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Quality of Life, Cognition, and Social Cognition in Schizophrenia

  • Sofia BrissosEmail author
  • Guilherme Pereira
  • Vicent Balanzá-Martinez
Chapter

Abstract

Nowadays, the main objective in treating patients with schizophrenia (SZ) is not only to attain and maintain symptomatic remission, in order to reach recovery, but also to avoid relapses and reach a level of personal and social functioning, as well as of quality of life (QoL), as near as possible to that of the general population (Hasan et al. 2013). In that sense, psychosocial functioning and QoL are increasingly recognized as important treatment outcomes in SZ (Juckel and Morosini 2008; Remington et al. 2010; Figueira and Brissos 2011).

Keywords

Negative Symptom Social Cognition Emotional Intelligence Social Cognition Training Negative Social Comparison 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Addington J, Addington D. Social and cognitive functioning in psychosis. Schizophr Res. 2008;99(1):176–81.Google Scholar
  2. Addington J, Saeedi H, Addington D. Influence of social perception and social knowledge on cognitive and social functioning in early psychosis. Br J Psychiatry. 2006;189(4):373–8.PubMedCrossRefGoogle Scholar
  3. Aki H, Tomotake M, Kaneda Y, Iga J-I, Kinouchi S, Shibuya-Tayoshi S, Tayoshi S-Y, Motoki I, Moriguchi K, Sumitani S. Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia. Psychiatry Res. 2008;158(1):19–25.PubMedCrossRefGoogle Scholar
  4. Alptekin K, Akvardar Y, Akdede BB, Dumlu K, Işık D, Pirinçci F, Yahssin S, Kitiş A. Is quality of life associated with cognitive impairment in schizophrenia? Prog Neuro-Psychopharmacol Biol Psychiatry. 2005;29(2):239–44.CrossRefGoogle Scholar
  5. American Psychiatric Association. Diagnostic and statistical manual-text revision. 4th ed., text rev. Washington, DC: Author; 2000.Google Scholar
  6. Baron‐Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The “Reading the Mind in the Eyes” test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry. 2001;42(2):241–51.PubMedCrossRefGoogle Scholar
  7. Becchi A, Rucci P, Placentino A, Neri G, de Girolamo G. Quality of life in patients with schizophrenia—comparison of self-report and proxy assessments. Soc Psychiatry Psychiatr Epidemiol. 2004;39(5):397–401.PubMedCrossRefGoogle Scholar
  8. Bell MD, Corbera S, Johannesen JK, Fiszdon JM, Wexler BE. Social cognitive impairments and negative symptoms in schizophrenia: are there subtypes with distinct functional correlates? Schizophr Bull. 2013;39(1):186–96.PubMedCrossRefGoogle Scholar
  9. Bentall RP, Corcoran R, Howard R, Blackwood N, Kinderman P. Persecutory delusions: a review and theoretical integration. Clin Psychol Rev. 2001;21(8):1143–92.PubMedCrossRefGoogle Scholar
  10. Bowie CR, Leung WW, Reichenberg A, McClure MM, Patterson TL, Heaton RK, Harvey PD. Predicting schizophrenia patients’ real-world behavior with specific neuropsychological and functional capacity measures. Biol Psychiatry. 2008;63(5):505–11.PubMedCrossRefGoogle Scholar
  11. Boyer L, Aghababian V, Richieri R, Loundou A, Padovani R, Simeoni M, Auquier P, Lancon C. Insight into illness, neurocognition and quality of life in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2012;36(2):271–6.CrossRefGoogle Scholar
  12. Brekke JS, Kohrt B, Green MF. Neuropsychological functioning as a moderator of the relationship between psychosocial functioning and the subjective experience of self and life in schizophrenia. Schizophr Bull. 2001;27(4):697.PubMedCrossRefGoogle Scholar
  13. Brekke JS, Hoe M, Long J, Green MF. How neurocognition and social cognition influence functional change during community-based psychosocial rehabilitation for individuals with schizophrenia. Schizophr Bull. 2007;33(5):1247–56.PubMedPubMedCentralCrossRefGoogle Scholar
  14. Brekke J, Hoe M, Green M. Neurocognitive change, functional change and service intensity during community-based psychosocial rehabilitation for schizophrenia. Psychol Med. 2009;39(10):1637–47.PubMedCrossRefGoogle Scholar
  15. Brissos S, Dias VV, Soeiro-de-Souza MG, Balanzá-Martínez V, Kapczinski F. The impact of a history of psychotic symptoms on cognitive function in euthymic bipolar patients: a comparison with schizophrenic patients and healthy controls. Rev Bras Psiquiatr. 2011a;33(4):353–61.PubMedCrossRefGoogle Scholar
  16. Brissos S, Dias VV, Balanzá-Martinez V, Carita AI, Figueira ML. Symptomatic remission in schizophrenia patients: relationship with social functioning, quality of life, and neurocognitive performance. Schizophr Res. 2011b;129(2):133–6.PubMedCrossRefGoogle Scholar
  17. Brissos S, Dias VV, Carita AI, Martinez-Arán A. Quality of life in bipolar type I disorder and schizophrenia in remission: clinical and neurocognitive correlates. Psychiatry Res. 2008;160(1):55–62.Google Scholar
  18. Brüne M. Emotion recognition, ‘theory of mind,’ and social behavior in schizophrenia. Psychiatry Res. 2005;133(2):135–47.PubMedCrossRefGoogle Scholar
  19. Burton S. Symptom domains of schizophrenia: the role of atypical antipsychotic agents. J Psychopharmacol. 2006;20(6 suppl):6–19.PubMedCrossRefGoogle Scholar
  20. Caqueo-Urízar A, Boyer L, Baumstarck K, Gilman SE. Subjective perceptions of cognitive deficits and their influences on quality of life among patients with schizophrenia. Qual Life Res. 2015;24(11):2753–60.PubMedCrossRefGoogle Scholar
  21. Chino B, Nemoto T, Fujii C, Mizuno M. Subjective assessments of the quality of life, well‐being and self‐efficacy in patients with schizophrenia. Psychiatry Clin Neurosci. 2009;63(4):521–28.Google Scholar
  22. Chisholm D, Bhugra D. Sociocultural and economic aspects of quality of life measurement. Eur Psychiatry. 1997;12(4):210–5.PubMedCrossRefGoogle Scholar
  23. Chue P. The relationship between patient satisfaction and treatment outcomes in schizophrenia. J Psychopharmacol. 2006;20(6 Suppl):38–56.PubMedCrossRefGoogle Scholar
  24. Combs DR, Penn DL, Wicher M, Waldheter E. The Ambiguous Intentions Hostility Questionnaire (AIHQ): a new measure for evaluating hostile social-cognitive biases in paranoia. Cogn Neuropsychiatry. 2007;12(2):128–43.PubMedCrossRefGoogle Scholar
  25. Corbera S, Wexler BE, Ikezawa S, Bell MD. Factor structure of social cognition in schizophrenia: is empathy preserved? Schizophr Res Treatment. 2013;2013:409205.PubMedPubMedCentralCrossRefGoogle Scholar
  26. Corcoran R, Mercer G, Frith CD. Schizophrenia, symptomatology and social inference: investigating “theory of mind” in people with schizophrenia. Schizophr Res. 1995;17(1):5–13.PubMedCrossRefGoogle Scholar
  27. Corrigan PW. The social perceptual deficits of schizophrenia. Psychiatry. 1997;60(4):309–26.PubMedGoogle Scholar
  28. Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: a review. Schizophr Bull. 2006;32 Suppl 1:S44–63.PubMedPubMedCentralCrossRefGoogle Scholar
  29. Couture SM, Granholm EL, Fish SC. A path model investigation of neurocognition, theory of mind, social competence, negative symptoms and real-world functioning in schizophrenia. Schizophr Res. 2011;125(2):152–60.PubMedCrossRefGoogle Scholar
  30. Dickinson D, Coursey RD. Independence and overlap among neurocognitive correlates of community functioning in schizophrenia. Schizophr Res. 2002;56(1):161–70.Google Scholar
  31. Dickerson F, Ringel N, Parente F. Subjective quality of life in out‐patients with schizophrenia: clinical and utilization correlates. Acta Psychiatr Scand. 1998;98(2):124–7.PubMedCrossRefGoogle Scholar
  32. Evans JD, Heaton RK, Paulsen JS, Palmer BW, Patterson T, Jeste DV. The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients. Biol Psychiatry. 2003;53(5):422–30.PubMedCrossRefGoogle Scholar
  33. Figueira ML, Brissos S. Measuring psychosocial outcomes in schizophrenia patients. Curr Opin Psychiatry. 2011;24(2):91–9.PubMedGoogle Scholar
  34. Fiske ST, Taylor SE. Social cognition. 2nd ed. New York: McGraw-Hill; 1991. p. 16–5.Google Scholar
  35. Fiszdon JM, Choi J, Goulet J, Bell MD. Temporal relationship between change in cognition and change in functioning in schizophrenia. Schizophr Res. 2008;105(1):105–13.Google Scholar
  36. Fitzgerald PB, Williams C, Corteling N, Filia S, Brewer K, Adams A, De Castella A, Rolfe T, Davey P, Kulkarni J. Subject and observer-rated quality of life in schizophrenia. Acta Psychiatr Scand. 2001;103(5):387–92.PubMedCrossRefGoogle Scholar
  37. Fujii DE, Wylie AM, Nathan JH. Neurocognition and long-term prediction of quality of life in outpatients with severe and persistent mental illness. Schizophrenia Res. 2004;69(1):67–73.Google Scholar
  38. Gallotti M, Frith CD. Social cognition in the we-mode. Trends Cogn Sci. 2013;17(4):160–5.PubMedCrossRefGoogle Scholar
  39. Garrido G, Barrios M, Penadés R, Enríquez M, Garolera M, Aragay N, Pajares M, Vallès V, Delgado L, Alberni J. Computer-assisted cognitive remediation therapy: cognition, self-esteem and quality of life in schizophrenia. Schizophr Res. 2013;150(2):563–9.PubMedCrossRefGoogle Scholar
  40. Gigaux J, Le Gall D, Jollant F, Lhuillier J, Richard-Devantoy S. Cognitive inhibition and quality of life in schizophrenia: a pilot study. Schizophr Res. 2013;143(2):297–300.PubMedCrossRefGoogle Scholar
  41. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996;153(3):321.PubMedCrossRefGoogle Scholar
  42. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the “right stuff”? Schizophr Bull. 2000;26(1):119.PubMedCrossRefGoogle Scholar
  43. Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res. 2004;72(1):41–51.PubMedCrossRefGoogle Scholar
  44. Green MF, Penn DL, Bentall R, Carpenter WT, Gaebel W, Gur RC, Kring AM, Park S, Silverstein SM, Heinssen R. Social cognition in schizophrenia: an NIMH workshop on definitions, assessment, and research opportunities. Schizophr Bull. 2008;34(6):1211–20.PubMedPubMedCentralCrossRefGoogle Scholar
  45. Harvey PD, Keefe RS. Methods for delivering and evaluating the efficacy of cognitive enhancement. In: Cognitive Enhancement. Springer International Publishing; 2015. p. 5–25.Google Scholar
  46. Harvey PD, Velligan DI, Bellack AS. Performance-based measures of functional skills: usefulness in clinical treatment studies. Schizophr Bull. 2007;33(5):1138–48.PubMedPubMedCentralCrossRefGoogle Scholar
  47. Hasan A, Falkai P, Wobrock T, Lieberman J, Glenthoj B, Gattaz WF, Thibaut F, Möller H-J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects. World J Biol Psychiatry. 2013;14(1):2–44.PubMedCrossRefGoogle Scholar
  48. Hasson-Ohayon I, Avidan-Msika M, Mashiach-Eizenberg M, Kravetz S, Rozencwaig S, Shalev H, Lysaker PH. Metacognitive and social cognition approaches to understanding the impact of schizophrenia on social quality of life. Schizophr Res. 2014;161(2):386–91.PubMedGoogle Scholar
  49. Hayhurst KP, Massie JA, Dunn G, Lewis SW, Drake RJ. Validity of subjective versus objective quality of life assessment in people with schizophrenia. BMC Psychiatry. 2014;14(1):365.PubMedPubMedCentralCrossRefGoogle Scholar
  50. Heinrichs RW, Zakzanis KK. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998;12(3):426.PubMedCrossRefGoogle Scholar
  51. Heinrichs DW, Hanlon TE, Carpenter WT. The Quality of Life Scale: an instrument for rating the schizophrenic deficit syndrome. Schizophr Bull. 1984;10(3):388.PubMedCrossRefGoogle Scholar
  52. Herrman H, Hawthorne G, Thomas R. Quality of life assessment in people living with psychosis. Soc Psychiatry Psychiatr Epidemiol. 2002;37(11):510–8.PubMedCrossRefGoogle Scholar
  53. Herman M. Neurocognitive functioning and quality of life among dually diagnosed and non‐substance abusing schizophrenia inpatients. Int J Ment Health Nurs. 2004;13(4):282–91.Google Scholar
  54. Hoe M, Nakagami E, Green M, Brekke J. The causal relationships between neurocognition, social cognition and functional outcome over time in schizophrenia: a latent difference score approach. Psychol Med. 2012;42(11):2287–99.PubMedCrossRefGoogle Scholar
  55. Hofer A, Kemmler G, Eder U, Edlinger M, Hummer M, Fleischhacker WW. Quality of life in schizophrenia: the impact of psychopathology, attitude toward medication, and side effects. J Clin Psychiatry. 2004;65(7):932–9.PubMedCrossRefGoogle Scholar
  56. Hofer A, Baumgartner S, Bodner T, Edlinger M, Hummer M, Kemmler G, Rettenbacher MA, Fleischhacker WW. Patient outcomes in schizophrenia II: the impact of cognition. Eur Psychiatry. 2005;20(5):395–402.PubMedCrossRefGoogle Scholar
  57. Horan WP, Kern RS, Green MF, Penn DL. Social cognition training for individuals with schizophrenia: emerging evidence. Am J Psychiatr Rehabil. 2008;11(3):205–52.CrossRefGoogle Scholar
  58. Hoyle RH. Structural equation modeling: concepts, issues, and applications. Thousand Oaks: Sage Publications; 1995.Google Scholar
  59. Jakovljević M, Tomić Z, Maslov B, Skoko I. New image of psychiatry, mass media impact and public relations. Psychiatr Danub. 2010;22(2):145–8.PubMedGoogle Scholar
  60. Juckel G, Morosini PL. The new approach: psychosocial functioning as a necessary outcome criterion for therapeutic success in schizophrenia. Curr Opin Psychiatry. 2008;21(6):630–9.PubMedCrossRefGoogle Scholar
  61. Karow A, Pajonk FG. Insight and quality of life in schizophrenia: recent findings and treatment implications. Curr Opin Psychiatry. 2006;19(6):637–41.PubMedCrossRefGoogle Scholar
  62. Karow A, Wittmann L, Schöttle D, Schäfer I, Lambert M. The assessment of quality of life in clinical practice in patients with schizophrenia. Dialogues Clin Neurosci. 2014;16(2):185.PubMedPubMedCentralGoogle Scholar
  63. Keefe R. The longitudinal course of cognitive impairment in schizophrenia: an examination of data from premorbid through posttreatment phases of illness. J Clin Psychiatry. 2013;75:8–13.CrossRefGoogle Scholar
  64. Keefe RS, Harvey PD. Cognitive impairment in schizophrenia. In: Novel antischizophrenia treatments. Springer Berlin Heidelberg; 2012. p. 11–37.Google Scholar
  65. Kilian R, Angermeyer MC. The effects of antipsychotic treatment on quality of life of schizophrenic patients under naturalistic treatment conditions: an application of random effect regression models and propensity scores in an observational prospective trial. Qual Life Res. 2005;14(5):1275–89.PubMedCrossRefGoogle Scholar
  66. Kinderman P, Bentall RP. Causal attributions in paranoia and depression: internal, personal, and situational attributions for negative events. J Abnorm Psychol. 1997;106(2):341.PubMedCrossRefGoogle Scholar
  67. Kitchen H, Rofail D, Heron L, Sacco P. Cognitive impairment associated with schizophrenia: a review of the humanistic burden. Adv Ther. 2012;29(2):148–62.PubMedCrossRefGoogle Scholar
  68. Kohler CG, Martin E A, Kujawski E, Bilker W, Gur RE, Gur RC. No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia. Cogn Neuropsychiatry. 2007;12(5):412–21.Google Scholar
  69. Kret ME, Ploeger A. Emotion processing deficits: a liability spectrum providing insight into comorbidity of mental disorders. Neurosci Biobehav Rev. 2015;52:153–71.PubMedCrossRefGoogle Scholar
  70. Kurtz MM. Neurocognition as a predictor of response to evidence-based psychosocial interventions in schizophrenia: what is the state of the evidence? Clin Psychol Rev. 2011;31(4):663–72.PubMedPubMedCentralCrossRefGoogle Scholar
  71. Kurtz MM, Tolman A. Neurocognition, insight into illness and subjective quality-of-life in schizophrenia: what is their relationship? Schizophr Res. 2011;127(1):157–62.PubMedPubMedCentralCrossRefGoogle Scholar
  72. Kurtz MM, Wexler BE, Fujimoto M, Shagan DS, Seltzer JC. Symptoms versus neurocognition as predictors of change in life skills in schizophrenia after outpatient rehabilitation. Schizophr Res. 2008;102(1):303–11.PubMedPubMedCentralCrossRefGoogle Scholar
  73. Kurtz MM, Bronfeld M, Rose J. Cognitive and social cognitive predictors of change in objective versus subjective quality-of-life in rehabilitation for schizophrenia. Psychiatry Res. 2012;200(2):102–7.PubMedPubMedCentralCrossRefGoogle Scholar
  74. Kurtz MM, Olfson RH, Rose J. Self-efficacy and functional status in schizophrenia: relationship to insight, cognition and negative symptoms. Schizophr Res. 2013;145(1):69–74.PubMedCrossRefGoogle Scholar
  75. Lambert M, Schimmelmann BG, Karow A, Naber D. Subjective well-being and initial dysphoric reaction under antipsychotic drugs-concepts, measurement and clinical relevance. Pharmacopsychiatry. 2003;36:S181–90.PubMedCrossRefGoogle Scholar
  76. Langdon R, Michie PT, Ward PB, McConaghy N, Catts SV, Coltheart M. Defective self and/or other mentalising in schizophrenia: a cognitive neuropsychological approach. Cogn Neuropsychiatry. 1997;2(3):167–93.PubMedCrossRefGoogle Scholar
  77. Langdon R, Ward PB, Coltheart M. Reasoning anomalies associated with delusions in schizophrenia. Schizophr Bull. 2010;36(2):321–30.PubMedCrossRefGoogle Scholar
  78. Lehman AF. Measures of quality of life among persons with severe and persistent mental disorders. Soc Psychiatry Psychiatr Epidemiol. 1996;31(2):78–88.PubMedCrossRefGoogle Scholar
  79. Lehman AF. A quality of life interview for the chronically mentally ill. Eval Program Plann. 1988;11(1):51–62.CrossRefGoogle Scholar
  80. Lin C-H, Huang C-L, Chang Y-C, Chen P-W, Lin C-Y, Tsai GE, Lane H-Y. Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia. Schizophr Res. 2013;146(1):231–7.PubMedCrossRefGoogle Scholar
  81. Lipkovich IA, Deberdt W, Csernansky JG, Sabbe B, Keefe RS, Kollack-Walker S. Relationships among neurocognition, symptoms and functioning in patients with schizophrenia: a path-analytic approach for associations at baseline and following 24 weeks of antipsychotic drug therapy. BMC psychiatry. 2009;9(1):1.Google Scholar
  82. Lysaker PH, Carcione A, Dimaggio G, Johannesen J, Nicolò G, Procacci M, Semerari A. Metacognition amidst narratives of self and illness in schizophrenia: associations with neurocognition, symptoms, insight and quality of life. Acta Psychiatr Scand. 2005;112(1):64–71.PubMedCrossRefGoogle Scholar
  83. Lysaker PH, Davis LW. Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition. Health Qual Life Outcomes. 2004;2(1):1.Google Scholar
  84. Maat A, Fett A-K, Derks E, Investigators G. Social cognition and quality of life in schizophrenia. Schizophr Res. 2012;137(1):212–8.PubMedCrossRefGoogle Scholar
  85. Margariti M, Ploumpidis D, Economou M, Christodoulou GN, Papadimitriou GN. Quality of life in schizophrenia spectrum disorders: associations with insight and psychopathology. Psychiatry Res. 2015;225(3):695–701.PubMedCrossRefGoogle Scholar
  86. Matsui M, Sumiyoshi T, Arai H, Higuchi Y, Kurachi M. Cognitive functioning related to quality of life in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2008;32(1):280–7.CrossRefGoogle Scholar
  87. Mayer JD, Salovey P, Caruso DR, Sitarenios G. Emotional intelligence as a standard intelligence. Emotion (Washington, DC). 2001;1(3):232–42.CrossRefGoogle Scholar
  88. Mehta UM, Bhagyavathi HD, Thirthalli J, Kumar KJ, Gangadhar BN. Neurocognitive predictors of social cognition in remitted schizophrenia. Psychiatry Res. 2014;219(2):268–74. doi: 10.1016/j.psychres.2014.05.055.PubMedCrossRefGoogle Scholar
  89. Moncrieff J, Cohen D, Mason J. The subjective experience of taking antipsychotic medication: a content analysis of internet data. Acta Psychiatr Scand. 2009;120(2):102–11.PubMedCrossRefGoogle Scholar
  90. Munton AG, Silvester J, Stratton P. Attributions in action: a practical approach to coding qualitative data. John Wiley & Sons Inc.; 1999.Google Scholar
  91. Nahum M, Fisher M, Loewy R, Poelke G, Ventura J, Nuechterlein KH, Hooker CI, Green MF, Merzenich MM, Vinogradov S. A novel, online social cognitive training program for young adults with schizophrenia: a pilot study. Schizophr Res Cogn. 2014;1(1):e11–9.PubMedPubMedCentralCrossRefGoogle Scholar
  92. Narvaez JM, Twamley EW, McKibbin CL, Heaton RK, Patterson TL. Subjective and objective quality of life in schizophrenia. Schizophr Res. 2008;98(1):201–8.PubMedCrossRefGoogle Scholar
  93. Norman RM, Malla AK, McLean T, Voruganti LP, Cortese L, McIntosh E, Cheng S, Rickwood A. The relationship of symptoms and level of functioning in schizophrenia to general wellbeing and the Quality of Life Scale. Acta Psychiatr Scand. 2000;102(4):303–9.PubMedCrossRefGoogle Scholar
  94. Nuechterlein KH, Subotnik KL, Green MF, Ventura J, Asarnow RF, Gitlin MJ, Yee CM, Gretchen-Doorly D, Mintz J. Neurocognitive predictors of work outcome in recent-onset schizophrenia. Schizophr Bull. 2011;37 Suppl 2:S33–40.PubMedPubMedCentralCrossRefGoogle Scholar
  95. Papaioannou D, Brazier J, Parry G. How valid and responsive are generic health status measures, such as EQ-5D and SF-36, in schizophrenia? A systematic review. Value Health. 2011;14(6):907–20.PubMedPubMedCentralCrossRefGoogle Scholar
  96. Patterson TL, Goldman S, McKibbin CL, Hughs T, Jeste DV. UCSD Performance-Based Skills Assessment: development of a new measure of everyday functioning for severely mentally ill adults. Schizophr Bull. 2001;27(2):235–45.PubMedCrossRefGoogle Scholar
  97. Penn DL, Corrigan PW, Bentall RP, Racenstein J, Newman L. Social cognition in schizophrenia. Psychol Bull. 1997;121(1):114.PubMedCrossRefGoogle Scholar
  98. Percudani M, Barbui C, Tansella M. Effect of second-generation antipsychotics on employment and productivity in individuals with schizophrenia. Pharmacoeconomics. 2004;22(11):701–18.PubMedCrossRefGoogle Scholar
  99. Priebe S, Katsakou C, Yeeles K, Amos T, Morriss R, Wang D, Wykes T. Predictors of clinical and social outcomes following involuntary hospital admission: a prospective observational study. Eur Arch Psychiatry Clin Neurosci. 2011;261(5):377–86.PubMedCrossRefGoogle Scholar
  100. Prouteau A, Verdoux H, Briand C, Lesage A, Lalonde P, Nicole L, Reinharz D, Stip E. Cognitive predictors of psychosocial functioning outcome in schizophrenia: a follow-up study of subjects participating in a rehabilitation program. Schizophr Res. 2005;77(2):343–53.PubMedCrossRefGoogle Scholar
  101. Reine G, Lancon C, Di Tucci S, Sapin C, Auquier P. Depression and subjective quality of life in chronic phase schizophrenic patients. Acta Psychiatr Scand. 2003;108(4):297–303.PubMedCrossRefGoogle Scholar
  102. Remington G, Foussias G, Agid O. Progress in defining optimal treatment outcome in schizophrenia. CNS Drugs. 2010;24(1):9–20.PubMedCrossRefGoogle Scholar
  103. Roberts DL, Penn DL. Social cognition and interaction training (SCIT) for outpatients with schizophrenia: a preliminary study. Psychiatry Res. 2009;166(2):141–7.PubMedCrossRefGoogle Scholar
  104. Roberts DL, Penn DL, Labate D, Margolis SA, Sterne A. Transportability and feasibility of Social Cognition And Interaction Training (SCIT) in community settings. Behav Cogn Psychother. 2010;38(01):35–47.PubMedCrossRefGoogle Scholar
  105. Rosenheck R, Leslie D, Keefe R, McEvoy J, Swartz M, Perkins D, Stroup S, Hsiao JK, Lieberman J. Barriers to employment for people with schizophrenia. Am J Psychiatry. 2006;163(3):411–7.PubMedCrossRefGoogle Scholar
  106. Rosenthal R, Hall J, Archer D, DiMatteo M, Rogers P. The PONS test manual. New York: Irvington; 1979.Google Scholar
  107. Ruggeri M, Nose M, Bonetto C, Cristofalo D, Lasalvia A, Salvi G, Stefani B, Malchiodi F, Tansella M. Changes and predictors of change in objective and subjective quality of life Multiwave follow-up study in community psychiatric practice. Br J Psychiatry. 2005;187(2):121–30.PubMedCrossRefGoogle Scholar
  108. Savilla K, Kettler L, Galletly C. Relationships between cognitive deficits, symptoms and quality of life in schizophrenia. Aust N Z J Psychiatry. 2008;42(6):496–504.PubMedCrossRefGoogle Scholar
  109. Schmidt SJ, Mueller DR, Roder V. Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr Bull. 2011;37 Suppl 2:S41–54.PubMedPubMedCentralCrossRefGoogle Scholar
  110. Sergi MJ, Rassovsky Y, Widmark C, Reist C, Erhart S, Braff DL, Marder SR, Green MF. Social cognition in schizophrenia: relationships with neurocognition and negative symptoms. Schizophr Res. 2007;90(1):316–24.PubMedCrossRefGoogle Scholar
  111. Sota TL, Heinrichs RW. Demographic, clinical, and neurocognitive predictors of quality of life in schizophrenia patients receiving conventional neuroleptics. Compr Psychiatry. 2004;45(5):415–21.PubMedCrossRefGoogle Scholar
  112. Stone VE, Baron-Cohen S, Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci. 1998;10(5):640–56.PubMedCrossRefGoogle Scholar
  113. Subotnik KL, Nuechterlein KH, Green MF, Horan WP, Nienow TM, Ventura J, Nguyen AT. Neurocognitive and social cognitive correlates of formal thought disorder in schizophrenia patients. Schizophr Res. 2006;85(1):84–95.PubMedCrossRefGoogle Scholar
  114. Tas C, Danaci AE, Cubukcuoglu Z, Brüne M. Impact of family involvement on social cognition training in clinically stable outpatients with schizophrenia—a randomized pilot study. Psychiatry Res. 2012;195(1):32–8.PubMedCrossRefGoogle Scholar
  115. Tas C, Brown E, Cubukcuoglu Z, Aydemir O, Danaci AE, Brüne M. Towards an integrative approach to understanding quality of life in schizophrenia: the role of neurocognition, social cognition, and psychopathology. Compr Psychiatry. 2013;54(3):262–8.PubMedCrossRefGoogle Scholar
  116. The WHOQOL Group. The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization. Soc Sci Med. 1995;41(10):1403–9.CrossRefGoogle Scholar
  117. Tolman AW, Kurtz MM. Neurocognitive predictors of objective and subjective quality of life in individuals with schizophrenia: a meta-analytic investigation. Schizophr Bull. 2012;38(2):304–15.PubMedCrossRefGoogle Scholar
  118. Ueoka Y, Tomotake M, Tanaka T, Kaneda Y, Taniguchi K, Nakataki M, Numata S, Tayoshi S, Yamauchi K, Sumitani S. Quality of life and cognitive dysfunction in people with schizophrenia. Progr Neuro-Psychopharmacol Biol Psychiatry. 2011;35(1):53–9.CrossRefGoogle Scholar
  119. Van Hooren S, Versmissen D, Janssen I, Myin-Germeys I, à Campo J, Mengelers R, Van Os J, Krabbendam L. Social cognition and neurocognition as independent domains in psychosis. Schizophr Res. 2008;103(1):257–65.PubMedCrossRefGoogle Scholar
  120. Ventura J, Hellemann GS, Thames AD, Koellner V, Nuechterlein KH. Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophr Res. 2009;113(2):189–99.PubMedPubMedCentralCrossRefGoogle Scholar
  121. Ventura J, Wood RC, Jimenez AM, Hellemann GS. Neurocognition and symptoms identify links between facial recognition and emotion processing in schizophrenia: meta-analytic findings. Schizophr Res. 2013;151(1):78–84.PubMedPubMedCentralCrossRefGoogle Scholar
  122. Voruganti L, Heslegrave R, Awad A, Seeman M. Quality of life measurement in schizophrenia: reconciling the quest for subjectivity with the question of reliability. Psychol Med. 1998;28(01):165–72.PubMedCrossRefGoogle Scholar
  123. Voruganti L, Awad A, Parker G, Forrest C, Usmani Y, Fernando M, Senthilal S. Cognition, functioning and quality of life in schizophrenia treatment: results of a one-year randomized controlled trial of olanzapine and quetiapine. Schizophr Res. 2007;96(1):146–55.PubMedCrossRefGoogle Scholar
  124. Wegener S, Redoblado-Hodge MA, Wegener S, Redoblado-Hodge MA, Lucas S, Fitzgerald D, Harris A, Brennan J. Relative contributions of psychiatric symptoms and neuropsychological functioning to quality of life in first-episode psychosis. Aust N Z J Psychiatry. 2005;39(6):487–92.PubMedCrossRefGoogle Scholar
  125. Williams LM, Whitford TJ, Flynn G, Wong W, Liddell BJ, Silverstein S, Gordon E. General and social cognition in first episode schizophrenia: identification of separable factors and prediction of functional outcome using the IntegNeuro test battery. Schizophr Res. 2008;99(1):182–191.Google Scholar
  126. Woon P, Chia MY, Chan WY, Sim K. Neurocognitive, clinical and functional correlates of subjective quality of life in Asian outpatients with schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry. 2010;34(3):463–8.CrossRefGoogle Scholar
  127. Woonings FM, Appelo MT, Kluiter H, Slooff CJ, van den Bosch RJ. Learning (potential) and social functioning in schizophrenia. Schizophr Res. 2003;59(2):287–96.PubMedCrossRefGoogle Scholar
  128. Wykes T, Reeder C, Landau S, Everitt B, Knapp M, Patel A, Romeo R. Cognitive remediation therapy in schizophrenia. Br J Psychiatry. 2007;190(5):421–7.PubMedCrossRefGoogle Scholar
  129. Yamauchi K, Aki H, Tomotake M, Iga JI, Numata S, Motoki I, Izaki Y, Tayoshi S, Kinouchi S, Sumitani S. Predictors of subjective and objective quality of life in outpatients with schizophrenia. Psychiatry Clin Neurosci. 2008;62(4):404–11.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Sofia Brissos
    • 1
    Email author
  • Guilherme Pereira
    • 1
  • Vicent Balanzá-Martinez
    • 2
  1. 1.Department of PsychiatryCentro Hospitalar Psiquiátrico de Lisboa (Lisbon’s Psychiatric Hospitalar Centre)LisbonPortugal
  2. 2.Teaching Unit of Psychiatry, Department of Medicine, School of MedicineLa Fe University and Polytechnic Hospital, University of Valencia, CIBERSAMValenciaSpain

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