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Controversies in the Treatment of Infantile Haemangiomas with β-Blockers

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Practical Pediatric Dermatology

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Abstract

The management and therapy of infantile haemangioma (IH) have changed greatly over the years, especially after 2008 with the observation that propranolol, a non-selective β-blocker, influences IH growth and regression. Beta-blocking agents, in particular propranolol, are now widely used, both orally and topical. However, a uniform strategy is not yet available and currently a lot of patients with alarming and non-alarming IHs are being treated with different β-blockers, different dosages and different durations. Also management before and during treatment differs and side effects are not clear. We conclude that there are a lot of controversies in the treatment of IHs with β-blockers, and in this chapter, we discuss these controversies and substantiate these with the available evidence.

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Author information

Authors and Affiliations

  1. Department of Dermatology, Universitair Ziekenhuis Brussel (UZB), Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090, Brussels, Belgium

    Sherief R. Janmohamed MD, PhD, MHS, MSc

  2. Division of Dermatology, University Medicine Cluster, National University Hospital, Singapore, Singapore

    Nisha Suyien Chandran MRCP (UK)

  3. Department of Dermatology, Dermicis Skin Hospital – Alkmaar, Kinderhuid.nl – Rotterdam, Rotterdam, The Netherlands

    Arnold P. Oranje MD, PhD

Authors
  1. Sherief R. Janmohamed MD, PhD, MHS, MSc
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  2. Nisha Suyien Chandran MRCP (UK)
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  3. Arnold P. Oranje MD, PhD
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Correspondence to Arnold P. Oranje MD, PhD .

Editor information

Editors and Affiliations

  1. Rotterdam, The Netherlands

    Arnold P. Oranje

  2. Farwaniya, Kuwait

    Nawaf Al-Mutairi

  3. Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA

    Tor Shwayder

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Janmohamed, S.R., Chandran, N.S., Oranje, A.P. (2016). Controversies in the Treatment of Infantile Haemangiomas with β-Blockers. In: Oranje, A., Al-Mutairi, N., Shwayder, T. (eds) Practical Pediatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-32159-2_8

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  • DOI: https://doi.org/10.1007/978-3-319-32159-2_8

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