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Connectomics in Patients with Temporal Lobe Epilepsy

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The Physics of the Mind and Brain Disorders

Part of the book series: Springer Series in Cognitive and Neural Systems ((SSCNS,volume 11))

Abstract

The human brain is an amazingly complex structure whose functionality, including high-order cognitive functions, is determined by intricate connectivity patterns between tens of billions of neurons (Azevedo et al. 2009). The signaling between neurons is deceivingly simple, using binary-like electrical impulses, such that the multitude of brain functions, that are often performed concurrently, are the result of connectivity patterns across various spatial scales (Bullock et al. 1977; Budd and Kisvarday 2012), that implement a mixed sequential, parallel or hierarchical architecture. The brain regulates breathing and heart rate, collects and processes sensory information, and controls all the voluntary and involuntary movements and actions. While some of these functions are performed by well-defined areas of the brain (i.e. visual stimuli are processed solely by the primary visual cortex), some higher level functions (i.e. speech production, problem solving, music performance) can only be accomplished by various brain areas working together in a serial or, more likely, in a parallel or distributed design (Sigman and Dehaene 2008).

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References

  • Aertsen A, Preissl H (1991). Dynamics of activity and connectivity in physiological neuronal networks. In: Schuster HG (ed), Non linear dynamics and neuronal networks, p. 281–302

    Google Scholar 

  • Ahmadi ME, Hagler DJJ, McDonald CR, Tecoma ES, Iragui VJ, Dale AM, Halgren E (2009) Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy. AJNR Am J Neuroradiol 30:1740–1747

    CAS  Google Scholar 

  • Arena JE, Cerquetti D, Rossi M, Chaves H, Rollan C, Dossi DE, Merello M (2016) Influence of white matter MRI hyper-intensities on acute l-dopa response in patients with Parkinson’s disease. Parkinsonism Relat Disord 24:126–128

    CAS  Google Scholar 

  • Arya R, Leach JL, Horn PS, Greiner HM, Gelfand M, Byars AW, Arthur TM, Tenney JR, Jain SV, Rozhkov L, Fujiwara H, Rose DF, Mangano FT, Holland KD (2016) Clinical factors predict surgical outcomes in pediatric MRI-negative drug-resistant epilepsy. Seizure 41:56–61

    Google Scholar 

  • Azevedo FAC, Carvalho LRB, Grinberg LT, Farfel JM, Ferretti REL, Leite REP, Jacob Filho W, Lent R, Herculano-Houzel S (2009) Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol 513:532–541

    Google Scholar 

  • Baccalá LA, Alvarenga MY, Sameshima K, Jorge CL, Castro LH (2004) Graph theoretical characterization and tracking of the effective neural connectivity during episodes of mesial temporal epileptic seizure. [Online]. J Integr Neurosci 3:379–395. http://www.ncbi.nlm.nih.gov/pubmed/15657975 [12 Oct. 2016]

    Google Scholar 

  • Bartolomei F, Bettus G, Stam CJ, Guye M (2013) Interictal network properties in mesial temporal lobe epilepsy: a graph theoretical study from intracerebral recordings. Clin Neurophysiol 124:2345–2353

    CAS  Google Scholar 

  • Bernhardt B, Hong S-J, Bernasconi A, Bernasconi N (2013) Imaging structural and functional brain networks in temporal lobe epilepsy [Online]. Front Hum Neurosci 7:624. http://journal.frontiersin.org/article/10.3389/fnhum.2013.00624

    Google Scholar 

  • Besson P, Dinkelacker V, Valabregue R, Thivard L, Leclerc X, Baulac M, Sammler D, Colliot O, Lehericy S, Samson S, Dupont S (2014) Structural connectivity differences in left and right temporal lobe epilepsy. NeuroImage 100:135–144

    Google Scholar 

  • Bettus G, Guedj E, Joyeux F, Confort-Gouny S, Soulier E, Laguitton V, Cozzone PJ, Chauvel P, Ranjeva J-P, Bartolomei F, Guye M (2009) Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms. Hum Brain Mapp 30:1580–1591

    Google Scholar 

  • Bettus G, Bartolomei F, Confort-Gouny S, Guedj E, Chauvel P, Cozzone PJ, Ranjeva J-P, Guye M (2010) Role of resting state functional connectivity MRI in presurgical investigation of mesial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 81:1147–1154

    Google Scholar 

  • Bettus G, Ranjeva J-P, Wendling F, Benar CG, Confort-Gouny S, Regis J, Chauvel P, Cozzone PJ, Lemieux L, Bartolomei F, Guye M, Bénar CG, Confort-Gouny S, Régis J, Chauvel P, Cozzone PJ, Lemieux L, Bartolomei F, Guye M (2011) Interictal functional connectivity of human epileptic networks assessed by intracerebral EEG and BOLD signal fluctuations. PLoS One 6:e20071

    CAS  Google Scholar 

  • Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Björk-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisén J (2006) Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A 103:12564–12568

    CAS  Google Scholar 

  • Bihan DL, Breton E (1985) Imagerie de diffusion in-vivo par résonance magnétique nucléaire. C R Acad Sci 93:27–34

    Google Scholar 

  • Blinowska KJ (2011) Review of the methods of determination of directed connectivity from multichannel data. Med Biol Eng Comput 49:521–529

    Google Scholar 

  • Bressler SL, Seth AK (2011) Wiener-Granger causality: a well established methodology. NeuroImage 58:323–329

    Google Scholar 

  • Budd J, Kisvarday Z (2012) Communication and wiring in the cortical connectome. Front Neuroanat 6:42

    Google Scholar 

  • Bullock TH, Orkand R, Grinnell A (1977). Introduction to nervous systems. W.H. Freeman

    Google Scholar 

  • Centeno M, Carmichael DW (2014) Network connectivity in epilepsy: resting state fMRI and EEG-fMRI contributions. Front Neurol 5:93

    Google Scholar 

  • Conner CR, Ellmore TM, MA DS, Pieters TA, Potter AW, Tandon N (2011) Anatomic and electro-physiologic connectivity of the language system: A combined DTI-CCEP study. Comput Biol Med 41:1100–1109

    Google Scholar 

  • David O, Job AS, De Palma L, Hoffmann D, Minotti L, Kahane P (2013) Probabilistic functional tractography of the human cortex. NeuroImage 80:307–317

    Google Scholar 

  • Doležalová I, Brázdil M, Chrastina J, Hemza J, Hermanová M, JanouÅ¡ová E, Pažourková M, Kuba R (2016) Differences between mesial and neocortical magnetic-resonance-imaging-negative temporal lobe epilepsy. Epilepsy Behav 61:21–26

    Google Scholar 

  • Donos C, Mălîia MD, Mîndruţă I, Popa I, Ene M, Bălănescu B, Ciurea A, Barborica A (2016a) A connectomics approach combining structural and effective connectivity assessed by intracranial electrical stimulation. NeuroImage 132:344–358

    Google Scholar 

  • Donos C, Mîndruţă I, Ciurea J, Mălîia MD, Barborica A (2016b) A comparative study of the effects of pulse parameters for intracranial direct electrical stimulation in epilepsy. Clin Neurophysiol 127:91–101

    Google Scholar 

  • Duffau H, Denvil D, Capelle L (2002) Long term reshaping of language, sensory, and motor maps after glioma resection: a new parameter to integrate in the surgical strategy. [Online]. J Neurol Neurosurg Psychiatry 72:511–516. http://www.ncbi.nlm.nih.gov/pubmed/11909913 [12 Oct. 2016]

    CAS  Google Scholar 

  • Duffau H, Capelle L, Denvil D, Sichez N, Gatignol P, Lopes M, Mitchell M-C, Sichez J-P, Van Effenterre R (2003) Functional recovery after surgical resection of low grade gliomas in eloquent brain: hypothesis of brain compensation. [Online]. J Neurol Neurosurg Psychiatry 74:901–907. http://www.ncbi.nlm.nih.gov/pubmed/12810776 [12 Oct. 2016]

    CAS  Google Scholar 

  • Enatsu R, Jin K, Elwan S, Kubota Y, Piao Z, O’Connor T, Horning K, Burgess RC, Bingaman W, Nair DR (2012a) Correlations between ictal propagation and response to electrical cortical stimulation: a cortico-cortical evoked potential study. Epilepsy Res 101:76–87

    Google Scholar 

  • Enatsu R, Piao Z, O’Connor T, Horning K, Mosher J, Burgess R, Bingaman W, Nair D (2012b) Cortical excitability varies upon ictal onset patterns in neocortical epilepsy: a cortico-cortical evoked potential study. Clin Neurophysiol 123:252–260

    Google Scholar 

  • Enatsu R, Matsumoto R, Piao Z, O’Connor T, Horning K, Burgess RC, Bulacio J, Bingaman W, Nair DR (2013) Cortical negative motor network in comparison with sensorimotor network: a cortico-cortical evoked potential study. Cortex 49:2080–2096

    Google Scholar 

  • Enatsu R, Bulacio J, Nair DR, Bingaman W, Najm I, Gonzalez-Martinez J (2014) Posterior cingulate epilepsy: clinical and neurophysiological analysis. J Neurol Neurosurg Psychiatry 85:44–50

    Google Scholar 

  • Enatsu R, Gonzalez-Martinez J, Bulacio J, Kubota Y, Mosher J, Burgess RC, Najm I, Nair DR (2015) Connections of the limbic network: a corticocortical evoked potentials study. Cortex 62:20–33

    Google Scholar 

  • Englot DJ, Hinkley LB, Kort NS, Imber BS, Mizuiri D, Honma SM, Findlay AM, Garrett C, Cheung PL, Mantle M, Tarapore PE, Knowlton RC, Chang EF, Kirsch HE, Nagarajan SS (2015) Global and regional functional connectivity maps of neural oscillations in focal epilepsy. Brain 138:2249–2262

    Google Scholar 

  • Entz L, Tóth E, Keller CJ, Bickel S, Groppe DM, Fabó D, Kozák LR, ErÅ‘ss L, Ulbert I, Mehta AD (2014) Evoked effective connectivity of the human neocortex. Hum Brain Mapp 35:5736–5753

    Google Scholar 

  • Ernst A, Alkass K, Bernard S, Salehpour M, Perl S, Tisdale J, Possnert G, Druid H, Frisen J (2014) Neurogenesis in the striatum of the adult human brain. Cell 156:1072–1083

    CAS  Google Scholar 

  • Ettinger AB (1994) Structural causes of epilepsy. Tumors, cysts, stroke, and vascular malformations. [Online]. Neurol Clin 12:41–56. http://www.ncbi.nlm.nih.gov/pubmed/8183212 [12 Oct. 2016]

    CAS  Google Scholar 

  • Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, De Salles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N (2010) Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia 51:899–908

    Google Scholar 

  • Franaszczuk PJ, Bergey GK, KamiÅ„ski MJ (1994) Analysis of mesial temporal seizure onset and propagation using the directed transfer function method. [Online]. Electroencephalogr Clin Neurophysiol 91:413–427. http://www.ncbi.nlm.nih.gov/pubmed/7529681 [12 Oct. 2016]

    CAS  Google Scholar 

  • Freund P, Curt A, Friston K, Thompson A (2013) Tracking changes following spinal cord injury: insights from neuroimaging. Neuroscientist 19:116–128

    Google Scholar 

  • Friston KJ, Frith CD, Frackowiak RSJ (1993) Time-dependent changes in effective connectivity measured with PET. Hum Brain Mapp 1:69–79

    Google Scholar 

  • Friston KJ, Harrison L, Penny W (2003) Dynamic causal modelling. [Online]. NeuroImage 19:1273–1302. http://www.ncbi.nlm.nih.gov/pubmed/12948688 [12 Oct. 2016]

    CAS  Google Scholar 

  • Galarza M, Isaac C, Pellicer O, Mayes A, Broks P, Montaldi D, Denby C, Simeone F (2014) Jazz, guitar, and neurosurgery: the Pat Martino case report. World Neurosurg 81:651.e1–651.e7

    Google Scholar 

  • Gleissner U, Sassen R, Lendt M, Clusmann H, Elger CE, Helmstaedter C (2016) Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy. Epilepsy Res 51:287–296

    Google Scholar 

  • Gleissner U, Sassen R, Schramm J, Elger CE, Helmstaedter C (2005) Greater functional recovery after temporal lobe epilepsy surgery in children. Brain 128:2822–2829

    Google Scholar 

  • Gould E (2007) How widespread is adult neurogenesis in mammals? Nat Rev Neurosci 8:481–488

    CAS  Google Scholar 

  • Granger CWJ (1969) Investigating causal relations by econometric models and cross-spectral methods. Econometrica 37:424–438

    Google Scholar 

  • Haneef Z, Lenartowicz A, Yeh HJ, Levin HS, Engel J, Stern JM (2014) Functional connectivity of hippocampal networks in temporal lobe epilepsy. Epilepsia 55:137–145

    Google Scholar 

  • Harris NG, Verley DR, Gutman BA, Sutton RL (2016) Bi-directional changes in fractional anisotropy after experiment TBI: disorganization and reorganization? NeuroImage 133: 129–143

    CAS  Google Scholar 

  • Hart T, Kozlowski AJ, Whyte J, Poulsen I, Kristensen K, Nordenbo A, Heinemann AW (2014) Functional recovery after severe traumatic brain injury: an individual growth curve approach. Arch Phys Med Rehabil 95:2103–2110

    Google Scholar 

  • Hermann B, Seidenberg M, Lee E-J, Chan F, Rutecki P (2007) Cognitive phenotypes in temporal lobe epilepsy. J Int Neuropsychol Soc 13:12–20

    Google Scholar 

  • Holmes M, Tucker D (2013) Identifying the epileptic network [Online]. Front Neurol 4:84. http://journal.frontiersin.org/article/10.3389/fneur.2013.00084

    Google Scholar 

  • Honey CJ, Kötter R, Breakspear M, Sporns O (2007) Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci U S A 104:10240–10245

    CAS  Google Scholar 

  • Hua K, Zhang J, Wakana S, Jiang H, Li X, Reich DS, Calabresi PA, Pekar JJ, van Zijl PCM, Mori S (2008) Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. NeuroImage 39:336–347

    Google Scholar 

  • Hutchinson E (2011) Neuroplasticity: functional recovery after stroke. Nat Rev Neurosci 12:4–4

    CAS  Google Scholar 

  • Iwasaki M, Enatsu R, Matsumoto R, Novak E, Thankappen B, Piao Z, O’Connor RT, Horning K, Bingaman W, Nair D (2010) Accentuated cortico-cortical evoked potentials in neocortical epilepsy in areas of ictal onset. Epileptic Disord 12:292–302

    Google Scholar 

  • Jaimes-Bautista AG, Rodríguez-Camacho M, Martínez-Juárez IE, Rodríguez-Agudelo Y, Jaimes-Bautista AG (2015) Semantic processing impairment in patients with temporal lobe epilepsy. Epilepsy Res Treat 2015:746745

    Google Scholar 

  • Jones SE, Beall EB, Najm I, Sakaie KE, Phillips MD, Zhang M, Gonzalez-Martinez JA (2014) Low consistency of four brain connectivity measures derived from intracranial electrode measurements. Front Neurol 5:1–11

    CAS  Google Scholar 

  • Kabat J, Król P (2012) Focal cortical dysplasia – review. [Online]. Pol J Radiol 77:35–43. http://www.ncbi.nlm.nih.gov/pubmed/22844307 [12 Oct. 2016]

    Google Scholar 

  • Kahane P, Minotti L, Hoffmann D, Lachaux J-P, Ryvlin P (2003) Invasive EEG in the definition of the seizure onset zone: depth electrodes. Handb Clin Neurophysiol 3:109–133

    Google Scholar 

  • Kahane P, Landré E, Minotti L, Francione S, Ryvlin P (2006) The Bancaud and Talairach view on the epileptogenic zone: a working hypothesis. [Online]. Epileptic Disord 8(Suppl 2):S16–S26. http://www.ncbi.nlm.nih.gov/pubmed/17012069 [12 Oct. 2016]

    Google Scholar 

  • Keller CJ, Honey CJ, Entz L, Bickel S, Groppe DM, Toth E, Ulbert I, Lado FA, Mehta AD (2014a) Corticocortical evoked potentials reveal projectors and integrators in human brain networks. J Neurosci 34:9152–9163

    CAS  Google Scholar 

  • Keller CJ, Honey CJ, Me P, Entz L, Ulbert I, Mehta AD (2014b) Mapping human brain networks with cortico-cortical evoked potentials. Philos Trans R Soc 369

    Google Scholar 

  • King MD, Houseman J, Roussel SA, Van Bruggen N, Williams SR, Gadian DG (1994) q-Space imaging of the brain. Magn Reson Med 32:707–713

    CAS  Google Scholar 

  • Klimes P, Duque JJ, Brinkmann B, Van Gompel J, Stead SM, St. Louis EK, Halamek J, Jurak P, Worrell G (2016). The functional organization of human epileptic hippocampus. J Neurophysiol 115: jn.00089.2016

    Google Scholar 

  • Ko AL, Weaver KE, Hakimian S, Ojemann JG (2013) Identifying functional networks using endogenous connectivity in gamma band electrocorticography. Brain Connect 3:491–502

    Google Scholar 

  • Kopell NJ, Gritton HJ, Whittington MA, Kramer MA (2014) Beyond the connectome: the dynome. Neuron 83:1319–1328

    CAS  Google Scholar 

  • Kramer MA, Cash SS (2012) Epilepsy as a disorder of cortical network organization. Neuroscience 18:360–372

    Google Scholar 

  • Kwan P, Brodie MJ (2000) Early identification of refractory epilepsy. N Engl J Med 342:314–319

    CAS  Google Scholar 

  • Li K, Guo L, Nie J, Li G, Liu T (2009) Review of methods for functional brain connectivity detection using fMRI. Comput Med Imaging Graph 33:131–139

    Google Scholar 

  • Libero LE, Burge WK, Deshpande HD, Pestilli F, Kana RK (2016) White matter diffusion of major fiber tracts implicated in autism spectrum disorder. Brain Connect. doi:10.1089/brain.2016.0442

  • Liu H-H, Wang J, Chen X-M, Li J-P, Ye W, Zheng J (2016) Reduced local diffusion homogeneity as a biomarker for temporal lobe epilepsy. Medicine (Baltimore) 95:e4032

    CAS  Google Scholar 

  • Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412:150–157

    CAS  Google Scholar 

  • Lu Y, Yang L, Worrell GA, He B (2012) Seizure source imaging by means of FINE spatio-temporal dipole localization and directed transfer function in partial epilepsy patients. Clin Neurophysiol 123:1275–1283

    Google Scholar 

  • Lüders HO, Najm I, Nair D, Widdess-Walsh P, Bingman W (2006) The epileptogenic zone: general principles. [Online]. Epileptic Disord 8(Suppl 2):S1-9. http://www.ncbi.nlm.nih.gov/pubmed/17012067 [3 May 2016]

    Google Scholar 

  • Matsumoto R, Nair DR, LaPresto E, Najm I, Bingaman W, Shibasaki H, Lüders HO (2004) Functional connectivity in the human language system: a cortico-cortical evoked potential study. Brain 127:2316–2330

    Google Scholar 

  • Matsumoto R, Nair DR, LaPresto E, Bingaman W, Shibasaki H, Lüders HO (2007) Functional connectivity in human cortical motor system: a cortico-cortical evoked potential study. Brain 130:181–197

    Google Scholar 

  • Matsuzaki N, Juhasz C, Asano E (2013) Cortico-cortical evoked potentials and stimulation-elicited gamma activity preferentially propagate from lower- to higher-order visual areas. Clin Neurophysiol 124:1290–1296

    Google Scholar 

  • Morgan VL, Sonmezturk HH, Gore JC, Abou-Khalil B (2012) Lateralization of temporal lobe epilepsy using resting functional magnetic resonance imaging connectivity of hippocampal networks. Epilepsia 53:1628–1635

    Google Scholar 

  • Mori S (Susumu), Crain BJ (2005). MRI atlas of human white matter. Elsevier

    Google Scholar 

  • Mottonen T, Katisko J, Haapasalo J, Tahtinen T, Kiekara T, Kahara V, Peltola J, Ohman J, Lehtimaki K (2015) Defining the anterior nucleus of the thalamus (ANT) as a deep brain stimulation target in refractory epilepsy: delineation using 3 T MRI and intraoperative microelectrode recording. NeuroImage Clin 7:823–829

    CAS  Google Scholar 

  • Mullen T, Acar ZA, Worrell G, Makeig S (2011) Modeling cortical source dynamics and interactions during seizure. Conf Proc Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Conf 2011:1411–1414

    Google Scholar 

  • Penny WD (2012) Comparing dynamic causal models using AIC, BIC and free energy. NeuroImage 59:319–330

    CAS  Google Scholar 

  • Pittau F, Grova C, Moeller F, Dubeau F, Gotman J (2012) Patterns of altered functional connectivity in mesial temporal lobe epilepsy. Epilepsia 53:1013–1023

    Google Scholar 

  • Pittau F, Grouiller F, Spinelli L, Seeck M, Michel C, Vulliemoz S (2014) The role of functional neuroimaging in pre-surgical epilepsy evaluation [Online]. Front Neurol 5:31. http://journal.frontiersin.org/article/10.3389/fneur.2014.00031

    Google Scholar 

  • Rosa MJ, Daunizeau J, Friston KJ (2010) EEG-fMRI integration: a critical review of biophysical modeling and data analysis approaches. [Online]. J Integr Neurosci 9:453–476. http://www.ncbi.nlm.nih.gov/pubmed/21213414 [12 Oct. 2016]

    CAS  Google Scholar 

  • Salek-Haddadi A, Friston KJ, Lemieux L, Fish DR (2003) Studying spontaneous EEG activity with fMRI. [Online]. Brain Res Brain Res Rev 43:110–133. http://www.ncbi.nlm.nih.gov/pubmed/14499465 [12 Oct. 2016]

    CAS  Google Scholar 

  • Scharfman HE (2007) The neurobiology of epilepsy. [Online]. Curr Neurol Neurosci Rep 7: 348–354. http://www.ncbi.nlm.nih.gov/pubmed/17618543 [12 Oct. 2016]

    CAS  Google Scholar 

  • Scharfman HE (2010) Seizing an opportunity: broader definitions of epilepsy may lead to better treatments. [Online]. Cerebrum 2010. http://www.ncbi.nlm.nih.gov/pubmed/21152380 [12 Oct. 2016]

  • Schevon CA, Goodman RR, McKhann GJ, Emerson RG (2010) Propagation of epileptiform activity on a submillimeter scale. J Clin Neurophysiol 27:406–411

    CAS  Google Scholar 

  • Seth AK, Barrett AB, Barnett L (2015) Granger causality analysis in neuroscience and neuroimaging. J Neurosci 35:3293–3297

    CAS  Google Scholar 

  • Sigman M, Dehaene S (2008) Brain mechanisms of serial and parallel processing during dual-task performance. J Neurosci 28:7585–7598

    CAS  Google Scholar 

  • Song S-K, Sun S-W, Ramsbottom MJ, Chang C, Russell J, Cross AH (2002) Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. [Online]. NeuroImage 17:1429–1436. http://www.ncbi.nlm.nih.gov/pubmed/12414282 [12 Oct. 2016]

    Google Scholar 

  • Sporns O, Tononi G, Kötter R (2005) The human connectome: a structural description of the human brain [Online]. PLoS Comput Biol 1:e42. http://dx.plos.org/10.1371%2Fjournal.pcbi.0010042

    Google Scholar 

  • Stam CJ, van Dijk BW (2002) Synchronization likelihood: an unbiased measure of generalized synchronization in multivariate data sets. Phys D Nonlinear Phenom 163:236–251

    Google Scholar 

  • Stephan KE, Weiskopf N, Drysdale PM, Robinson PA, Friston KJ (2007) Comparing hemodynamic models with DCM. NeuroImage 38:387–401

    Google Scholar 

  • Stoop R, Pralong E (2000) Functional connections and epileptic spread between hippocampus, entorhinal cortex and amygdala in a modified horizontal slice preparation of the rat brain. [Online]. Eur J Neurosci 12:3651–3663. http://www.ncbi.nlm.nih.gov/pubmed/11029635 [12 Oct. 2016]

    CAS  Google Scholar 

  • Tousseyn S, Dupont P, Goffin K, Sunaert S, Van Paesschen W (2014) Sensitivity and specificity of interictal EEG-fMRI for detecting the ictal onset zone at different statistical thresholds [Online]. Front Neurol 5:131. http://journal.frontiersin.org/article/10.3389/fneur.2014.00131

    Google Scholar 

  • Ugurbil K. (2016) What is feasible with imaging human brain function and connectivity using functional magnetic resonance imaging [Online]. Philos Trans R Soc B Biol Sci 371. http://rstb.royalsocietypublishing.org/content/371/1705/20150361.abstract

  • Valentín A, Anderson M, Alarcón G, Seoane JJG, Selway R, Binnie CD, Polkey CE (2002) Responses to single pulse electrical stimulation identify epileptogenesis in the human brain in vivo. Brain 125:1709–1718

    Google Scholar 

  • van Graan LA, Lemieux L, Chaudhary UJ (2015) Methods and utility of EEG-fMRI in epilepsy. Quant Imaging Med Surg 5:300–312

    Google Scholar 

  • van Mierlo P, Carrette E, Hallez H, Vonck K, Van Roost D, Boon P, Staelens S (2011) Accurate epileptogenic focus localization through time-variant functional connectivity analysis of intracranial electroencephalographic signals. NeuroImage 56:1122–1133

    Google Scholar 

  • van Mierlo P, Carrette E, Hallez H, Raedt R, Meurs A, Vandenberghe S, Van Roost D, Boon P, Staelens S, Vonck K (2013) Ictal-onset localization through connectivity analysis of intracranial EEG signals in patients with refractory epilepsy. Epilepsia 54:1409–1418

    Google Scholar 

  • Wang X, Zhang C, Wang Y, Hu W, Shao X, Zhang J-G, Zhang K (2016) Prognostic factors for seizure outcome in patients with MRI-negative temporal lobe epilepsy: a meta-analysis and systematic review. Seizure 38:54–62

    CAS  Google Scholar 

  • Warren CP, Hu S, Stead M, Brinkmann BH, Bower MR, Worrell GA (2010) Synchrony in normal and focal epileptic brain: the seizure onset zone is functionally disconnected. J Neurophysiol 104:3530–3539

    Google Scholar 

  • Watrous AJ, Tandon N, Conner CR, Pieters T, Ekstrom AD (2013) Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval. Nat Neurosci 16:349–356

    CAS  Google Scholar 

  • Wedeen VJ, Hagmann P, Tseng W-YI, Reese TG, Weisskoff RM (2005) Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med 54:1377–1386

    Google Scholar 

  • Wilke C, van Drongelen W, Kohrman M, He B (2009) Identification of epileptogenic foci from causal analysis of ECoG interictal spike activity. Clin Neurophysiol 120:1449–1456

    CAS  Google Scholar 

  • Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S (2014) Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. Hum Brain Mapp 35:4345–4361

    Google Scholar 

  • Yasuda CL, Chen Z, Beltramini GC, Coan AC, Morita ME, Kubota B, Bergo F, Beaulieu C, Cendes F, Gross DW (2015) Aberrant topological patterns of brain structural network in temporal lobe epilepsy. Epilepsia 56:1992–2002

    Google Scholar 

  • Yeh F-C, Tseng W-YI (2011) NTU-90: a high angular resolution brain atlas constructed by q-space diffeomorphic reconstruction. NeuroImage 58:91–99

    Google Scholar 

  • Zaehle T, Geiser E, Alter K, Jancke L, Meyer M (2008) Segmental processing in the human auditory dorsal stream. Brain Res 1220:179–190

    CAS  Google Scholar 

  • Zhuo C, Liu M, Wang L, Tian H, Tang J (2016) Diffusion tensor MR imaging evaluation of callosal abnormalities in schizophrenia: a meta-analysis. PLoS One 11:e0161406

    Google Scholar 

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Authors and Affiliations

  1. Physics Department, University of Bucharest, Bucharest, Romania

    Cristian Donos & Andrei Barborica

  2. Neurology Department, University Emergency Hospital, Bucharest, Romania

    Ioana Mindruta, Mihai Maliia & Irina Popa

  3. Neurology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

    Ioana Mindruta

  4. Department of Neurosurgery, Bagdasar-Arseni Emergency Hospital, Bucharest, Romania

    Jean Ciurea

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  1. Cristian Donos
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  2. Andrei Barborica
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  3. Ioana Mindruta
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  4. Mihai Maliia
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  5. Irina Popa
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  6. Jean Ciurea
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Corresponding author

Correspondence to Andrei Barborica .

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Editors and Affiliations

  1. Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA

    Ioan Opris

  2. Greenville Health System, University of South Carolina, School of Medicine Greenville, Greenville, SC, USA

    Manuel F. Casanova

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Donos, C., Barborica, A., Mindruta, I., Maliia, M., Popa, I., Ciurea, J. (2017). Connectomics in Patients with Temporal Lobe Epilepsy. In: Opris, I., Casanova, M.F. (eds) The Physics of the Mind and Brain Disorders. Springer Series in Cognitive and Neural Systems, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-319-29674-6_20

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