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Neuroimaging Studies of Bipolar Depression: Therapeutic Implications

  • Jonathan SavitzEmail author
  • Harvey M. Morris
  • Wayne C. Drevets
Chapter
Part of the Milestones in Drug Therapy book series (MDT)

Abstract

Bipolar disorder (BD) is characterized by pathophysiological changes to the visceromotor network, disrupting the regulation of endocrine and autonomic responses to stress and, hence, emotion and behavior. Specifically, reductions in gray matter volume and/or cortical thickness and a concomitant increase in glutamatergic neurotransmission are observed in the pregenual (pgACC) and subgenual anterior cingulate cortex (sgACC); the orbitofrontal, frontal polar, and ventrolateral prefrontal cortex (PFC); and the posterior cingulate, ventral striatum, and hippocampus. Neuroreceptor imaging data provide preliminary evidence for serotonin, serotonin transporter (5-HTT), dopamine receptor, and cholinergic system dysfunction in BD. Recent PET imaging data also suggest microglial cell activation in mood disorders. Oft-reported abnormalities of the deep frontal and basal ganglia white matter, and enlargement of the third and lateral ventricles are likely associated with cerebrovascular disease. Mood stabilizers and antidepressant drugs may attenuate pathological limbic activity, increase neurotrophic processes, and decrease inflammation, restoring balance to the system.

Keywords

Bipolar disorder (BD) Neuroimaging Amygdala Hippocampus Prefrontal cortex Glutamate 

References

  1. Abdallah CG, Sanacora G, Duman RS, Krystal JH (2015) Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics. Annu Rev Med 66:509–523PubMedCrossRefGoogle Scholar
  2. Adler CM, Holland SK, Schmithorst V, Wilke M, Weiss KL, Pan H, Strakowski SM (2004) Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 6(3):197–203PubMedCrossRefGoogle Scholar
  3. Ahearn EP, Steffens DC, Cassidy F, Van Meter SA, Provenzale JM, Seldin MF, Weisler RH, Krishnan KR (1998) Familial leukoencephalopathy in bipolar disorder. Am J Psychiatry 155(11):1605–1607PubMedCrossRefGoogle Scholar
  4. Alonso G (2000) Prolonged corticosterone treatment of adult rats inhibits the proliferation of oligodendrocyte progenitors present throughout white and gray matter regions of the brain. Glia 31(3):219–231PubMedCrossRefGoogle Scholar
  5. Altshuler LL, Bartzokis G, Grieder T, Curran J, Jimenez T, Leight K, Wilkins J, Gerner R, Mintz J (2000) An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biol Psychiatry 48(2):147–162PubMedCrossRefGoogle Scholar
  6. Anand A, Verhoeff P, Seneca N, Zoghbi SS, Seibyl JP, Charney DS, Innis RB (2000) Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am J Psychiatry 157(7):1108–1114PubMedCrossRefGoogle Scholar
  7. Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK (2011) Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13(4):406–413PubMedCrossRefGoogle Scholar
  8. Anstey KJ, Jorm AF, Reglade-Meslin C, Maller J, Kumar R, von Sanden C, Windsor TD, Rodgers B, Wen W, Sachdev P (2006) Weekly alcohol consumption, brain atrophy, and white matter hyperintensities in a community-based sample aged 60 to 64 years. Psychosom Med 68(5):778–785PubMedCrossRefGoogle Scholar
  9. Aston C, Jiang L, Sokolov BP (2005) Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Mol Psychiatry 10(3):309–322PubMedCrossRefGoogle Scholar
  10. Banasr M, Duman RS (2008) Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol Psychiatry 64(10):863–870PubMedPubMedCentralCrossRefGoogle Scholar
  11. Banasr M, Hery M, Printemps R, Daszuta A (2004) Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology 29(3):450–460PubMedCrossRefGoogle Scholar
  12. Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G (2010) Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry 15(5):501–511PubMedCrossRefGoogle Scholar
  13. Barton DA, Esler MD, Dawood T, Lambert EA, Haikerwal D, Brenchley C, Socratous F, Hastings J, Guo L, Wiesner G, Kaye DM, Bayles R, Schlaich MP, Lambert GW (2008) Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy. Arch Gen Psychiatry 65(1):38–46PubMedCrossRefGoogle Scholar
  14. Barysheva M, Jahanshad N, Foland-Ross L, Altshuler LL, Thompson PM (2013) White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study. Neuroimage Clin 2:558–568PubMedPubMedCentralCrossRefGoogle Scholar
  15. Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL, Mandelkern MA, Bramen J, Voytek B, Woods R, Mazziotta JC, Whybrow PC (2005) Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry 10(5):456–469PubMedCrossRefGoogle Scholar
  16. Baumann B, Danos P, Krell D, Diekmann S, Leschinger A, Stauch R, Wurthmann C, Bernstein HG, Bogerts B (1999) Reduced volume of limbic system-affiliated basal ganglia in mood disorders: preliminary data from a postmortem study. J Neuropsychiatry Clin Neurosci 11(1):71–78PubMedCrossRefGoogle Scholar
  17. Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, Trakhtenbroit M, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Soares JC (2007) Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry 62:7–16PubMedPubMedCentralCrossRefGoogle Scholar
  18. Benes FM, Vincent SL, Todtenkopf M (2001) The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects. Biol Psychiatry 50(6):395–406PubMedCrossRefGoogle Scholar
  19. Benson BE, Carson RE, Kiesewetter DO, Herscovitch P, Eckelman WC, Post RM, Ketter TA (2004) A potential cholinergic mechanism of procaine’s limbic activation. Neuropsycho pharmacology 29:1239–1250Google Scholar
  20. Beyer JL, Kuchibhatla M, Payne ME, Moo-Young M, Cassidy F, Macfall J, Krishnan KR (2004) Hippocampal volume measurement in older adults with bipolar disorder. Am J Geriatr Psychiatry 12(6):613–620PubMedCrossRefGoogle Scholar
  21. Bhagwagar Z, Rabiner EA, Sargent PA, Grasby PM, Cowen PJ (2004) Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635. Mol Psychiatry 9(4):386–392PubMedCrossRefGoogle Scholar
  22. Biegon A, Essar N, Israeli M, Elizur A, Bruch S, Bar-Nathan AA (1990) Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Psychopharmacology (Berl) 102(1):73–75CrossRefGoogle Scholar
  23. Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, Emmerich S, Dhawan V, Eidelberg D, Kocsis JH, Silbersweig DA (1999) Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry 156(12):1986–1988PubMedGoogle Scholar
  24. Boehmer C, Palmada M, Rajamanickam J, Schniepp R, Amara S, Lang F (2006) Post-translational regulation of EAAT2 function by co-expressed ubiquitin ligase Nedd4-2 is impacted by SGK kinases. J Neurochem 97(4):911–921PubMedCrossRefGoogle Scholar
  25. Boileau I, Warsh JJ, Guttman M, Saint-Cyr JA, McCluskey T, Rusjan P, Houle S, Wilson AA, Meyer JH, Kish SJ (2008) Elevated serotonin transporter binding in depressed patients with Parkinson’s disease: a preliminary PET study with [11C]DASB. Mov Disord 23(12):1776–1780PubMedCrossRefGoogle Scholar
  26. Boldrini M, Underwood MD, Mann JJ, Arango V (2008) Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res 42(6):433–442PubMedCrossRefGoogle Scholar
  27. Bonanno G, Giambelli R, Raiteri L, Tiraboschi E, Zappettini S, Musazzi L, Raiteri M, Racagni G, Popoli M (2005) Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus. J Neurosci 25(13):3270–3279PubMedCrossRefGoogle Scholar
  28. Botteron KN, Vannier MW, Geller B, Todd RD, Lee BC (1995) Preliminary study of magnetic resonance imaging characteristics in 8- to 16-year-olds with mania. J Am Acad Child Adolesc Psychiatry 34(6):742–749PubMedCrossRefGoogle Scholar
  29. Botteron KN, Raichle ME, Drevets WC, Heath AC, Todd RD (2002) Volumetric reduction in left subgenual prefrontal cortex in early onset depression. Biol Psychiatry 51(4):342–344PubMedCrossRefGoogle Scholar
  30. Bowen DM, Najlerahim A, Procter AW, Francis PT, Murphy E (1989) Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life. Proc Natl Acad Sci USA 86(23):9504–9508PubMedPubMedCentralCrossRefGoogle Scholar
  31. Bowley MP, Drevets WC, Ongur D, Price JL (2002) Low glial numbers in the amygdala in major depressive disorder. Biol Psychiatry 52(5):404–412PubMedCrossRefGoogle Scholar
  32. Boycott HE, Wilkinson JA, Boyle JP, Pearson HA, Peers C (2008) Differential involvement of TNF alpha in hypoxic suppression of astrocyte glutamate transporters. Glia 56(9):998–1004PubMedCrossRefGoogle Scholar
  33. Brambilla P, Harenski K, Nicoletti M, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2003) MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res 37(4):287–295PubMedCrossRefGoogle Scholar
  34. Brambilla P, Nicoletti M, Sassi RB, Mallinger AG, Frank E, Keshavan MS, Soares JC (2004) Corpus callosum signal intensity in patients with bipolar and unipolar disorder. J Neurol Neurosurg Psychiatry 75(2):221–225PubMedPubMedCentralGoogle Scholar
  35. Calhoun VD, Maciejewski PK, Pearlson GD, Kiehl KA (2008) Temporal lobe and “default” hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum Brain Mapp 29(11):1265–1275PubMedPubMedCentralCrossRefGoogle Scholar
  36. Cannon M, Jones PB, Murray RM (2002) Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry 159(7):1080–1092PubMedCrossRefGoogle Scholar
  37. Cannon DM, Carson RE, Nugent AC, Eckelman WC, Kiesewetter DO, Williams J, Rollis D, Drevets M, Gandhi S, Solorio G, Drevets WC (2006a) Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder. Arch Gen Psychiatry 63(7):741–747PubMedCrossRefGoogle Scholar
  38. Cannon DM, Ichise M, Fromm SJ, Nugent AC, Rollis D, Gandhi SK, Klaver JM, Charney DS, Manji HK, Drevets WC (2006b) Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biol Psychiatry 60(3):207–217PubMedCrossRefGoogle Scholar
  39. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC (2007) Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biol Psychiatry 62(8):870–877PubMedCrossRefGoogle Scholar
  40. Cannon DM, Klaver JK, Gandhi SK, Solorio G, Peck SA, Erickson K, Akula N, Savitz J, Eckelman WC, Furey ML, Sahakian BJ, McMahon FJ, Drevets WC (2011) Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder. Mol Psychiatry 16(4):407–418PubMedCrossRefGoogle Scholar
  41. Carpenter M, Sutin J (1983) Human neuroanatomy, 8th edn. Williams and Wilkins, Baltimore, MDGoogle Scholar
  42. Carter CJ (2007a) EIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull 33:1343–1353PubMedPubMedCentralCrossRefGoogle Scholar
  43. Carter CJ (2007b) Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability. Neurochem Int 50(3):461–490PubMedCrossRefGoogle Scholar
  44. Cecil KM, DelBello MP, Morey R, Strakowski SM (2002) Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 4(6):357–365PubMedCrossRefGoogle Scholar
  45. Chabriat H, Vahedi K, Iba-Zizen MT, Joutel A, Nibbio A, Nagy TG, Krebs MO, Julien J, Dubois B, Ducrocq X et al (1995) Clinical spectrum of CADASIL: a study of 7 families. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Lancet 346(8980):934–939PubMedCrossRefGoogle Scholar
  46. Chakos MH, Lieberman JA, Alvir J, Bilder R, Ashtari M (1995) Caudate nuclei volumes in schizophrenic patients treated with typical antipsychotics or clozapine. Lancet 345(8947):456–457PubMedCrossRefGoogle Scholar
  47. Chandley MJ, Szebeni K, Szebeni A, Crawford J, Stockmeier CA, Turecki G, Miguel-Hidalgo JJ, Ordway GA (2013) Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder. J Psychiatry Neurosci 38(4):276–284PubMedPubMedCentralCrossRefGoogle Scholar
  48. Chase HW, Nusslock R, Almeida JR, Forbes EE, LaBarbara EJ, Phillips ML (2013) Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression. Bipolar Disord 15(8):839–854PubMedPubMedCentralCrossRefGoogle Scholar
  49. Cheng JD, de Vellis J (2000) Oligodendrocytes as glucocorticoids target cells: functional analysis of the glycerol phosphate dehydrogenase gene. J Neurosci Res 59(3):436–445PubMedCrossRefGoogle Scholar
  50. Choudary PV, Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE Jr, Akil H, Watson SJ, Jones EG (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci USA 102(43):15653–15658PubMedPubMedCentralCrossRefGoogle Scholar
  51. Coryell W, Nopoulos P, Drevets W, Wilson T, Andreasen NC (2005) Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications. Am J Psychiatry 162(9):1706–1712PubMedCrossRefGoogle Scholar
  52. Cotter D, Mackay D, Landau S, Kerwin R, Everall I (2001a) Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 58(6):545–553PubMedCrossRefGoogle Scholar
  53. Cotter DR, Pariante CM, Everall IP (2001b) Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Res Bull 55(5):585–595PubMedCrossRefGoogle Scholar
  54. Cotter D, Mackay D, Chana G, Beasley C, Landau S, Everall IP (2002) Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cereb Cortex 12(4):386–394PubMedCrossRefGoogle Scholar
  55. Cousins DA, Aribisala B, Nicol Ferrier I, Blamire AM (2013) Lithium, gray matter, and magnetic resonance imaging signal. Biol Psychiatry 73(7):652–657PubMedCrossRefGoogle Scholar
  56. Czeh B, Lucassen PJ (2007) What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? Eur Arch Psychiatry Clin Neurosci 257:250–260PubMedCrossRefGoogle Scholar
  57. Czeh B, Pudovkina O, van der Hart MG, Simon M, Heilbronner U, Michaelis T, Watanabe T, Frahm J, Fuchs E (2005) Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression. Psychopharmacology (Berl) 180(3):548–557CrossRefGoogle Scholar
  58. Dager SR, Friedman SD (2000) Brain imaging and the effects of caffeine and nicotine. Ann Med 32(9):592–599PubMedCrossRefGoogle Scholar
  59. Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9(1):46–56PubMedPubMedCentralCrossRefGoogle Scholar
  60. Davis M, Shi C (1999) The extended amygdala: are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety? Ann N Y Acad Sci 877:281–291PubMedCrossRefGoogle Scholar
  61. de Castro AG, Bajbouj M, Schlattmann P, Lemke H, Heuser I, Neu P (2008) Cerebrovascular reactivity in depressed patients without vascular risk factors. J Psychiatr Res 42:78–82PubMedCrossRefGoogle Scholar
  62. DelBello MP, Zimmerman ME, Mills NP, Getz GE, Strakowski SM (2004) Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 6(1):43–52PubMedCrossRefGoogle Scholar
  63. Desmond DW, Moroney JT, Lynch T, Chan S, Chin SS, Mohr JP (1999) The natural history of CADASIL: a pooled analysis of previously published cases. Stroke 30(6):1230–1233PubMedCrossRefGoogle Scholar
  64. Dickstein DP, Milham MP, Nugent AC, Drevets WC, Charney DS, Pine DS, Leibenluft E (2005) Frontotemporal alterations in pediatric bipolar disorder: results of a voxel-based morphometry study. Arch Gen Psychiatry 62(7):734–741PubMedCrossRefGoogle Scholar
  65. Drevets WC (2001) Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 11(2):240–249PubMedCrossRefGoogle Scholar
  66. Drevets WC (2007) Orbitofrontal cortex function and structure in depression. Ann N Y Acad Sci 1121:499–527PubMedCrossRefGoogle Scholar
  67. Drevets WC, Price JL (2005) Neuroimaging and neuropathological studies of mood disorders. In: Licinio JWM (ed) Biology of depression: from novel insights to therapeutic strategies, vol 1. Wiley-VCH Verlag GmbH & Co., Weinheim, pp 427–466CrossRefGoogle Scholar
  68. Drevets WC, Todd RD (2005) Depression, mania and related disorders. In: Rubin E, Zorumski C (eds) Adult psychiatry, 2nd edn. Blackwell, Oxford, pp 91–129Google Scholar
  69. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME (1992) A functional anatomical study of unipolar depression. J Neurosci 12(9):3628–3641PubMedGoogle Scholar
  70. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386(6627):824–827PubMedCrossRefGoogle Scholar
  71. Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, Huang Y, Gautier C, Mathis C (1999) PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry 46(10):1375–1387PubMedCrossRefGoogle Scholar
  72. Drevets WC, Bogers W, Raichle ME (2002a) Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 12(6):527–544PubMedCrossRefGoogle Scholar
  73. Drevets WC, Price JL, Bardgett ME, Reich T, Todd RD, Raichle ME (2002b) Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacol Biochem Behav 71(3):431–447PubMedCrossRefGoogle Scholar
  74. Drevets WC, Gadde K, Krishnan KRR (2004) Neuroimaging studies of depression. In: Charney DS, Nestler EJ, Bunney BJ (eds) The neurobiological foundation of mental illness, 2nd edn. Oxford University Press, New York, pp 461–490Google Scholar
  75. Drevets WC, Thase ME, Moses-Kolko EL, Price J, Frank E, Kupfer DJ, Mathis C (2007) Serotonin-1A receptor imaging in recurrent depression: replication and literature review. Nucl Med Biol 34(7):865–877PubMedPubMedCentralCrossRefGoogle Scholar
  76. Dufouil C, de Kersaint-Gilly A, Besancon V, Levy C, Auffray E, Brunnereau L, Alperovitch A, Tzourio C (2001) Longitudinal study of blood pressure and white matter hyperintensities: the EVA MRI Cohort. Neurology 56(7):921–926PubMedCrossRefGoogle Scholar
  77. Duman RS (2014) Neurobiology of stress, depression, and rapid acting antidepressants: remodeling synaptic connections. Depress Anxiety 31(4):291–296PubMedPubMedCentralCrossRefGoogle Scholar
  78. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59(12):1116–1127PubMedCrossRefGoogle Scholar
  79. Dupont RM, Jernigan TL, Butters N, Delis D, Hesselink JR, Heindel W, Gillin JC (1990) Subcortical abnormalities detected in bipolar affective disorder using magnetic resonance imaging. Clinical and neuropsychological significance. Arch Gen Psychiatry 47(1):55–59PubMedCrossRefGoogle Scholar
  80. Duric V, Banasr M, Stockmeier CA, Simen AA, Newton SS, Overholser JC, Jurjus GJ, Dieter L, Duman RS (2013) Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects. Int J Neuropsychopharmacol 16(1):69–82PubMedCrossRefGoogle Scholar
  81. Eastwood SL, Harrison PJ (2000) Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs. Mol Psychiatry 5(4):425–432PubMedCrossRefGoogle Scholar
  82. Elvsashagen T, Westlye LT, Boen E, Hol PK, Andreassen OA, Boye B, Malt UF (2013) Bipolar II disorder is associated with thinning of prefrontal and temporal cortices involved in affect regulation. Bipolar Disord 15(8):855–864PubMedCrossRefGoogle Scholar
  83. Emsell L, Chaddock C, Forde N, Van Hecke W, Barker GJ, Leemans A, Sunaert S, Walshe M, Bramon E, Cannon D, Murray R, McDonald C (2014) White matter microstructural abnormalities in families multiply affected with bipolar I disorder: a diffusion tensor tractography study. Psychol Med 44(10):2139–2150Google Scholar
  84. Fatemi SH, Earle JA, McMenomy T (2000) Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry 5(6):654–663, 571PubMedCrossRefGoogle Scholar
  85. Figiel GS, Krishnan KR, Rao VP, Doraiswamy M, Ellinwood EH Jr, Nemeroff CB, Evans D, Boyko O (1991) Subcortical hyperintensities on brain magnetic resonance imaging: a comparison of normal and bipolar subjects. J Neuropsychiatry Clin Neurosci 3(1):18–22PubMedCrossRefGoogle Scholar
  86. Flugge G (1995) Dynamics of central nervous 5-HT1A-receptors under psychosocial stress. J Neurosci 15(11):7132–7140PubMedGoogle Scholar
  87. Foland-Ross LC, Thompson PM, Sugar CA, Madsen SK, Shen JK, Penfold C, Ahlf K, Rasser PE, Fischer J, Yang Y, Townsend J, Bookheimer SY, Altshuler LL (2011) Investigation of cortical thickness abnormalities in lithium-free adults with bipolar I disorder using cortical pattern matching. Am J Psychiatry 168(5):530–539PubMedPubMedCentralCrossRefGoogle Scholar
  88. Folstein MF, Robinson R, Folstein S, McHugh PR (1985) Depression and neurological disorders. New treatment opportunities for elderly depressed patients. J Affect Disord Suppl 1:S11–S14CrossRefGoogle Scholar
  89. Forester BP, Finn CT, Berlow YA, Wardrop M, Renshaw PF, Moore CM (2008) Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study. Bipolar Disord 10(6):691–700PubMedPubMedCentralCrossRefGoogle Scholar
  90. Fornito A, Yucel M, Wood SJ, Bechdolf A, Carter S, Adamson C, Velakoulis D, Saling MM, McGorry PD, Pantelis C (2009) Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder. Br J Psychiatry 194(5):426–433PubMedCrossRefGoogle Scholar
  91. Frangou S, Donaldson S, Hadjulis M, Landau S, Goldstein LH (2005) The Maudsley Bipolar Disorder Project: executive dysfunction in bipolar disorder I and its clinical correlates. Biol Psychiatry 58(11):859–864PubMedCrossRefGoogle Scholar
  92. Frazier JA, Giedd JN, Kaysen D, Albus K, Hamburger S, Alaghband-Rad J, Lenane MC, McKenna K, Breier A, Rapoport JL (1996) Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. Am J Psychiatry 153(4):564–566PubMedCrossRefGoogle Scholar
  93. Furey ML, Drevets WC (2006) Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. Arch Gen Psychiatry 63(10):1121–1129PubMedPubMedCentralCrossRefGoogle Scholar
  94. Geschwind N (1965a) Disconnexion syndromes in animals and man. I. Brain 88:237–294PubMedCrossRefGoogle Scholar
  95. Geschwind N (1965b) Disconnexion syndromes in animals and man. II. Brain 88:585–644PubMedCrossRefGoogle Scholar
  96. Giakoumatos CI, Nanda P, Mathew IT, Tandon N, Shah J, Bishop JR, Clementz BA, Pearlson GD, Sweeney JA, Tamminga CA, Keshavan MS (2015) Effects of lithium on cortical thickness and hippocampal subfield volumes in psychotic bipolar disorder. J Psychiatr Res 61:180–187PubMedCrossRefGoogle Scholar
  97. Goldstein IB, Bartzokis G, Guthrie D, Shapiro D (2002) Ambulatory blood pressure and brain atrophy in the healthy elderly. Neurology 59(5):713–719PubMedCrossRefGoogle Scholar
  98. Golembiowska K, Dziubina A (2000) Effect of acute and chronic administration of citalopram on glutamate and aspartate release in the rat prefrontal cortex. Pol J Pharmacol 52(6):441–448PubMedGoogle Scholar
  99. Gonzalez-Burgos G, Lewis DA (2008) GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia. Schizophr Bull 34(5):944–961PubMedPubMedCentralCrossRefGoogle Scholar
  100. Gonzalez-Burgos G, Cho RY, Lewis DA (2015) Alterations in cortical network oscillations and parvalbumin neurons in schizophrenia. Biol Psychiatry 77(12):1031–1040PubMedPubMedCentralCrossRefGoogle Scholar
  101. Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby L, Santarelli L, Beck S, Hen R (2002) Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416(6879):396–400PubMedCrossRefGoogle Scholar
  102. Gunstad J, Cohen RA, Tate DF, Paul RH, Poppas A, Hoth K, Macgregor KL, Jefferson AL (2005) Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease. Blood Press 14(6):353–358PubMedPubMedCentralCrossRefGoogle Scholar
  103. Gustafson DR, Steen B, Skoog I (2004) Body mass index and white matter lesions in elderly women. An 18-year longitudinal study. Int Psychogeriatr 16(3):327–336PubMedCrossRefGoogle Scholar
  104. Haarman BC, Riemersma-Van der Lek RF, de Groot JC, Ruhe HG, Klein HC, Zandstra TE, Burger H, Schoevers RA, de Vries EF, Drexhage HA, Nolen WA, Doorduin J (2014) Neuroinflammation in bipolar disorder – A [(11)C]-(R)-PK11195 positron emission tomography study. Brain Behav Immun 40:219–225PubMedCrossRefGoogle Scholar
  105. Hafeman DM, Bebko G, Bertocci MA, Fournier JC, Bonar L, Perlman SB, Travis M, Gill MK, Diwadkar VA, Sunshine JL, Holland SK, Kowatch RA, Birmaher B, Axelson D, Horwitz SM, Arnold LE, Fristad MA, Frazier TW, Youngstrom EA, Findling RL, Drevets W, Phillips ML (2014) Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: attenuated by medication. J Psychiatr Res 58:129–136PubMedPubMedCentralCrossRefGoogle Scholar
  106. Hahn T, Marquand AF, Ehlis AC, Dresler T, Kittel-Schneider S, Jarczok TA, Lesch KP, Jakob PM, Mourao-Miranda J, Brammer MJ, Fallgatter AJ (2011) Integrating neurobiological markers of depression. Arch Gen Psychiatry 68(4):361–368PubMedCrossRefGoogle Scholar
  107. Hajek T, Kopecek M, Hoschl C, Alda M (2012) Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis. J Psychiatry Neurosci 37(5):333–343PubMedPubMedCentralCrossRefGoogle Scholar
  108. Hamakawa H, Kato T, Murashita J, Kato N (1998) Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. Eur Arch Psychiatry Clin Neurosci 248(1):53–58PubMedCrossRefGoogle Scholar
  109. Hamidi M, Drevets WC, Price JL (2004) Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes. Biol Psychiatry 55(6):563–569PubMedCrossRefGoogle Scholar
  110. Hannestad J, Taylor WD, McQuoid DR, Payne ME, Krishnan KR, Steffens DC, Macfall JR (2006) White matter lesion volumes and caudate volumes in late-life depression. Int J Geriatr Psychiatry 21(12):1193–1198PubMedCrossRefGoogle Scholar
  111. Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P, Gould TD, Manji HK, Chen G (2004) Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. J Neurosci 24(29):6590–6599PubMedCrossRefGoogle Scholar
  112. Hashimoto K, Sawa A, Iyo M (2007) Increased levels of glutamate in brains from patients with mood disorders. Biol Psychiatry 62(11):1310–1316PubMedCrossRefGoogle Scholar
  113. Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC (2007) Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 64(2):193–200PubMedCrossRefGoogle Scholar
  114. Hasler G, Fromm S, Carlson PJ, Luckenbaugh DA, Waldeck T, Geraci M, Roiser JP, Neumeister A, Meyers N, Charney DS, Drevets WC (2008) Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. Arch Gen Psychiatry 65(5):521–531PubMedPubMedCentralCrossRefGoogle Scholar
  115. Hatton SN, Lagopoulos J, Hermens DF, Scott E, Hickie IB, Bennett MR (2013) Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits. Int J Bipolar Disord 1:3PubMedPubMedCentralCrossRefGoogle Scholar
  116. Haznedar MM, Roversi F, Pallanti S, Baldini-Rossi N, Schnur DB, Licalzi EM, Tang C, Hof PR, Hollander E, Buchsbaum MS (2005) Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry 57(7):733–742PubMedCrossRefGoogle Scholar
  117. Hercher C, Chopra V, Beasley CL (2014) Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci 39(6):376–385PubMedPubMedCentralCrossRefGoogle Scholar
  118. Herman JP, Cullinan WE (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary- adrenocortical axis. Trends Neurosci 20(2):78–84PubMedCrossRefGoogle Scholar
  119. Hickie I, Scott E, Mitchell P, Wilhelm K, Austin MP, Bennett B (1995) Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression. Biol Psychiatry 37(3):151–160PubMedCrossRefGoogle Scholar
  120. Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, Yurgelun-Todd D, Zarate C, Kikinis R, Jolesz FA, McCarley RW (1999) Subgenual cingulate cortex volume in first-episode psychosis. Am J Psychiatry 156(7):1091–1093PubMedPubMedCentralGoogle Scholar
  121. Hirvonen J, Karlsson H, Kajander J, Lepola A, Markkula J, Rasi-Hakala H, Nagren K, Salminen JK, Hietala J (2008) Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. Int J Neuropsychopharmacol 11(4):465–476PubMedCrossRefGoogle Scholar
  122. Holthoff VA, Beuthien-Baumann B, Zundorf G, Triemer A, Ludecke S, Winiecki P, Koch R, Fuchtner F, Herholz K (2004) Changes in brain metabolism associated with remission in unipolar major depression. Acta Psychiatr Scand 110(3):184–194PubMedCrossRefGoogle Scholar
  123. Honer WG, Falkai P, Chen C, Arango V, Mann JJ, Dwork AJ (1999) Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness. Neuroscience 91(4):1247–1255PubMedCrossRefGoogle Scholar
  124. Ionescu DF, Luckenbaugh DA, Niciu MJ, Richards EM, Zarate CA Jr (2015) A single infusion of ketamine improves depression scores in patients with anxious bipolar depression. Bipolar Disord 17(4):438–443PubMedCrossRefGoogle Scholar
  125. Izquierdo A, Wellman CL, Holmes A (2006) Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice. J Neurosci 26(21):5733–5738PubMedCrossRefGoogle Scholar
  126. Janowsky DS, Overstreet DH, Nurnberger JIJ (1994) Is cholinergic sensitivity a genetic marker for the affective disorders? Am J Med Genet 54:335–344PubMedCrossRefGoogle Scholar
  127. Janssen J, Aleman-Gomez Y, Schnack H, Balaban E, Pina-Camacho L, Alfaro-Almagro F, Castro-Fornieles J, Otero S, Baeza I, Moreno D, Bargallo N, Parellada M, Arango C, Desco M (2014) Cortical morphology of adolescents with bipolar disorder and with schizophrenia. Schizophr Res 158(1–3):91–99PubMedCrossRefGoogle Scholar
  128. Janus C, D’Amelio S, Amitay O, Chishti MA, Strome R, Fraser P, Carlson GA, Roder JC, St George-Hyslop P, Westaway D (2000) Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes. Neurobiol Aging 21(4):541–549PubMedCrossRefGoogle Scholar
  129. Jernigan TL, Zisook S, Heaton RK, Moranville JT, Hesselink JR, Braff DL (1991) Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Arch Gen Psychiatry 48(10):881–890PubMedCrossRefGoogle Scholar
  130. Johnston-Wilson NL, Sims CD, Hofmann JP, Anderson L, Shore AD, Torrey EF, Yolken RH (2000) Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol Psychiatry 5(2):142–149PubMedCrossRefGoogle Scholar
  131. Jovanovic H, Perski A, Berglund H, Savic I (2011) Chronic stress is linked to 5-HT(1A) receptor changes and functional disintegration of the limbic networks. Neuroimage 55(3):1178–1188PubMedCrossRefGoogle Scholar
  132. Kato T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T (1996) Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. J Psychiatry Neurosci 21(4):248–254PubMedPubMedCentralGoogle Scholar
  133. Kegeles LS, Malone KM, Slifstein M, Ellis SP, Xanthopoulos E, Keilp JG, Campbell C, Oquendo M, Van Heertum RL, Mann JJ (2003) Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders. Am J Psychiatry 160(1):76–82PubMedCrossRefGoogle Scholar
  134. Kertesz A, Black SE, Tokar G, Benke T, Carr T, Nicholson L (1988) Periventricular and subcortical hyperintensities on magnetic resonance imaging. ‘Rims, caps, and unidentified bright objects’. Arch Neurol 45(4):404–408PubMedCrossRefGoogle Scholar
  135. Kessler RC, Chiu WT, Demler O, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the national comorbidity survey replication. Arch Gen Psychiatry 62(6):617–627PubMedPubMedCentralCrossRefGoogle Scholar
  136. Ketter TA, Drevets WC (2002) Neuroimaging studies of bipolar depression: functional neuropathology, treatment effects, and predictors of clinical response. Clin Neurosci Res 2:182–192CrossRefGoogle Scholar
  137. Ketter TA, Andreason PJ, George MS, Lee C, Gill DS, Parekh PI, Willis MW, Herscovitch P, Post RM (1996) Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry 53:59–69PubMedCrossRefGoogle Scholar
  138. Ketter TA, Kimbrell TA, George MS, Dunn RT, Speer AM, Benson BE, Willis MW, Danielson A, Frye MA, Herscovitch P, Post RM (2001) Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biol Psychiatry 49(2):97–109PubMedCrossRefGoogle Scholar
  139. Kilbourne AM, Cornelius JR, Han X, Pincus HA, Shad M, Salloum I, Conigliaro J, Haas GL (2004) Burden of general medical conditions among individuals with bipolar disorder. Bipolar Disord 6(5):368–373PubMedCrossRefGoogle Scholar
  140. Kim S, Webster MJ (2010) Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders. Mol Psychiatry 15(3):326–336PubMedCrossRefGoogle Scholar
  141. Kim JS, Chang MY, Yu IT, Kim JH, Lee SH, Lee YS, Son H (2004) Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo. J Neurochem 89(2):324–336PubMedCrossRefGoogle Scholar
  142. Kimoto S, Zaki MM, Bazmi HH, Lewis DA (2015) Altered markers of cortical gamma-aminobutyric acid neuronal activity in schizophrenia: role of the NARP gene. JAMA Psychiatry 72(8):747–756PubMedPubMedCentralCrossRefGoogle Scholar
  143. Kinney DK, Yurgelun-Todd DA, Levy DL, Medoff D, Lajonchere CM, Radford-Paregol M (1993) Obstetrical complications in patients with bipolar disorder and their siblings. Psychiatry Res 48(1):47–56PubMedCrossRefGoogle Scholar
  144. Kinney DK, Yurgelun-Todd DA, Tohen M, Tramer S (1998) Pre- and perinatal complications and risk for bipolar disorder: a retrospective study. J Affect Disord 50(2–3):117–124PubMedCrossRefGoogle Scholar
  145. Knopman DS, Mosley TH, Catellier DJ, Sharrett AR (2005) Cardiovascular risk factors and cerebral atrophy in a middle-aged cohort. Neurology 65(6):876–881PubMedCrossRefGoogle Scholar
  146. Krishnan KR, Doraiswamy PM, Figiel GS, Husain MM, Shah SA, Na C, Boyko OB, McDonald WM, Nemeroff CB, Ellinwood EH Jr (1991) Hippocampal abnormalities in depression. J Neuropsychiatry Clin Neurosci 3(4):387–391PubMedCrossRefGoogle Scholar
  147. Kruger S, Seminowicz D, Goldapple K, Kennedy SH, Mayberg HS (2003) State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge. Biol Psychiatry 54(11):1274–1283PubMedCrossRefGoogle Scholar
  148. Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF (2002) Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Mol Psychiatry 7(Suppl 1):S71–S80PubMedCrossRefGoogle Scholar
  149. Kumar J, Iwabuchi S, Oowise S, Balain V, Palaniyappan L, Liddle PF (2015) Shared white-matter dysconnectivity in schizophrenia and bipolar disorder with psychosis. Psychol Med 45(4):759–770PubMedCrossRefGoogle Scholar
  150. Lan MJ, Chhetry BT, Oquendo MA, Sublette ME, Sullivan G, Mann JJ, Parsey RV (2014) Cortical thickness differences between bipolar depression and major depressive disorder. Bipolar Disord 16(4):378–388PubMedPubMedCentralCrossRefGoogle Scholar
  151. Lawrence NS, Williams AM, Surguladze S, Giampietro V, Brammer MJ, Andrew C, Frangou S, Ecker C, Phillips ML (2004) Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol Psychiatry 55(6):578–587PubMedCrossRefGoogle Scholar
  152. LeDoux J (2003) The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 23(4–5):727–738PubMedCrossRefGoogle Scholar
  153. Lee EE, Della Selva MP, Liu A, Himelhoch S (2015) Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis. Gen Hosp Psychiatry 37(2):178–184PubMedCrossRefGoogle Scholar
  154. Lenze E, Cross D, McKeel D, Neuman RJ, Sheline YI (1999) White matter hyperintensities and gray matter lesions in physically healthy depressed subjects. Am J Psychiatry 156(10):1602–1607PubMedCrossRefGoogle Scholar
  155. Lewis DA, Curley AA, Glausier JR, Volk DW (2012) Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Trends Neurosci 35(1):57–67PubMedCrossRefGoogle Scholar
  156. Lochhead RA, Parsey RV, Oquendo MA, Mann JJ (2004) Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxel-based morphometry. Biol Psychiatry 55(12):1154–1162PubMedCrossRefGoogle Scholar
  157. Lopez JF, Chalmers DT, Little KY, Watson SJ (1998) A.E. Bennett Research Award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for the neurobiology of depression. Biol Psychiatry 43(8):547–573PubMedCrossRefGoogle Scholar
  158. Lyoo IK, Lee HK, Jung JH, Noam GG, Renshaw PF (2002) White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders. Compr Psychiatry 43(5):361–368PubMedCrossRefGoogle Scholar
  159. Lyoo IK, Kim MJ, Stoll AL, Demopulos CM, Parow AM, Dager SR, Friedman SD, Dunner DL, Renshaw PF (2004a) Frontal lobe gray matter density decreases in bipolar I disorder. Biol Psychiatry 55(6):648–651PubMedCrossRefGoogle Scholar
  160. Lyoo IK, Streeter CC, Ahn KH, Lee HK, Pollack MH, Silveri MM, Nassar L, Levin JM, Sarid-Segal O, Ciraulo DA, Renshaw PF, Kaufman MJ (2004b) White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects. Psychiatry Res 131(2):135–145PubMedCrossRefGoogle Scholar
  161. Lyoo IK, Sung YH, Dager SR, Friedman SD, Lee JY, Kim SJ, Kim N, Dunner DL, Renshaw PF (2006) Regional cerebral cortical thinning in bipolar disorder. Bipolar Disord 8(1):65–74PubMedCrossRefGoogle Scholar
  162. MacDonald ML, Naydenov A, Chu M, Matzilevich D, Konradi C (2006) Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder. Bipolar Disord 8(3):255–264PubMedPubMedCentralCrossRefGoogle Scholar
  163. Mah L, Zarate CA Jr, Singh J, Duan YF, Luckenbaugh DA, Manji HK, Drevets WC (2007) Regional cerebral glucose metabolic abnormalities in bipolar II depression. Biol Psychiatry 61(6):765–775PubMedCrossRefGoogle Scholar
  164. Maller JJ, Thaveenthiran P, Thomson RH, McQueen S, Fitzgerald PB (2014) Volumetric, cortical thickness and white matter integrity alterations in bipolar disorder type I and II. J Affect Disord 169:118–127PubMedCrossRefGoogle Scholar
  165. Manelis A, Ladouceur CD, Graur S, Monk K, Bonar LK, Hickey MB, Dwojak AC, Axelson D, Goldstein BI, Goldstein TR, Bebko G, Bertocci MA, Hafeman DM, Gill MK, Birmaher B, Phillips ML (2015) Altered amygdala-prefrontal response to facial emotion in offspring of parents with bipolar disorder. Brain 138(Pt 9):2777–2790PubMedPubMedCentralCrossRefGoogle Scholar
  166. Manji HK, Moore GJ, Chen G (2000) Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biol Psychiatry 48(8):740–754PubMedCrossRefGoogle Scholar
  167. Manji HK, Drevets WC, Charney DS (2001) The cellular neurobiology of depression. Nat Med 7(5):541–547PubMedCrossRefGoogle Scholar
  168. Mark RJ, Ashford JW, Goodman Y, Mattson MP (1995) Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology. Neurobiol Aging 16(2):187–198PubMedCrossRefGoogle Scholar
  169. Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silberberg G, Wu C (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5(10):793–807PubMedCrossRefGoogle Scholar
  170. Martinez P, Ronsaville D, Gold PW, Hauser P, Drevets WC (2002) Morphometric abnormalities in adolescent offspring of depressed mothers. Soc Neurosci Abstr 32Google Scholar
  171. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45(5):651–660PubMedCrossRefGoogle Scholar
  172. McEwen BS, Magarinos AM (2001) Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders. Hum Psychopharmacol 16(S1):S7–S19PubMedCrossRefGoogle Scholar
  173. McEwen BS, Olie JP (2005) Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine. Mol Psychiatry 10(6):525–537PubMedCrossRefGoogle Scholar
  174. McEwen BS, Magarinos AM, Reagan LP (2002) Structural plasticity and tianeptine: cellular and molecular targets. Eur Psychiatry 17(Suppl 3):318–330PubMedCrossRefGoogle Scholar
  175. McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW (2015) A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Psychol Med 45(4):693–704PubMedCrossRefGoogle Scholar
  176. Medina KL, Nagel BJ, Park A, McQueeny T, Tapert SF (2007) Depressive symptoms in adolescents: associations with white matter volume and marijuana use. J Child Psychol Psychiatry 48(6):592–600PubMedPubMedCentralCrossRefGoogle Scholar
  177. Meyer JH, Houle S, Sagrati S, Carella A, Hussey DF, Ginovart N, Goulding V, Kennedy J, Wilson AA (2004) Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry 61:1271–1279PubMedCrossRefGoogle Scholar
  178. Meyer JH, McNeely HE, Sagrati S, Boovariwala A, Martin K, Verhoeff NP, Wilson AA, Houle S (2006) Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study. Am J Psychiatry 163(9):1594–1602PubMedCrossRefGoogle Scholar
  179. Miguel-Hidalgo JJ, Waltzer R, Whittom AA, Austin MC, Rajkowska G, Stockmeier CA (2010) Glial and glutamatergic markers in depression, alcoholism, and their comorbidity. J Affect Disord 127(1–3):230–240PubMedPubMedCentralCrossRefGoogle Scholar
  180. Milad MR, Quinn BT, Pitman RK, Orr SP, Fischl B, Rauch SL (2005) Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc Natl Acad Sci USA 102(30):10706–10711PubMedPubMedCentralCrossRefGoogle Scholar
  181. Miracle AD, Brace MF, Huyck KD, Singler SA, Wellman CL (2006) Chronic stress impairs recall of extinction of conditioned fear. Neurobiol Learn Mem 85(3):213–218PubMedCrossRefGoogle Scholar
  182. Moore GJ, Galloway MP (2002) Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders. Psychopharmacol Bull 36(2):5–23PubMedGoogle Scholar
  183. Moore GJ, Bebchuk JM, Wilds IB, Chen G, Manji HK (2000) Lithium-induced increase in human brain grey matter. Lancet 356(9237):1241–1242PubMedCrossRefGoogle Scholar
  184. Moore GJ, Cortese BM, Glitz DA, Zajac-Benitez C, Quiroz JA, Uhde TW, Drevets WC, Manji HK (2009) A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients. J Clin Psychiatry 70(5):699–705PubMedCrossRefGoogle Scholar
  185. Mourao-Miranda J, Oliveira L, Ladouceur CD, Marquand A, Brammer M, Birmaher B, Axelson D, Phillips ML (2012) Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents. PLoS One 7(2):e29482PubMedPubMedCentralCrossRefGoogle Scholar
  186. Musselman DL, Tomer A, Manatunga AK, Knight BT, Porter MR, Kasey S, Marzec U, Harker LA, Nemeroff CB (1996) Exaggerated platelet reactivity in major depression. Am J Psychiatry 153(10):1313–1317PubMedCrossRefGoogle Scholar
  187. Nauta WJH, Domesick V (1984) Afferent and efferent relationships of the basal ganglia. In: Evered D, O’Conner M (eds) Function of the basal ganglia. Pitman Press, LondonGoogle Scholar
  188. Nemeroff CB, Musselman DL (2000) Are platelets the link between depression and ischemic heart disease? Am Heart J 140(4 Suppl):57–62PubMedCrossRefGoogle Scholar
  189. Neumeister A, Nugent AC, Waldeck T, Geraci M, Schwarz M, Bonne O, Bain EE, Luckenbaugh DA, Herscovitch P, Charney DS, Drevets WC (2004) Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry 61(8):765–773PubMedCrossRefGoogle Scholar
  190. Neumeister A, Hu XZ, Luckenbaugh DA, Schwarz M, Nugent AC, Bonne O, Herscovitch P, Goldman D, Drevets WC, Charney DS (2006) Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry 63(9):978–986PubMedCrossRefGoogle Scholar
  191. Newcomer JW (2006) Medical risk in patients with bipolar disorder and schizophrenia. J Clin Psychiatry 67(Suppl 9):25–30, discussion 36–42PubMedGoogle Scholar
  192. Nobler MS, Oquendo MA, Kegeles LS, Malone KM, Campbell CC, Sackeim HA, Mann JJ (2001) Decreased regional brain metabolism after ect. Am J Psychiatry 158(2):305–308PubMedCrossRefGoogle Scholar
  193. Novak V, Last D, Alsop DC, Abduljalil AM, Hu K, Lepicovsky L, Cavallerano J, Lipsitz LA (2006) Cerebral blood flow velocity and periventricular white matter hyperintensities in type 2 diabetes. Diabetes Care 29(7):1529–1534PubMedPubMedCentralCrossRefGoogle Scholar
  194. Nugent AC, Milham MP, Bain EE, Mah L, Cannon DM, Marrett S, Zarate CA, Pine DS, Price JL, Drevets WC (2006) Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage 30(2):485–497PubMedCrossRefGoogle Scholar
  195. Nugent AC, Bain EE, Carlson PJ, Neumeister A, Bonne O, Carson RE, Eckelman W, Herscovitch P, Zarate CA Jr, Charney DS, Drevets WC (2013) Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression. Eur Neuropsychopharmacol 23(8):822–829PubMedPubMedCentralCrossRefGoogle Scholar
  196. Oertel-Knochel V, Reuter J, Reinke B, Marbach K, Feddern R, Alves G, Prvulovic D, Linden DE, Knochel C (2015) Association between age of disease-onset, cognitive performance and cortical thickness in bipolar disorders. J Affect Disord 174:627–635PubMedCrossRefGoogle Scholar
  197. Ohara K, Isoda H, Suzuki Y, Takehara Y, Ochiai M, Takeda H, Igarashi Y, Ohara K (1998) Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar I affective disorder. Psychiatry Res 84(2-3):55–60PubMedCrossRefGoogle Scholar
  198. Olsavsky AK, Brotman MA, Rutenberg JG, Muhrer EJ, Deveney CM, Fromm SJ, Towbin K, Pine DS, Leibenluft E (2012) Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder. J Am Acad Child Adolesc Psychiatry 51(3):294–303PubMedPubMedCentralCrossRefGoogle Scholar
  199. Ongur D, Drevets WC, Price JL (1998) Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95(22):13290–13295PubMedPubMedCentralCrossRefGoogle Scholar
  200. Ongur D, Ferry AT, Price JL (2003) Architectonic subdivision of the human orbital and medial prefrontal cortex. J Comp Neurol 460(3):425–449PubMedCrossRefGoogle Scholar
  201. Ovbiagele B, Saver JL (2006) Cerebral white matter hyperintensities on MRI: current concepts and therapeutic implications. Cerebrovasc Dis 22(2–3):83–90PubMedCrossRefGoogle Scholar
  202. Pantazopoulos H, Stone D, Walsh J, Benes FM (2004) Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics. Synapse 54(3):147–155PubMedCrossRefGoogle Scholar
  203. Pantazopoulos H, Lange N, Baldessarini RJ, Berretta S (2007) Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry 61(5):640–652PubMedCrossRefGoogle Scholar
  204. Paul IA, Skolnick P (2003) Glutamate and depression: clinical and preclinical studies. Ann N Y Acad Sci 1003:250–272PubMedCrossRefGoogle Scholar
  205. Pavuluri MN, Henry DB, Nadimpalli SS, O’Connor MM, Sweeney JA (2006) Biological risk factors in pediatric bipolar disorder. Biol Psychiatry 60(9):936–941PubMedCrossRefGoogle Scholar
  206. Pavuluri MN, O’Connor MM, Harral E, Sweeney JA (2007) Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry 62(2):158–167PubMedCrossRefGoogle Scholar
  207. Pearlson GD, Wong DF, Tune LE, Ross CA, Chase GA, Links JM, Dannals RF, Wilson AA, Ravert HT, Wagner HN Jr et al (1995) In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder. Arch Gen Psychiatry 52(6):471–477PubMedCrossRefGoogle Scholar
  208. Phillips ML, Swartz HA (2014) A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research. Am J Psychiatry 171(8):829–843PubMedPubMedCentralCrossRefGoogle Scholar
  209. Phillips ML, Drevets WC, Rauch SL, Lane R (2003) Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 54(5):515–528PubMedCrossRefGoogle Scholar
  210. Phillips ML, Ladouceur CD, Drevets WC (2008) A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 13(9):829, 833–857Google Scholar
  211. Pilc A, Wieronska JM, Skolnick P (2013) Glutamate-based antidepressants: preclinical psychopharmacology. Biol Psychiatry 73(12):1125–1132PubMedCrossRefGoogle Scholar
  212. Pillai JJ, Friedman L, Stuve TA, Trinidad S, Jesberger JA, Lewin JS, Findling RL, Swales TP, Schulz SC (2002) Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res 114(1):51–56PubMedCrossRefGoogle Scholar
  213. Pitt D, Nagelmeier IE, Wilson HC, Raine CS (2003) Glutamate uptake by oligodendrocytes: Implications for excitotoxicity in multiple sclerosis. Neurology 61(8):1113–1120PubMedCrossRefGoogle Scholar
  214. Politis M, Wu K, Loane C, Turkheimer FE, Molloy S, Brooks DJ, Piccini P (2010) Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures. Neurology 75(21):1920–1927PubMedCrossRefGoogle Scholar
  215. Price JL, Drevets WC (2010) Neurocircuitry of mood disorders. Neuropsychopharmacology 35(1):192–216PubMedCrossRefGoogle Scholar
  216. Price JL, Drevets WC (2012) Neural circuits underlying the pathophysiology of mood disorders. Trends Cogn Sci 16(1):61–71PubMedCrossRefGoogle Scholar
  217. Radley JJ, Rocher AB, Rodriguez A, Ehlenberger DB, Dammann M, McEwen BS, Morrison JH, Wearne SL, Hof PR (2008) Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex. J Comp Neurol 507(1):1141–1150PubMedPubMedCentralCrossRefGoogle Scholar
  218. Rajkowska G, Miguel-Hidalgo JJ (2007) Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets 6(3):219–233PubMedPubMedCentralCrossRefGoogle Scholar
  219. Rajkowska G, Stockmeier CA (2013) Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets 14(11):1225–1236PubMedPubMedCentralCrossRefGoogle Scholar
  220. Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, Overholser JC, Roth BL, Stockmeier CA (1999) Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 45(9):1085–1098PubMedCrossRefGoogle Scholar
  221. Regenold WT, Phatak P, Marano CM, Gearhart L, Viens CH, Hisley KC (2007) Myelin staining of deep white matter in the dorsolateral prefrontal cortex in schizophrenia, bipolar disorder, and unipolar major depression. Psychiatry Res 151(3):179–188PubMedCrossRefGoogle Scholar
  222. Rich BA, Vinton DT, Roberson-Nay R, Hommer RE, Berghorst LH, McClure EB, Fromm SJ, Pine DS, Leibenluft E (2006) Limbic hyperactivation during processing of neutral facial expressions in children with bipolar disorder. Proc Natl Acad Sci USA 103(23):8900–8905PubMedPubMedCentralCrossRefGoogle Scholar
  223. Rimol LM, Hartberg CB, Nesvag R, Fennema-Notestine C, Hagler DJ Jr, Pung CJ, Jennings RG, Haukvik UK, Lange E, Nakstad PH, Melle I, Andreassen OA, Dale AM, Agartz I (2010) Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry 68(1):41–50PubMedCrossRefGoogle Scholar
  224. Salerno JA, Murphy DG, Horwitz B, DeCarli C, Haxby JV, Rapoport SI, Schapiro MB (1992) Brain atrophy in hypertension. A volumetric magnetic resonance imaging study. Hypertension 20(3):340–348PubMedCrossRefGoogle Scholar
  225. Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH (1999) Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 56(11):1043–1047PubMedCrossRefGoogle Scholar
  226. Sargent PA, Kjaer KH, Bench CJ, Rabiner EA, Messa C, Meyer J, Gunn RN, Grasby PM, Cowen PJ (2000) Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry 57(2):174–180PubMedCrossRefGoogle Scholar
  227. Sassi RB, Brambilla P, Hatch JP, Nicoletti MA, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC (2004) Reduced left anterior cingulate volumes in untreated bipolar patients. Biol Psychiatry 56(7):467–475PubMedCrossRefGoogle Scholar
  228. Savitz J, Drevets WC (2009a) Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 33(5):699–771PubMedPubMedCentralCrossRefGoogle Scholar
  229. Savitz JB, Drevets WC (2009b) Imaging phenotypes of major depressive disorder: genetic correlates. Neuroscience 164(1):300–330PubMedPubMedCentralCrossRefGoogle Scholar
  230. Savitz J, Nugent AC, Bogers W, Liu A, Sills R, Luckenbaugh DA, Bain EE, Price JL, Zarate C, Manji HK, Cannon DM, Marrett S, Charney DS, Drevets WC (2010) Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication. Neuroimage 49(4):2966–2976PubMedCrossRefGoogle Scholar
  231. Savitz JB, Rauch SL, Drevets WC (2013) Clinical application of brain imaging for the diagnosis of mood disorders: the current state of play. Mol Psychiatry 18(5):528–539PubMedPubMedCentralCrossRefGoogle Scholar
  232. Savitz J, Dantzer R, Wurfel BE, Victor TA, Ford BN, Bodurka J, Bellgowan PS, Teague TK, Drevets WC (2014a) Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder. Psychoneuroendocrinology 52C:200–211Google Scholar
  233. Savitz JB, Price JL, Drevets WC (2014b) Neuropathological and neuromorphometric abnormalities in bipolar disorder: view from the medial prefrontal cortical network. Neurosci Biobehav Rev 42:132–147PubMedCrossRefGoogle Scholar
  234. Setiawan E, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Rajkowska G, Suridjan I, Kennedy JL, Rekkas PV, Houle S, Meyer JH (2015) Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry 72(3):268–275PubMedPubMedCentralCrossRefGoogle Scholar
  235. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA (2001) Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry 50(9):651–658PubMedCrossRefGoogle Scholar
  236. Sheline YI, Gado MH, Kraemer HC (2003) Untreated depression and hippocampal volume loss. Am J Psychiatry 160(8):1516–1518PubMedCrossRefGoogle Scholar
  237. Shively CA, Friedman DP, Gage HD, Bounds MC, Brown-Proctor C, Blair JB, Henderson JA, Smith MA, Buchheimer N (2006) Behavioral depression and positron emission tomography-determined serotonin 1A receptor binding potential in cynomolgus monkeys. Arch Gen Psychiatry 63(4):396–403PubMedCrossRefGoogle Scholar
  238. Shulman RG, Rothman DL, Behar KL, Hyder F (2004) Energetic basis of brain activity: implications for neuroimaging. Trends Neurosci 27(8):489–495PubMedCrossRefGoogle Scholar
  239. Sibille E, Morris HM, Kota RS, Lewis DA (2011) GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders. Int J Neuropsychopharmacol 14(6):721–734PubMedPubMedCentralCrossRefGoogle Scholar
  240. Sokolov BP (2007) Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? Int J Neuropsychopharmacol 10(4):547–555Google Scholar
  241. Son H, Yu IT, Hwang SJ, Kim JS, Lee SH, Lee YS, Kaang BK (2003) Lithium enhances long-term potentiation independently of hippocampal neurogenesis in the rat dentate gyrus. J Neurochem 85(4):872–881PubMedCrossRefGoogle Scholar
  242. Starkstein SE, Robinson RG (1989) Affective disorders and cerebral vascular disease. Br J Psychiatry 154:170–182PubMedCrossRefGoogle Scholar
  243. Steffens DC, Helms MJ, Krishnan KR, Burke GL (1999) Cerebrovascular disease and depression symptoms in the cardiovascular health study. Stroke 30(10):2159–2166PubMedCrossRefGoogle Scholar
  244. Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, Sarnyai Z, Mawrin C, Brisch R, Bielau H, Meyer zu Schwabedissen L, Bogerts B, Myint AM (2011) Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation 8:94PubMedPubMedCentralCrossRefGoogle Scholar
  245. Stewart CA, Reid IC (2000) Repeated ECS and fluoxetine administration have equivalent effects on hippocampal synaptic plasticity. Psychopharmacology (Berl) 148(3):217–223CrossRefGoogle Scholar
  246. Stockmeier CA (2003) Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter. J Psychiatr Res 37(5):357–373PubMedCrossRefGoogle Scholar
  247. Stockmeier CA, Shapiro LA, Dilley GE, Kolli TN, Friedman L, Rajkowska G (1998) Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J Neurosci 18(18):7394–7401PubMedGoogle Scholar
  248. Stockmeier CA, Mahajan GJ, Konick LC, Overholser JC, Jurjus GJ, Meltzer HY, Uylings HB, Friedman L, Rajkowska G (2004) Cellular changes in the postmortem hippocampus in major depression. Biol Psychiatry 56(9):640–650PubMedPubMedCentralCrossRefGoogle Scholar
  249. Strakowski SM, DelBello MP, Zimmerman ME, Getz GE, Mills NP, Ret J, Shear P, Adler CM (2002) Ventricular and periventricular structural volumes in first- versus multiple-episode bipolar disorder. Am J Psychiatry 159(11):1841–1847PubMedCrossRefGoogle Scholar
  250. Suhara T, Nakayama K, Inoue O, Fukuda H, Shimizu M, Mori A, Tateno Y (1992) D1 dopamine receptor binding in mood disorders measured by positron emission tomography. Psychopharmacology (Berl) 106(1):14–18CrossRefGoogle Scholar
  251. Sussmann JE, Lymer GK, McKirdy J, Moorhead TW, Munoz Maniega S, Job D, Hall J, Bastin ME, Johnstone EC, Lawrie SM, McIntosh AM (2009) White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disord 11(1):11–18PubMedCrossRefGoogle Scholar
  252. Swayze VW, Andreasen NC, Alliger RJ, Yuh WT, Ehrhartdt JC (1992) Subcortical and temporal lobe structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biol Psychiatry 31:221–240PubMedCrossRefGoogle Scholar
  253. Taylor MJ, Selvaraj S, Norbury R, Jezzard P, Cowen PJ (2009) Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients. J Affect Disord 119(1–3):186–189PubMedPubMedCentralCrossRefGoogle Scholar
  254. The World Health Organization (WHO) (2001) The World health report 2001. wwwwhoint, Switzerland, GenevaGoogle Scholar
  255. Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, Starkey M, Webster MJ, Yolken RH, Bahn S (2003) Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. Lancet 362(9386):798–805PubMedCrossRefGoogle Scholar
  256. Todtenkopf MS, Vincent SL, Benes FM (2005) A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain. Schizophr Res 73(1):79–89PubMedCrossRefGoogle Scholar
  257. Torgerson CM, Irimia A, Leow AD, Bartzokis G, Moody TD, Jennings RG, Alger JR, Van Horn JD, Altshuler LL (2013) DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. Brain Imaging Behav 7(2):129–139PubMedPubMedCentralCrossRefGoogle Scholar
  258. Uranova N, Orlovskaya D, Vikhreva O, Zimina I, Kolomeets N, Vostrikov V, Rachmanova V (2001) Electron microscopy of oligodendroglia in severe mental illness. Brain Res Bull 55(5):597–610PubMedCrossRefGoogle Scholar
  259. Uranova NA, Vostrikov VM, Orlovskaya DD, Rachmanova VI (2004) Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium. Schizophr Res 67(2–3):269–275PubMedCrossRefGoogle Scholar
  260. Versace A, Andreazza AC, Young LT, Fournier JC, Almeida JR, Stiffler RS, Lockovich JC, Aslam HA, Pollock MH, Park H, Nimgaonkar VL, Kupfer DJ, Phillips ML (2014) Elevated serum measures of lipid peroxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder. Mol Psychiatry 19(2):200–208PubMedCrossRefGoogle Scholar
  261. Vidal-Gonzalez I, Vidal-Gonzalez B, Rauch SL, Quirk GJ (2006) Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear. Learn Mem 13(6):728–733PubMedPubMedCentralCrossRefGoogle Scholar
  262. Vostrikov VM, Uranova NA, Orlovskaya DD (2007) Deficit of perineuronal oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders. Schizophr Res 94(1–3):273–280PubMedCrossRefGoogle Scholar
  263. Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S (2002) Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci 22(15):6810–6818PubMedGoogle Scholar
  264. Vyas A, Bernal S, Chattarji S (2003) Effects of chronic stress on dendritic arborization in the central and extended amygdala. Brain Res 965(1–2):290–294PubMedCrossRefGoogle Scholar
  265. Vythilingam M, Heim C, Newport J, Miller AH, Anderson E, Bronen R, Brummer M, Staib L, Vermetten E, Charney DS, Nemeroff CB, Bremner JD (2002) Childhood trauma associated with smaller hippocampal volume in women with major depression. Am J Psychiatry 159(12):2072–2080PubMedPubMedCentralCrossRefGoogle Scholar
  266. Wang F, Jackowski M, Kalmar JH, Chepenik LG, Tie K, Qiu M, Gong G, Pittman BP, Jones MM, Shah MP, Spencer L, Papademetris X, Constable RT, Blumberg HP (2008) Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. Br J Psychiatry 193(2):126–129PubMedPubMedCentralCrossRefGoogle Scholar
  267. Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston EE, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP (2009) Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 66(5):516–521PubMedPubMedCentralCrossRefGoogle Scholar
  268. Watanabe Y, Gould E, Daniels DC, Cameron H, McEwen BS (1992) Tianeptine attenuates stress-induced morphological changes in the hippocampus. Eur J Pharmacol 222(1):157–162PubMedCrossRefGoogle Scholar
  269. Webster MJ, Knable MB, Johnston-Wilson N, Nagata K, Inagaki M, Yolken RH (2001) Immunohistochemical localization of phosphorylated glial fibrillary acidic protein in the prefrontal cortex and hippocampus from patients with schizophrenia, bipolar disorder, and depression. Brain Behav Immun 15(4):388–400PubMedCrossRefGoogle Scholar
  270. Wellman CL (2001) Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J Neurobiol 49(3):245–253PubMedCrossRefGoogle Scholar
  271. Wilke M, Kowatch RA, DelBello MP, Mills NP, Holland SK (2004) Voxel-based morphometry in adolescents with bipolar disorder: first results. Psychiatry Res 131(1):57–69PubMedCrossRefGoogle Scholar
  272. Xiang L, Szebeni K, Szebeni A, Klimek V, Stockmeier CA, Karolewicz B, Kalbfleisch J, Ordway GA (2008) Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNA in major depression. Brain Res 1207:214–224PubMedPubMedCentralCrossRefGoogle Scholar
  273. Yamamoto J, Suh J, Takeuchi D, Tonegawa S (2014) Successful execution of working memory linked to synchronized high-frequency gamma oscillations. Cell 157(4):845–857PubMedCrossRefGoogle Scholar
  274. Yatham LN, Liddle PF, Lam RW, Shiah IS, Lane C, Stoessl AJ, Sossi V, Ruth TJ (2002) PET study of the effects of valproate on dopamine D(2) receptors in neuroleptic- and mood-stabilizer-naive patients with nonpsychotic mania. Am J Psychiatry 159(10):1718–1723PubMedCrossRefGoogle Scholar
  275. Yucel K, Taylor VH, McKinnon MC, Macdonald K, Alda M, Young LT, Macqueen GM (2008) Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsychopharmacology 33:361–367PubMedCrossRefGoogle Scholar
  276. Yuksel C, Ongur D (2010) Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders. Biol Psychiatry 68(9):785–794PubMedPubMedCentralCrossRefGoogle Scholar
  277. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD (2000) fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord 2(3 Pt 2):237–248PubMedCrossRefGoogle Scholar
  278. Zarate CA Jr, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, Charney DS, Manji HK (2004) An open-label trial of riluzole in patients with treatment-resistant major depression. Am J Psychiatry 161(1):171–174PubMedCrossRefGoogle Scholar
  279. Zarate CA Jr, Brutsche NE, Ibrahim L, Franco-Chaves J, Diazgranados N, Cravchik A, Selter J, Marquardt CA, Liberty V, Luckenbaugh DA (2012) Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry 71(11):939–946PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland (outside the USA)  2016

Authors and Affiliations

  • Jonathan Savitz
    • 1
    • 2
    Email author
  • Harvey M. Morris
    • 1
  • Wayne C. Drevets
    • 3
  1. 1.Laureate Institute for Brain ResearchTulsaUSA
  2. 2.Faculty of Community MedicineThe University of TulsaTulsaUSA
  3. 3.Janssen Pharmaceuticals of J&J, Inc.TitusvilleUSA

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