Abstract
Bullous diseases, both inherited and autoimmune, may be encountered on the inpatient consultation service. Neonates may be born with blisters and it is important to be aware of first and foremost the importance of ruling out an infectious process. The family history and morphology of the lesions may provide important clues to the diagnosis. Once infection has been ruled out, in cases without a family history of bullous disease, the autosomal recessive forms of genetically inherited blistering disease such as epidermolysis bullosa although rare, are more common than the autoimmune bullous disease in neonates. Acquired forms of blistering in the category of autoimmune remain rare, but become more common as children mature. Sudden presentations of large acral blisters in infants should prompt consideration of infantile bullous pemphigoid after hand-foot-mouth disease or other infection is ruled out. Linear IgA bullous disease, also known as chronic bullous disease of childhood, is often initially mistaken for impetigo and although may be superinfected and partially respond to oral antibiotics, the diagnosis may only become clear with the clinical course or the astute clinician recognizing and initiating a workup for the condition. Regardless of the cause of the blisters, careful wound care with non-adherent dressings and monitoring for signs or symptoms of superinfection must be performed.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Sarkell B, Blaylock WK, Vernon H. Congenital neonatal herpes simplex infection. J Am Acad Dermatol. 1992;27(5):817–21.
Koch LH, Fisher RG, Chen C, Foster MM, Bass WT, William JV. Congenital herpes simplex virus infection: two unique cutaneous presentations associated with probable intrauterine transmission. J Am Acad Dermatol. 2009;60:312–5.
Paller A, Mancini A. Bullous disorders of childhood (Chapter 13). In: Paller AS, Mancini AJ, editors. Hurwitz clinical pediatric dermatology. 4th ed. Philadelphia: Elsevier; 2011.
Berk DR, Jazayeri L, Marinkovich MP, Sundram UN, Bruckner AL. Diagnosing epidermolysis bullosa type and subtype in infancy using immunofluorescence microscopy: the Stanford experience. Pediatr Dermatol. 2013;30(2):226–33.
Fine JD, Bruckner-Tuderman LB, Eady RA, Bauer EA, Bauer JW, Has C, et al. Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification. J Am Acad Dermatol. 2014;70:1103–26.
Intong LRA, Murrell DF. How to take skin biopsies for epidermolysis bullosa. Dermatol Clin. 2010;28:197–200.
Takeichi T, Liu L, Fong K, Ozoemena L, McMillan JR, Salam A, Campbell P, Akiyama M, Mellerio JE, McLean WH, Simpson MA, McGrath JA. Whole-exome sequencing improves mutation detection in a diagnostic epidermolysis bullosa laboratory. Br J Dermatol. 2015;172(1):94–100.
Gonzalez ME. Evaluation and treatment of the newborn with epidermolysis bullosa. Semin Perinatol. 2013;37(1):32–9.
Eichenfield LF, Frieden IJ, editors. Neonatal and infant dermatology. 3rd ed. London: Elsevier Saunders; 2015.
Fortuna G, Marinkovich MP. Linear immunoglobulin A bullous dermatosis. Dermatol Clin. 2012;30:38–50.
Venning VA. Linear IgA disease: clinical presentation, diagnosis, and pathogenesis. Dermatol Clin. 2011;29:453–8.
Kneisel A, Hertl M. Autoimmune bullous skin diseases. Part 1: clinical manifestations. J German Soc Dermatol. 2011;10:844–57.
De la Fuente A, Hernández-Martin Á, et al. Postvaccination bullous pemphigoid in infancy: report of three new cases and literature review. Pediatr Dermatol. 2013;30(6):741–4.
Lynch M, Devaney D, et al. Bullae of the hands, feet, and perioral area in a 3-month-old infant. Pediatr Dermatol. 2013;30(1):135–6.
Prost-Squarcioni C, Caux F. Epidermolysis bullosa acquisita (Chapter 40). In: Murrell DF, editor. Blistering diseases: clinical features, pathogenesis, treatment. Sydney: Springer; 2015.
Léauté-Labrèze C, Lamireau T, Chawki D, Maleville J, Taïeb A. Diagnosis, classification, and management of erythema multiforme and Stevens–Johnson syndrome. Arch Dis Child. 2000;83:347–52.
Levin DL, Esterly NB, Herman JJ, Boxall LBH. The Sweet syndrome in children. J Pediatr. 1981;99(1):73–8.
Cooper SM, Powell J, Wojnarowska F. Linear IgA disease: successful treatment with erythromycin. Clin Exp Dermatol. 2002;27(8):677–9.
Siegfried EC, Sirawan S. Chronic bullous disease of childhood: successful treatment with dicloxacillin. J Am Acad Dermatol. 1998;35(5):797–800.
Mintz EM, Morel KD. Treatment of chronic bullous disease of childhood (Chapter 57). In: Murrell DF, editor. Blistering diseases: clinical features, pathogenesis, treatment. Sydney: Springer; 2015.
Edhegard K, Hall III R. Dapsone (Chapter 18). In: Wolverton SE, editor. Comprehensive dermatologic drug therapy. Philadelphia: Elsevier; 2013.
Ladhani S, Evans RW. Staphylococcal scalded skin syndrome. Arch Dis Child. 1998;78:85–8.
Howard R, Frieden IJ. Vesicles, pustules, bullae, erosions, and ulcerations (Chapter 10). In: Schachner LE, Frieden IJ, Esterly NB, editors. Neonatal and infant dermatology. Philadelphia: Elsevier; 2008.
Golitz LE, Weston WL, Lane AT. Bullous mastocytosis: diffuse cutaneous mastocytosis with extensive blisters mimicking scalded skin syndrome or erythema multiforme. Pediatr Dermatol. 1984;1(4):288–94.
Reis-Filho EG, Silva Tde A, et al. Bullous pemphigoid in a 3-month-old infant: case report and literature review of this dermatosis in childhood. An Bras Dermatol. 2013;88(6):961–5.
Weitz N, Mintz E, Morel K. Autoimmune bullous diseases of childhood (Chapter 5). In: Tom WL, editor. Severe skin diseases in children: beyond topical therapy. Berlin: Springer; 2014. p. 67–90.
Martinez-De Pablo MI, González-Enseñat MA, et al. Childhood bullous pemphigoid: clinical and immunological findings in a series of 4 cases. Arch Dermatol. 2007;143(2):215–20.
Amos BMD, Deng JS, et al. Bullous pemphigoid in infancy: case report and literature review. Pediatr Dermatol. 1998;15(2):108–11.
Marcus KA, Halbertsma FJ, van Steensel MA. A case of juvenile bullous pemphigoid—successful treatment with diaminodiphenylsulfone and prednisone. Pediatr Dermatol. 2009;26:55–8.
Simmons RN, Bruckner AL, Prok LD. Blisters in a 4-year-old: an unexpected diagnosis. Pediatr Dermatol. 2013;30(1):135–6.
Wolverton SE. Systemic corticosteroids (Chapter 12). In: Wolverton SE, editor. Comprehensive dermatologic drug therapy. Philadelphia: Elsevier; 2013.
Das D, Das A, Debbarman P. Childhood bullous pemphigoid. Indian Pediatr. 2013;50(12):1179.
Red Book®. 2015 report of the committee on infectious disease. 30th ed; 2015.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Tamesis, M.E., Morel, K.D. (2016). Bullous Disorders of Childhood. In: Hogeling, M. (eds) Case-Based Inpatient Pediatric Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-31569-0_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-31569-0_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-31567-6
Online ISBN: 978-3-319-31569-0
eBook Packages: MedicineMedicine (R0)