Abstract
In this article we address ion channels formed by Transient Receptor Potential Canonical (TRPC) proteins and Orai proteins and the phenomenon of store-operated Ca2+ entry (SOCE) as they relate to vascular remodelling and two dominant cell types in this biology, the vascular smooth muscle cells and the endothelial cells. Emphasis is placed on studies published by our group but there is also general introduction for non-experts, critical evaluation, and debate of current concepts, controversies, and future perspectives. Overall we believe that this is an interesting and important area of biology that still raises unsolved questions and substantial technical challenges if full understanding is to be achieved. It is our opinion that within these mechanisms there are important targets for the discovery and development of novel therapeutic agents to address key unsolved disease challenges in the cardiovascular, cancer and many other fields.
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Acknowledgements
Our work in this area has been supported by research grants from the Wellcome Trust, Medical Research Council and British Heart Foundation. H.L.A. is supported by a Studentship from the British Heart Foundation.
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Beech, D.J., Li, J., McKeown, L., Appleby, H.L. (2016). TRPC and Orai Channels in Store-Operated Calcium Entry and Vascular Remodelling. In: Levitan, PhD, I., Dopico, MD, PhD, A. (eds) Vascular Ion Channels in Physiology and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-29635-7_13
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DOI: https://doi.org/10.1007/978-3-319-29635-7_13
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