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Craniopharyngioma

  • Lauren Ostling
  • Daphne A. Haas-Kogan
  • Robert H. Lustig
  • Nalin GuptaEmail author
Chapter
Part of the Pediatric Oncology book series (PEDIATRICO)

Abstract

Craniopharyngiomas are histologically benign neuroepithelial tumors that arise from rests of squamous cell epithelium that remain along the path of the primitive craniopharyngeal duct and adenohypophysis. Although considered benign (WHO grade I) tumors of the sellar region, they have a propensity to adhere to adjacent structures such as the hypothalamus and optic chiasm. This feature can prevent a complete resection from being achieved. Furthermore, even if a complete resection is achieved, there is the possibility of significant postoperative morbidity. Currently, there are reports in the literature favoring a variety of approaches such as gross total resection, subtotal resection with radiation, or intracystic therapy, including 32phosphorous, bleomycin, and interferon-alpha. In the pediatric population, the short-term and long-term adverse effects of radiation therapy must be carefully weighed against the potential surgical morbidity.

Keywords

Diabetes Insipidus Optic Chiasm Subtotal Resection Gross Total Resection Proton Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  • Lauren Ostling
    • 1
    • 2
  • Daphne A. Haas-Kogan
    • 3
  • Robert H. Lustig
    • 4
    • 5
  • Nalin Gupta
    • 6
    Email author
  1. 1.Department of Neurological SurgeryUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Department of Neurological SurgeryUCSF Benioff Children’s Hospital OaklandOaklandUSA
  3. 3.Department of Radiation OncologyBrigham and Women’s Hospital, Dana-Farber Cancer Institute and Boston Children’s HospitalBostonUSA
  4. 4.Department of Pediatrics & Institute for Health Policy StudiesUniversity of CaliforniaSan FranciscoUSA
  5. 5.UCSF Benioff Children’s Hospital San FranciscoSan FranciscoUSA
  6. 6.Division of Pediatric Neurosurgery, Departments of Neurological Surgery and PediatricsUniversity of California San Francisco & UCSF Benioff Children’s HospitalSan FranciscoUSA

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