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Allergic Disease

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Immunopharmacology

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Abstract

This chapter focuses on the etiology, pathogenesis, and immunotherapeutic strategies for the allergic disease. In atopic individuals IgE is produced after exposure to low levels of environmental or food allergens instead of IgG. The first part of this chapter is devoted to defining hypersensitivity disease, IgE-mediated responses, and regulation of IgE synthesis. IgE synthesis is regulated by heredity, natural history of antigen exposure, nature of antigen, helper T cells, and cytokines. This is followed by a discussion of hygiene hypothesis in the etiology of allergic disease and mechanism of allergic inflammation. T cells, cytokines, and cytokine-dependent signaling pathways play a crucial role in the development and pathogenesis of the disease. In this regard the roles of IL-4, IL-5, IL-9, and IL-13 along with IL-4/STAT6 signaling, Notch-signaling pathway, and IL-2/STAT5 pathway are discussed. The applications of immunotherapy and sublingual immunotherapy for traditional allergy as well as allergy to food and seminal plasma are described.

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Bibliography

  • Aberg N, Sundell J, Eriksson B, Hesselmar B (1996) Prevalence of allergic disease in school children in relation to family history, upper respiratory tract infections and residential characteristics. Allergy 51:232–237

    CAS  PubMed  Google Scholar 

  • Akdis CA, Blaser K (2003) Histamine in the immune regulation of allergic inflammation. J All Clin Immunol 112:15–22

    Article  CAS  Google Scholar 

  • Akdis CA, Blasker K (1999) IL-10-induced anergy in peripheral T cells and reactivation by micro environmental cytokines: two key steps in specific immunotherapy. FASEB J 13:603–609

    CAS  PubMed  Google Scholar 

  • Akdis M, Blaser K, Akdis CA (2005) T regulatory cells in allergy: novel concepts in the pathogenesis, prevention and treatment of allergic diseases. J All Clin Immunol 116:9961–9969

    Article  CAS  Google Scholar 

  • Alam R, Kampern G (2002) Cytokines in allergic inflammation. J Clin All Immunol 16:255–274

    CAS  Google Scholar 

  • Amsen D, Antov A, Flavell RA (2009) The different faces of notch in T-helper-cell differentiation. Nat Rev Immunol 9:116–124

    Article  CAS  PubMed  Google Scholar 

  • Annesi I, Oryszczyn M, Frette C, Neukirch F et al (1992) Total circulating IgE and FEV1 in adult men: an epidemiologic longitudinal study. Chest 101:642–648

    Article  CAS  PubMed  Google Scholar 

  • Annunziato F, Cosmi L, Galli G, Beltrame C et al (1999) Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol 65:691–699

    CAS  PubMed  Google Scholar 

  • Bach J-F (2002) The effects of infections on susceptibility to autoimmune and allergic diseases. NEJM 347:911–920

    Article  PubMed  Google Scholar 

  • Barnes PJ (1991) Neuropeptides and asthma. Am Rev Respir Dis 143:S28

    Article  CAS  PubMed  Google Scholar 

  • Barnes PJ (1999) Anti-IgE antibody therapy for asthma. NEJM 341:2006–2008

    Article  CAS  PubMed  Google Scholar 

  • Barnes PJ (2000) New directions in allergic diseases: mechanism based anti-inflammatory therapies. J All Clin Immunol 106:5–16

    Article  CAS  Google Scholar 

  • Beasley R, Burgess R, Crane J, Pearce N et al (1993) Pathology of asthma and its clinical implications. J All Clin Immunol 92:148–154

    Article  CAS  Google Scholar 

  • Bisset LR, Schmid-Grendelmeier P (2005) Chemokines and their receptors in the pathogenesis of allergic asthma: progress and perspective. Curr Opin Pulm Med 11:35–42

    Article  CAS  PubMed  Google Scholar 

  • Boulet LP, Chapman KR, Cote J, Kalra S et al (1997) Inhibitory effects of an anti-IgE antibody E25 on allergen-induced early asthmatic response. Am J Respir Crit Care Med 155:1835–1840

    Article  CAS  PubMed  Google Scholar 

  • Bousquet J, Jeffery PK, Busse WW, Johnson M et al (2000) Asthma: from bronchoconstriction to airway inflammation and remodeling. Am J Respir Crit Care Med 161:1720–1745

    Article  CAS  PubMed  Google Scholar 

  • Boyce JA, Assad A, Burks AW, Jones SM et al (2010) Guidelines for the diagnosis and management of food allergy in the United States. J Allergy Clin Immunol 126:S1–S58

    Article  PubMed  PubMed Central  Google Scholar 

  • Braun-Fahrlander C, Riedler J, Herz U, Eder W et al (2002) Environmental exposure to endotoxin and its relation to asthma in school-age children. NEJM 347:869–877

    Article  PubMed  Google Scholar 

  • Burks AW, Jones SM, Wood RA, Fleischer DM et al (2012) Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 367:233–243

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burrows B, Martinez FD, Halonen M, Barbee RA et al (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. NEJM 320:271–277

    Article  CAS  PubMed  Google Scholar 

  • Busse WW (2000) Mechanisms and advances in allergic diseases. J All Clin Immunol 105:S593–S598

    Article  CAS  Google Scholar 

  • Busse W, Kraft M (2005) Cysteinyl leukotrienes in allergic inflammation: strategic target for therapy. Chest 127:1312–1326

    CAS  PubMed  Google Scholar 

  • Busse WW, Coffman RL, Gelfand EW, Kay AB et al (1995) Mechanisms of persistent airway inflammation in asthma. A role for T cells and T-cell products. Am J Resp Crit Care Med 152:388–393

    Article  CAS  PubMed  Google Scholar 

  • Busse WW, Fahy JV, Rick RB (1998) A pilot study of the effects of an anti-IgE antibody (E25) on airway inflammation in moderate-severe asthma. Am J Respir Crit Care Med 157:456A

    Article  Google Scholar 

  • Chen W, Hershey GKK (2007) Signal transducer and activator of transcriptional signals in allergic disease. J All Clin Immunol 119:529–541

    Article  CAS  Google Scholar 

  • Cherwinski HM, Schumaker JH, Brown KD, Mosmann TR (1987) Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 166:1299–1244

    Article  Google Scholar 

  • Chung F (2001) Anti-inflammatory cytokines in asthma and allergy: interleukin 10, interleukin 12, interferon gamma mediators. Inflammation 10:51–59

    CAS  Google Scholar 

  • Cohn L, Homer RJ, Niu N, Bottomly K (1999) T helper 1 cells and interferon regulate allergic airway inflammation and mucus production. J Exp Med 190:1309–1317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Contopoulos-Loannidis DG, Kouri LN, Loannidis JPA (2007) Genetic predisposition to asthma and atopy. Respiration 74:8–12

    Article  Google Scholar 

  • Corren J, Diaz-Sanchez D, Reimann J, Saxon A, Adelman D (1998) Effects of anti-IgE antibody therapy on nasal reactivity to allergen and IgE synthesis in vivo. J All Clin Immunol 101:S105

    Article  Google Scholar 

  • Cosmi L, Annunziato F, Iwasaki M, Galli G et al (2000) CRTH2 is the most reliable marker for detection of circulating human type 2 Th2 and type 2 T cytotoxic cells in health and disease. Eur J Immunol 30:2972–2979

    Article  CAS  PubMed  Google Scholar 

  • Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL et al (2006) Immunotherapy with a ragweed-toll like receptor 9 agonist vaccine for allergic rhinitis. NEJM 355:1445–1455

    Article  CAS  PubMed  Google Scholar 

  • Cui ZH, Joetham M, Aydintug MK, Hahn YS et al (2003) Reversal of allergic airway hyperactivity after long term allergen challenge depends on (gamma) (delta) T cells. Am J Resp Crit Care Med 168:1324–1332

    Article  PubMed  Google Scholar 

  • Davis P (2005) Carl Prausnitz and the mysteries of allergy. Biomed Sci December:1247

    Google Scholar 

  • Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E et al (2011) The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 12:295–303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dello Iacono I, Verga MC, Tripodi S (2012) Oral immunotherapy for egg allergy in children. N Engl J Med 367:1471; author reply 1472–1473

    Article  PubMed  CAS  Google Scholar 

  • Demoly P, Bousquet J (1997) Anti-IgE therapy for asthma. Am J Respir Crit Care Med 155:1825–1827

    Article  CAS  PubMed  Google Scholar 

  • Denburg JA (ed) (1998) Allergy and allergic disease: the new mechanisms and therapeutics. Humana Press, Totowa. ISBN 0-89603-404-6

    Google Scholar 

  • Durham SR, Walker SM, Varga EM, Jacobsen MR et al (1999) Long-term clinical efficacy of grass pollen immunotherapy. NEJM 341:468–475

    Article  CAS  PubMed  Google Scholar 

  • Elias JA (2000) Airway remodeling in asthma. Am J Resp Crit Care Med 161:S168–S171

    Article  CAS  PubMed  Google Scholar 

  • Emanuel MB (1988) Hay fever, a post industrial revolution epidemic: a history of its growth during the 19th century. Clin Allergy 18:295–304

    Article  CAS  PubMed  Google Scholar 

  • Erpenbeck VJ, Hohlfeld JM, Discher M, Krentel H et al (2003) Increased messenger RNA expression of C-maf and GATA-3 after segmental allergen challenge in allergic asthmatics. Chest 123:370S–371S

    Google Scholar 

  • Fahey JV, Fleming HE, Wong HH, Liu J et al (1997) The effect of an anti-IgE monoclonal antibody on the early-and late-phase responses to allergen inhalation in asthmatic subjects. Am J Respir Crit Care Med 155:1828–1834

    Article  Google Scholar 

  • Fireman P (2003) Understanding asthma pathophysiology. Allergy Asthma Proc 24:79–83

    CAS  PubMed  Google Scholar 

  • Freeman J (1911) Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine. Lancet 2:814–817

    Article  Google Scholar 

  • Freeman J (1914) Vaccination against hay fever: report of results during the first three years. Lancet 1:1178–1180

    Article  Google Scholar 

  • Frew AJ, Kay AB (1990) Eosinophils and T-lymphocytes in late phase allergic reactions. J All Clin Immunol 85:533–539

    Article  CAS  Google Scholar 

  • Frew AJ, Corrigan CJ, Maestrelli P, Tsai JJ et al (1989) T lymphocytes in allergen-induced late-phase reaction and asthma. Int Archaeol Allergy Appl Immunol 88:63–67

    Article  CAS  Google Scholar 

  • Galli SJ (1993) New concepts about the mast cells. NEJM 328:257–265

    Article  CAS  PubMed  Google Scholar 

  • Gangur V, Oppenheim JJ (2000) Are chemokines essential or secondary participants in allergic responses? Ann All Asthma Immunol 84:569–581

    Article  CAS  Google Scholar 

  • Gell PGH, Coombs RRA (eds) (1963) Clinical aspects of immunology, 1st edn. Blackwell, Oxford

    Google Scholar 

  • Gould HJ, Sutton BJ, Beavil AJ, Beavil RL et al (2003) The biology of IgE and the basis of allergic disease. Ann Rev Immunol 21:579–628

    Article  CAS  Google Scholar 

  • Guarner F, Bourdet-Sicard R, Brandtzaeg P, Gill HS et al (2006) Mechanisms of disease: the hygiene hypothesis revisited. Nat Clin Pract Gastroenterol Hepatol 3:275–284

    Article  CAS  PubMed  Google Scholar 

  • Hang LW, Hsia TC, Chen WC, Chen HY et al (2003) Tap 1 gene Acc1 polymorphism is associated with atopic bronchial asthma. J Clin Anal 17:57–60

    Article  CAS  Google Scholar 

  • Hauber HP, Bergeron C, Hamid Q (2004) IL-9 in allergic inflammation. Int Arch All Immunol 134:79–87

    Article  CAS  Google Scholar 

  • Hawrylowicz CM, O’Garra A (2005) Potential role of interleukin-10 secreting regulatory T cells in allergy and asthma. Nat Rev Immunol 5:271–283

    Article  CAS  PubMed  Google Scholar 

  • Hennino A, Vocanson M, Toussiant Y, Rodet K et al (2007) Skin-infiltrating CD8+ T cells initiate atopic dermatitis lesions. J Immunol 178:5571–5577

    Article  CAS  PubMed  Google Scholar 

  • Hollingsworth JW, Whitehead GS, Lin K, Nakano H et al (2006) TLR4 signaling attenuates ongoing allergic inflammation. J Immunol 176:5856–5862

    Article  CAS  PubMed  Google Scholar 

  • Howarth PH, Salagean M, Dokic D (2000) Allergic rhinitis: not purely a histamine-related disease. Allergy 55:7–16

    Article  PubMed  Google Scholar 

  • http://reference.medscape.com/drug/oralair-grass-pollens-allergen-extract-999883

  • http://www.centerwatch.com/drug-information/fda-approved-drugs/drug/1313/oralair-sweet-vernal-orchard-perennial-rye-timothy-and-kentucky-blue-grass-mixed-pollens-allergen-extract

  • http://www.futuremedicine.com/doi/abs/10.2217/imt.12.147

  • http://www.uptodate.com/contents/allergic-reactions-to-seminal-plasma

  • Illig T, Wjst M (2002) Genetics of asthma and related phenotypes. Paediatr Resp Rev 3:47–51

    Google Scholar 

  • Ishizaka K, Ishizaka T (1967) Identification of gamma-E-antibodies as carrier of reaginic activity. J Immunol 99:1187–1198

    CAS  PubMed  Google Scholar 

  • Ishizaka K, Ishizaka T, Terry WD (1967) Antigenic structure of gamma-E-globulin and reaginic antibody. J Immunol 99:849–858

    CAS  PubMed  Google Scholar 

  • Islam SA, Luster AD (2012) T cell homing to epithelial barriers in allergic disease. Nat Med 18:5705–715. doi:10.1038/nm.2760

    Google Scholar 

  • Johansson SGO (1967) Raised levels of a new immunoglobulin class (IgND) in asthma. Lancet 2:951–953

    Article  CAS  PubMed  Google Scholar 

  • Johansson SGO, Bennich H, Wide L (1968) A new class of immunoglobulins in human serum. Immunology 14:265–272

    CAS  PubMed  PubMed Central  Google Scholar 

  • Joos GF, DeSwert KO, Schelfhout V, Pauwels RA (2003) The role of neural inflammation in asthma and chronic obstructive pulmonary disease. Ann N Y Acad Sci 992:218–230

    Article  CAS  PubMed  Google Scholar 

  • Kaliner M, Lemanske R (1984) Inflammatory responses to mast cell granules. Fed Proc 43:2846–2851

    CAS  PubMed  Google Scholar 

  • Kalliomaki M, Salminen S, Poussa T, Arvilommi H et al (2003) Probiotics and prevention of atopic disease: 4 year follow up of a randomized placebo controlled trial. Lancet 361:1869–1871

    Article  PubMed  Google Scholar 

  • Karlsson MR, Rugtveit J, Brandtzaeg P (2004) Allergen responsive CD4+ CD25+ regulatory T cells in children who have outgrown cow’s milk allergy. J Exp Med 12:1679–1688

    Article  Google Scholar 

  • Kaufman HS, Frick OL (1976) The development of allergy in infants of allergic parents: a prospective study concerning the role of heredity. Ann Allergy 37:410–415

    CAS  PubMed  Google Scholar 

  • Kay AB (2001a) Allergy and allergic diseases – first of two parts. NEJM 344:30–37

    Article  CAS  PubMed  Google Scholar 

  • Kay AB (2001b) Allergy and allergic diseases – second of two parts. NEJM 344:109–113

    Article  CAS  PubMed  Google Scholar 

  • Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT et al (2012) The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 129:448–455

    Article  CAS  PubMed  Google Scholar 

  • Kim JS, Sampson HA (2012) Food allergy: a glimpse into the inner workings of gut immunology. Curr Opin Gastroenterol 28:99–103

    Article  CAS  PubMed  Google Scholar 

  • Kozyrskyj AL, Ernst P, Becker AB (2007) Increased risk of childhood asthma from antibiotic use in early life. Chest 131:1753–1759

    Article  PubMed  Google Scholar 

  • Lasley MV (1999) Allergic disease prevention and risk factor identification. Immunol All Clin N Am 19:149–159

    Article  Google Scholar 

  • Lauener RP, Birchler T, Adamski J, Braun-Fahrlander C et al (2002) Expression of CD14 and Toll-like receptor 2 in farmer’s children. Lancet 36:465–466

    Article  Google Scholar 

  • Lawlor GJ, Fischer TJ, Adelman DC (eds) (1995) Manual of allergy and immunology, 3rd edn. Lippincott-Raven, Philadelphia

    Google Scholar 

  • Lee-Wong M, Collins JS, Nozad C, Resnik DJ (2008) Diagnosis and treatment of human seminal plasma hypersensitivity. Obstet Gyenol 111:538–539

    Article  Google Scholar 

  • Lichtenstein LM, Ishizaka K, Norman PS, Sobotka AD et al (1973) IgE antibody measurements in ragweed hay fever relationship to clinical severity and the results of immunotherapy. J Clin Invest 52:472–482

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Luckacs NW (2001) Role of chemokines in the pathogenesis of asthma. Nat Rev Immunol 1:108–116

    Article  CAS  Google Scholar 

  • Maier E, Hebenstreit D, Posselt G, Hammerl P et al (2011) Inhibition of suppressive T cell factor 1 (TCF-1) isoforms in naive CD4+ T cells is mediated by IL-4/STAT6 signaling. J Biol Chem 286:919–928

    Article  CAS  PubMed  Google Scholar 

  • Maier E, Duschl A, Horejs-Hoeck J (2012) STAT6-dependent and independent mechanisms in Th2 polarization. Eur J Immunol 42:2827–2833

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Martinez FD (2007) Gene-environment interaction in asthma: with apologies t William of Ockham. Proc Am Thorac Soc 4:26–31

    Article  PubMed  PubMed Central  Google Scholar 

  • Miyahara N, Takeda K, Kodama T, Joetham A et al (2004) Contribution of antigen-primed CD8+ T cells to the development of airway hyper-responsiveness and inflammation is associated with IL-13. J Immunol 172:2549–2558

    Article  CAS  PubMed  Google Scholar 

  • Mosmann TR, Coffman R (1989) TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Ann Rev Immunol 7:145–173

    Article  CAS  Google Scholar 

  • Nagata K, Tanaka K, Ogawa K, Kemmostu K et al (1999) Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 162:1278–1286

    CAS  PubMed  Google Scholar 

  • Nakajima H, Takatsu K (2007) Role of cytokines in allergic airway inflammation. Int Arch All Immunol 142:265–273

    Article  CAS  Google Scholar 

  • Nassenstein C, Braun A, Erpenbeck A, Lommatzsch M et al (2003) The neurotrophins nerve growth factors, brain derived neurotrophic factor, neurotrophin 3 and neurotrophin 4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med 198:455–467

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nassenstein C, Braun A, Nockher WA, Renz H (2005) Neurotrophin effects of eosinophils in allergic inflammation. Curr All Asthma Rep 5:204–211

    Article  CAS  Google Scholar 

  • Netting M, Makrides M, Gold M, Quinn P et al (2013) Heated allergens and induction of tolerance in food allergic children. Nutrient 5:2028–2046

    Article  CAS  Google Scholar 

  • Ngoc PL, Gold DR, Tzianbos AO, Weiss ST et al (2005) Cytokines, allergy and asthma. Curr Opin All Clin Immunol 5:161–166

    Article  CAS  Google Scholar 

  • Nigo YI, Yamashita M, Hirahara K, Shinnakasu R (2006) Regulation of allergic airway inflammation through the Toll-like receptor 4-mediated modification of mast cell function. PNAS USA 103:2286–2291

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nockher WA, Renz H (2006) Neurotrophins and asthma: novel insight into neuroimmune interaction. J All Clin Immunol 117:67–71

    Article  CAS  Google Scholar 

  • Noon L (1911) Prophylactic inoculation against hay fever. Lancet 1:1572–1573

    Article  Google Scholar 

  • Norman PS, Ohman JL, Long AA, Creticos PS et al (1996) Treatment of cat allergy with T-cell reactive peptides. Am J Respir Crit Care Med 154:1623–1628

    Article  CAS  PubMed  Google Scholar 

  • Nowak-Wegrzym A, Samson HA (2011) Future therapies for food allergies. J Allergy Clin Immunol 127:558–573

    Article  Google Scholar 

  • O’Byrne PM (2006) Cytokines and their antagonists for the treatment of asthma. Chest 130:244–250

    Article  PubMed  CAS  Google Scholar 

  • Ohmichi Y, Hirakawa J, Yasuyuki I, Fukuda M et al (2011) Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. J Exp Med 208:1015–1025

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oliver PM, Cao X, Worthen GS, Shi P et al (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity 25:929–940

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Olivier CE (2013) Food allergy. J Allergy Ther S3:004. doi:10.4172/2155-6121.S3-004

    Google Scholar 

  • Ono S (2000) Molecular genetics of allergic diseases. Ann Rev Immunol 18:347–366

    Article  CAS  Google Scholar 

  • Oppenheimer JJ, Nelson HS, Bock SA, Christensen F et al (1992) Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 90:256–262

    Article  CAS  PubMed  Google Scholar 

  • Panina-Bordignon P, Papi A, Mariani M, DiLucia P (2001) The C-C chemokine receptors and CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest 107:1357–1364

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Passalacqua G (2007) Allergic rhinitis and its impact on asthma update. Allergen immunotherapy. J All Clin Immunol 119:881–891

    Article  Google Scholar 

  • Pepys J (1994) “Atopy;” a study in definition. Allergy 49:397–399

    Article  CAS  PubMed  Google Scholar 

  • Pernis AB, Rothman PB (2002) JAK-STAT signaling in asthma. J Clin Invest 109:1279–1283

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Platts-Mills TA (2001) The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med 164:S1–S5

    Article  CAS  PubMed  Google Scholar 

  • Prussin C, Metcalfe DD (2003) IgE, mast cells, basophils and eosinophils. J All Clin Immunol 111:5486–5494

    Google Scholar 

  • Racila DM, Kline JN (2005) Perspectives in asthma: molecular use of microbial products in asthma prevention and treatment. J All Clin Immunol 116:1202–1205

    Article  CAS  Google Scholar 

  • Rajan TV (2003) The Gell-Coombs classification of hypersensitivity reactions: a reinterpretation. Trends Immunol 24:376–379

    Article  CAS  PubMed  Google Scholar 

  • Ray A, Cohn L (1999) TH2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J Clin Invest 104:995–1006

    Article  Google Scholar 

  • Reynolds C, Ozerovitch L, Wilsen R, Altmann D et al (2007) Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis. Thorax 62:279–279

    CAS  PubMed  PubMed Central  Google Scholar 

  • Robertson DG, Kerigan AT, Hargreave FE, Chalmers R et al (1974) Late asthmatic responses induced by ragweed pollen allergen. J All Clin Immunol 54:244–254

    Article  CAS  Google Scholar 

  • Rochlitzer S, Nassenstein C, Braun A (2006) The contribution of neurotrophins to the pathogenesis of allergic asthma. Biochem Soc Trans 34:594–599

    Article  CAS  PubMed  Google Scholar 

  • Romagnani S (1994) Lymphokine production by human T cells in disease states. Ann Rev Immunol 12:227–257

    Article  CAS  Google Scholar 

  • Romagnani S (2000) The roles of lymphocytes in allergic disease. J All Clin Immunol 105:399–408

    Article  CAS  Google Scholar 

  • Romagnani S (2002) Cytokines and chemoattractants in allergic inflammation. Mol Immunol 38:881–885

    Article  CAS  PubMed  Google Scholar 

  • Rothenberg ME (1998) Eosinophilia. NEJM 338:1592–1600, S32

    Article  CAS  PubMed  Google Scholar 

  • Schaub BM, Lauener R, Von ME (2006) The many faces of the hygiene hypothesis. J All Clin Immunol 117:969–977

    Article  Google Scholar 

  • Schmitz N, Kurrer M, Kopf M (2003) The IL-1 receptor 1 is critical for TH2 cell type airway immune responses in a mild but not in more severe asthma model. Eur J Immunol 33:991–1000

    Article  CAS  PubMed  Google Scholar 

  • Schnare M, Barton GM, Holt AC, Taked K et al (2001) Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2:947–950

    Article  CAS  PubMed  Google Scholar 

  • Schoenwetter WF (2000) Allergic rhinitis: epidemiology and natural history. Allergy Asthma Proc 21:1–6

    Article  CAS  PubMed  Google Scholar 

  • Sel S, Wegmann M, Sel S, Bauer S et al (2007) Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and Il-10. J Immunol 178:7805–7813

    Article  CAS  PubMed  Google Scholar 

  • Seneviratne SL, Jones L, King AS, Black A et al (2002) Allergen specific CD8+ T cells in atopic disease. J Clin Invest 110:P1283–P1291

    Article  Google Scholar 

  • Serafin WE, Austen KF (1987) Mediators of immediate hypersensitivity reactions. NEJM 317:30–34

    Article  CAS  PubMed  Google Scholar 

  • Shimizu K, Chiba S, Kumano K, Hosoya N et al (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem 274:32961–32969

    Article  CAS  PubMed  Google Scholar 

  • Shimizu K, Chiba S, Hosoya N, Kumano K et al (2000) Binding of Delta1, Jagged1, and Jagged 2 to notch2 rapidly induces cleavage. Nuclear translocation and hyperphosphorylation of notch2. Mol Cell Biol 20:6913–6922

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shimizu K, Chiba S, Saito T, Kumano K et al (2001) Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J Biol Chem 276:25753–25758

    Article  CAS  PubMed  Google Scholar 

  • Simpson JL, Grissell TV, Douwes J, Scott RJ et al (2007) Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 62:211–218

    Article  PubMed  Google Scholar 

  • Solley GO, Gleich GJ, Jordon RE, Schroeter AL (1976) The late phase of the immediate wheal and flare skin reaction. Its dependence upon IgE antibodies. J Clin Invest 58:408–420

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Spitz E, Gelfand EW, Sheffer AL, Austen KF (1972) Serum IgE in clinical immunology and allergy. J All Clin Immunol 49:337–347

    Article  CAS  Google Scholar 

  • Strachan DP (1989) Hay fever, hygiene and household size. Br Med J 299:1259–1260

    Article  CAS  Google Scholar 

  • Strachan DP (2000a) Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax 55:S2–S10

    Article  PubMed  PubMed Central  Google Scholar 

  • Strachan DP (2000b) Family size, infection and atopy: the first decade of the “hygiene hypothesis”. Thorax 1:S2–S10

    Article  Google Scholar 

  • Strachan DP, Wong HJ, Spector TD (2001) Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins. J All Clin Immunol 108:901–907

    Article  CAS  Google Scholar 

  • Takatori H, Nakajima H, Hirose K, Kagami S et al (2005) Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J Immunol 174:3734–3740

    Article  CAS  PubMed  Google Scholar 

  • Takhar P, Smurthwaite L, Coker HA, Fear DJ et al (2005) Allergen derives class switching to IgE in the nasal mucosa in allergic rhinitis. J Immunol 174:5024–5032

    Article  CAS  PubMed  Google Scholar 

  • Umetuse DT, DeKruff RH (2006) The regulation of allergy and asthma. Immunol Rev 212:238–255

    Article  Google Scholar 

  • Undem BJ, Carr MJ (2002) The role of nerves in asthma. Curr All Asthma Rep 2:159–165

    Article  Google Scholar 

  • Van Hove CL, Maes T, Joos GF, Tournoy KG (2007) Prolonged inhaled allergen exposure can induce persistent tolerance. Am J Respir Cell Mol Biol 36:573–584

    Article  PubMed  CAS  Google Scholar 

  • van Panhuys N, Tang SC, Prout M, Camberis M et al (2008) In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci U S A 105:12423–12428

    Article  PubMed  PubMed Central  Google Scholar 

  • Varney VA, Gaga M, Frew AJ, Eber VR et al (1991) Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by anti-allergic drugs. Br Med J 302:265–269

    Article  CAS  Google Scholar 

  • Von Mutius E (2002) Environmental factors influencing the development of progression of pediatric asthma. J All Clin Immunol 109:525–532

    Article  Google Scholar 

  • Wagner R (1968) Clemens Von Pirquet: his life and work. The John Hopkins Press, Baltimore

    Google Scholar 

  • Wang YH, Ito T, Wang YH, Homey B et al (2006) Maintenance and polarization of human Th2 central memory T cells by thymic stromal lymphopoietin activated dendritic cells. Immunity 24:827–838

    Article  CAS  PubMed  Google Scholar 

  • Weber RW (1997) Immunotherapy with allergens. JAMA 278:1881–1887

    Article  CAS  PubMed  Google Scholar 

  • Weiss ST (2002) Eat dirt – the hygiene hypothesis and allergic diseases. N Engl J Med 347:930–931

    Article  PubMed  Google Scholar 

  • Widdicombe JG (2003) Overview of neural pathways in allergy and asthma. Pulm Pharmacol Ther 16:23–30

    Article  CAS  PubMed  Google Scholar 

  • Wills-Karp M (2001) IL-12/IL-13 axis in allergic asthma. J All Clin Immunol 107:9–18

    Article  CAS  Google Scholar 

  • Wisniewski J, Agrawal R, Woodfolk JA (2013) Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin Exp Allergy 43:164–176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Woodfolk JA (2007) T-cell responses to allergens. J All Clin Immunol 119:280–294

    Article  CAS  Google Scholar 

  • Yu Q, Sharma A, Oh SY, Moon HG et al (2009) T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol 10:992–999

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yu Q, Sharma A, Ghosh A, Sen JM (2011) T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis. J Immunol 186:3946–3952

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhu J, Cote-Sierra J, Guo L, Paul WE (2003) STAT5 activation plays a critical role in Th2 differentiation. Immunity 19:739–748

    Article  CAS  PubMed  Google Scholar 

  • Zuany-Amorim C, Ruffie C, Haile S, Vargaftig BB et al (1998) Requirement of γδ T cells in allergic airway inflammation. Science 280:1265–1267

    Article  CAS  PubMed  Google Scholar 

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  1. Pharmacy Sciences, Creighton University, Omaha, Nebraska, USA

    Manzoor M. Khan

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Khan, M.M. (2016). Allergic Disease. In: Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-30273-7_6

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