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Pediatric CNS Tumors pp 145–169Cite as

Craniopharyngioma

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Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Craniopharyngiomas are histologically benign neuroepithelial tumors that arise from rests of squamous cell epithelium that remain along the path of the primitive craniopharyngeal duct and adenohypophysis. Although considered benign (WHO grade I) tumors of the sellar region, they have a propensity to adhere to adjacent structures such as the hypothalamus and optic chiasm. This feature can prevent a complete resection from being achieved. Furthermore, even if a complete resection is achieved, there is the possibility of significant postoperative morbidity. Currently, there are reports in the literature favoring a variety of approaches such as gross total resection, subtotal resection with radiation, or intracystic therapy, including 32phosphorous, bleomycin, and interferon-alpha. In the pediatric population, the short-term and long-term adverse effects of radiation therapy must be carefully weighed against the potential surgical morbidity.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA

    Lauren Ostling MD

  2. Department of Neurological Surgery, UCSF Benioff Children’s Hospital Oakland, Oakland, CA, USA

    Lauren Ostling MD

  3. Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Boston Children’s Hospital, Boston, MA, USA

    Daphne A. Haas-Kogan MD

  4. Department of Pediatrics & Institute for Health Policy Studies, University of California, San Francisco, CA, USA

    Robert H. Lustig MD, MSL

  5. UCSF Benioff Children’s Hospital San Francisco, San Francisco, CA, USA

    Robert H. Lustig MD, MSL

  6. Division of Pediatric Neurosurgery, Departments of Neurological Surgery and Pediatrics, University of California San Francisco & UCSF Benioff Children’s Hospital, San Francisco, CA, USA

    Nalin Gupta MD, PhD

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  1. Lauren Ostling MD
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  2. Daphne A. Haas-Kogan MD
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  3. Robert H. Lustig MD, MSL
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Correspondence to Nalin Gupta MD, PhD .

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  1. San Francisco, California, USA

    Nalin Gupta

  2. San Francisco, California, USA

    Anuradha Banerjee

  3. Boston, Massachusetts, USA

    Daphne A. Haas-Kogan

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Ostling, L., Haas-Kogan, D.A., Lustig, R.H., Gupta, N. (2017). Craniopharyngioma. In: Gupta, N., Banerjee, A., Haas-Kogan, D. (eds) Pediatric CNS Tumors. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-30789-3_7

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