Abstract
Drug discovery has been focusing for some time on protein-protein (PP) associations, the basic molecular events in biology. The recruitment of protein complexes is required to initiate and propagate signaling cascades, regulate enzyme activity, articulate and control mechanistic processes involving molecular motors, etc. When such associations engage altered binding partners, complex formation may lead to deregulation of biological functions and the drug-based disruption of the aberrant associations may represent new therapeutic opportunities.
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Fernández, A. (2016). Structure-Based Drug Discovery Without Structure: Working Around the Paradox to Disrupt Protein-Protein Associations. In: Physics at the Biomolecular Interface. Soft and Biological Matter. Springer, Cham. https://doi.org/10.1007/978-3-319-30852-4_16
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DOI: https://doi.org/10.1007/978-3-319-30852-4_16
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