Abstract
Current use of the term “geometric phagedenism” will result in confusion, unless the term is defined in relation to its word origin and historical meaning to dermatologists. In 1908, Louis Brocq used this term to refer to a series of patients with rapidly extending, destructive ulcers, often with circular, elliptical, or geometric edges. Using the term phagedenism (phageton [Greek] means consumption) emphasizes the destructive nature, the “consuming” of surrounding tissue. Brocq also included elegant descriptions and trends in morphology of ulcers, including the gradually sloping infiltrated and erythematous area external to the “ridge” (border of the active ulcer), the sharp, often undermined internal edge “dimpled by purulent cavities.” Histopathology was noted to include a heavy neutrophilic infiltrate with extensive necrosis, and Brocq correctly noted the lack of transmissibility.
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References
Brocq L. A new contribution to the study of geometric phagedenism. Ann Dermatol Syphiligy (Paris). 1916:1–39.
Farhi D. The clinical and histopathological description of geometric phagedenism (pyoderma gangrenosum) by Louis Brocq one century ago. Arch Dermatol. 2008;144(6):755.
Brunsting LA, Goeckerman WH, O’Leary PA. Pyoderma (ecthyma) gangrenosum. Clinical and experimental observations in five cases occurring in adults. Arch Derm Syphilol. 1930;22:655–80.
Marks DJB, Rahman FZ, Yu RC, McCartney S, Bloom S, Segal AW. An exuberant inflammatory response to E coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. Gut. 2006;55(11):1662–3.
Binus AM, Qureshi AA, Li VW, Winterfield LS. Pyoderma gangrenosum: a retrospective review of patient characteristics, comorbidities and therapy in 103 patients. Br J Dermatol. 2011;165(6):1244–50.
Al Ghazal P, Herberger K, Schaller K, et al. Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. Orphanet J Rare Dis. 2013;8:136.
Von den Driesch P. Pyoderma gangrenosum: a report of 44 cases with follow-up. Br J Dermatol. 1997;137(6):1000–5.
Powell FC, Schroeter AL, Perry HO, Su WP. Direct immunofluorescence in pyoderma gangrenosum. Br J Dermatol. 1983;108(3):287–93.
Su WP, Schroeter AL, Perry HA, Powell FC. Histopathologic and immunopathologic study of pyoderma gangrenosum. J Cutan Pathol. 1986;13(5):323–30.
Nerella P, Daniela A, Guido M, Fabbri P. Leukocyte chemotaxis and pyoderma gangrenosum. Int J Dermatol. 1985;24(1):45–7.
Norris DA, Weston WL, Thome G, Humbert JR. Pyoderma gangrenosum. Abnormal monocyte function corrected in vitro with hydrocortisone. Arch Dermatol. 1978;114(6):906–11.
Oka M, Berking C, Nesbit M, et al. Interleukin-8 overexpression is present in pyoderma gangrenosum ulcers and leads to ulcer formation in human skin xenografts. Lab Invest. 2000;80:595–604.
Hadi A, Lebwohl M. Clinical features of pyoderma gangrenosum and current diagnostic trends. JAAD. 2011;64:950–4.
Callen JP, Jackson JM. Pyoderma gangrenosum: an update. Rheum Dis Clin North Am. 2007;33:787–802.
Jackson JM, Callen JP. Pyoderma gangrenosum: an expert commentary. Expert Rev Dermatol. 2006;1:391–401.
Langan SM, Groves RW, Card TR, Gulliform MC. Incidence, mortality, and disease associations of pyoderma gangrenosum in the United Kingdom: a retrospective cohort study. J Invest Dermatol. 2012;132(9):2166–70.
Sanders S, Tahan SR, Kwan T, et al. Giant cells in pyoderma gangrenosum. J Cutan Pathol. 2001;28:97–100.
Saracino A, Kelly R, Liew D, Chong A. Pyoderma gangrenosum requiring inpatient management: a report of 26 cases with follow up. Australas J Dermatol. 2011;52(3):218–21.
Sitjas D, Puig L, Cuatrecasas M, de Moragas JM. Acute febrile neutrophilic dermatosis (Sweet’s syndrome). Int J Dermatol. 1993;32:261–8.
Johnson RB, Lazarus GS. Therapeutic efficacy in the treatment of pyoderma gangrenosum. Arch Dermatol. 1982;118:76–84.
Elgart G, et al. Treatment of pyoderma gangrenosum with cyclosporine: results in seven patients. J Am Acad Dermatol. 1991;24:83–6.
Agarwal A, Andrews JM. Systemic review: IBD-associated pyoderma gangrenosum in the biologic era, the response to therapy. Aliment Pharmacol Ther. 2013;38(6):563–72.
Al Ghazal P, Dissemond J. Therapy of pyoderma gangrenosum in Germany: results of a survey among wound experts. J Dtsch Dermatol Ges. 2015;13(4):317–24.
Li J, Kelly R. Treatment of pyoderma gangrenosum with mycophenolate mofetil as a steroid-sparing agent. J Am Acad Dermatol. 2013;69(4):565–9.
Eaton PA, Callen JP. Mycophenolate mofetil as therapy for pyoderma gangrenosum. Arch Dermatol. 2009;145(7):781–5.
Lyon CC, et al. Topical tacrolimus in the management of peristomal pyoderma gangrenosum. J Dermatolog Treat. 2001;12:13–7.
Lorincz AL, Pearson RW. Sulfapyridine and sulphone-type drugs in dermatology. Arch Dermatol. 1962;85:42–56.
Berth-Jones J, Tan SV, Graham-Brown RA, Pembroke AC. The successful use of minocycline in pyoderma ganagrenosum-a report of seven cases and review of the literature. J Dermatol Treat. 1989;1:23–5.
Mazokopakis EE, et al. Improvement of ulcerative pyoderma gangrenosum with hyperbaric oxygen therapy. Dermatol Ther. 2011;24(1):134–6.
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Crowe, D.R. (2016). Pyoderma Gangrenosum. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_24
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