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Assessing and Treating Co-occurring Substance Abuse

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Treating Comorbid Opioid Use Disorder in Chronic Pain

Abstract

Estimates of co-occurring substance abuse in patients with chronic pain and opioid use disorder vary between 3 and 48 % based on the population studied and the definition of opioid use disorder. This chapter reviews the abuse patterns of the various substances abused by patients with chronic pain and comorbid opioid dependence and explores the interaction of specific substances with opioids. Rationale for the need to assess and treat for specific substances of abuse is discussed based on current literature and approach to assessment and treatment of these comorbid substances is also discussed.

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References

  1. Morasco BJ, Gritzner S, Lewis L, Oldham R, Turk DC, Dobscha SK. Systematic review of prevalence, correlates, and treatment outcomes for chronic non-cancer pain in patients with comorbid substance use disorder. Pain. 2011;152(3):488–97.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Chang Y-P, Compton P. Management of chronic pain with chronic opioid therapy in patients with substance use disorders. Addict Sci Clin Pract. 2013;8:21.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Edlund MJ, Steffick D, Hudson T, Harris KM, Sullivan M. Risk factors for clinically recognized opioid abuse and dependence among veterans using opioids for chronic non-cancer pain. Pain. 2007;129(3):355–62.

    Article  PubMed  Google Scholar 

  4. Huffman KL, Shella ER, Sweis G, Griffith SD, Scheman J, Covington EC. Nonopioid substance use disorders and opioid dose predict therapeutic opioid addiction. J Pain. 2015;16(2):126–34.

    Article  PubMed  Google Scholar 

  5. Larson MJ, Paasche-Orlow M, Cheng DM, Lloyd-Travaglini C, Saitz R, Samet JH. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction. 2007;102(5):752–60.

    Article  PubMed  Google Scholar 

  6. Caldeiro RM, Malte CA, Calsyn DA, Baer JS, Nichol P, Kivlahan DR, et al. The association of persistent pain with out-patient addiction treatment outcomes and service utilization. Addiction. 2008;103(12):1996–2005.

    Article  PubMed  Google Scholar 

  7. Dunn KE, Brooner RK, Clark MR. Severity and interference of chronic pain in methadone-maintained outpatients: pain in methadone-maintenance patients. Pain Med. 2014;15(9):1540–8.

    Article  PubMed  Google Scholar 

  8. Webster LR, Webster RM. Predicting aberrant behaviors in opioid-treated patients: preliminary validation of the Opioid Risk Tool. Pain Med. 2005;6(6):432–42.

    Article  PubMed  Google Scholar 

  9. Weisner CM, Campbell CI, Ray GT, Saunders K, Merrill JO, Banta-Green C, et al. Trends in prescribed opioid therapy for non-cancer pain for individuals with prior substance use disorders. Pain. 2009;145(3):287–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Campbell G, Nielsen S, Bruno R, Lintzeris N, Cohen M, Hall W, et al. The Pain and Opioids IN Treatment study: characteristics of a cohort using opioids to manage chronic non-cancer pain. Pain. 2015;156(2):231–42.

    Article  CAS  PubMed  Google Scholar 

  11. Dhingra L, Perlman DC, Masson C, Chen J, McKnight C, Jordan AE, et al. Longitudinal analysis of pain and illicit drug use behaviors in outpatients on methadone maintenance. Drug Alcohol Depend. 2015;149:285–9.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Calcaterra S, Glanz J, Binswanger IA. National trends in pharmaceutical opioid related overdose deaths compared to other substance related overdose deaths: 1999-2009. Drug Alcohol Depend. 2013;131(3):263–70.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Madadi P, Hildebrandt D, Lauwers AE, Koren G. Characteristics of opioid-users whose death was related to opioid-toxicity: a population-based study in Ontario, Canada. PLoS One. 2013;8(4), e60600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Baca CT, Yahne CE. Smoking cessation during substance abuse treatment: What you need to know. J Subst Abuse Treat. 2009;36(2):205–19.

    Article  PubMed  Google Scholar 

  15. Fishbain DA, Cole B, Lewis JE, Gao J. Is smoking associated with alcohol-drug dependence in patients with pain and chronic pain patients? An evidence-based structured review. Pain Med. 2012;13(9):1212–26.

    Article  PubMed  Google Scholar 

  16. Hooten WM, Townsend CO, Bruce BK, Warner DO. The effects of smoking status on opioid tapering among patients with chronic pain. Anesth Analg. 2009;108(1):308–15.

    Article  PubMed  Google Scholar 

  17. Wahawisan J, Kolluru S, Nguyen T, Molina C, Speake J. Methadone toxicity due to smoking cessation—a case report on the drug-drug interaction involving cytochrome P450 isoenzyme 1A2. Ann Pharmacother. 2011;45(6), e34.

    Article  PubMed  Google Scholar 

  18. Ali NA, Marshall RW, Allen EM, Graham DF, Richens A. Comparison of the effects of therapeutic doses of meptazinol and a dextropropoxyphene/paracetamol mixture alone and in combination with ethanol on ventilatory function and saccadic eye movements. Br J Clin Pharmacol. 1985;20(6):631–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Gudin JA, Mogali S, Jones JD, Comer SD. Risks, management, and monitoring of combination opioid, benzodiazepines, and/or alcohol use. Postgrad Med. 2013;125(4):115–30.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Zacny JP, Gutierrez S. Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers. Psychopharmacology (Berl). 2011;218(3):471–81.

    Article  CAS  Google Scholar 

  21. Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH. Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology. 1990;73(5):826–30.

    Article  CAS  PubMed  Google Scholar 

  22. Faroqui MH, Cole M, Curran J. Buprenorphine, benzodiazepines and respiratory depression. Anaesthesia. 1983;38(10):1002–3.

    Article  CAS  PubMed  Google Scholar 

  23. Skurtveit S, Furu K, Bramness J, Selmer R, Tverdal A. Benzodiazepines predict use of opioids—a follow-up study of 17,074 men and women. Pain Med. 2010;11(6):805–14.

    Article  PubMed  Google Scholar 

  24. Hermos JA, Young MM, Gagnon DR, Fiore LD. Characterizations of long-term oxycodone/acetaminophen prescriptions in veteran patients. Arch Intern Med. 2004;164(21):2361–6.

    Article  PubMed  Google Scholar 

  25. Bachhuber MA, Saloner B, Cunningham CO, Barry CL. Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010. JAMA Intern Med. 2014;174(10):1668–73.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Abrams DI, Couey P, Shade SB, Kelly ME, Benowitz NL. Cannabinoid-opioid interaction in chronic pain. Clin Pharmacol Ther. 2011;90(6):844–51.

    Article  CAS  PubMed  Google Scholar 

  27. Degenhardt L, Lintzeris N, Campbell G, Bruno R, Cohen M, Farrell M, et al. Experience of adjunctive cannabis use for chronic non-cancer pain: findings from the Pain and Opioids IN Treatment (POINT) study. Drug Alcohol Depend. 2015;147:144–50.

    Article  PubMed  Google Scholar 

  28. Reisfield GM, Wasan AD, Jamison RN. The prevalence and significance of cannabis use in patients prescribed chronic opioid therapy: a review of the extant literature. Pain Med. 2009;10(8):1434–41.

    Article  PubMed  Google Scholar 

  29. Reisfield GM. Medical cannabis and chronic opioid therapy. J Pain Palliat Care Pharmacother. 2010;24(4):356–61.

    Article  PubMed  Google Scholar 

  30. Magnano AR, Talathoti NB, Hallur R, Jurus DT, Dizon J, Holleran S, et al. Effect of Acute Cocaine Administration on the QTc Interval of Habitual Users. Am J Cardiol. 2006;97(8):1244–6.

    Article  CAS  PubMed  Google Scholar 

  31. Meghani SH, Wiedemer NL, Becker WC, Gracely EJ, Gallagher RM. Predictors of resolution of aberrant drug behavior in chronic pain patients treated in a structured opioid risk management program. Pain Med. 2009;10(5):858–65.

    Article  PubMed  Google Scholar 

  32. Ives TJ, Chelminski PR, Hammett-Stabler CA, Malone RM, Perhac JS, Potisek NM, et al. Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res. 2006;6:46.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Akbik H, Butler SF, Budman SH, Fernandez K, Katz NP, Jamison RN. Validation and clinical application of the Screener and Opioid Assessment for Patients with Pain (SOAPP). J Pain Symptom Manage. 2006;32(3):287–93.

    Article  PubMed  Google Scholar 

  34. Tsuang MT, Lyons MJ, Meyer JM, Doyle T, Eisen SA, Goldberg J, et al. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch Gen Psychiatry. 1998;55(11):967–72.

    Article  CAS  PubMed  Google Scholar 

  35. Kahan M, Wilson L, Mailis-Gagnon A, Srivastava A. National Opioid Use Guideline Group. Canadian guideline for safe and effective use of opioids for chronic noncancer pain: clinical summary for family physicians. Part 2: special populations. Can Fam Physician. 2011;57(11):1269–76. e419–28.

    PubMed  PubMed Central  Google Scholar 

  36. Fiore MC, Bailey WC, Cohen SJ, Dorfman SF, Goldstein MG, Gritz ER, et al. Smoking cessation. Clinical practice guideline no. 18 (AHCPR Publication No. 96-0692). Rockville, MD: US Department of Health and Human Services. Public Health Serv Agency Health Care Policy Res; 1996.

    Google Scholar 

  37. Kahan M, Mailis-Gagnon A, Wilson L, Srivastava A. National Opioid Use Guideline Group. Canadian guideline for safe and effective use of opioids for chronic noncancer pain: clinical summary for family physicians. Part 1: general population. Can Fam Physician. 2011;57(11):1257–66. e407–18.

    PubMed  PubMed Central  Google Scholar 

  38. Manchikanti L, Abdi S, Atluri S, Balog CC, Benyamin RM, Boswell MV, et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part 2—guidance. Pain Physician. 2012;15(3 Suppl):S67–116.

    PubMed  Google Scholar 

  39. Christo PJ, Manchikanti L, Ruan X, Bottros M, Hansen H, Solanki DR, et al. Urine drug testing in chronic pain. Pain Physician. 2011;14(2):123–43.

    PubMed  Google Scholar 

  40. Helander A, Böttcher M, Fehr C, Dahmen N, Beck O. Detection times for urinary ethyl glucuronide and ethyl sulfate in heavy drinkers during alcohol detoxification. Alcohol Alcohol. 2009;44(1):55–61.

    Article  CAS  PubMed  Google Scholar 

  41. Manchikanti L, Abdi S, Atluri S, Balog CC, Benyamin RM, Boswell MV, et al. American Society of Interventional Pain Physicians (ASIPP) guidelines for responsible opioid prescribing in chronic non-cancer pain: Part I—evidence assessment. Pain Physician. 2012;15(3 Suppl):S1–65.

    PubMed  Google Scholar 

  42. Sullivan MD, Edlund MJ, Steffick D, Unützer J. Regular use of prescribed opioids: association with common psychiatric disorders. Pain. 2005;119(1-3):95–103.

    Article  PubMed  Google Scholar 

  43. Cheatle MD, Gallagher RM. Chronic pain and comorbid mood and substance use disorders: a biopsychosocial treatment approach. Curr Psychiatry Rep. 2006;8(5):371–6.

    Article  PubMed  Google Scholar 

  44. Haibach JP, Beehler GP, Dollar KM, Finnell DS. Moving toward integrated behavioral intervention for treating multimorbidity among chronic pain, depression, and substance-use disorders in primary care. Med Care. 2014;52(4):322–7.

    Article  PubMed  Google Scholar 

  45. Petrakis IL, Carroll KM, Nich C, Gordon LT, McCance-Katz EF, Frankforter T, et al. Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction. 2000;95(2):219–28.

    Article  CAS  PubMed  Google Scholar 

  46. Campbell BK, Wander N, Stark MJ, Holbert T. Treating cigarette smoking in drug-abusing clients. J Subst Abuse Treat. 1995;12(2):89–94.

    Article  CAS  PubMed  Google Scholar 

  47. Lingford-Hughes AR, Welch S, Peters L, Nutt DJ, British Association for Psychopharmacology, Expert Reviewers Group. BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP. J Psychopharmacol. 2012;26(7):899–952.

    Article  CAS  PubMed  Google Scholar 

  48. Agerwala SM, McCance-Katz EF. Integrating screening, brief intervention, and referral to treatment (SBIRT) into clinical practice settings: a brief review. J Psychoactive Drugs. 2012;44(4):307–17.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Jyothsna Karlapalem M.B.B.S. .

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Karlapalem, J., Broderick, M.L. (2016). Assessing and Treating Co-occurring Substance Abuse. In: Matthews, A., Fellers, J. (eds) Treating Comorbid Opioid Use Disorder in Chronic Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-29863-4_17

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  • DOI: https://doi.org/10.1007/978-3-319-29863-4_17

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