Abstract
Imaging in general is currently playing a pivotal role in the clinical management of several serious diseases, either communicable or non-communicable, affecting the central nervous system (CNS). Regarding nuclear medicine imaging specifically, it must be emphasised that dating back as far as the mid-1970s, great advances in our understanding of the physiology of the brain, both in health and in disease, were achieved thanks to the unique capability of radionuclide methods to explore functional aspects.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
James ML, Gambhir SS (2012) A molecular imaging primer: modalities, imaging agents, and applications. Physiol Rev 92:897–965
Costa DC, Verhoeff NP, Cullum ID et al (1990) In vivo characterisation of 3-iodo-6-methoxybenzamide 123I in humans. Eur J Nucl Med 16:813–816
Abi-Dargham A, Gandelman MS, DeErausquin GA et al (1996) SPECT imaging of dopamine transporters in human brain with iodine-123-fluoroalkyl analogs of beta-CIT. J Nucl Med 37:1129–1133
Kung HF, Kim HJ, Kung MP, Meegalla SK, Plössl K, Lee HK (1996) Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur J Nucl Med 23:1527–1530
Britz-Cunningham SH, Adelstein SJ (2003) Molecular targeting with radionuclides: state of the science. J Nucl Med 44:1945–1961
Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M (2007) Nuclear imaging in cancer theranostics. Q J Nucl Med Mol Imaging 51:152–163
Srivastava SC (2012) Paving the way to personalized medicine: production of some promising theragnostic radionuclides at Brookhaven National Laboratory. Semin Nucl Med 42:151–163
Fink JR, Muzi M, Peck M, Krohn KA (2015) Multimodality brain tumor imaging: MR imaging, PET, and PET/MR imaging. J Nucl Med 56:1554–1561
Seibyl J, Zubal IG, Jennings D, Marek K, Doraiswamy PM (2011) Molecular PET imaging in multicenter Alzheimer’s therapeutic trials: current trends and implementation strategies. Expert Rev Neurother 11:1783–1793
Jiménez Bonilla JF, Carril Carril JM (2013) Molecular neuroimaging in degenerative dementias. Rev Esp Med Nucl Imagen Mol 32:301–309
Heiss WD (2014) PET imaging in ischemic cerebrovascular disease: current status and future directions. Neurosci Bull 30:713–732
Peng S, Eidelberg D, Ma Y (2014) Brain network markers of abnormal cerebral glucose metabolism and blood flow in Parkinson’s disease. Neurosci Bull 30:823–837
Politis M (2014) Neuroimaging in Parkinson disease: from research setting to clinical practice. Nat Rev Neurol 10:708–722
Ba F, Martin WR (2015) Dopamine transporter imaging as a diagnostic tool for parkinsonism and related disorders in clinical practice. Parkinsonism Relat Disord 21:87–94
Miller DB, O’Callaghan JP (2015) Biomarkers of Parkinson’s disease: present and future. Metabolism 64(3 Suppl 1):S40–S46
Hirao K, Pontone GM, Smith GS (2015) Molecular imaging of neuropsychiatric symptoms in Alzheimer’s and Parkinson’s disease. Neurosci Biobehav Rev 49:157–170
Weingarten CP, Sundman MH, Hickey P, Chen NK (2015) Neuroimaging of Parkinson’s disease: expanding views. Neurosci Biobehav Rev 59:16–52
Hricak H, Choi BI, Scott AM, Sugimura K et al (2010) Global trends in hybrid imaging 1. Radiology 257:498–506
Segall G (2012) SNM and global cooperation. J Nucl Med 53:19N
Pringsheim T, Jette N, Frolkis A, Steeves TD (2014) The prevalence of Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 29:1583–1590
Disorders N (2006) Public health challenges. World Health Organization, Geneva
Kalaria RN, Maestre GE, Arizaga R et al (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 7:812–826
World Health Organization. Dementia – A public health priority. Geneva: World Health Organization; 2012.
Park JA, Kim JY, Lee YJ et al (2012) Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe. ACS Med Chem Lett 4:216–219
Mariani G, Bruselli L, Kuwert T et al (2010) A review on the clinical uses of SPECT/CT. Eur J Nucl Med Mol Imaging 37:1959–1985
Buck AK, Nekolla S, Ziegler S et al (2008) SPECT/CT. J Nucl Med 49:1305–1319
Warwick JM, Rubow S, du Toit M, Beetge E, Carey P, Dupont P (2011) The role of CT-based attenuation correction and collimator blurring correction in striatal SPECT quantification. Int J Mol Imaging 2011:195037
Hayashi M, Deguchi J, Utsunomiya K et al (2005) Comparison of methods of attenuation and scatter correction in brain perfusion SPECT. J Nucl Med Technol 33:224–229
Ciarmiello A, Giovacchini G, Guidotti C et al (2013) Weighted registration of 123I-FP-CIT SPECT images improves accuracy of binding potential estimates in pathologically low striatal uptake. J Cell Physiol 228:2086–2094
Schillaci O, Danieli R, Manni C, Simonetti G (2004) Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation? Nucl Med Commun 25:705–710
Berti V, Pupi A, Mosconi L (2011) PET/CT in diagnosis of movement disorders. Ann N Y Acad Sci 1228:93–108
Calabria F, Chiaravalloti A, Di Pietro B, Grasso C, Schillaci O (2012) Molecular imaging of brain tumors with 18F-DOPA PET and PET/CT. Nucl Med Commun 33:563–570
Segtnan EA, Hess S, Grupe P, Høilund-Carlsen PF (2015) 18F-fluorodeoxyglucose PET/computed tomography for primary brain tumors. PET Clin 10:59–73
Shivamurthy VK, Tahari AK, Marcus C, Subramaniam RM (2015) Brain FDG PET and the diagnosis of dementia. AJR Am J Roentgenol 204:W76–W85
Wray R, Solnes L, Mena E, Meoded A, Subramaniam RM (2015) 18F-Flourodeoxy-glucose PET/computed tomography in brain tumors: value to patient management and survival outcomes. PET Clin 10:423–430
Heiss WD (2009) The potential of PET/MR for brain imaging. Eur J Nucl Med Mol Imaging 36(Suppl 1):S105–S112
Bisdas S, Nägele T, Schlemmer HP et al (2010) Switching on the lights for real-time multimodality tumor neuroimaging: the integrated positron-emission tomography/MR imaging system. AJNR Am J Neuroradiol 31:610–614
Garibotto V, Heinzer S, Vulliemoz S et al (2013) Clinical applications of hybrid PET/MRI in neuroimaging. Clin Nucl Med 38:e13–e18
Von Schulthess GK, Kuhn FP, Kaufmann P, Veit-Haibach P (2013) Clinical positron emission tomography/magnetic resonance imaging applications. Semin Nucl Med 43:3–10
Burgos N, Cardoso MJ, Thielemans K et al (2014) Attenuation correction synthesis for hybrid PET-MR scanners: application to brain studies. IEEE Trans Med Imaging 33:2332–2341
Barthel H, Schroeter ML, Hoffmann KT, Sabri O (2015) PET/MR in dementia and other neurodegenerative diseases. Semin Nucl Med 45:224–233
Kashyap R, Dondi M, Paez D, Mariani G (2013) Hybrid imaging worldwide – Challenges and opportunities for the developing world: a report of a technical meeting organized by the IAEA. Semin Nucl Med 43:208–223
Paez D, Orellana P, Gutierrez C, Ramirez R, Mut F, Torres L (2015) Current status of nuclear medicine practice in Latin America and the Caribbean. J Nucl Med 56:1629–1634
Olssen M, Codd JA, O’Neill A-M (2004) Education policy: globalization, citizenship and democracy. Sage Publications, London
Osman MM, Cohade C, Fishman EK et al (2005) Clinically significant incidental findings on the unenhanced CT portion of PET/CT studies: frequency in 250 patients. J Nucl Med 46:1352–1355
Bruzzi JF, Truong MT, Marom EM et al (2006) Incidental findings on integrated PET/CT that do not accumulate 18F-FDG. AJR Am J Roentgenol 187:1116–1123
Goetze S, Pannu HK, Wahl RL (2006) Clinically significant abnormal findings on the “nondiagnostic” CT portion of low-amperage-CT attenuation-corrected myocardial perfusion SPECT/CT studies. J Nucl Med 47:1312–1318
Muzaffar R, Kudva G, Nguyen NC et al (2011) Incidental diagnosis of thrombus within an aneurysm on 18F-FDG PET/CT: frequency in 926 patients. J Nucl Med 52:1408–1411
Fathala A, Aljefri A, Alsugair A et al (2011) Coronary artery calcification detected by PET/CT scan as a marker of myocardial ischemia/coronary artery disease. Nucl Med Commun 32:273–278
Tootell A, Vinjamuri S, Elias M, Hogg P (2012) Clinical evaluation of the computed tomography attenuation correction map for myocardial perfusion imaging: the potential for incidental pathology detection. Nucl Med Commun 33:1122–1126
Zandieh S, Schütz M, Bernt R, Zwerina J, Haller J (2013) An incidentally found inflamed uterine myoma causing low abdominal pain, using Tc-99m-tektrotyd single photon emission computed tomography-CT hybrid imaging. Korean J Radiol 14:841–844
Wuest W, Lell M, May MS, Saake M, Kuwert T, Uder M, Linke R (2015) Thoracic non-osseous lesions in cancer patients detected in low-dose CT images acquired as part of skeletal SPECT/CT examinations. Nuklearmedizin 54:173–177
International Atomic Energy Agency (IAEA) – Statute of the IAEA. Available online at http://www.iaea.org/About/about_statute.html. 1956. Last accessed online 10 May 2015.
Dondi M, Kashyap R, Paez D, Pascual T, Zaknun J, Mut Bastos F, Pynda Y (2011) Trends in nuclear medicine in developing countries. J Nucl Med 52(Suppl 2):16S–23S
Dondi M (2013) Guest editorial: IAEA approach to meet nuclear medicine needs of the emerging world. Semin Nucl Med 43:159–160
Pascual TN, Dondi M, Paez D, Kashyap R, Nunez-Miller R (2013) IAEA programs in empowering the nuclear medicine profession through online educational resources. Semin Nucl Med 43:161–166
Casas-Zamora JA, Kashyap R (2013) The IAEA technical cooperation programme and nuclear medicine in the developing world: objectives, trends, and contributions. Semin Nucl Med 43:172–180
Meghzifene A, Sgouros G (2013) IAEA support to medical physics in nuclear medicine. Semin Nucl Med 43:181–187
Duatti A, Bhonsle U (2013) Strengthening radiopharmacy practice in IAEA Member States. Semin Nucl Med 43:188–194
Patterson HE, Nunez M, Philotheou GM, Hutton BF (2013) Meeting the challenges of global nuclear medicine technologist training in the 21st century: the IAEA Distance Assisted Training (DAT) program. Semin Nucl Med 43:195–201
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Paez, D., Mariani, G., Pascual, T.N.B., Kashyap, R. (2016). Worldwide Challenges and Opportunities of Hybrid Imaging: Perspective from the International Atomic Energy Agency (IAEA). In: Ciarmiello, A., Mansi, L. (eds) PET-CT and PET-MRI in Neurology. Springer, Cham. https://doi.org/10.1007/978-3-319-31614-7_19
Download citation
DOI: https://doi.org/10.1007/978-3-319-31614-7_19
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-31612-3
Online ISBN: 978-3-319-31614-7
eBook Packages: MedicineMedicine (R0)