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Cancer and Zebrafish pp 3–19Cite as

Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 916))

Abstract

Over a decade has elapsed since the first genetically-engineered zebrafish cancer model was described. During this time remarkable progress has been made. Sophisticated genetic tools have been built to generate oncogene expressing cancers and characterize multiple models of solid and blood tumors. These models have led to unique insights into mechanisms of tumor initiation and progression. New drug targets have been identified, particularly through the functional analysis of cancer genomes. Now in the second decade, zebrafish cancer models are poised for even faster growth as they are used in high-throughput genetic analyses to elucidate key mechanisms underlying critical cancer phenotypes.

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Acknowledgments

We sincerely apologize to those colleagues whose work was not included in this review. Funding for this effort was supported in part by the NIH (R01AR063850 to C.C.), the Department of Defense (CA120099 to C.C.), the Kimmel Scholar Award to C.C., and the American Cancer Society Research Scholar Award to C.C.

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Authors and Affiliations

  1. Program in Molecular Medicine and Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605, USA

    Craig J. Ceol

  2. Departments of Surgery and Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA

    Yariv Houvras

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  1. Craig J. Ceol
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  2. Yariv Houvras
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Correspondence to Craig J. Ceol or Yariv Houvras .

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Editors and Affiliations

  1. Molecular Pathology and Cancer Center, Massachusetts General Hospital, CHARLESTOWN, Massachusetts, USA

    David M. Langenau

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Ceol, C.J., Houvras, Y. (2016). Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery. In: Langenau, D. (eds) Cancer and Zebrafish. Advances in Experimental Medicine and Biology, vol 916. Springer, Cham. https://doi.org/10.1007/978-3-319-30654-4_1

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