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Pemphigus Vulgaris and Paraneoplastic Pemphigus

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Deadly Dermatologic Diseases

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Abstract

The disease pemphigus encompasses a group of related blistering conditions characterized by circulating antibodies against keratinocyte cell surface antigens important in mediating cell-to-cell adhesion (Becker and Gaspari, Dermatol Clin, 1993;11:429; Lever. J Am Acad Dermatol. 1979;1:2). Of the various types and forms of the disease including pemphigus foliaceus, pemphigus erythematosus, IgA pemphigus, and pemphigus vegetans, it is pemphigus vulgaris (PV) and paraneoplastic pemphigus (PP) that constitute the most important causes of mortality. Overall, these disorders are quite rare, with an estimated prevalence of between 1 in 100,000 for PV and less than 1 in 1,000,000 for PP. Both disorders are seen principally in aged adults with a near equal gender distribution. PV is more commonly observed among Jews and individuals of Mediterranean descent, whereas there is no known ethnic predilection for PP.

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Author information

Authors and Affiliations

  1. Director of Dermatopathology, Dermatology Specialists of Florida, Panama City, FL, USA

    Michael B. Morgan

  2. Staff Dermatopathologist, Advanced Dermatology and Cosmetic Surgery, Clermont, FL, USA

    Michael B. Morgan

  3. Professor of Dermatology, Michigan State College of Medicine, Tampa, FL, USA

    Michael B. Morgan

Authors
  1. Jeff Kushner DO
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  2. Michael B. Morgan
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Correspondence to Michael B. Morgan .

Editor information

Editors and Affiliations

  1. Assistant Professor Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    David R. Crowe

  2. Dermpath Diagnostics, Tampa, Florida, USA

    Michael Morgan

  3. MetroHealth Medical Center, Cleveland, Ohio, USA

    Stephen Somach

  4. Washington, District of Columbia, USA

    Kara Trapp

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© 2016 Springer International Publishing Switzerland

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Kushner, J., Morgan, M.B. (2016). Pemphigus Vulgaris and Paraneoplastic Pemphigus. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_38

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  • DOI: https://doi.org/10.1007/978-3-319-31566-9_38

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31564-5

  • Online ISBN: 978-3-319-31566-9

  • eBook Packages: MedicineMedicine (R0)

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