What’s Next in the Field of Bone Health in Pediatrics? Research Considerations



The aim of this chapter is to introduce promising new tools for the pediatric field able to assess bone microarchitectural structure and texture at the central and axial skeleton using Magnetic Resonance Imaging (MRI), Finite Element Analysis from computed tomography scans or Trabecular Bone Score (TBS) from Dual Energy X-Ray Absorptiometry (DXA) scans. Although all three of these technologies have been used more widely in adults, the promise of enhanced information and improved predictability of fracture offer complementary value to the areal Bone Mineral Density (aBMD) for the diagnosis of skeletal implications of multiple pathological conditions that may affect the skeletal development during growth. This chapter includes a description of each technology and mathematical framework as well as its clinical use in adults and potential applications and limitations for pediatric patients.


Magnetic resonance imaging Finite element analysis Trabecular bone score Research considerations Bone health 


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Radiology and Biomedical ImagingUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Mechanical Engineering and BioengineeringUniversity of CaliforniaBerkeleyUSA
  3. 3.Department of Bone DensitometryHospital Sant Joan De DeuBarcelonaSpain
  4. 4.Department of Rare Skeletal Disease, Children’s HospitalUniversity of CologneCologneGermany
  5. 5.Research and Development DepartmentMedimaps SASUMerignacFrance

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