Fux CA, Stoodley P (2005) App Env Microbiol 71:2175
Rusconi R, Lecuyer S, Autrusson N, Guglielmini L, Stone HA (2011) Biophys J 100:1392
Seminara A, Angelini TE, Wilking JN, Vlamikas H, Ebrahim S, Kolter R, Weitz DA, Brenner MP (2012) Proc Nat Acad Sci 109:1116
Shaw T, Winston M, Rupp CJ, Klapper I, Stoodley P (2004) Phys Rev Lett 93:098102
Shirtliff M, Leid J (2009) The role of biofilms in device-related infections. Springer, Berlin
Smith SB, Cui Y, Bustamante C (1996) Science 271:795
Song JL, Au KH, Huynh KT, Packman AI (2014) Biotech Bioeng 111:597
Song F, Koo H, Ren D (2015) J Dent Res 94:1027
Stewart PS (2012) Biofouling 28:187
Storm C, Pastore JL, MacKintosh FC, Lubensky TC, Janmey PA (2005) Nature 435:191
Stoodley P, Lewandowski Z, Boyle JD, Lappin-Scott HM (1999a) Env Microbiol 1:447
Stoodley P, Lewandowski Z, Boyle JD, Lappin-Scott HM (1999b) Biotech Bioeng 65:84
Szomolay B, Cogan NG (2015) Env Microbiol 17:1870–1883
Taherzadeh D, Picioreanu C, Horn H (2012) Biophys J 102:1483
Thullner M, Baveye P (2008) Biotech Bioeng 99:1337–1351
Tierra G, Pavissich JP, Nerenberg R, Xu Z, Alber MS (2015) J Roy Soc Interface 12:20150045
Towler BW, Cunningham A, Stoodley P, McKittrick L (2007) Biotech Bioeng 96:259
Tuson HH, Weibel DB (2013) Soft Matter 9:4368
Verkaik MJ, Busscher HJ, Rustema-Abbing M, Slomp AM, Abbas F, van der Mei HC (2010) Clin Oral Invest 14:403–409
Vo GD, Heys J (2011) Biotech Bioeng 108:1893
Vogt SJ, Sanderlin AB, Seymour JD, Codd SL (2013) Biotech Bioeng 110:1366
Walter JT et al (2004) Eur J Oral Sci 112:412–418
Weaver WM, Milisavljevic V, Miller JF, Di Carlo D (2012) App Env Microbiol 78:5890
Wilking JN, Angelini TE, Seminara A, Brenner MP, Weitz DA (2011) MRS Bull 36:385–391
Wilson M, Devine D (2003) Medical implications of biofilms. CUP, Cambridge
Wloka M, Rehage H, Flemming H-C, Wingender J (2004) Coll Poly Sci 282:1067
Xu Z, Meakin P, Tartakovsky A, Scheibe TD (2011) Phys Rev E 83:066702
Zrelli K, Galy O, Latour-Lambert P, Kirwan L, Ghigo JM, Beloin C, Henry N (2013) New J Phys 15:125026
Acknowledgment
DAH is funded by the Biomedical Health Research Centre, University of Leeds, UK.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Head, D. (2016). Biomechanical Analysis of Infectious Biofilms. In: Leake, M. (eds) Biophysics of Infection. Advances in Experimental Medicine and Biology, vol 915. Springer, Cham. https://doi.org/10.1007/978-3-319-32189-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-319-32189-9_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-32187-5
Online ISBN: 978-3-319-32189-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)