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Prostate Sarcomas and Squamous Cell Carcinomas

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Rare Genitourinary Tumors

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Abstract

Primary prostate sarcomas are rare tumors arising from nonepithelial mesenchymal components of the prostate stroma. These tumors account for less than 0.1 % of prostate malignancy in adults. Leiomyosarcomas are the most common histological subtype in adults, whereas rhabdomyosarcoma is more common in pediatric patients. Surgery remains the mainstay in treatment and the surgical approach varies depending on tumor extent. Radical prostatectomy is appropriate for those patients whose tumors are confined to the prostate. Cystoprostatectomy or total pelvic exenteration is the preferred approach for those patients with significant bladder or rectal invasion. Systemic chemotherapy and preoperative radiation therapy may be considered preoperatively in locally advanced cases or as definite treatment in those patients with metastatic disease. Although the overall prognosis for patients with prostate sarcomas remains poor, surgical resection with or without preoperative chemotherapy and radiation can cure select patients without metastatic disease.

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Authors and Affiliations

  1. Department of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, USA

    Louis L. Pisters MD

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  1. Louis L. Pisters MD
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Correspondence to Louis L. Pisters MD .

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Editors and Affiliations

  1. Department of Oncology, Mayo Clinic, Division of Medical Oncology, Rochester, Minnesota, USA

    Lance Pagliaro

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Pisters, L.L. (2016). Prostate Sarcomas and Squamous Cell Carcinomas. In: Pagliaro, L. (eds) Rare Genitourinary Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-30046-7_15

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  • DOI: https://doi.org/10.1007/978-3-319-30046-7_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-30044-3

  • Online ISBN: 978-3-319-30046-7

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