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Basic Science of Wound Healing

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Book cover Critical Limb Ischemia

Abstract

Normally the process of wound healing is a highly complex but well-orchestrated sequence of cellular and biochemical events that results in the reestablishment of tissue integrity and function. As the metabolic activity at the site of tissue injury intensifies, there is a high demand for nutrients and oxygen to support the repair processes. Oxygen is required for the proper synthesis and assembly of collagen and other extracellular matrix elements. In contrast, in pathologic states such as diabetic, pressure, and venous stasis ulcers, there is a significant reduction in the availability of oxygen that results in chronic, non-healing wounds. The adverse ischemic microenvironment in these chronic ulcers drives an intense and prolonged inflammatory process resulting in extensive matrix destruction, infection, and a continuous non-healing state. Once the inflammation and infection are controlled, the oxygen supply can be restored to the ulcer site and tissue repair can proceed.

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Author information

Authors and Affiliations

  1. Surgery Department, Virginia Commonwealth University Medical Center, 1200 East Marshall Street, 980454, Richmond, VA, 23298, USA

    Stephanie R. Goldberg MD

  2. Biochemistry and Molecular Biology, Virginia Commonwealth University Medical Center, Richmond, VA, USA

    Robert F. Diegelmann PhD

Authors
  1. Stephanie R. Goldberg MD
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  2. Robert F. Diegelmann PhD
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Editor information

Editors and Affiliations

  1. Loyola University Medical Center, Maywood, Illinois, USA

    Robert S. Dieter

  2. Northwestern Medicine Central DuPage Hospital, Glen Ellyn, Illinois, USA

    Raymond A. Dieter, Jr

  3. The University of Tennessee Medical Center, Knoxville, Tennessee, USA

    Raymond A. Dieter, III

  4. West Virginia University, Charleston, West Virginia, USA

    Aravinda Nanjundappa

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Goldberg, S.R., Diegelmann, R.F. (2017). Basic Science of Wound Healing. In: Dieter, R., Dieter, Jr, R., Dieter, III, R., Nanjundappa, A. (eds) Critical Limb Ischemia. Springer, Cham. https://doi.org/10.1007/978-3-319-31991-9_14

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  • DOI: https://doi.org/10.1007/978-3-319-31991-9_14

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