Abstract
Multicentric reticulohistiocytosis was first named by Goltz and Laymon in 1954, although the literature is muddled with prior reports of conditions with similar features. Multiple cutaneous papules and nodules arise most distinctly on the dorsum of the hands and the face but also less commonly involving the extensor extremities, scalp, and mucosa. Papules arise over a period of weeks to months and present before, with, or after a characteristic mutilating arthritis which is symmetric and involves the distal and the axial skeleton. Adding to the morbidity of a disabling condition is an unsettling association with internal malignancy. Demographic features include a predominance of Caucasian patients (>75 %). Disease often begins in the fourth decade of life, and most studies reveal a female predominance of 3:1. There is no documented tendency to occur with familial predisposition.
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Crowe, D.R. (2016). Multicentric Reticulohistiocytosis. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_19
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DOI: https://doi.org/10.1007/978-3-319-31566-9_19
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