Abstract
In this paper we have studied the physical properties of magnetic nanocomplexes (MNCs) consisting of ferromagnetic iron oxide nanoparticles (FMION) or superparamagnetic iron oxide nanoparticles (SPION) loaded with antitumor drug doxorubicin (DOXO). The methods of magnetometry, electron paramagnetic resonance spectra, and absorption spectroscopy were used. The changes of electromagnetic waves from SPION and FMION under the influence of constant magnetic field (CMF) were analyzed. It was observed that MNC containing SPION and DOXO has larger coercivity as compared to MNC of FMION and DOXO. MNC comprising of SPION and DOXO has g-factors of 2.00, 2.30, and 4.00. MNC of FMION and DOXO has the g-factor of 2.50, and the integrated intensity of electron spin resonance signal is higher. MNC containing SPION and DOXO has absorption maximum shifts in the region (465–480) nm. MNC of FMION and DOXO has the absorption maximum in the range of (390–430) nm. On average the intensity of an alternating magnetic field (AMF) at different values of CMF is higher when SPION is used than FMION. The results presented here along with our earlier biological results open up promising prospects for future studies of cancer magnetic nanotherapy using MNC of SPION and DOXO.
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References
Hayashi K, Nakamura M, Sakamoto W et al (2013) Superparamagnetic nanoparticle clusters for cancer theranostics combining magnetic resonance imaging and hyperthermia treatment. Theranostics 3(6):366–376
Ortega D, Pankhurst QA (2013) Magnetic hyperthermia. In: O’Brien P (ed) Nanoscience, vol 1, Nanostructures through chemistry. Royal Society of Chemistry, Cambridge, pp 60–88. doi:10.1039/9781849734844-00060
Giustini AJ, Petryk AA, Cassim SM et al (2010) Magnetic nanoparticle hyperthermia in cancer treatment. Nano Life 1(01n02):17–32. doi:10.1142/S1793984410000067
Dutz S, Hergt R (2013) Magnetic nanoparticle heating and heat transfer on a microscale: basic principles, realities and physical limitations of hyperthermia for tumour therapy. Int J Hyperthermia 29(8):790–800
Orel V, Shevchenko A, Romanov A et al (2015) Magnetic properties and antitumor effect of nanocomplexes of iron oxide and doxorubicin. Nanomed Nanotech Biol Med 11(1):47–55
Zhang H, Ji Z, Xia T et al (2012) Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6(5):4349–4368. doi:10.1021/nn3010087
Burello E, Worth AP (2011) A theoretical framework for predicting the oxidative stress potential of oxide nanoparticles. Nanotoxicology 5(2):228–235. doi:10.3109/17435390.2010.502980
Xu Y, Schoonen MAA (2000) The absolute energy positions of conduction and valence bands of selected semiconducting minerals. Am Mineral 85(4):543–556
Ghodbane S, Lahbib A, Ammari M et al (2015) Does static magnetic field-exposure induced oxidative stress and apoptosis in rat kidney and muscle? Effect of vitamin E and selenium supplementations. Gen Physiol Biophys 34:217–219
Okano H (2008) Effects of static magnetic fields in biology: role of free radicals. Front Biosci 13:6106–6125
Chomoucka J, Drbohlavova J, Huska D (2010) Magnetic nanoparticles and targeted drug delivering. Pharmacol Res 62(2):144–149. doi:10.1016/j.phrs.2010.01.014
Hayashi K, Moriya M, Sakamoto W et al (2009) Chemoselective synthesis of folic acid-functionalized magnetite nanoparticles via click chemistry for magnetic hyperthermia. Chem Mater 21:1318–1325
Bedanta S, Kleemann W (2009) Supermagnetism. J Phys D Appl Phys 42(1):013001. doi:10.1088/0022-3727/42/1/013001
Orel V, Romanov A, Rykhalskyi A (2016) Antitumor effect of superparamagnetic iron oxide nanoparticles conjugated with doxorubicin during magnetic nanotherapy of Lewis lung carcinoma. Materialwiss Werkstofftech 47:165–171
Orel VE, Shevchenko AD, Rykhalskyi OY (2015) Investigation of nonlinear magnetic properties magneto-mechano-chemical synthesized nanocomplex from magnetite and antitumor antibiotic doxorubicin. In: Fesenko O, Yatsenko L (eds) Nanocomposites, nanophotonics, nanobiotechnology and applications. Springer Proceedings in Physics, vol 156. pp 103–110. doi:10.1007/978-3-319-06611-0_8
Laurent S, Mahmoudi M (2011) Superparamagnetic iron oxide nanoparticles and cancer. Int J Mol Epidemiol Genet 2(4):367–390
Nikolov N, Orel V, Smolanka I et al (2008) Apparatus for short-wave inductothermy “Magnetotherm”. In: Katushev A, Dekhtyar Y, Spigulis J (eds) Proceedings of NBC. Springer, Berlin, pp 294–298
Orel VE, Dzyatkovskaya NN, Kruchkov EI et al (2014) The effect of the inhomogeneous magnetic fields on the antitumor activity of magnetic nanotherapy. In: 2014 I.E. 34th International Conference on Electronics and Nanotechnology (ELNANO), pp 329–333. doi:10.1109/ELNANO.2014.6873909
Panchuk RR, Prylutska SV, Chumak VV et al (2015) Application of С60 fullerene-doxorubicin complex for tumor cell treatment in vitro and in vivo. J Biomed Nanotechnol 11(7):1139–1152
Prylutskyy YI, Evstigneev MP, Pashkova IS et al (2014) Characterization of C60 fullerene complexation with antibiotic doxorubicin. Phys Chem Chem Phys 16(42):23164–23172
Prylutskyy YI, Evstigneev MP, Cherepanov VV et al (2015) Structural organization of С60 fullerene, doxorubicin and their complex in physiological solution as promising antitumor agents. J Nanopart Res 17(1):45–49
Ustinov VV, Rinkevich AB, Perov DV et al (2013) Giant antiresonance in electromagnetic wave reflection from a 3D structure with ferrite spinel nanoparticles. Tech Phys 58(4):568–577
Orel VE, Romanov AV (2014) Cancer magnetic nanotherapy. LAP Lambert Academic, Saarbrücken
Liu H, Li XZ, Leng YJ, Wang C (2007) Kinetic modeling of electro-Fenton reaction in aqueous solution. Water Res 41:161–167
Orel VE, Kudryavets YI, Bezdenezhnih NA et al (2005) Mechanochemically activated doxorubicin nanoparticles in combination with 40MHz frequency irradiation on A-549 lung carcinoma cells. Drug Deliv 12(3):171–178
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Orel, V. et al. (2016). Comparative Study of Ferromagnetic and Superparamagnetic Iron Oxide Nanoparticles Loaded with Antitumor Drug Doxorubicin. In: Fesenko, O., Yatsenko, L. (eds) Nanophysics, Nanophotonics, Surface Studies, and Applications. Springer Proceedings in Physics, vol 183. Springer, Cham. https://doi.org/10.1007/978-3-319-30737-4_27
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