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Diagnosis and Management of Wound Infections

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Critical Limb Ischemia

Abstract

Wound infections represent a major cause of morbidity, amputations, and increased health-care costs in the US population. A primary risk factor for lower extremity wounds is diabetes. According to the Centers for Disease Control and Prevention, the number of Americans diagnosed with diabetes has skyrocketed in the past three decades: from 5.6 million in 1980 to 20.9 million in 2011. Consequently, the number of discharges during this same time period for lower extremity amputations and wound infections has also increased.

Infection of a skin ulcer in both diabetic and nondiabetic populations has been shown to lead to decreased healing, increased treatment costs, and increased morbidity for patients. Diabetic wound infections have been shown to increase the risk for hospitalization and lower extremity amputation by 55- and 150-fold, respectively (Lavery et al., Diabetes Res Clin Pract 83:347–352, 2009). Due to increasing rates of diabetes, increased obesity in the population, and a longer life span of patients with diabetes, it is expected that lower extremity wounds will become an increasingly burdensome public health problem in the coming years (Lipsky et al., Clin Infect Dis 54:e132–e173, 2012), and an understanding of the best methods for diagnosis and treatment of wound infections will become increasingly important for physicians involved in the care of these patients.

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Authors and Affiliations

  1. Department of Medicine, Section of Infectious Diseases, University of Illinois at Chicago, Chicago, IL, USA

    Alfredo J. Mena Lora MD

  2. Department of Medicine; Section of Infectious Diseases, Immunology, and International Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Jesica A. Herrick MD, MS

  3. Department of Internal Medicine, Jesse Brown VA, Chicago, IL, USA

    Bradley Recht MD

  4. Infectious Disease, Alexian Brothers Medical Center, Elk Grove Village, Chicago, IL, USA

    Ivette Murphy-Aguilu DO

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  1. Alfredo J. Mena Lora MD
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  4. Ivette Murphy-Aguilu DO
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Editors and Affiliations

  1. Loyola University Medical Center, Maywood, Illinois, USA

    Robert S. Dieter

  2. Northwestern Medicine Central DuPage Hospital, Glen Ellyn, Illinois, USA

    Raymond A. Dieter, Jr

  3. The University of Tennessee Medical Center, Knoxville, Tennessee, USA

    Raymond A. Dieter, III

  4. West Virginia University, Charleston, West Virginia, USA

    Aravinda Nanjundappa

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Lora, A.J.M., Herrick, J.A., Recht, B., Murphy-Aguilu, I. (2017). Diagnosis and Management of Wound Infections. In: Dieter, R., Dieter, Jr, R., Dieter, III, R., Nanjundappa, A. (eds) Critical Limb Ischemia. Springer, Cham. https://doi.org/10.1007/978-3-319-31991-9_46

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