Skip to main content
SpringerLink
Log in

Skin Signs of Systemic Diseases

  • Chapter
  • First Online:
Book cover Case-Based Inpatient Pediatric Dermatology

  • 1117 Accesses

Abstract

This chapter discusses examples of neutrophilic dermatoses and panniculitides, which represent a spectrum of non-infectious inflammatory conditions of the epidermis, dermis, and subcutaneous tissue. They can be associated with systemic diseases, including malignancies, and autoimmune and autoinflammatory disorders. Histopathological examination of the lesions is integral to the diagnosis of these cutaneous or subcutaneous inflammatory conditions. Treatment includes management of the associated systemic disease, in conjunction with a range of anti-inflammatory and immune-modulatory therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Prat L, Bouaziz JD, Wallach D, Vignon-Pennamen MD, Bagot M. Neutrophilic dermatoses as systemic diseases. Clin Dermatol. 2014;32(3):376–88.

    Article  PubMed  Google Scholar 

  2. Saavedra AP, Kovacs SC, Moschella SL. Neutrophilic dermatoses. Clin Dermatol. 2006;24(6):470–81.

    Article  PubMed  Google Scholar 

  3. Berk D, Bayliss SJ. Neutrophilic dermatoses in children. Pediatr Dermatol. 2008;25(5):509–19.

    Article  PubMed  Google Scholar 

  4. Su WP, Liu HN. Diagnostic criteria for Sweet’s syndrome. Cutis. 1986;37(3):167–74.

    CAS  PubMed  Google Scholar 

  5. Sutra-Loubet C, Carlotti A, Guillemette J, Wallach D. Neutrophilic panniculitis. J Am Acad Dermatol. 2004;50(2):280–5.

    Article  PubMed  Google Scholar 

  6. Cohen PR. Neutrophilic dermatoses: a review of current treatment options. Am J Clin Dermatol. 2009;10(5):301–12.

    Article  PubMed  Google Scholar 

  7. Webb K, Hlela C, Jordaan HF, Suliman S, Scriba T, Lipsker D, Scott C. A review and proposed approach to the neutrophilic dermatoses of childhood. Pediatr Dermatol. 2015;32(4):437–46.

    Article  PubMed  Google Scholar 

  8. Cohen PR. Sweet’s syndrome—a comprehensive review of an acute febrile neutrophilic dermatosis. Orphanet J Rare Dis. 2007;2:34.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Dabade TS, Davis MDP. Diagnosis and treatment of the neutrophilic dermatoses (pyoderma gangrenosum, Sweet’s syndrome). Dermatol Ther. 2011;24(2):273–84.

    Article  PubMed  Google Scholar 

  10. Fazili TJ, Duncan D, Wanji L. Sweet’s syndrome. Am J Med. 2010;123(8):694–6.

    Article  PubMed  Google Scholar 

  11. Moraes AJP, Soares PMF, Zapata AL, Lotito APN, Sallum AME, Silva CAA. Panniculitis in childhood and adolescence. Pediatr Int. 2006;48(1):48–53.

    Article  PubMed  Google Scholar 

  12. Torrelo A, Hernandez A. Panniculitis in children. Dermatol Clin. 2008;26(4):491–500.

    Article  PubMed  Google Scholar 

  13. Delgado-Jimenez Y, Fraga J, Garcia-Diez A. Infective panniculitis. Dermatol Clin. 2008;26(4):471–80.

    Article  PubMed  Google Scholar 

  14. Chan MP. Neutrophilic panniculitis: algorithmic approach to a heteregeneous group of disorders. Arch Pathol Lab Med. 2014;138(10):1337–43.

    Article  PubMed  Google Scholar 

  15. Polcari IC, Stein SL. Panniculitis in childhood. Dermatol Ther. 2010;23(4):356–67.

    Article  PubMed  Google Scholar 

  16. Diaz Cascajo C, Borghi S, Weyers W. Panniculitis: definition of terms and diagnostic strategy. Am J Dermatopathol. 2000;22(6):530–49.

    Article  CAS  PubMed  Google Scholar 

  17. Requena L, Yus ES. Panniculitis. Part I. Mostly septal panniculitis. J Am Acad Dermatol. 2001;45(2):163–83.

    Article  CAS  PubMed  Google Scholar 

  18. Requena LR, Yus ES. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001;45(3):325–61.

    Article  CAS  PubMed  Google Scholar 

  19. Torrelo A, Patel S, Colmenero I, Gurbindo D, Lendinez F, Hernandez A, et al. Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome. J Am Acad Dermatol. 2010;62(3):489–95.

    Article  PubMed  Google Scholar 

  20. Powell FC, Su WPD, Perry HO. Pyoderma gangrenosum: classification and management. J Am Acad Dermtol. 1996;34:395–409.

    Article  CAS  Google Scholar 

  21. Ormerod AD, Thomas KS, Craig FE, et al. Comparison of the two most commonly used treatments for pyoderma gangrenosum: results of the STOP GAP randomised controlled trial. BMJ. 2015;350:h2958. doi:10.1136/bmj.h2958.

    Google Scholar 

  22. Nozawa T, Hara R, Kinoshita J, et al. Infliximab for a girl with refractory pyoderma gangrenosum. Nihon Rinsho Meneki Gakkai Kaishi. 2008;31:454–9.

    Article  CAS  PubMed  Google Scholar 

  23. Kaur MR, Lewis HM. Severe recalcitrant pyoderma gangrenosum treated with infliximab. Br J Dermatol. 2005;153:689–91.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology and Infectious Diseases, Sydney Children’s Hospital, High Street, Randwick, NSW, 2031, Australia

    Adam Bartlett BSc, MBBS, MPHTM & Pamela Palasanthiran MBBS, MD, FRACP

  2. Division of Dermatology, University of California, Los Angeles, 52-121 CHS, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA

    Marcia Hogeling MD

  3. Department Paediatric Dermatology, Sydney Children’s Hospital, High Street, Randwick, NSW, 2031, Australia

    Orli Wargon MBBS (Hons1), MClin, Ed, FACD

Authors
  1. Adam Bartlett BSc, MBBS, MPHTM
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pamela Palasanthiran MBBS, MD, FRACP
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marcia Hogeling MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Orli Wargon MBBS (Hons1), MClin, Ed, FACD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Adam Bartlett BSc, MBBS, MPHTM .

Editor information

Editors and Affiliations

  1. Director of Pediatric Dermatology, UCLA Division of Dermatology, Los Angeles, California, USA

    Marcia Hogeling

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Bartlett, A., Palasanthiran, P., Hogeling, M., Wargon, O. (2016). Skin Signs of Systemic Diseases. In: Hogeling, M. (eds) Case-Based Inpatient Pediatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-31569-0_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31569-0_14

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31567-6

  • Online ISBN: 978-3-319-31569-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation