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Neoplastic and Infiltrative Diseases

  • Ellen S. Haddock
  • Wynnis L. TomEmail author
Chapter
  • 892 Downloads

Abstract

Several pediatric neoplasms present as nonspecific pink, red-blue, or purple-colored nodules on the skin. A benign process versus one of malignant potential can be difficult to determine clinically, making index of suspicion and histologic examination important. This chapter highlights four neoplastic conditions that may present in early childhood and uses a case-based approach to discuss the appropriate workup.

Keywords

Neoplastic Cancer Leukemia cutis Acute lymphoid leukemia Acute myeloid leukemia Blueberry muffin phenotype Neuroblastoma Fibrosarcoma Infantile myofibroma Myofibromatosis 

Abbreviations

ALL

Acute lymphoid leukemia

AML

Acute myeloid leukemia

BCL

B cell lymphoma

CBC

Complete blood count

CT

Computed tomography

FISH

Fluorescence in situ hybridization

GLUT1

Glucose transporter 1

HVA

Homovanillic acid

LDH

Lactate dehydrogenase

MIBG

Metaiodobenzylguanidine

MLL

Mixed lineage leukemia

MRI

Magnetic resonance imaging

NB84

Neuroblastoma 84

NFP

Neurofilament protein

NSE

Neuron-specific enolase

NTRK3

Neurotrophic tyrosine kinase receptor type 3

Pax-5

Paired box 5

PCR

Polymerase chain reaction

PELVIS

Perineal hemangioma, external genitalia malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus, skin tag

PGP9.5

Protein gene product 9.5

PHOX2B

Paired-like homeobox 2b

SMA

Smooth muscle actin

TdT

Terminal deoxynucleotidyl transferase

TORCH

Toxoplasmosis, other, rubella, cytomegalovirus, herpes

TSEB

Total skin electron beam

VMA

Vanillylmandelic acid

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.School of MedicineUniversity of California, San Diego and Pediatric & Adolescent Dermatology, Rady Children’s HospitalSan DiegoUSA
  2. 2.Departments of Dermatology and PediatricsUniversity of California, San Diego and Rady Children’s HospitalSan DiegoUSA

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