Skip to main content

Comprehensive CT Imaging in Acute Chest Pain

  • Chapter
  • First Online:
Book cover Multidetector-Row CT of the Thorax

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 1476 Accesses

Abstract

Triple rule-out (TRO) CT simultaneously evaluates the coronary arteries, aorta and pulmonary arteries for the patient presenting with acute chest pain in the emergency department. Compared to dedicated coronary CT angiography (cCTA), TRO CT requires slightly more intravenous contrast and a higher radiation dose. Appropriate patient selection is essential. TRO CT is most appropriate for patients at low to intermediate risk for acute coronary syndrome and in whom alternative diagnoses, such as pulmonary embolism or acute aortic pathology, are being considered. Adequate patient selection, preparation, premedication, and monitoring ensure a high-quality diagnostic study. The major differences between TRO CT and dedicated cCTA are scan length and injection technique. Compared to cCTA, where images are obtained between the carina and diaphragm, TRO CT must include the entire thoracic aorta and the pulmonary arteries. Injection protocols are tailored to provide high levels of arterial enhancement in the left- (coronary arteries and aorta) and right-sided circulations (pulmonary arteries). Different strategies may be employed to limit radiation exposure, including electrocardiogram (ECG) tube current modulation and prospective ECG gating. When performed with careful attention to technique, TRO CT provides high-quality diagnostic opacification of the coronary arteries, aorta and pulmonary arteries equal to that of dedicated CT angiography. A negative study allows for the safe and rapid discharge from the emergency department and a reduction in subsequent testing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ayaram D, Bellolio MF, Murad MH et al (2013) Triple rule-out computed tomographic angiography for chest pain: a diagnostic systematic review and meta-analysis. Acad Emerg Med 20:861–871

    Article  PubMed  Google Scholar 

  • Bamberg F, Marcus R, Sommer W et al (2012) Diagnostic image quality of a comprehensive high-pitch dual-spiral cardiothoracic CT protocol in patients with undifferentiated acute chest pain. Eur J Radiol 81:3697–3702

    Article  PubMed  Google Scholar 

  • Bhuiya FA, Pitts SR, McCaig LF (2010) Emergency department visits for chest pain and abdominal pain: United States, 1999–2008. NCHS Data Brief 43:1–8

    PubMed  Google Scholar 

  • Budoff MJ, Dowe D, Jollis JG et al (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 52:1724–1732

    Article  PubMed  Google Scholar 

  • Cademartiri F, Mollet NR, van der Lugt A et al (2005) Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation. Radiology 236:661–665

    Article  PubMed  Google Scholar 

  • Chang SA, Choi SI, Choi EK et al (2008a) Usefulness of 64-slice multidetector computed tomography as an initial diagnostic approach in patients with acute chest pain. Am Heart J 156:375–383

    Article  PubMed  Google Scholar 

  • Chang AM, Shofer FS, Weiner MG et al (2008b) Actual financial comparison of four strategies to evaluate patients with potential acute coronary syndromes. Acad Emerg Med 15:649–655

    Article  PubMed  Google Scholar 

  • Chen ML, Mo YH, Wang YC et al (2012) 64-slice CT angiography for the detection of functionally significant coronary stenoses: comparison with stress myocardial perfusion imaging. Br J Radiol 85:368–376

    Article  PubMed  PubMed Central  Google Scholar 

  • Chun EJ, Lee W, Choi YH et al (2008) Effects of nitroglycerin on the diagnostic accuracy of electrocardiogram-gated coronary computed tomography angiography. J Comput Assist Tomogr 32:86–92

    Article  PubMed  Google Scholar 

  • Dodd JD, Kalva S, Pena A et al (2008) Emergency cardiac CT for suspected acute coronary syndrome: qualitative and quantitative assessment of coronary, pulmonary and aortic image quality. AJR Am J Roentgenol 191:870–877

    Article  PubMed  PubMed Central  Google Scholar 

  • Ferencik M, Nomura CH, Maurovich-Horvat P et al (2006) Quantitative parameters of image quality in 64-slice computed tomography angiography of the coronary arteries. Eur J Radiol 57:373–379

    Article  PubMed  Google Scholar 

  • Gallagher MJ, Raff GL (2008) Use of multislice CT for the evaluation of emergency room patients with chest pain: the so-called “triple rule-out”. Catheter Cardiovasc Interv 71:92–99

    Article  PubMed  Google Scholar 

  • Gallagher MJ, Ross MA, Raff GL, Goldstein JA, O’Neill WW, O’Neil B (2007) The diagnostic accuracy of 64-slice computed tomography coronary angiography compared with stress nuclear imaging in emergency department low-risk chest pain patients. Ann Emerg Med 49:125–136

    Article  PubMed  Google Scholar 

  • Ghanima W, Almaas V, Aballi S et al (2005) Management of suspected pulmonary embolism (PE) by D-dimer and multi-slice computed tomography in outpatients: an outcome study. J Thromb Haemost 3:1926–1932

    Article  CAS  PubMed  Google Scholar 

  • Ghaye B, Remy J, Remy-Jardin M (2002) Non-traumatic thoracic emergencies: CT diagnosis of acute pulmonary embolism: the first 10 years. Eur Radiol 12:1886–1905

    Article  PubMed  Google Scholar 

  • Gil BN, Ran K, Tamar G, Shmuell F, Eli A (2007) Prevalence of significant noncardiac findings on coronary multidetector computed tomography angiography in asymptomatic patients. J Comput Assist Tomogr 31:1–4

    Article  PubMed  Google Scholar 

  • Goldstein JA, Gallagher MJ, O’Neill WW, Ross MA, O’Neil BJ, Raff GL (2007) A randomized controlled trial of multi-slice coronary computed tomography for evaluation of acute chest pain. J Am Coll Cardiol 49:863–871

    Article  PubMed  Google Scholar 

  • Goldstein JA, Chinnaiyan KM, Abidov A et al (2011) The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) trial. J Am Coll Cardiol 58:1414–1422

    Article  PubMed  Google Scholar 

  • Gruettner J, Fink C, Walter T et al (2013) Coronary computed tomography and triple rule out CT in patients with acute chest pain and an intermediate cardiac risk profile. Part 1: impact on patient management. Eur J Radiol 82:100–105

    Article  PubMed  Google Scholar 

  • Haidary A, Bis K, Vrachliotis T, Kosuri R, Balasubramaniam M (2007) Enhancement performance of a 64-slice triple rule-out protocol vs 16-slice and 10-slice multidetector CT-angiography protocols for evaluation of aortic and pulmonary vasculature. J Comput Assist Tomogr 31:917–923

    Article  PubMed  Google Scholar 

  • Halpern EJ, Levin DC, Zhang S, Takakuwa KM (2009) Comparison of image quality and arterial enhancement with a dedicated coronary CTA protocol versus a triple rule-out coronary CTA protocol. Acad Radiol 16:1039–1048

    Article  PubMed  Google Scholar 

  • Halpern EJ, Gingold EL, WHite H, Read K (2014) Evaluation of coronary artery image quality with knowledge-based iterative model reconstruction. Acad Radiol 21:805–811

    Article  PubMed  Google Scholar 

  • Hamada S, Takamiya M, Kimura K, Imakita S, Nakajima N, Naito H (1992) Type A aortic dissection: evaluation with ultrafast CT. Radiology 183:155–158

    Article  CAS  PubMed  Google Scholar 

  • Hecht HS, Bhatti T (2008) How much calcium is too much calcium for coronary computerized tomographic angiography? J Cardiovasc Comput Tomogr 2:183–187

    Article  PubMed  Google Scholar 

  • Henzler T, Gruettner J, Meyer M et al (2013) Coronary computed tomography and triple rule out CT in patients with acute chest pain and an intermediate cardiac risk for acute coronary syndrome: part 2: economic aspects. Eur J Radiol 82:106–111

    Article  PubMed  Google Scholar 

  • Hoffmann U, Truong QA, Schoenfeld DA et al (2012) Coronary CT angiography versus standard evaluation in acute chest pain. N Engl J Med 367:299–308

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hollander JE, Chang AM, Shofer FS et al (2009) One-year outcomes following coronary computerized tomographic angiography for evaluation of emergency department patients with potential acute coronary syndrome. Acad Emerg Med 16:693–698

    Article  PubMed  Google Scholar 

  • Johnson TR, Nikolaou K, Wintersperger BJ et al (2007) ECG-gated 64-MDCT angiography in the differential diagnosis of acute chest pain. AJR Am J Roentgenol 188:76–82

    Article  PubMed  Google Scholar 

  • Johnson TR, Nikolaou K, Becker A et al (2008) Dual-source CT for chest pain assessment. Eur J Radiol 18:773–780

    Article  Google Scholar 

  • Kligerman SJ, White CS (2014) Image quality and feasibility of an ultralow-dose high-pitch helical triple-rule-out computed tomography angiography acquired in the caudocranial direction. J Thorac Imaging 29:50–59

    Article  PubMed  Google Scholar 

  • Kolansky DM (2009) Acute coronary syndromes: morbidity, mortality, and pharmacoeconomic burden. Am J Manag Care 15:S36–S41

    PubMed  Google Scholar 

  • Lee HY, Song IS, Yoo SM et al (2011) Rarity of isolated pulmonary embolism and acute aortic syndrome occurring outside of the field of view of dedicated coronary CT angiography. Acta Radiol 52:378–384

    Article  PubMed  Google Scholar 

  • Litmanovich D, Zamboni GA, Hauser TH, Lin PJ, Clouse ME, Raptopoulos V (2008) ECG-gated chest CT angiography with 64-MDCT and tri-phasic IV contrast administration regimen in patients with acute non-specific chest pain. Eur Radiol 18:308–317

    Article  PubMed  Google Scholar 

  • Litt HI, Gatsonis C, Snyder B et al (2012) CT angiography for safe discharge of patients with possible acute coronary syndromes. N Engl J Med 366:1393–1403

    Article  CAS  PubMed  Google Scholar 

  • Madder RD, Raff GL, Hickman L et al (2011) Comparative diagnostic yield and 3-month outcomes of “triple rule-out” and standard protocol coronary CT angiography in the evaluation of acute chest pain. J Cardiovasc Comput Tomogr 5:165–171

    Article  PubMed  Google Scholar 

  • Meijboom WB, Meijs MF, Schuijf JD et al (2008) Diagnostic accuracy of 64-slice computed tomography coronary angiography: a prospective, multicenter, multivendor study. J Am Coll Cardiol 52:2135–2144

    Article  PubMed  Google Scholar 

  • Miller JM, Rochitte CE, Dewey M et al (2008) Diagnostic performance of coronary angiography by 64-row CT. N Engl J Med 359:2324–2336

    Article  CAS  PubMed  Google Scholar 

  • Onuma Y, Tanabe K, Nakazawa G et al (2006) Noncardiac findings in cardiac imaging with multidetector computed tomography. J Am Coll Cardiol 48:402–406

    Article  PubMed  Google Scholar 

  • Oser RF, Zuckerman DA, Gutierrez FR, Brink JA (1996) Anatomic distribution of pulmonary emboli at pulmonary angiography: implications for cross-sectional imaging. Radiology 199:31–35

    Article  CAS  PubMed  Google Scholar 

  • Perisinakis K, Seimenis I, Tzedakis A, Papadakis AE, Damilakis J (2012) Triple-rule-out computed tomography angiography with 256-slice computed tomography scanners: patient-specific assessment of radiation burden and associated cancer risk. Invest Radiol 47:109–115

    Article  PubMed  Google Scholar 

  • Prologo JD, Gilkeson RC, Diaz M, Asaad J (2004) CT pulmonary angiography: a comparative analysis of the utilization patterns in emergency department and hospitalized patients between 1998 and 2003. AJR Am J Roentgenol 183:1093–1096

    Article  PubMed  Google Scholar 

  • Quiroz R, Kucher N, Zou KH et al (2005) Clinical validity of a negative computed tomography scan in patients with suspected pulmonary embolism: a systematic review. JAMA 293:2012–2017

    Article  CAS  PubMed  Google Scholar 

  • Rahmani N, Jeudy J, White CS (2009) Triple rule-out and dedicated coronary artery CTA: comparison of coronary artery image quality. Acad Radiol 16:604–609

    Article  PubMed  Google Scholar 

  • Rogers IS, Banerji D, Siegel EL et al (2011) Usefulness of comprehensive cardiothoracic computed tomography in the evaluation of acute undifferentiated chest discomfort in the emergency department (CAPTURE). Am J Cardiol 107:643–650

    Article  PubMed  Google Scholar 

  • Ropp A, Lin CT, White CS (2015) Coronary computed tomography angiography for the assessment of acute chest pain in the emergency department: evidence, guidelines, and tips for implementation. J Thorac Imaging

    Google Scholar 

  • Rubinshtein R, Halon DA, Gaspar T et al (2007) Impact of 64-slice cardiac computed tomographic angiography on clinical decision-making in emergency department patients with chest pain of possible myocardial ischemic origin. Am J Cardiol 100:1522–1526

    Article  PubMed  Google Scholar 

  • Savino G, Herzog C, Costello P, Schoepf UJ (2006) 64 slice cardiovascular CT in the emergency department: concepts and first experiences. Radiol Med 111:481–496

    Article  CAS  PubMed  Google Scholar 

  • Schertler T, Frauenfelder T, Stolzmann P et al (2009) Triple rule-out CT in patients with suspicion of acute pulmonary embolism: findings and accuracy. Acad Radiol 16:708–717

    Article  PubMed  Google Scholar 

  • Schlett CL, Banerji D, Siegel E et al (2011) Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial. JACC Cardiovasc Imaging 4:481–491

    Article  PubMed  PubMed Central  Google Scholar 

  • Sebastia C, Pallisa E, Quiroga S, Alvarez-Castells A, Dominguez R, Evangelista A (1999) Aortic dissection: diagnosis and follow-up with helical CT. Radiographics 19:45–60; quiz 149–150

    Article  CAS  PubMed  Google Scholar 

  • Shapiro MD, Dodd JD, Kalva S et al (2009) A comprehensive electrocardiogram-gated 64-slice multidetector computed tomography imaging protocol to visualize the coronary arteries, thoracic aorta, and pulmonary vasculature in a single breath hold. J Comput Assist Tomogr 33:225–232

    Article  PubMed  Google Scholar 

  • Shiga T, Wajima Z, Apfel CC, Inoue T, Ohe Y (2006) Diagnostic accuracy of transesophageal echocardiography, helical computed tomography, and magnetic resonance imaging for suspected thoracic aortic dissection: systematic review and meta-analysis. Arch Intern Med 166:1350–1356

    Article  PubMed  Google Scholar 

  • Takakuwa KM, Halpern EJ (2008) Evaluation of a “triple rule-out” coronary CT angiography protocol: use of 64-Section CT in low-to-moderate risk emergency department patients suspected of having acute coronary syndrome. Radiology 248:438–446

    Article  PubMed  Google Scholar 

  • Takakuwa KM, Halpern EJ, Gingold EL, Levin DC, Shofer FS (2009) Radiation dose in a “triple rule-out” coronary CT angiography protocol of emergency department patients using 64-MDCT: the impact of ECG-based tube current modulation on age, sex, and body mass index. AJR Am J Roentgenol 192:866–872

    Article  PubMed  Google Scholar 

  • Takakuwa KM, Halpern EJ, Shofer FS (2011) A time and imaging cost analysis of low-risk ED observation patients: a conservative 64-section computed tomography coronary angiography “triple rule-out” compared to nuclear stress test strategy. Am J Emerg Med 29:187–195

    Article  PubMed  Google Scholar 

  • Vrachliotis TG, Bis KG, Haidary A et al (2007) Atypical chest pain: coronary, aortic, and pulmonary vasculature enhancement at biphasic single-injection 64-section CT angiography. Radiology 243:368–376

    Article  PubMed  Google Scholar 

  • Wexler L, Brundage B, Crouse J et al (1996) Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association. Writing Group. Circulation 94:1175–1192

    Article  CAS  PubMed  Google Scholar 

  • Willoteaux S, Lions C, Gaxotte V, Negaiwi Z, Beregi JP (2004) Imaging of aortic dissection by helical computed tomography (CT). Eur Radiol 14:1999–2008

    Article  PubMed  Google Scholar 

  • Wittram C (2007) How I, do it: CT pulmonary angiography. AJR Am J Roentgenol 188:1255–1261

    Article  PubMed  Google Scholar 

  • Wittram C, Yoo AJ (2007) Transient interruption of contrast on CT pulmonary angiography: proof of mechanism. J Thorac Imaging 22:125–129

    Article  PubMed  Google Scholar 

  • Wnorowski AM, Halpern EJ (2016) Diagnostic Yield of Triple-Rule-Out CT in an Emergency Setting. AJR Am J Roentgenol. W1–W7. [Epub ahead of print]

    Google Scholar 

  • Yoshida S, Akiba H, Tamakawa M et al (2003) Thoracic involvement of type A aortic dissection and intramural hematoma: diagnostic accuracy–comparison of emergency helical CT and surgical findings. Radiology 228:430–435

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Amelia M. Wnorowski .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing

About this chapter

Cite this chapter

Wnorowski, A.M., Halpern, E.J. (2016). Comprehensive CT Imaging in Acute Chest Pain. In: Schoepf, U., Meinel, F. (eds) Multidetector-Row CT of the Thorax. Medical Radiology(). Springer, Cham. https://doi.org/10.1007/978-3-319-30355-0_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-30355-0_18

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-30353-6

  • Online ISBN: 978-3-319-30355-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics