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Chemotherapy

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Pediatric CNS Tumors

Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Chemotherapy is increasingly used in the multimodal management of childhood brain tumors, with the therapeutic goals of optimizing survival and reducing radiation-related morbidity. The numerous chemotherapy treatment protocols for pediatric brain tumors reflect the extreme heterogeneity of these neoplasms. For example, in the setting of average-risk medulloblastoma and germinoma, which have high cure rates with radiation treatment alone, chemotherapy is used to reduce radiation doses, yet maintain high cure rates. For infants with malignant brain tumors, who are particularly vulnerable to radiation-related morbidity, chemotherapy has been used to delay radiation treatment. Similarly, in the setting of unresectable, low-grade astrocytoma, chemotherapy can provide prolonged disease stabilization, perhaps allowing for delay or deferral of radiation.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Departments of Pediatrics and Neurological Surgery, University of California San Francisco & UCSF Benioff Children’s Hospital, 550 16th St, 4th Floor, 0434, San Francisco, CA, 94143, USA

    Theodore Nicolaides MD

  2. Blood and Marrow Transplant Program, Department of Pediatrics, University of California San Francisco & UCSF Benioff Children’s Hospital, 550 16th Street, 4th Floor, 0434, San Francisco, CA, 94143-0434, USA

    Biljana Horn MD

  3. Division of Hematology/Oncology, Departments of Pediatrics, University of California San Francisco & UCSF Benioff Children’s Hospital, 550 16th St, 4th Floor, 0434, San Francisco, CA, 94143, USA

    Anuradha Banerjee MD

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  1. Theodore Nicolaides MD
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  2. Biljana Horn MD
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  3. Anuradha Banerjee MD
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Correspondence to Theodore Nicolaides MD .

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  1. San Francisco, California, USA

    Nalin Gupta

  2. San Francisco, California, USA

    Anuradha Banerjee

  3. Boston, Massachusetts, USA

    Daphne A. Haas-Kogan

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Nicolaides, T., Horn, B., Banerjee, A. (2017). Chemotherapy. In: Gupta, N., Banerjee, A., Haas-Kogan, D. (eds) Pediatric CNS Tumors. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-30789-3_15

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