Abstract
In this chapter, the ways in which cerebral autoregulation can be assessed through measurements of physiological parameters will be presented. The first work in this area dates from the 1940s and the following decades have seen very substantial progress made in the accuracy and repeatability of clinical measurement techniques in a variety of forms, leading towards very rich sources of data.
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Aaslid R (2006) Cerebral autoregulation and vasomotor reactivity. Front Neurol Neurosci 21:216–228
Aaslid R, Markwalder TM, Nornes H (1982) Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57(6):769–774
Al-Rawi PG, Smielewski P, Kirkpatrick PJ (2001) Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head. Stroke 32(11):2492–2500
Birch AA, Neil-Dwyer G, Murrills AJ (2002) The repeatability of cerebral autoregulation assessment using sinusoidal lower body negative pressure. Physiol Meas 23(1):73–83
Brown CM, Dütsch M, Hecht MJ, Neundörfer B, Hilz MJ (2003) Assessment of cerebrovascular and cardiovascular responses to lower body negative pressure as a test of cerebral autoregulation. J Neurol Sci 208(1–2):71–78
Brown CM, Dütsch M, Ohring S, Neundörfer B, Hilz MJ (2004) Cerebral autoregulation is compromised during simulated fluctuations in gravitational stress. Eur J Appl Physiol 91(2–3):279–286
Caicedo A, Naulaers G, Van Huffel S (2013) Preprocessing by means of subspace projections for continuous Cerebral Autoregulation assessment using NIRS. Conf Proc IEEE Eng Med Biol Soc 2013:2032–2035
Cavill G, Simpson EJ, Mahajan RP (1998) Factors affecting assessment of cerebral autoregulation using the transient hyperaemic response test. Br J Anaesth 81(3):317–321
Claassen JA, Levine BD, Zhang R (2009) Dynamic cerebral autoregulation during repeated squat-stand maneuvers. J Appl Physiol (1985) 106(1):153–160
de Boorder MJ, Hendrikse J, van der Grond J (2004) Phase-contrast magnetic resonance imaging measurements of cerebral autoregulation with a breath-hold challenge: a feasibility study. Stroke 35(6):1350–1354
de Jong DLK, van Spijker GJ, Hoedemaekers AWE, Meulenbroek OV, Claassen JAHR (2015) Measuring blood pressure oscillations in the MRI. In: Proceedings of the 5th international meeting of the cerebral autoregulation research network. Southampton, UK
de Smet D, Vanderhaegen J, Naulaers G, Van Huffel S (2010a) Optimization of the coherence measurement computed by means of the Welch averaged periodogram method for assessment of impaired cerebral autoregulation. Adv Exp Med Biol 662:163–168
de Smet D, Jacobs J, Ameye L, Vanderhaegen J, Naulaers G, Lemmers P, van Bel F, Wolf M, Van Huffel S (2010b) The partial coherence method for assessment of impaired cerebral autoregulation using near-infrared spectroscopy: potential and limitations. Adv Exp Med Biol 662:219–224
Delpy DT, Cope M (1997) Quantification in tissue near-infrared spectroscopy. Phil Trans R Soc Lond B 352:649–659
Duncan A, Meek JH, Clemence M, Elwell CE, Tyszczuk L, Cope M, Delpy D (1995) Optical pathlength measurements on adult head, calf and forearm and the head of the newborn infant using phase resolved optical spectroscopy. Phys Med Biol 40:295–304
Eames PJ, Potter JF, Panerai RB (2005) Assessment of cerebral autoregulation from ectopic heartbeats. Clin Sci (Lond) 109(1):109–115
Edwards AD, Wyatt JS, Richardson C, Delpy DT, Cope M, Reynolds EO (1988) Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy. Lancet 2(8614):770–771
Elting JW, Aries MJ, van der Hoeven JH, Vroomen PC, Maurits NM (2014) Reproducibility and variability of dynamic cerebral autoregulation during passive cyclic leg raising. Med Eng Phys 36(5):585–591
Germon TJ, Kane NM, Manara AR, Nelson RJ (1994) Near-infrared spectroscopy in adults: effects of extracranial ischaemia and intracranial hypoxia on estimation of cerebral oxygenation. Br J Anaesth 73(4):503–506
Giller CA (1991) A bedside test for cerebral autoregulation using transcranial Doppler ultrasound. Acta Neurochir (Wien) 108(1–2):7–14
Giller CA, Bowman G, Dyer H, Mootz L, Krippner W (1993) Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32(5):737–741; discussion 741–742
Gisolf J, Stok WJ, Oei SI, Immink RV, vanLieshout JJ, Karemaker JM (2002) Dynamic cerebral autoregulation under sinusoidal gravitational loading. J Gravit Physiol. 9(1):P85–P86
Horsfield MA, Jara JL, Saeed NP, Panerai RB, Robinson TG (2013) Regional differences in dynamic cerebral autoregulation in the healthy brain assessed by magnetic resonance imaging. PLoS ONE 8(4):e62588
Ingvar DH, Lassen NA (1965) Methods for cerebral blood flow measurements in man. Br J Anaesth 37:216–224
Jöbsis FF (1977) Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198(4323):1264–1267
Kainerstorfer JM, Sassaroli A, Tgavalekos KT, Fantini S (2015) Cerebral autoregulation in the microvasculature measured with near-infrared spectroscopy. J Cereb Blood Flow Metab 35(6):959–966
Katsogridakis E, Bush G, Fan L, Birch AA, Simpson DM, Allen R, Potter JF, Panerai RB (2012) Random perturbations of arterial blood pressure for the assessment of dynamic cerebral autoregulation. Physiol Meas 33(2):103–116
Katsogridakis E, Bush G, Fan L, Birch AA, Simpson DM, Allen R, Potter JF, Panerai RB (2013) Detection of impaired cerebral autoregulation improves by increasing arterial blood pressure variability. J Cereb Blood Flow Metab 33(4):519–523
Kazan SM (2009) DPhil thesis. University of Oxford
Kety SS, Schmidt CF (1948) The nitrous oxide method for the quantitative determination of cerebral blood flow in man: theory, procedure and normal values. J Clin Invest. 27(4):476–483
Kirkpatrick PJ, Smielewski P, Al-Rawi P, Czosnyka M (1998) Resolving extra- and intracranial signal changes during adult near infrared spectroscopy. Neurol Res 20(Suppl 1):S19–S22
Kontos HA (1989) Validity of cerebral arterial blood flow calculations from velocity measurements. Stroke 20(1):1–3
Lassen NA, Ingvar DH (1961) The blood flow of the cerebral cortex determined by radioactive krypton. Experientia 15(17):42–43
Lefthériotis G, Preckel MP, Fizanne L, Victor J, Dupuis JM, Saumet JL (1998) Effect of head-upright tilt on the dynamic of cerebral autoregulation. Clin Physiol 18(1):41–47
Liu J, Simpson DM, Allen R (2005) High spontaneous fluctuation in arterial blood pressure improves the assessment of cerebral autoregulation. Physiol Meas 26(5):725–741
Liu J, Zhu YS, Hill C, Armstrong K, Tarumi T, Hodics T, Hynan LS, Zhang R (2013) Cerebral autoregulation of blood velocity and volumetric flow during steady-state changes in arterial pressure. Hypertension 62(5):973–979
Lorenz M, Sterzer P, Sitzer M (2006) [Evaluation of different protocols for the leg cuff technique for measurement of dynamic cerebral autoregulation]. Ultraschall Med 27(4):368–373. German
Lorenz MW, Gonzalez M, Lienerth C, Loesel N, Thoelen N, Sitzer M (2007) Influence of temporal insonation window quality on the assessment of cerebral autoregulation with transcranial Doppler sonography. Ultrasound Med Biol 33(10):1540–1545
Lorenz MW, Thoelen N, Loesel N, Lienerth C, Gonzalez M, Humpich M, Roelz W, Dvorak F, Sitzer M (2008) Assessment of cerebral autoregulation with transcranial Doppler sonography in poor bone windows using constant infusion of an ultrasound contrast agent. Ultrasound Med Biol 34(3):345–353
Lorenz MW, Loesel N, Thoelen N, Gonzalez M, Lienerth C, Dvorak F, Rölz W, Humpich M, Sitzer M (2009) Effects of poor bone window on the assessment of cerebral autoregulation with transcranial Doppler sonography—a source of systematic bias and strategies to avoid it. J Neurol Sci 283(1–2):49–56
Mahajan RP, Cavill G, Simpson EJ (1998) Reliability of the transient hyperemic response test in detecting changes in cerebral autoregulation induced by the graded variations in end-tidal carbon dioxide. Anesth Analg 87(4):843–849
Mahony PJ, Panerai RB, Deverson ST, Hayes PD, Evans DH (2000) Assessment of the thigh cuff technique for measurement of dynamic cerebral autoregulation. Stroke 31(2):476–480
Müller HR, Casty M, Loeb J, Haefele M, Boccalini P (1992) [Assessment of cerebral autoregulation using transcranial Doppler sonography under lower body negative pressure]. Schweiz Rundsch Med Prax 81(51):1548–1554. German
Numan T, Bain AR, Hoiland RL, Smirl JD, Lewis NC, Ainslie PN (2014) Static autoregulation in humans: a review and reanalysis. Med Eng Phys 36(11):1487–1495
Ogoh S, Sato K, Fisher JP, Seifert T, Overgaard M, Secher NH (2011) The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects. Clin Physiol Funct Imag 31(6):445–451
Okell TW, Chappell MA, Kelly ME, Jezzard P (2013) Cerebral blood flow quantification using vessel-encoded arterial spin labeling. J Cereb Blood Flow Metab 33(11):1716–1724
Panerai RB (1998) Assessment of cerebral pressure-autoregulation in humans—a review of measurement methods. Physiol Meas 19:305–338
Panerai RB, Dawson SL, Eames PJ, Potter JF (2001) Cerebral blood flow velocity response to induced and spontaneous sudden changes in arterial blood pressure. Am J Physiol Heart Circ Physiol 280(5):H2162–H2174
Payne SJ, Mohammad J, Tisdall MM, Tachtsidis I (2011) Effects of arterial blood gas levels on cerebral blood flow and oxygen transport. Biomed Opt Express. 2(4):966–979
Petersen NH, Ortega-Gutierrez S, Reccius A, Masurkar A, Huang A, Marshall RS (2014) Comparison of non-invasive and invasive arterial blood pressure measurement for assessment of dynamic cerebral autoregulation. Neurocrit Care 20(1):60–68
Poulin MJ, Liang PJ, Robbins PA (1996) Dynamics of the cerebral blood flow response to step changes in end-tidal PCO2 and PO2 in humans. J Appl Physiol (1985) 81(3):1084–1095
Rosengarten B, Kaps M (2002) Cerebral autoregulation in middle cerebral artery territory precedes that of posterior cerebral artery in human cortex. Cerebrovasc Dis 13(1):21–25
Sammons EL, Samani NJ, Smith SM, Rathbone WE, Bentley S, Potter JF, Panerai RB (2007) Influence of noninvasive peripheral arterial blood pressure measurements on assessment of dynamic cerebral autoregulation. J Appl Physiol (1985) 103(1):369–375
Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL (2000) MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31(7):1672–1678
Smielewski P, Czosnyka M, Kirkpatrick P, McEroy H, Rutkowska H, Pickard JD (1996) Assessment of cerebral autoregulation using carotid artery compression. Stroke 27(12):2197–2203
Sommerlade L, Schelter B, Timmer J, Reinhard M (2012) Grading of dynamic cerebral autoregulation without blood pressure recordings: a simple Doppler-based method. Ultrasound Med Biol 38(9):1546–1551
Sorond FA, Serrador JM, Jones RN, Shaffer ML, Lipsitz LA (2009) The sit-to-stand technique for the measurement of dynamic cerebral autoregulation. Ultrasound Med Biol 35(1):21–29
Stewart JM, Medow MS, DelPozzi A, Messer ZR, Terilli C, Schwartz CE (2013) Middle cerebral O2 delivery during the modified Oxford maneuver increases with sodium nitroprusside and decreases during phenylephrine. Am J Physiol Heart Circ Physiol 304(11):H1576–H1583
Torizuka K, Hamamoto K, Morita R, Mukai T, Kosaka T, Handa J, Nishitani H (1971) Regional cerebral blood flow measurement with xenon 133 and the scinticamera. Am J Roentgenol Radium Ther Nucl Med. 112(4):691–700
Tzeng YC, Ainslie PN, Cooke WH, Peebles KC, Willie CK, MacRae BA, Smirl JD, Horsman HM, Rickards CA (2012) Assessment of cerebral autoregulation: the quandary of quantification. Am J Physiol Heart Circ Physiol 303(6):H658–H671
van Beek AH, Olde Rikkert MG, Pasman JW, Hopman MT, Claassen JA (2010) Dynamic cerebral autoregulation in the old using a repeated sit-stand maneuver. Ultrasound Med Biol 36(2):192–201
Verbree J, Bronzwaer AS, Ghariq E, Versluis MJ, Daemen MJ, van Buchem MA, Dahan A, van Lieshout JJ, van Osch MJ (2014) Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra-high-field MRI. J Appl Physiol (1985) 117(10):1084–1089
Wagner BP, Ammann RA, Bachmann DC, Born S, Schibler A (2011) Rapid assessment of cerebral autoregulation by near-infrared spectroscopy and a single dose of phenylephrine. Pediatr Res 69(5 Pt 1):436–441
Wagner M, Magerkurth J, Volz S, Jurcoane A, Singer OC, Neumann-Haefelin T, Zanella FE, Deichmann R, Hattingen E (2012) T2′- and PASL-based perfusion mapping at 3 Tesla: influence of oxygen-ventilation on cerebral autoregulation. J Magn Reson Imaging 36(6):1347–1352
Warnert EA, Murphy K, Hall JE, Wise RG (2015) Noninvasive assessment of arterial compliance of human cerebral arteries with short inversion time arterial spin labeling. J Cereb Blood Flow Metab 35(3):461–468
Willie CK, Macleod DB, Shaw AD, Smith KJ, Tzeng YC, Eves ND, Ikeda K, Graham J, Lewis NC, Day TA, Ainslie PN (2012) Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol 590(Pt 14):3261–3275
Wintermark M, Sesay M, Barbier E, Borbély K, Dillon WP, Eastwood JD, Glenn TC, Grandin CB, Pedraza S, Soustiel JF, Nariai T, Zaharchuk G, Caillé JM, Dousset V, Yonas H (2005) Comparative overview of brain perfusion imaging techniques. Stroke 36(9):e83–e99
Wolf ME (2015) Functional TCD: regulation of cerebral hemodynamics–cerebral autoregulation, vasomotor reactivity, and neurovascular coupling. Front Neurol Neurosci 36:40–56
Wyatt JS, Cope M, Delpy DT, Richardson CE, Edwards AD, Wray S, Reynolds EO (1990) Quantitation of cerebral blood volume in human infants by near-infrared spectroscopy. J Appl Physiol (1985) 68(3):1086–1091
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Payne, S. (2016). Measurement Techniques. In: Cerebral Autoregulation. SpringerBriefs in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-31784-7_2
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DOI: https://doi.org/10.1007/978-3-319-31784-7_2
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