Skip to main content

Palliative Care in Chronic Illness and Multimorbidity

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Textbook of Palliative Care

Abstract

Extended chronic phases of life-limiting illness and increasing multimorbidity present growing challenges that require a new approach to healthcare. A population-based approach is needed to harmonize policies, systems, and services relating to chronic and palliative care. Partnerships are needed between different healthcare disciplines and specialties, and between health services and communities. Technology will likely play an increasingly important role in transferring real-time information (including advance care planning), delivering virtual clinical assessment and care, and strengthening care coordination. During periods of stability, people with chronic illness and their families should be actively involved in keeping well and helped to “prepare for the worst while hope for the best” to support sustained coping. A rapid response is needed to clinical events that helps people return to stability and optimal function, and institutes preventative action to reduce the risk of future clinical events wherever possible. Transitions between chronic and end of life phases of illness and different settings (community, residential, and hospital) need focal support to prevent people “falling through the gaps.” The optimal timing of referral to specialist palliative care services is the subject of ongoing debate and research, but there is consensus that referral should be based on need rather than on diagnosis. Consumer advocacy is likely to play an important role in raising awareness about the need for palliative care during the chronic phase of illness and advocating for appropriate resourcing, policy, and legislation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Abel J. How to build compassionate communities at the end of life. Compassionate Communities Symposium. Sydney; 2017.

    Google Scholar 

  • Abraham WT, Smith SA. Devices in the management of advanced, chronic heart failure. Nat Rev Cardiol. 2013;10(2):98–110.

    Article  PubMed  Google Scholar 

  • Agar M, Luckett T, Phillips J. Role of palliative care in survivorship. Cancer Forum. 2015;39(2):90–4.

    Google Scholar 

  • Allen Watts K, Malone E, Dionne-Odom JN, McCammon S, Currie E, Hicks J, Tucker RO, Wallace E, Elk R, Bakitas M. Can you hear me now?: improving palliative care access through telehealth. Res Nurs Health. 2021;44(1):226–37.

    Article  PubMed  Google Scholar 

  • Aulino F, Foley K. The project on death in America. J R Soc Med. 2001;94(9):492–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Australian Department of Health and Aged Care. Evaluation of the Health Care Homes trial – final evaluation report; 2022.

    Google Scholar 

  • Bandini JI, Scherling A, Farmer C, Fratkin M, Mistler B, Ast K, Ahluwalia SC. Experiences with telehealth for outpatient palliative care: findings from a mixed-methods study of patients and providers across the United States. J Palliat Med. 2022;25(7):1079–87.

    Article  PubMed  Google Scholar 

  • Batalden M, Batalden P, Margolis P, Seid M, Armstrong G, Opipari-Arrigan L, Hartung H. Coproduction of healthcare service. BMJ Qual Saf. 2016;25(7):509–17.

    Article  PubMed  Google Scholar 

  • Beernaert K, Deliens L, De Vleminck A, Devroey D, Pardon K, Block LV, Cohen J. Is there a need for early palliative Care in Patients with life-limiting illnesses? Interview study with patients about experienced care needs from diagnosis onward. Am J Hosp Palliat Care. 2016;33(5):489–97.

    Article  PubMed  Google Scholar 

  • Boyd K, Murray SA. Recognising and managing key transitions in end of life care. BMJ. 2010;341:c4863.

    Article  PubMed  Google Scholar 

  • Brannstrom M, Ekman I, Norberg A, Boman K, Strandberg G. Living with severe chronic heart failure in palliative advanced home care. Eur J Cardiovasc Nurs. 2006;5(4):295–302.

    Article  PubMed  Google Scholar 

  • Brown MM. Transitions of care. In: Daaleman TP, Helton MR, editors. Chronic illness care: principles and practice. Cham: Springer International Publishing; 2018. p. 369–73.

    Chapter  Google Scholar 

  • Burge F, Lawson B, Mitchell G. How to move to a palliative approach to care for people with multimorbidity. BMJ. 2012;345:e6324.

    Article  PubMed  Google Scholar 

  • Calam MJ, Gwynn A, Perkins P. The role of specialist palliative care in managing patients with multimorbidity. BMJ Support Palliat Care. 2012;2(1):48–50.

    Article  PubMed  Google Scholar 

  • Canadian Hospice Palliative Care Association. Integrating a palliative approach into the management of chronic, life-threatening diseases: who, how and when? Ottawa: CHPCA; 2013.

    Google Scholar 

  • Clayton JM, Hancock K, Parker S, Butow PN, Walder S, Carrick S, Currow D, Ghersi D, Glare P, Hagerty R, Olver IN, Tattersall MHN. Sustaining hope when communicating with terminally ill patients and their families: a systematic review. Psycho-Oncology. 2008;17(7):641–59.

    Article  PubMed  Google Scholar 

  • Cohen-Mansfield J, Skornick-Bouchbinder M, Brill S. Trajectories of end of life: a systematic review. J Gerontol Ser B. 2017;73(4):564–72.

    Article  Google Scholar 

  • Corbin J, Strauss A. Unending work and care: managing chronic illness at home. San Francisco: Jossey-Bass; 1988.

    Google Scholar 

  • Dasgupta I, Rayner HC. In good conscience – safely withholding dialysis in the elderly. Semin Dial. 2009;22(5):476–9.

    Article  PubMed  Google Scholar 

  • Davison SN, Simpson C. Hope and advance care planning in patients with end stage renal disease: qualitative interview study. BMJ. 2006;333(7574):886.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Groot V, Beckerman H, Lankhorst GJ, Bouter LM. How to measure comorbidity. A critical review of available methods. J Clin Epidemiol. 2003;56(3):221–9.

    Article  PubMed  Google Scholar 

  • Disalvo D, Agar M, Caplan G, Murtagh FE, Luckett T, Heneka N, Hickman L, Kinchin I, Trethewie S, Sheehan C, Urban K, Cohen J, Harlum J, Long B, Parker T, Schaefer I, Phillips J. Virtual models of care for people with palliative care needs living in their own home: a systematic meta-review and narrative synthesis. Palliat Med. 2021;35(8):1385–406.

    Article  PubMed  Google Scholar 

  • Dzingina MD, Higginson IJ. Public health and palliative care in 2015. Clin Geriatr Med. 2015;31(2):253–63.

    Article  PubMed  Google Scholar 

  • Feinstein AR. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis. 1970;23(7):455–68.

    Article  CAS  PubMed  Google Scholar 

  • Feuz C. Hoping for the best while preparing for the worst: a literature review of the role of Hope in palliative cancer patients. J Med Imaging Radiat Sci. 2012;43:168–74.

    Article  PubMed  Google Scholar 

  • Firkins J, Hansen L, Driessnack M, Dieckmann N. Quality of life in “chronic” cancer survivors: a meta-analysis. J Cancer Surviv. 2020;14(4):504–17.

    Article  PubMed  Google Scholar 

  • Flanagan S, Damery S, Combes G. The effectiveness of integrated care interventions in improving patient quality of life (QoL) for patients with chronic conditions. An overview of the systematic review evidence. Health Qual Life Outcomes. 2017;15(1):188.

    Article  PubMed  PubMed Central  Google Scholar 

  • Foley H, Steel A, Cramer H, Wardle J, Adams J. Disclosure of complementary medicine use to medical providers: a systematic review and meta-analysis. Sci Rep. 2019;9(1):1573.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Forbat L, Liu WM, Koerner J, Lam L, Samara J, Chapman M, Johnston N. Reducing time in acute hospitals: a stepped-wedge randomised control trial of a specialist palliative care intervention in residential care homes. Palliat Med. 2020;34(5):571–9.

    Article  PubMed  Google Scholar 

  • Ganesh K, Massagué J. Targeting metastatic cancer. Nat Med. 2021;27(1):34–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Glare PA, Virik K. Can we do better in end-of-life care? The mixed management model and palliative care. Med J Aust. 2001;175(10):530–3.

    Article  CAS  PubMed  Google Scholar 

  • Goodman C, Dening T, Gordon AL, Davies SL, Meyer J, Martin FC, Gladman JR, Bowman C, Victor C, Handley M, Gage H, Iliffe S, Zubair M. Effective health care for older people living and dying in care homes: a realist review. BMC Health Serv Res. 2016;16(1):269.

    Article  PubMed  PubMed Central  Google Scholar 

  • Groth T, Stegmayr BG, Ash SR, Kuchinka J, Wieringa FP, Fissell WH, Roy S. Wearable and implantable artificial kidney devices for end-stage kidney disease treatment – current status and review. Artif Organs 2022; 47(4):649–666.

    Google Scholar 

  • Gunn KM, Skrabal Ross X, McLoughlin M, McDonald S, Olver I. The psychosocial experiences and supportive care preferences of organ transplant recipients and their carers who live in regional Australia. Aust J Rural Health. 2021;29(1):92–105.

    Article  PubMed  Google Scholar 

  • Hajat C, Stein E. The global burden of multiple chronic conditions: a narrative review. Prev Med Rep. 2018;12:284–93.

    Article  PubMed  PubMed Central  Google Scholar 

  • Harley C, Pini S, Bartlett YK, Velikova G. Defining chronic cancer: patient experiences and self-management needs. BMJ Support Palliat Care. 2015;5(4):343–50.

    Article  PubMed  Google Scholar 

  • Huber MT, Highland JD, Krishnamoorthi VR, Tang JW-Y. Utilizing the electronic health record to improve advance care planning: a systematic review. Am J Hosp Palliat Med®. 2018;35(3):532–41.

    Article  Google Scholar 

  • Hudon C, Chouinard M-C, Pluye P, El Sherif R, Bush PL, Rihoux B, Poitras M-E, Lambert M, Zomahoun HTV, Légaré F. Characteristics of case management in primary care associated with positive outcomes for frequent users of health care: a systematic review. Ann Family Med. 2019;17(5):448–58.

    Article  Google Scholar 

  • Institute of Medicine. Living well with chronic illness: a call for public health action. Washington, DC: The National Academies Press; 2012.

    Google Scholar 

  • Johnston MC, Crilly M, Black C, Prescott GJ, Mercer SW. Defining and measuring multimorbidity: a systematic review of systematic reviews. Eur J Pub Health. 2018;29(1):182–9.

    Article  Google Scholar 

  • Kinch Westerdahl A, Sjöblom J, Mattiasson A-C, Rosenqvist M, Frykman V. Implantable cardioverter-defibrillator therapy before death: high risk for painful shocks at end of life. Circulation. 2014;129(4):422–9.

    Article  PubMed  Google Scholar 

  • Kochovska S, Luckett T, Agar M, Phillips JL. Impacts on employment, finances, and lifestyle for working age people facing an expected premature death: a systematic review. Palliat Support Care. 2018;16(3):347–64.

    Article  PubMed  Google Scholar 

  • Kochovska S, Ferreira DH, Luckett T, Phillips JL, Currow DC. Earlier multidisciplinary palliative care intervention for people with lung cancer: a systematic review and meta-analysis. Transl Lung Cancer Res. 2020;9(4):1699–709.

    Article  PubMed  PubMed Central  Google Scholar 

  • Larson AM, Curtis JR. Integrating palliative care for liver transplant candidates: “too well for transplant, too sick for life”. JAMA. 2006;295(18):2168–76.

    Article  CAS  PubMed  Google Scholar 

  • Lorig KR, Holman H. Self-management education: history, definition, outcomes, and mechanisms. Ann Behav Med. 2003;26(1):1–7.

    Article  PubMed  Google Scholar 

  • Luckett T, Davidson PM, Green A, Boyle F, Stubbs J, Lovell M. Assessment and management of adult cancer pain: a systematic review and synthesis of recent qualitative studies aimed at developing insights for managing barriers and optimizing facilitators within a comprehensive framework of patient care. J Pain Symptom Manag. 2013;46(2):229–53.

    Article  Google Scholar 

  • Luckett T, Sellars M, Tieman J, Pollock CA, Silvester W, Butow PN, Detering KM, Brennan F, Clayton JM. Advance care planning for adults with CKD: a systematic integrative review. Am J Kidney Dis. 2014;63(5):761–70.

    Article  PubMed  Google Scholar 

  • Lunney JR, Lynn J, Hogan C. Profiles of older medicare decedents. J Am Geriatr Soc. 2002;50(6):1108–12.

    Article  PubMed  Google Scholar 

  • Maciasz RM, Arnold RM, Chu E, Park SY, White DB, Vater LB, Schenker Y. Does it matter what you call it? A randomized trial of language used to describe palliative care services. Support Care Cancer. 2013;21(12):3411–9.

    Article  CAS  PubMed  Google Scholar 

  • Marks R, Allegrante JP, Lorig K. A review and synthesis of research evidence for self-efficacy-enhancing interventions for reducing chronic disability: implications for health education practice (part II). Health Promot Pract. 2005;6(2):148–56.

    Article  PubMed  Google Scholar 

  • Mason B, Nanton V, Epiphaniou E, Murray SA, Donaldson A, Shipman C, Daveson BA, Harding R, Higginson IJ, Munday D, Barclay S, Dale J, Kendall M, Worth A, Boyd K. ‘My body’s falling apart.’ Understanding the experiences of patients with advanced multimorbidity to improve care: serial interviews with patients and carers. BMJ Support Palliat Care. 2016;6(1):60–5.

    Article  PubMed  Google Scholar 

  • Matarese M, Lommi M, De Marinis MG, Riegel B. A systematic review and integration of concept analyses of self-care and related concepts. J Nurs Scholarsh. 2018;50(3):296–305.

    Article  PubMed  Google Scholar 

  • May P, Garrido MM, Cassel JB, Kelley AS, Meier DE, Normand C, Stefanis L, Smith TJ, Morrison RS. Palliative care Teams’ cost-saving effect is larger for cancer patients with higher numbers of comorbidities. Health Aff (Millwood). 2016;35(1):44–53.

    Article  PubMed  Google Scholar 

  • McCorkle R, Ercolano E, Lazenby M, Schulman-Green D, Schilling LS, Lorig K, Wagner EH. Self-management: enabling and empowering patients living with cancer as a chronic illness. CA Cancer J Clin. 2011;61(1):50–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mendes A. Demedicalising the cardiac patient. Br J Card Nurs. 2015;10:577.

    Article  Google Scholar 

  • Molina EH, Rosete AÁ, Flores SL, Uruena TP. Integrated palliative and end-of-life care. Handbook integrated care. Springer; 2021. p. 733–745.

    Google Scholar 

  • Murray SA, Kendall M, Boyd K, Sheikh A. Illness trajectories and palliative care. BMJ Br Med J. 2005;330(7498):1007–11.

    Article  Google Scholar 

  • Murray MA, Fiset V, Young S, Kryworuchko J. Where the dying live: a systematic review of determinants of place of end-of-life cancer care. Oncol Nurs Forum. 2009;36(1):69–77.

    Article  PubMed  Google Scholar 

  • National Gold Standards Framework. The Gold Standards Framework Proactive Identification Guidance (PIG). 2016, from. https://www.goldstandardsframework.org.uk/cd-content/uploads/files/PIG/NEW%20PIG%20-%20%20%2020.1.17%20KT%20vs17.pdf

  • National Institute for Health and Care Excellence. Multimorbidity: clinical assessment and management – nice.org.uk/guidance/ng56. London: NICE; 2016.

  • Nguyen H, Manolova G, Daskalopoulou C, Vitoratou S, Prince M, Prina AM. Prevalence of multimorbidity in community settings: a systematic review and meta-analysis of observational studies. J Comorb. 2019;9:2235042X19870934.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ohman M, Soderberg S, Lundman B. Hovering between suffering and enduring: the meaning of living with serious chronic illness. Qual Health Res. 2003;13(4):528–42.

    Article  PubMed  Google Scholar 

  • Oliver-Baxter J, Bywood P, Brown L. Integrated care: what policies support and influence integration in health care across New Zealand, England, Canada and the United States? PHCRIS Policy Issue Review. Adelaide, Primary Health Care Research & Information Service; 2013.

    Google Scholar 

  • Palliative Care Australia. Palliative care service development guidelines. Melbourne; 2018.

    Google Scholar 

  • Pask S, Pinto C, Bristowe K, van Vliet L, Nicholson C, Evans CJ, George R, Bailey K, Davies JM, Guo P, Daveson BA, Higginson IJ, Murtagh FEM. A framework for complexity in palliative care: a qualitative study with patients, family carers and professionals. Palliat Med. 2018;32(6):1078–90.

    Article  PubMed  Google Scholar 

  • Patel P, Lyons L. Examining the knowledge, awareness, and perceptions of palliative care in the general public over time: a scoping literature review. Am J Hosp Palliat Med®. 2020;37(6):481–7.

    Article  Google Scholar 

  • Patinadan PV, Tan-Ho G, Choo PY, Ho AHY. Resolving anticipatory grief and enhancing dignity at the end-of life: a systematic review of palliative interventions. Death Stud. 2022;46(2):337–50.

    Article  PubMed  Google Scholar 

  • Petrillo LA, Ritchie CS. The challenges of symptom management for patients with multimorbidity in research and practice: a thematic review. Prog Palliat Care. 2016;24:262–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Phillips JL, Currow DC. Cancer as a chronic disease. Collegian. 2010;17:47–50.

    Article  PubMed  Google Scholar 

  • Price M, Bellwood P, Kitson N, Davies I, Weber J, Lau F. Conditions potentially sensitive to a personal health record (PHR) intervention, a systematic review. BMC Med Inform Decis Mak. 2015;15:32.

    Article  PubMed  PubMed Central  Google Scholar 

  • Reeve E, Thompson W, Farrell B. Deprescribing: a narrative review of the evidence and practical recommendations for recognizing opportunities and taking action. Eur J Intern Med. 2017;38:3–11.

    Article  PubMed  Google Scholar 

  • Roychowdhury S, Chinnaiyan AM. Translating cancer genomes and transcriptomes for precision oncology. CA Cancer J Clin. 2016;66(1):75–88.

    Article  PubMed  Google Scholar 

  • Sallnow L, Richardson H, Murray SA, Kellehear A. The impact of a new public health approach to end-of-life care: a systematic review. Palliat Med. 2016;30(3):200–11.

    Article  PubMed  Google Scholar 

  • Sanders C, Rogers A, Gately C, Kennedy A. Planning for end of life care within lay-led chronic illness self-management training: the significance of ‘death awareness’ and biographical context in participant accounts. Soc Sci Med. 2008;66(4):982–93.

    Article  PubMed  Google Scholar 

  • Sepulveda CM, Yoshida A, Ulrich T. Palliative care: the World Health Organisation’s global perspective. J Pain Symptom Manag. 2002;24:91–6.

    Article  Google Scholar 

  • Shen Z, Ruan Q, Yu Z, Sun Z. Chronic kidney disease-related physical frailty and cognitive impairment: a systemic review. Geriatr Gerontol Int. 2016;17(4):529–44.

    Article  PubMed  Google Scholar 

  • Smith SM, Wallace E, Clyne B, Boland F, Fortin M. Interventions for improving outcomes in patients with multimorbidity in primary care and community setting: a systematic review. Syst Rev. 2021;10(1):271.

    Article  PubMed  PubMed Central  Google Scholar 

  • Soliman A, Akgün K, Coffee J, Kapo J, Morrison L, Blatt L, Schulman-Green D, Feder S. The quality of telehealth-delivered palliative care during the initial COVID-19 pandemic surge (S530). J Pain Symptom Manag. 2022;63(5):921–2.

    Article  Google Scholar 

  • Stokes J, Guthrie B, Mercer SW, Rice N, Sutton M. Multimorbidity combinations, costs of hospital care and potentially preventable emergency admissions in England: a cohort study. PLoS Med. 2021;18(1):e1003514.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stromberg A, Fluur C, Miller J, Chung ML, Moser DK, Thylen I. ICD recipients’ understanding of ethical issues, ICD function, and practical consequences of withdrawing the ICD in the end-of-life. Pacing Clin Electrophysiol. 2014;37(7):834–42.

    Article  PubMed  Google Scholar 

  • Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733–42.

    Article  CAS  PubMed  Google Scholar 

  • Thorne S, Roberts D, Sawatzky R. Unravelling the tensions between chronic disease management and end-of-life planning. Res Theory Nurs Pract. 2016;30(2):91–103.

    Article  PubMed  Google Scholar 

  • Verbrugge LM, Lepkowski JM, Imanaka Y. Comorbidity and its impact on disability. Milbank Q. 1989;67(3–4):450–84.

    Article  CAS  PubMed  Google Scholar 

  • Vernon E, Hughes MC, Kowalczyk M. Measuring effectiveness in community-based palliative care programs: a systematic review. Soc Sci Med. 2022;296:114731.

    Article  PubMed  Google Scholar 

  • Wordingham SE, Swetz KM. Palliative care issues in advanced cardiac disease. In: Ethical issues in cardiovascular medicine. Routledge; 2021. p. 61–79.

    Chapter  Google Scholar 

  • World Health Organization. WHO definition of palliative care. 2013. Retrieved February 22, 2017, from http://www.who.int/cancer/palliative/definition/en/

  • World Health Organization. Continuity and coordination of care: a practice brief to support implementation of the WHO Framework on integrated people-centred health services. Madrid: WHO; 2018.

    Google Scholar 

  • World Health Organization. Global Health estimates 2019: deaths by cause, age, sex, by country and by region, 2000–2019. Geneva: WHO; 2020.

    Google Scholar 

  • World Health Organization (WHO). Innovative Care for chronic conditions: building blocks for action. Geneva: WHO; 2002.

    Google Scholar 

  • Zafar SY, Peppercorn JM, Schrag D, Taylor DH, Goetzinger AM, Zhong X, Abernethy AP. The financial toxicity of cancer treatment: a pilot study assessing out-of-pocket expenses and the insured cancer patient’s experience. Oncologist. 2013;18(4):381–90.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tim Luckett .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Luckett, T., Agar, M., Phillips, J. (2023). Palliative Care in Chronic Illness and Multimorbidity. In: MacLeod, R.D., Van den Block, L. (eds) Textbook of Palliative Care. Springer, Cham. https://doi.org/10.1007/978-3-319-31738-0_64-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31738-0_64-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31738-0

  • Online ISBN: 978-3-319-31738-0

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Palliative Care in Chronic Illness and Multimorbidity
    Published:
    27 October 2023

    DOI: https://doi.org/10.1007/978-3-319-31738-0_64-2

  2. Original

    Palliative Care in Chronic Illness and Multimorbidity
    Published:
    11 January 2018

    DOI: https://doi.org/10.1007/978-3-319-31738-0_64-1