Abstract
The innovating advent of TeraWatt lasers able to drive laser-plasma accelerators and produce ultra-short relativistic electron beams in the MeV range, combined with ultrafast spectroscopy methods, opens exciting opportunities for the emerging domain of high energy radiation femtochemistry (HERF). In synergy with low energy radiation femtochemistry (LERF) , HERF favours the development of new conceptual approaches for pulsed radiation biology and medicine. The unprecedented high dose rate delivered by ultrashort relativistic electron beams (1012–1013 Gy s−1) with laser techniques can be used to investigate the spatio-temporal approach of early radiation processes. The chapter focuses on early physico-chemical phenomena which occur in the prethermal regime of secondary electrons, considering the sub-structures of tracks and very short-lived quantum probes. This interdisciplinary breakthrough would provide guidance for the real-time nanodosimetry of molecular targets in integrated biologically relevant environments and would open new perspectives for the conceptualisation of time-dependent molecular RBE (Relative Biological Effectiveness), in synergy with particle based anticancer radiotherapies.
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Gauduel, Y.A. (2016). Laser-Plasma Accelerators Based Ultrafast Radiation Biophysics. In: Giulietti, A. (eds) Laser-Driven Particle Acceleration Towards Radiobiology and Medicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-31563-8_2
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