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The Genetic Basis of Bipolar Disorder

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Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy

Part of the book series: Milestones in Drug Therapy ((MDT))

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Abstract

The high heritability of bipolar disorder (BD) means that a full understanding of etiology must account for the strong influence of inherited genetic variation. An energetic search for specific genetic risk factors over the past 25 years has begun to bear fruit, but most of the genetic risk for BD remains unexplained. In this chapter, we will review the genetic epidemiology of BD, studies aimed at identifying genes that confer risk for the illness, functional genomic studies that seek to elucidate the pathophysiology of BD from the level of genes and gene networks, and pharmacogenomic studies that aim to identify genetic markers of treatment outcome. We conclude with a view to future directions that may ultimately lead to a more complete understanding of this common, severe mental illness and better approaches to diagnosis and treatment.

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Disclosures

Supported by the NIMH Intramural Research Program. Dr. Hou received additional support from the Brain & Behavior Research Foundation.

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  1. Human Genetics Branch, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA

    Liping Hou PhD

  2. Human Genetics Branch, National Institutes of Health, Bldg. 35, Rm 1A-202, 35 Convent Drive, MSC 3719, Bethesda, MD, 20892-3719, USA

    Francis J. McMahon MD

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  1. Liping Hou PhD
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Correspondence to Francis J. McMahon MD .

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  1. Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA

    Carlos A. Zarate Jr.

  2. Janssen Pharmaceuticals of Johnson and Johnson, Janssen Research and Development, Titusville, New Jersey, USA

    Husseini K. Manji

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Hou, L., McMahon, F.J. (2016). The Genetic Basis of Bipolar Disorder. In: Zarate Jr., C., Manji, H. (eds) Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis, and Pharmacotherapy. Milestones in Drug Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-31689-5_5

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