Abstract
The basics of stereoselective reactions and reaction stereochemistry—the relation of stereoselectivity to the topology of tetrahedral and planar units in organic molecules—are discussed. The kinetic control of enantioselective reactions and characteristics of enantioselective and diastereoslective reactions is presented. Asymmetric syntheses are exemplified by the hydrogenation of C=O and C=NR bonds in prochiral substrates catalyzed by organometallic complexes with chiral phosphine ligands. The mechanism of asymmetric alkylation of stabilized carbanions in specifically designed chiral substrates and the practicability of this method in the preparation of optically pure α-alkyl carboxylic acids are discussed. The synthetic approach to chiral auxiliaries and importance of recycling are presented.
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Šunjić, V., Petrović Peroković, V. (2016). Stereoisomers and Stereoselective Reactions—“Departure into Third Dimension”. In: Organic Chemistry from Retrosynthesis to Asymmetric Synthesis. Springer, Cham. https://doi.org/10.1007/978-3-319-29926-6_3
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DOI: https://doi.org/10.1007/978-3-319-29926-6_3
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