Abstract
The last 20 years, knowledge on human brain development has grown exponentially due to magnetic resonance imaging (MRI) and functional MRI. At the age of 6, the brain has reached his adult size. From that point on, connections and synapses continue to develop in order to reach a complete network of neuronal pathways. This chapter covers the description of normal brain development in adolescence and its relation to cognitive functioning. We discuss changes in white and gray matter, sex specificity, and changes in cortical thickness. On a functional cognitive level, adolescents with CHD display a high variability, usually below expectation. A high percentage of them need remedial services during their school career. Attention and executive functioning are mostly affected. Visual-spatial problems, difficulty with reading and orthographic skills, and reduced social cognition are also mentioned. Smaller brain volumes and mainly white and gray matter injury in frontoparietal areas, the uncinate fasciculus (UF), and the middle cerebellar peduncle (MCP) are highly associated with the experienced cognitive weaknesses. In the second part of this chapter, we look into psychosocial development during adolescence. The life phase of adolescence onto adulthood is characterized by constant change and may especially pose challenges for those afflicted with chronic illness. Although the majority of patients with CHD seem to tackle identity formation issues in a normal way, there is a subgroup significantly at risk for adapting maladjusted identity processes, leaving them vulnerable for constant worrying about where their lives should lead them, psychosocial difficulties, lowered self-esteem, and higher levels of depressive symptoms.
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References
Andropoulos D, Hunter J, Nelson D et al (2010) Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. J Thorac Cardiovasc Surg 139(3):543–556
Ardila A, Rosselli M, Matute E et al (2011) Gender differences in cognitive development. Dev Psychol 47:984–990
Arnett JJ (2000) Emerging adulthood – a theory of development from the late teens through the twenties. Am Psychol 55:469–480
Arnett JJ (2004) Emerging adulthood the winding road from the late teens through the twenties. Oxford University Press, Oxford
Beaulieu C, Plewes C, Paulson L et al (2005) Imaging brain connectivity in children with diverse reading ability. Neuroimage 25:1266–1271
Bechtel N, Kobel M, Penner I et al (2009) Decreased fractional anisotropy in the middle cerebellar peduncle in children with epilepsy and/or attention deficit/hyperactivity disorder: a preliminary study. Epilepsy Behav 15(3):294–298
Bellinger D, Wypij D, Rivkin M et al (2011) Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure. Neuropsychological assessment and structural brain imaging. Circulation 124:1361–1369
Ben-Shachar M, Dougherty R, Wandell B (2007) White matter pathways in reading. Curr Opin Neurobiol 17:258–270
Blakemore S (2012) Imaging brain development. Neuroimage 61:397–406
Blakemore S, Robbins T (2012) Decision-making in the adolescent brain. Nat Neurosci 15:1184–1191
Boes A, Tranel D, Anderson S et al (2008) Right anterior cingulated: a neuroanatomical correlate of aggression and defiance in boys. Behav Neurosci 122:677–684
Bosma HA (1985) Identity development in adolescence. Cah Psychol Cogn 5:453–454
Bramen J, Hranilovich J, Dhal R et al (2011) Puberty influences medial temporal lobe and cortical grey matter maturation differently in boys than girls matched for sexual maturity. Cereb Cortex 21(3):636–646
Bramen J, Hranilovich J, Dahl R et al (2012) Sex matters during adolescence: testosterone-related cortical thickness maturation differs between boys and girls. PLoS One 7(3):e33850
Brewster R, King T, Burns T et al (2015) White matter integrity dissociates verbal memory and auditory attention span in emerging adults with congenital heart disease. J Int Neuropsychol Soc 21:22–33
Cassidy A, White M, DeMaso D et al (2015) Executive function in children and adolescents with critical cyanotic congenital heart disease. J Int Neuropsychol Soc 20:34–49
Cromer J, Shembri A, Harel B et al (2015) The nature and rate of cognitive maturation from late childhood to adulthood. Front Psychol 6(704):1–12
Crossland DS, Jackson SP, Lyall R, Burn J, O’Sullivan JJ (2005) Employment and advice regarding careers for adults with congenital heart disease. Cardiol Young 15:391–395
Dennison M, Whittle S, Yücel M et al (2013) Mapping subcortical brain maturation during adolescence: evidence of hemispheric and sex specific longitudinal changes. Dev Sci 16(5):772–791
Erikson EH (1963) Identity, youth, and crisis. Norton, New York
Erikson EH (1980) Identity and the life cycle. Norton, New York
Erus G, Battapady H, Satterthwaite T et al (2015) Imaging patterns of brain development and their relationship to cognition. Cereb Cortex 25:1676–1684
Fair D, Dosenbach N, Church J et al (2007) Development of distinct control networks through segregation and integration. Proc Natl Acad Sci U S A 104(33):13507–13512
Frith C, Frith U (2007) Social cognition in humans. Curr Biol 17:724–732
Galvan A, Hare T, Parra C et al (2006) Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents. J Neurosci 26:6885–6892
Giedd J, Castellanos F, Rajapakse J et al (1997) Sexual dimorphism of the developing human brain. Prog Neuropsychopharmacol Biol Psychiatry 21(8):1185–1201
Giedd J, Blumenthal J, Jeffries N et al (1999) Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 2:861–863
Giedd J, Clasen L, Lenroot R et al (2006) Puberty-related influences on brain development. Mol Cell Endocrinol 245–255:154–162
Goossens E et al (2011) Transfer of adolescents with congenital heart disease from pediatric cardiology to adult health care: an analysis of transfer destinations. J Am Coll Cardiol 57:2368–2374
Havighurst RJ (1972) Developmental tasks and education, 3rd edn. McKay, D. Co, New York
Heinrichs A, Holschen A, Krings T et al (2014) Neurologic and psycho-intellectual outcome related to structural brain imaging in adolescents and young adults after neonatal arterial switch operation for transposition of the great arteries. J Thorac Cardiovasc Surg 148:2190–2199
Hu S, Pruessner J, Coupé P et al (2013) Volumetric analysis of medial temporal lobe structures in brain development from childhood to adolescence. Neuroimage 74:279–287
Kamphuis M, Vliegen HW, Verloove-Vanhorick SP, Ottenkamp J, Vogels T (2005) Employment and work-related handicaps in young adults with congenital heart disease. Ned Tijdschr Geneeskd 149:1107–1112
Karsdorp PA, Everaerd W, Kindt M, Mulder BJ (2007) Psychological and cognitive functioning in children and adolescents with congenital heart disease: a meta-analysis. J Pediatr Psychol 32:527–541
Klingberg T, Vaidya C, Gabrieli J et al (1999) Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. Neuroreport 10:2817–2821
Kobel M, Bechtel N, Specht K et al (2010) Structural and functional images approaches in attention deficit/hyperactivity disorder: does the temporal lobe play a key role? Psychiatry Res 183(3):230–236
Koolschijn C, Crone E (2013) Sex differences and structural brain maturation from childhood to early adulthood. Dev Cogn Neurosci 5:106–118
Koolschijn C, Peper J, Crone E (2014) The influence of sex steroids on structural brain maturation in adolescence. PLoS One 9(1):e83929
Lebel C, Beaulieu C (2011) Longitudinal development of human brain wiring continues from childhood into adulthood. J Neurosci 31(30):10937–10947
Lenroot R, Gogtay N, Greenstein D et al (2007) Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage 36:1065–1073
Liu F, Day M, Muniz L et al (2008) Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci 11(3):334–343
Loy R, Gerlag J, McEwen B (1988) Autoradiographic localization of estradiol-binding in the rat hippocampal formation and entorhinal cortex. Brain Res 467(2):245–251
Lu L, Leonard C, Thompson P et al (2007) Normal developmental changes in inferior frontal grey matter are associated with improvement in phonological processing: a longitudinal MRI analysis. Cereb Cortex 17:1092–1099
Lu L, Dapretto M, O’Hare ED et al (2009) Relationships between brain activation and brain structure in normally developing children. Cereb Cortex 19:2595–2604
Luyckx K, Goossens E, Van Damme C, Moons P, I-DETACH Investigators (2011) Identity formation in adolescents with congenital cardiac disease: a forgotten issue in the transition to adulthood. Cardiol Young 21:411–420
Luyckx K, Goossens L, Soenens B, Beyers W, Vansteenkiste M (2005) Identity statuses based on 4 rather than 2 identity dimensions: extending and refining Marcia’s paradigm. J Youth Adolesc 34:605–618
Luyckx K, Goossens L, Soenens B, Beyers W (2006) Unpacking commitment and exploration: preliminary validation of an integrative model of late adolescent identity formation. J Adolesc 29:361–378
Luyckx K, Schwartz SJ, Berzonsky MD, Soenens B, Vansteenkiste M, Smits I, Goossens L (2008) Capturing ruminative exploration: extending the four-dimensional model of identity formation in late adolescence. J Res Pers 42:58–82
Luyckx K, Seiffge-Krenke I, Schwartz SJ, Goossens L, Weets I, Hendrieckx C, Groven C (2008) Identity development, coping, and adjustment in emerging adults with a chronic illness: the sample case of type 1 diabetes. J Adolesc Health 43:451–458
Lyon ME, Kuehl K, McCarter R (2006) Transition to adulthood in congenital heart disease: missed adolescent milestones. J Adolesc Health 39:121–124
Marcia JE (1980) Identity in adolescence. In: Handbook of adolescent psychology. Wiley, New York, pp 159–187
Marcia JE (1989) Identity diffusion differentiated. Proc XXIV Int Congr Psychol 7:289–294
McMurray R, Kendeall L, Parsons JM, Quirk J, Veldtman GR, Lewin LJP, Sloper P (2001) A life less ordinary: growing up and coping with congenital heart disease. Coron Health Care 5:51–57
Meeus W (1996) Studies on identity development in adolescence: an overview of research and some new data. J Youth Adolesc 25:569–598
Miatton M (2015) Neuropsychological aspects in children and adolescents with ConHD. In: Clinical psychology and congenital heart disease – lifelong psychological aspects and interventions. Springer, Milan
Miller S, McQuillen P, Hamrick S et al (2007) Abnormal brain development in newborns with congenital heart disease. N Engl J Med 357(9):1928–1938
Moons P, Bovijn L, Budts W, Belmans A, Gewillig M (2010) Temporal trends in survival to adulthood among patients born with congenital heart disease from 1970 to 1992 in Belgium. Circulation 122:2264–2272
Mussatto KA, Sawin KJ, Schiffman R, Leske J, Simpson P, Marino BS (2014) The importance of self-perceptions to psychosocial adjustment in adolescents with heart disease. J Pediatr Health Care 28:251–261
Nguyen T, McCracken J, Ducharme S et al (2013) Testosterone-related cortical maturation across childhood and adolescence. Cereb Cortex 23(6):1424–1432
Ostby Y, Tamnes C, Fjell A et al (2012) Dissociating memory processes in the developing brain: the role of hippocampal volume and cortical thickness in recall after minutes versus days. Cereb Cortex 22(5):381–390
Paus T (2005) Mapping brain maturation and cognitive development during adolescence. Trends Cogn Neurosci 9:60–68
Paus T, Zijdenbos A, Worsley K et al (1999) Structural maturation of neural pathways in children and adolescents: in vivo study. Science 283(5409):1908–1911
Paus T, Keshavan M, Giedd J (2008) Why do many psychiatric disorders emerge during adolescence? Nat Rev Neurosci 9:947–957
Piaget J (1952) The origins of intelligence in children. International University Press, New York
Pierpaoli C, Basser P (1996) Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 36:893–906
Pike NA, Evangelista LS, Doering LV, Eastwood JA, Lewis AB, Child JS (2012) Sex and age differences in body-image, self-esteem, and body mass index in adolescents and adults after single-ventricle palliation. Pediatr Cardiol 33:705–712
Pinquart M, Pfeiffer JP (2015) Solving developmental tasks in adolescents with a chronic physical illness or physical/sensory disability: a meta-analysis. Int J Disabil Dev Educ 62:249–264
Porter J, Collins P, Muetzel R (2011) Associations between cortical thickness and verbal fluency in childhood, adolescence and young adulthood. Neuroimage 55(4):1865–1877
Rivkin M, Watson C, Scopppettuolo L et al (2013) Adolescents with D-transposition of the great arteries repaired in early infancy demonstrate reduced white matter microstructure associated with clinical risk factors. J Thorac Cardiovasc Surg 146(3):543–549
Rollins C, Watson C, Asaro L et al (2014) White matter microstructure and cognition in adolescents with congenital heart disease. J Pediatr 165:936–944
Sato J, Salum G, Gadelha A et al (2015) Decreased centrality of subcortical regions during the transition to adolescence: a functional connectivity study. Neuroimage 104:44–51
Schwartz SJ, Zamboanga BL, Luyckx K, Meca A, Ritchie RA (2013) Identity in emerging adulthood: reviewing the field and looking forward. Emerg Adulthood 1:96–113
Shaw P, Kabani N, Lerch J et al (2008) Neurodevelopmental trajectories of the human cerebral cortex. J Neurosci 28:3586–3594
Shilling C, Kühn S, Paus T et al (2013) Cortical thickness of superior frontal cortex predicts impulsiveness and perceptual reasoning in adolescence. Mol Psychiatry 18:624–630
Skranes J, Vangberg T, Kulseng S et al (2007) Clinical findings and white matter abnormalities seen on diffusion tensor imaging in adolescents with very low birth weight. Brain 130:654–666
Somerville L, Jones R, Casey B (2010) A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues. Brain Cogn 72:124–133
Sowell E, Delis D, Stiles J et al (2001) Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study. J Int Neuropsychol Soc 7(3):312–322
Sowell E, Peterson B, Thompson P et al (2003) Mapping cortical change across the human life span. Nat Neurosci 6:309–315
Sowell E, Thompson P, Leonard C et al (2004) Longitudinal mapping of cortical thickness and brain growth in normal children. J Neurosci 24:8223–8231
Squeglia L, Jacobus J, Sorg S et al (2013) Early adolescent cortical thinning is related to better neuropsychological performance. J Int Neuropsychol Soc 19:962–970
Stevens M, Pearlson G, Calhoun V (2009) Changes in the interaction of resting-state neural networks from adolescence to adulthood. Hum Brain Mapp 30(8):2356–2366
Sullivan E, Zahr N, Rohlfing T et al (2010) Fiber tracking functionally distinct components of the internal capsule. Neuropsychologia 48:4155–4163
Takeuchi H, Sekiguchi A, Taki Y et al (2010) Training of working memory impacts structural connectivity. J Neurosci 30:3297–3303
Taki Y, Thyreau B, Hashizume H et al (2013) Linear and curvilinear correlations of brain white matter volume, fractional anisotropy, and mean diffusivity with age using voxel-based and region of interest analyses in 246 healthy children. Hum Brain Mapp 34:1842–1865
Tamnes C, Fjell A, Ostby Y et al (2011) The brain dynamics of intellectual development: waxing and waning white and gray matter. Neuropsychologia 49(13):3605–3611
Turken A, Whitfield-Gabrieli S, Bammer R et al (2008) Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies. Neuroimage 42:1032–1044
Van Leijenhorst L, Westenberg P, Crone E (2008) A developmental study of risky decisions on the cake gambling task: age and gender analyses of probability estimation and reward evaluation. Dev Neuropsychol 33:179–196
Van Rijen EHM et al (2003) Psychosocial functioning of the adult with congenital heart disease: a 20–33 years follow-up. Eur Heart J 24:673–683
Von Der Heide R, Skipper L, Klobusicky E et al (2013) Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis. Brain 136:1692–1707
Von Rhein M, Scheer I, Loenneker T et al (2011) Structural brain lesions in adolescents with congenital heart disease. J Pediatr 158:984–989
Von Rhein M, Buchmann A, Hagmann C et al (2014) Brain volumes predict neurodevelopment in adolescents after surgery for congenital heart disease. Brain 137:268–276
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Miatton, M., Sarrechia, I. (2016). Neurological and Psychosocial Development in Adolescence. In: Schwerzmann, M., Thomet, C., Moons, P. (eds) Congenital Heart Disease and Adolescence. Congenital Heart Disease in Adolescents and Adults. Springer, Cham. https://doi.org/10.1007/978-3-319-31139-5_5
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