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Vascular Ion Channels in Physiology and Disease pp 349–380Cite as

Membrane Lipids and Modulation of Vascular Smooth Muscle Ion Channels

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Abstract

In vascular smooth muscle (VSM), lipids regulate the function of many cellular proteins, including ion channels. Lipids can directly target ion channels or regulate ion channels indirectly, that is, through interactions with cell signalling molecules that eventually target the ion channel. We summarize current knowledge on VSM ion channel regulation by lipids, whether lipids are originated in the smooth muscle itself, vascular endothelium, or paracrine or circulation sources, with a focus on possible direct interaction between lipid molecules and the proteins that constitute the VSM ion channel complex. We also describe the contribution of such lipid-VSM ion channel interaction to VSM physiology and pathophysiology. However, more than one mechanism or type of interaction may be involved in lipid-induced regulation of VSM ion channels and some mechanisms are not mutually exclusive, which adds significant complexity to the field. Understanding the mechanisms that underlie lipid modulation of VSM ion channels, however, is necessary for developing novel therapeutic approaches to improve vascular function and prevent or counteract widespread cardio/cerebrovascular disorders.

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, The University of Tennessee Health Science Center, 874 Union Ave., Memphis, TN, 38163, USA

    Alex M. Dopico M.D., Ph.D., Anna N. Bukiya & Guruprasad Kuntamallappanavar

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  1. Alex M. Dopico M.D., Ph.D.
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  2. Anna N. Bukiya
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Correspondence to Alex M. Dopico M.D., Ph.D. .

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  1. University of Illinois at Chicago, Chicago, Illinois, USA

    Irena Levitan, PhD

  2. The University of Tennessee, Memphis, Tennessee, USA

    Alex M. Dopico, MD, PhD

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Dopico, A.M., Bukiya, A.N., Kuntamallappanavar, G. (2016). Membrane Lipids and Modulation of Vascular Smooth Muscle Ion Channels. In: Levitan, PhD, I., Dopico, MD, PhD, A. (eds) Vascular Ion Channels in Physiology and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-29635-7_16

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