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The Effects of Social Experience on the Stress System and Immune Function in Nonhuman Primates

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Social Inequalities in Health in Nonhuman Primates

Part of the book series: Developments in Primatology: Progress and Prospects ((DIPR))

Abstract

There is growing recognition that social factors, such as low socioeconomic status, can predispose individuals to certain illnesses throughout their lifespan and that the physiological mechanisms involve complex interactions between the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system, and the immune system. Here, we reviewed studies in nonhuman primate models of social adversity, specifically social subordination and social instability which suggest that similar stress-related biomarkers of allostasis in human social adversity, such as glucocorticoid resistance and systemic inflammation, are also found in nonhuman primates. Although many statistically significant effects of social stress have been identified in nonhuman primates, the importance of sex, individual, and species-level differences is less clear.

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Authors and Affiliations

  1. Yerkes National Primate Research Center, Division of Developmental and Cognitive Neuroscience, Emory University, 615 Michael Street, Suite 600, Atlanta, GA, 30322, USA

    Jordan Kohn

  2. Department of Pediatrics, Division of Pediatric Endocrinology, Emory University, 615 Michael Street, Suite 600, Atlanta, GA, 30322, USA

    Leonidas Panagiotakopoulos

  3. Department of Physiology, Emory University, 615 Michael Street, Suite 600, Atlanta, GA, 30322, USA

    Gretchen N. Neigh

  4. Department of Psychiatry and Behavioral Sciences, Emory University, 615 Michael Street, Suite 600, Atlanta, GA, 30322, USA

    Gretchen N. Neigh

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  1. Jordan Kohn
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  2. Leonidas Panagiotakopoulos
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  3. Gretchen N. Neigh
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Correspondence to Gretchen N. Neigh .

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Editors and Affiliations

  1. Pathology, Wake Forest School of Medicine, WINSTON SALEM, North Carolina, USA

    Carol A. Shively

  2. Psychiatry and Behavioral Sciences, Emory University, ATLANTA, Georgia, USA

    Mark E. Wilson

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Kohn, J., Panagiotakopoulos, L., Neigh, G.N. (2016). The Effects of Social Experience on the Stress System and Immune Function in Nonhuman Primates. In: Shively, C., Wilson, M. (eds) Social Inequalities in Health in Nonhuman Primates. Developments in Primatology: Progress and Prospects. Springer, Cham. https://doi.org/10.1007/978-3-319-30872-2_4

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