Skip to main content
SpringerLink
Log in
Book cover

Case Studies in Multiple Sclerosis pp 3–10Cite as

Optic neuritis

  • Chapter
  • First Online:

  • 1041 Accesses

Abstract

A 27-year-old Caucasian female presented with subacute painful monocular visual loss. Over 4 days, she developed discomfort in the left eye, made worse with eye movements, followed by progressive blurring of left eye vision. There were no right eye symptoms and no previous ocular history. She had been systemically well, with no recent infections or vaccinations. While giving a detailed history, she recalled fleeting episodes of limb paresthesia lasting minutes, with no other history of transient neurological symptoms. She was a smoker with a past history of asthma but took no regular medications. She had a cousin with multiple sclerosis (MS) and was very concerned about her own risk of developing the condition.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. The clinical profile of optic neuritis. Experience of the Optic Neuritis Treatment Trial. Optic Neuritis Study Group. Arch Ophthalmol. 1991;109:1673-1678.

    Google Scholar 

  2. Beck RW, Cleary PA, Backlund JC. The course of visual recovery after optic neuritis. Experience of the Optic Neuritis Treatment Trial. Ophthalmology. 1994;101:1771-1778.

    Google Scholar 

  3. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69:292-302.

    Google Scholar 

  4. Optic Neuritis Study Group. Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol. 2008;65:727-732.

    Google Scholar 

  5. Fisniku LK, Brex PA, Altmann DR, et al. Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain. 2008;131:808-817.

    Google Scholar 

  6. Tintore M, Rovira A, Arrambide G, et al. Brainstem lesions in clinically isolated syndromes. Neurology. 2010;75:1933-1938.

    Google Scholar 

  7. Young J, Quinn S, Hurrell M, Taylor B. Clinically isolated acute transverse myelitis: prognostic features and incidence. Mult Scler. 2009;15:1295-1302.

    Google Scholar 

  8. Jacobs L, Kinkel PR, Kinkel WR. Silent brain lesions in patients with isolated idiopathic optic neuritis. A clinical and nuclear magnetic resonance imaging study. Arch Neurol. 1986;43:452-455.

    Google Scholar 

  9. Ormerod IE, Bronstein A, Rudge P, et al. Magnetic resonance imaging in clinically isolated lesions of the brain stem. J Neurol Neurosurg Psychiatry.1986;49:737-743.

    Google Scholar 

  10. Tintoré M, Rovira A, Rio J, et al. Baseline MRI predicts future attacks and disability in clinically isolated syndromes. Neurology. 2006;67:968-972.

    Google Scholar 

  11. Miller DH, Chard DT, Ciccarelli O. Clinically isolated syndromes. Lancet Neurol. 2012;11:157-169.

    Google Scholar 

  12. Miller D, Barkhof F, Montalban X, Thompson A, Filippi M. Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis. Lancet Neurol. 2005;4:281-288.

    Google Scholar 

  13. Tintoré M, Rovira A, Rio J, et al. Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis? Neurology. 2008;70:1079-1083.

    Google Scholar 

  14. Compston A. McAlpine’s Multiple Sclerosis, 4th edn. Edinburgh: Churchill Livingstone; 2005.

    Google Scholar 

  15. OGorman C, Lin R, Stankovich J, Broadley SA. Modelling genetic susceptibility to multiple sclerosis with family data. Neuroepidemiology. 2013;40:1-12.

    Google Scholar 

  16. Di Pauli F, Reindl M, Ehling R, et al. Smoking is a risk factor for early conversion to clinically definite multiple sclerosis. Mult Scler. 2008;14:1026-1030.

    Google Scholar 

  17. The Optic Neuritis Study Group. Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up. Arch Neurol. 2008;65:727-732.

    Google Scholar 

  18. Beck RW, Gal RL. Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial. Arch Ophthalmol. 2008;126:994-995.

    Google Scholar 

  19. Comi G, Martinelli V, Rodegher M, et al. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet 1931;374:1503-1511.

    Google Scholar 

  20. Kappos L, Polman CH, Freedman MS, et al. Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes. Neurology. 2006;67:1242-1249.

    Google Scholar 

  21. Comi G, Filippi M, Barkhof F, et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet. 2001;357:1576-1582.

    Google Scholar 

  22. Jacobs LD, Beck RW, Simon JH, et al. Intramuscular interferon beta-1A therapy initiated during a first demyelinating event in multiple sclerosis. N Engl J Med. 2000;343:898-904.

    Google Scholar 

  23. Willoughby EW, Grochowski E, Li DKB, Oger J, Kastrukoff LF, Paty DW. Serial magnetic resonance scanning in multiple sclerosis: A second prospective study in relapsing patients. Ann Neurol. 1989;25:43-49.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada

    Mahtab Ghadiri

Authors
  1. Mahtab Ghadiri
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. McGill University , MONTREAL, Québec, Canada

    Paul S. Giacomini

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Ghadiri, M. (2017). Optic neuritis. In: Giacomini, P. (eds) Case Studies in Multiple Sclerosis. Adis, Cham. https://doi.org/10.1007/978-3-319-31190-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-31190-6_1

  • Published:

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-31188-3

  • Online ISBN: 978-3-319-31190-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation