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Tissue Transplantation

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Immunopharmacology

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Abstract

In transplantation, organs, cells, or tissue is harvested from one individual and grafted into another individual. The transplant could be autologous, where the transplanted graft is from the same individual or it could be allogeneic, where the graft is transplanted in a genetically different individual. In this chapter, the focus is predominantly on allogeneic transplantation. The ability to distinguish self from nonself resides in the HLA molecules, which are identified for the purpose of tissue typing to find a compatible donor when necessary. Recognition of grafted tissue as self or nonself is the result of inheritance of codominant genes. The mechanism of rejection involves both the innate and acquired immune responses, and various cell types and molecules particularly T cells, NK cells, adhesion molecules, and antibodies have roles in these processes. This forms a significant part of the discussion. Lastly, transplantation of individual tissue and cell types including the kidney, liver, pancreas, heart, lung, hematopoietic stem cells, and bone marrow is described. There is discussion of graft-versus-host disease and ways to minimize the rejection process.

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  1. Pharmacy Sciences, Creighton University, Omaha, Nebraska, USA

    Manzoor M. Khan

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Khan, M.M. (2016). Tissue Transplantation. In: Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-30273-7_8

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