Skin Signs of Systemic Diseases

  • Adam BartlettEmail author
  • Pamela Palasanthiran
  • Marcia Hogeling
  • Orli Wargon


This chapter discusses examples of neutrophilic dermatoses and panniculitides, which represent a spectrum of non-infectious inflammatory conditions of the epidermis, dermis, and subcutaneous tissue. They can be associated with systemic diseases, including malignancies, and autoimmune and autoinflammatory disorders. Histopathological examination of the lesions is integral to the diagnosis of these cutaneous or subcutaneous inflammatory conditions. Treatment includes management of the associated systemic disease, in conjunction with a range of anti-inflammatory and immune-modulatory therapies.


Neutrophilic dermatosis Sweet’s syndrome Pyoderma gangrenosum Panniculitis Cutaneous findings of systemic disease 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Adam Bartlett
    • 1
    Email author
  • Pamela Palasanthiran
    • 1
  • Marcia Hogeling
    • 2
  • Orli Wargon
    • 3
  1. 1.Department of Immunology and Infectious DiseasesSydney Children’s HospitalRandwickAustralia
  2. 2.Division of DermatologyUniversity of California, Los AngelesLos AngelesUSA
  3. 3.Department Paediatric DermatologySydney Children’s HospitalRandwickAustralia

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