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Multiple Cutaneous Leiomyomas

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Deadly Dermatologic Diseases
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Abstract

Cutaneous leiomyomas are uncommon tumors that arise from arrector pili (pilar leiomyoma), genital smooth muscle (genital leiomyoma), or vascular smooth muscle (angioleiomyoma). As multiple lesions, they may occur in association with uterine leiomyomas and, rarely, leiomyosarcomas, in the multiple cutaneous and uterine leiomyomatosis (MCUL) syndrome. More recently, cutaneous and uterine leiomyomas have been reported to occur in association with renal cell carcinoma in the hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. MCUL and HLRCC likely represent part of a spectrum of one disease.

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References

  1. Launonen V, Vierimaa O, Kiuru M, et al. Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A. 2001;98:3387–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Reed WB, Walker R, Horowitz R. Cutaneous leiomyomata with uterine leiomyomata. Acta Derm Venereol. 1973;53:409–16.

    CAS  PubMed  Google Scholar 

  3. Tomlinson IPM, Alam NA, Rowan AJ, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cancer. Nat Genet. 2002;30:406–10.

    Article  CAS  PubMed  Google Scholar 

  4. Rustin P. Mitochondria, from cell death to proliferation. Nat Genet. 2002;30:352–3.

    Article  CAS  PubMed  Google Scholar 

  5. Desideri E, Vegliante R, Ciriolo MR. Mitochondrial dysfunctions in cancer: genetic defects and oncogenic signaling impinging on TCA cycle activity. Cancer Lett. 2015;356:217–23.

    Article  CAS  PubMed  Google Scholar 

  6. Alam NA, Rowan AJ, Wortham NC, et al. Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum Mol Genet. 2003;12:1241–52.

    Article  CAS  PubMed  Google Scholar 

  7. Kiuru M, Launonen V, Hietala M, et al. Familial cutaneous leiomyomatosis is a two-hit condition associated with renal cell cancer of characteristic histopathology. Am J Pathol. 2001;159:825–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Lehtonen R, Kiuru M, Vanharanta S, et al. Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol. 2004;164:17–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wei M-H, Toure O, Glenn GM, et al. Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer. J Med Genet. 2006;43:18–27.

    Article  CAS  PubMed  Google Scholar 

  10. Alam NA, Olpin S, Leigh IM. Fumarate hydratase mutations and predisposition to cutaneous leiomyomas, uterine leiomyomas and renal cancer. Br J Dermatol. 2005;153:11–7.

    Article  CAS  PubMed  Google Scholar 

  11. Toro JR, Nickerson ML, Wei M-H, et al. Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. Am J Hum Genet. 2003;73:95–106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Raj S, Calonje E, Kraus M, et al. Cutaneous pilar leiomyoma: clinicopathologic analysis of 53 lesions in 45 patients. Am J Dermatopathol. 1997;19:2–9.

    Article  CAS  PubMed  Google Scholar 

  13. Cook DL, Pugliano-Mauro MA, Schultz ZL. Atypical pilar leiomyomatosis: an unusual presentation of multiple atypical cutaneous leiomyomas. J Cutan Pathol. 2013;40:564–8.

    Article  PubMed  Google Scholar 

  14. Weiler L, Poulalhon N, Slama A, Guillaud-Bataille M, Thomas L. Isolated cutaneous leiomyosarcoma revealing a novel germline mutation of fumarate hydratase gene. Br J Dermatol. 2015. doi:10.1111/bjd.13867 [Epub ahead of print].

    Google Scholar 

  15. Merino MJ, Torres-Cabala C, Pinto P, Linehan WM. The morphologic spectrum or kidney tumors in Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) syndrome. Am J Surg Pathol. 2007;31:1578–85.

    Article  PubMed  Google Scholar 

  16. Vergani R, Betti R, Uziel L, Tolomio E, Crosti C. Eruptive multiple sporadic cutaneous piloleiomyomas in a patient with chronic lymphocytic leukemia. Br J Dermatol. 2000;143:907–9.

    Article  CAS  PubMed  Google Scholar 

  17. Kanitakis J, Carbonnel E, Chouvet B, Labeille B, Claudy A. Cutaneous leiomyomas (piloleiomyomas) in adult patients with human immunodeficiency virus infection. Br J Dermatol. 2000;143:1338–40.

    Article  CAS  PubMed  Google Scholar 

  18. McClain K, Leach C, Jenson H. Association of Epstein-Barr virus with leiomyosarcomas in children with AIDS. N Engl J Med. 1995;332:12–8.

    Article  CAS  PubMed  Google Scholar 

  19. George S, Pulimood S, Jacob M, Chandi SM. Pain in multiple leiomyomas alleviated by nifedipine. Pain. 1997;73:101–2.

    Article  CAS  PubMed  Google Scholar 

  20. Onder M, Adişen E. A new indication of botulinum toxin: leiomyoma-related pain. J Am Acad Dermatol. 2008;60:325–8.

    Article  Google Scholar 

  21. Batchelor RJ, Lyon CC, Highet AS. Successful treatment of pain in two patients with cutaneous leiomyomata with the oral alpha-1 adrenoceptor antagonist, doxazosin. Br J Dermatol. 2004;150:775.

    Article  CAS  PubMed  Google Scholar 

  22. Pithukpakorn M, Toro JR. Hereditary Leiomyomatosis and Renal Cell Cancer. 2006 Jul 31 [Updated 2010 Nov 2]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle: University of Washington; 1993–2015. http://www.ncbi.nlm.nih.gov/books/NBK125.

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Correspondence to Stephen C. Somach MD .

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Somach, S.C. (2016). Multiple Cutaneous Leiomyomas. In: Crowe, D., Morgan, M., Somach, S., Trapp, K. (eds) Deadly Dermatologic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-31566-9_14

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  • DOI: https://doi.org/10.1007/978-3-319-31566-9_14

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31564-5

  • Online ISBN: 978-3-319-31566-9

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