Abstract
In 2013, the Spanish Agency of Medicines blocked the varicella vaccine distribution based on a partial coverage of the vaccine that hypothetically could induce an increase of cases in adults: as non vaccinated children reach adulthood without having had contact with the virus in case the herd immunity stopped the virus circulation, or a hypothetical loss of vaccine protection in the long run. Also, this measure wanted to avoid increasing the number of cases of herpes zoster in adults. In this paper we develop a mathematical model to study the transmission dynamics of varicella in order to assess the impact of the partial coverage of the vaccination program. This is of paramount importance because, from the Public Health point of view, the herd immunity may be an undesirable effect of the partial vaccination due to that varicella and/or herpes zoster in adults use to be severe.
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Lin, F., Hadler, J.L.: Epidemiology of primary varicella and herpes zoster hospitalizations: the pre-varicella vaccine era. J. Infect. Dis. 181(6), 1897–1905 (2000)
Lenne, X., Díez Domingo, J., Gil, A., Ridao, M., Lluch, J.A., Dervaux, B.: Economic evaluation of varicella vaccination in Spain-Results from a dynamic model. Vaccine 24(47–48), 6980–6989 (2006). http://dx.doi.org/10.1016/j.vaccine.2006.04.051
Halloran, M.E.: Epidemiologic effects of varicella vaccination. Infect. Dis. Clin. North. Am. 10(3), 631–655 (1996)
New RSC Communicable and Respiratory Disease Report for England & Wales, 36/2014. http://www.rcgp.org.uk/clinical-and-research/~/media/Files/CIRC/Research-and-Surveillance-Centre/RSC%20-%20Week%2036%20-%202014/RSC%20RCGP%20Weekly%20Report%20Wk%2036%20_2014_FINAL%20VERSION.ashx
Varicella report bulletin of the Community of Valencia (2010). http://www.sp.san.gva.es/DgspPortal/docs/Inf_Varicela_2010.pdf
Varicella report bulletin of the Community of Valencia (2011). http://www.sp.san.gva.es/DgspPortal/docs/Inf_Varicela_2011.pdf
Varicella report bulletin of the Community of Valencia (2012). http://www.sp.san.gva.es/DgspPortal/docs/Inf_Varicela_2012.pdf
Varicella report bulletin of the Community of Valencia (2013). http://www.sp.san.gva.es/DgspPortal/docs/Inf_Varicela_2013.pdf
Varicella report bulletin of the Community of Valencia (2014). http://www.sp.san.gva.es/DgspPortal/docs/Inf_Varicela_2014.pdf
Statistic site of the Valencian Government. http://www.ive.es
Poletti, P., Melegaro, A., Ajelli, M., del Fava, E., Guzzetta, G., Faustini, L., Scalia Tomba, G., Lopalco, P., Rizzo, C., Merler, S., Manfredi, P.: Perspectives on the impact of varicella immunization on herpes zoster. A model-based evaluation from three European Countries. PLoS ONE 8(4), e60732 (2013). http://dx.doi.org/10.1371/journal.pone.0060732
Peña-Rey, I., Martínez de Aragón, M.V., Villaverde, A., Terres, M., Alcalde, E., Suárez, B.: Epidemiología de la Varicela en España en los períodos de pre- y post-vacunación. Rev. Esp. de Salud Pública 83, 711–724 (2009). http://scielo.isciii.es/pdf/resp/v83n5/original3.pdf
Wolfram Research, Inc., Mathematica, Version 10.1, Champaign, IL (2015). http://www.wolfram.com/mathematica
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Díez-Gandía, A., Villanueva, R.J., Moraño, J.A., Acedo, L., Mollar, J., Díez-Domingo, J. (2016). Studying the Herd Immunity Effect of the Varicella Vaccine in the Community of Valencia, Spain. In: Ortuño, F., Rojas, I. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2016. Lecture Notes in Computer Science(), vol 9656. Springer, Cham. https://doi.org/10.1007/978-3-319-31744-1_4
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DOI: https://doi.org/10.1007/978-3-319-31744-1_4
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