Abstract
Certain disease states only (or almost only) occur in livers transplanted into a recipient patient. They generally represent immunologic phenomena or responses to surgical injury. The most common, and most nerve-racking, specimen a pathologist receives from a transplanted liver is a biopsy to rule out rejection. There are several subtypes of rejection, which fit differently into the postoperative time frame (Table 14.1). Although humoral rejection occurs first along the time line, it is discussed last because of its rarity.
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Suggested Reading
Adeyi O, Fischer SE, Guindi M. Liver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlation. Journal of Clinical Pathology. 63:47–74, 2010.
International Panel. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology. 25:658–63, 1997.
Sundaram SS, Melin-Aldana H, Neighbors K, Alonso EM. Histologic characteristics of late cellular rejection, significance of centrilobular injury, and long-term outcome in pediatric liver transplant recipients. Liver Transplantation. 12:58–64, 2006.
Kerkar N, Hadzić N, Davies ET, Portmann B, Donaldson PT, Rela M, Heaton ND, Vergani D, Mieli-Vergani G. De novo autoimmune hepatitis after liver transplantation. The Lancet. 351:409–13, 1998.
Hübscher SG. Antibody-mediated rejection in the liver allograft. Current Opinion in Organ Transplantation. 17:280–6, 2012.
Gaffey MJ, Boyd JC, Traweek ST, Ali MA, Rezeig M, Caldwell SH, Iezzoni JC, McCullough C, Stevenson WC, Khuroo S, Nezamuddin N, Ishitani MB, Pruett TL. Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation. Hepatology. 25:184–9, 1997.
Demetris AJ, Kelly DM, Eghtesad B, Fontes P, Wallis Marsh J, Tom K, Tan HP, Shaw-Stiffel T, Boig L, Novelli P, Planinsic R, Fung JJ, Marcos A. Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome. The American Journal of Surgical Pathology. 30:986–93, 2006.
Stange BJ, Glanemann M, Nuessler NC, Settmacher U, Steinmüller T, Neuhaus P. Hepatic artery thrombosis after adult liver transplantation. Liver Transplantation. 9:612–20, 2003.
Kotlyar DS, Campbell MS, Reddy KR. Recurrence of diseases following orthotopic liver transplantation. The American Journal of Gastroenterology. 101:1370–8, 2006.
Melin C, Miick R, Young NA, Ortiz J, Balasubramanian M. Approach to intraoperative consultation for donor liver biopsies. Archives of Pathology and Laboratory Medicine. 137:270–4, 2013.
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Gonzalez, R.S., Washington, K. (2016). Liver Transplantation. In: Non-Neoplastic Liver Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-31424-2_14
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DOI: https://doi.org/10.1007/978-3-319-31424-2_14
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