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Lymphomas of the Large Airways

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Book cover Diseases of the Central Airways

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Lymphoproliferative disorders can involve the lungs in 3 ways: (1) by hematogenous spread of non-Hodgkin’s lymphoma (NHL) or Hodgkin’s disease (HD), (2) by contiguous invasion from a hilar or mediastinal site of nodal lymphoma, or (3) by primary pulmonary/airway involvement. Lymphomas occurring primary to the lung are rare and account for <1 % of all primary pulmonary neoplasms and all extranodal non-Hodgkin’s lymphomas (NHLs). The clinical presentation and radiologic findings vary according to the location of the main lesion, which can occur mostly in the lung parenchyma or, as reported in rare cases, in the large airways. The diagnosis relies on the histologic evaluation of tissue samples and the confirmation of the presence of a lymphoid clonal proliferation by ancillary studies. The vast majority of primary pulmonary lymphomas are marginal zone B cell lymphomas of mucosa-associated lymphoid tissue (MALT). Other less common types of lymphoma occurring primary to the lung include diffuse large B cell lymphoma, lymphomatoid granulomatosis, anaplastic large cell lymphoma, and lymphoproliferative disorders associated with immunosuppressed states.

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Authors and Affiliations

  1. Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, A-90, Cleveland, OH, 44195, USA

    Hardeep S. Rai

  2. Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, A-90, Cleveland, OH, 44195, USA

    Andrea Valeria Arrossi

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  1. Hardeep S. Rai
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  2. Andrea Valeria Arrossi
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Correspondence to Hardeep S. Rai .

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Editors and Affiliations

  1. Family Endowed Chair in Lung Transplanta, Lerner College of Medicine Buoncore, Clevland, Ohio, USA

    Atul C. Mehta

  2. Louis A Johnson VA Medical Center, Fairmont, West Virginia, USA

    Prasoon Jain

  3. Cleveland Clinic, Cleveland, Ohio, USA

    Thomas R. Gildea

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Rai, H.S., Arrossi, A.V. (2016). Lymphomas of the Large Airways. In: Mehta, A., Jain, P., Gildea, T. (eds) Diseases of the Central Airways. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29830-6_13

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  • DOI: https://doi.org/10.1007/978-3-319-29830-6_13

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