Skip to main content

Rhenium: Coordination Chemistry and Radiopharmacy

  • Conference paper
  • First Online:
Crystallizing Ideas – The Role of Chemistry

Abstract

The interest in coordination chemistry of the metal rhenium is mainly due to the applications of its 186/188Re isotopes as therapeutic agents in nuclear medicine. In order to function as radiopharmaceuticals, stable complexes of this metal are required, and to this end the stable oxidation states +V (d2) and +I (d6) have received most attention. Our research results of the last few years on small molecules as ligands for rhenium in these oxidation states are reported here.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dilworth JR, Parrott SJ (1998) The biomedical chemistry of technetium and rhenium. Chem Soc Rev 27:43–55

    Article  CAS  Google Scholar 

  2. Jurisson S, Berning D, Jia W, Ma D (1993) Coordination compounds in nuclear medicine. Chem Rev 93:1137–1156

    Article  CAS  Google Scholar 

  3. Stagman I, Eckelman WC (1992) The chemistry of technetium in medicine. National Academy Press, Washington DC

    Google Scholar 

  4. Jurisson SS, Lydon JD (1999) Potential technetium small molecule radiopharmaceuticals. Chem Rev 99:2205–2218

    Article  CAS  Google Scholar 

  5. Fritzberg AR, Kasina S, Eshina D, Johnson DL (1986) Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med 27:111–116

    CAS  Google Scholar 

  6. Kung HF (2001) Development of Tc-99m labeled tropanes: TRODAT-1, as a dopamine transporter imaging agent. Nucl Med Biol 28:505–508

    Article  CAS  Google Scholar 

  7. Wester DW, Coveney JR, Nosco DL, Robbins MS, Dean RT (1991) Synthesis, characterization and myocardial uptake of cationic bis(arene)technetium(I) complexes. J Med Chem 34:3284–3290

    Article  CAS  Google Scholar 

  8. Dizio JP, Fiasschi R, Davison A, Jones AG, Katzenellenbogen JA (1991) Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential receptor-directed agents for diagnostic imaging or therapy. Bioconjug Chem 2:353–366

    Article  CAS  Google Scholar 

  9. Booysen I, Gerber TIA, Hosten E, Mayer P (2007) Monodentate imido coordination of 2-aminodiphenylamine to rhenium(V). J Coord Chem 60:1749–1753

    Article  CAS  Google Scholar 

  10. Gerber TIA, Betz R, Booysen IN, Potgieter KC, Mayer P (2011) Coordination of bidentate aniline derivatives to the fac-[Re(CO)3]+ core. Polyhedron 30:1739–1745

    Article  CAS  Google Scholar 

  11. Serdons K, Verduyckt T, Vanderghinste D, Borghgraef P, Cleynhens J, Van Leuven F, Kung H, Bormans G, Verbruggen A (2009) 11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid β in Alzheimer’s disease. Eur J Med Chem 44:1415–1426

    Article  CAS  Google Scholar 

  12. Oren I, Temiz P, Yalcin I, Sener E, Altanlar N (1998) Synthesis and antimicrobial activity of some novel 2,5- and/or 6-substituted benzoxazole and benzimidazole derivatives. Eur J Pharm Sci 7:153–160

    Article  Google Scholar 

  13. Booysen IN, Gerber TIA, Mayer P (2010) Reactions of the fac-[Re(CO)3]+ and [ReO]3+ moieties with substituted benzothiazoles. Inorg Chim Acta 363:1292–1296

    Article  CAS  Google Scholar 

  14. Booysen I, Gerber TIA, Mayer P (2008) A trigonal-bipyramidal oxorhenium(V) complex with a bidentate nitrogen-donor ligand. J Coord Chem 61:1525–1531

    Article  CAS  Google Scholar 

  15. Booysen I, Gerber TIA, Mayer P (2008) Unexpected formation of a new nitrosyl-rhenium(II) complex from oxorhenium(V). Inorg Chem Commun 11:461–464

    Article  CAS  Google Scholar 

  16. Couillens X, Gresier M, Turpin R, Darkguenave M, Coulias Y, Beauchamp AL (2002) Synthesis and characterisation of oxo- and phenylimido-rhenium(V) complexes containing bidentate phosphinoenolato ligands. J Chem Soc Dalton Trans 6:914–924

    Google Scholar 

  17. Booysen I, Gerber TIA, Hosten E, Mayer P (2007) Synthesis and characterization of a neutral rhenium(V) complex containing a tridentate chelate with an imido donor atom. J Coord Chem 60:1771–1776

    Article  CAS  Google Scholar 

  18. Booysen I, Gerber TIA, Hosten E, Luzipo D, Mayer P (2007) Synthesis and crystal structure of an oxorhenium(V) complex containing a tridentate imido-coordinated Schiff base. J Coord Chem 60:635–640

    Article  CAS  Google Scholar 

  19. Booysen I, Gerber TIA, Hosten E, Mayer P (2008) Synthesis and crystal structure of the first oxofree ‘3+3’ rhenium(V) complex. Inorg Chem Commun 11:33–35

    Article  CAS  Google Scholar 

  20. Abrahams A, Gerber TIA, Mayer P (2007) Synthesis and characterization of an oxo-bridged rhenium(V) complex with an amine-phenol tetradentate ligand. Bull Chem Soc Ethiop 21:83–88

    Article  CAS  Google Scholar 

  21. Gerber TIA, Luzipo D, Mayer P (2005) Different coordination modes of tetradentate Schiff bases in monomeric and dimeric oxorhenium(V) complexes. J Coord Chem 58:1505–1512

    Article  CAS  Google Scholar 

  22. Potgieter K, Mayer P, Gerber TIA, Booysen IN (2009) Coordination behaviour of the multidentate Schiff base 2,6-bis(2-hydroxyphenyliminomethyl)pyridine towards the fac-[Re(CO)3]+ and [ReO]3+ cores. Polyhedron 28:2808–2812

    Article  CAS  Google Scholar 

  23. Gerber TIA, Betz R, Booysen IN, Potgieter KC, Mayer P (2011) Coordination of bidentate aniline derivatives to the fac-[Re(CO)3]+ core. Polyhedron 30:1739–1745

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful to the Nelson Mandela Metropolitan University for financial support.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. I. A. Gerber .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this paper

Cite this paper

Gerber, T.I.A., Schoultz, X. (2016). Rhenium: Coordination Chemistry and Radiopharmacy. In: Ramasami, P., Gupta Bhowon, M., Jhaumeer Laulloo, S., Li Kam Wah, H. (eds) Crystallizing Ideas – The Role of Chemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-31759-5_3

Download citation

Publish with us

Policies and ethics