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Immune-Mediated Thrombocytopenia

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Nonmalignant Hematology

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Abstract

Thrombocytopenia is one of the most frequently encountered hematological disorders and occurs as a consequence of numerous pathophysiological mechanisms. One of the more common causes of thrombocytopenia is “immune thrombocytopenia” (ITP). Landmark studies on this disease performed more than 50 years ago demonstrated an important role for antibody-mediated platelet destruction in ITP (Harrington et al. 1951). Subsequent studies have revealed that bone marrow megakaryocytes are also affected by platelet autoantibodies (McMillan et al. 2004; Nugent et al. 2009) and that T cells may also contribute to platelet destruction and inhibit platelet production by megakaryocytes (Cines et al. 2009a; Semple and Provan 2012). As with other thrombocytopenic disorders, ITP may occur as a primary syndrome or may be secondary to underlying infectious, autoimmune, or malignant disorders (Cines et al. 2009a; Rodeghiero et al. 2009).

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Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH, USA

    Nikolaos Papadantonakis MD, PhD & Keith R. McCrae MD

  2. Department of Cellular and Molecular Medicine, Cleveland Clinic, Taussig Cancer Institute, 9500 Euclid Avenue, R4-018, Cleveland, OH, 44195, USA

    Keith R. McCrae MD

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  1. Nikolaos Papadantonakis MD, PhD
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Correspondence to Keith R. McCrae MD .

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Editors and Affiliations

  1. Cancer Treatment Centers of America, Department of Hematology and Bone Marrow Transplantion, Zion, Illinois, USA

    Syed A. Abutalib

  2. Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Jean M. Connors

  3. Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Margaret V. Ragni

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Papadantonakis, N., McCrae, K.R. (2016). Immune-Mediated Thrombocytopenia. In: Abutalib, S., Connors, J., Ragni, M. (eds) Nonmalignant Hematology. Springer, Cham. https://doi.org/10.1007/978-3-319-30352-9_19

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