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Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases

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Vascular Ion Channels in Physiology and Disease

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Abstract

Transient Receptor Potential Mucolipin 1 (TRPML1) channel protein, one of the TRPML family members, is a Ca2+-permeable membrane channel with a predominant location on the late endo/lysosomes. In arterial myocytes, it has been found that this ligand-gated channel is sensitive to NAADP (Nicotinic Acid Adenine Dinucleotide Phosphate), a secondary Ca2+ messenger, to generate Ca2+ release from lysosomes followed by a global Ca2+ release response from the sarcoplasmic reticulum through Ca2+-induced Ca2+ release mechanism (CICR), which is referred to as an intracellular two-phase Ca2+ release. In coronary artery, recent studies demonstrated that NAADP-sensitive lysosomal TRPML1 channels can be activated by a variety of pro-pathogenic stimuli such as endothelin 1 (ET-1), reactive oxidative species (ROS), and death receptor ligand (FasL). The defects or derangement of the lysosomal TRPMLl channel activity have been implicated in vascular injury or diseases such as endothelial dysfunction, apoptosis and even atherosclerosis.

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Acknowledgment

The works cited in the authors’ laboratory were supported by grants from the National Institutes of Health (HL075316, HL057244 and HL115068).

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  1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, 410 N. 12th Street, Richmond, VA, 23298, USA

    Fan Zhang M.D., Ph.D. & Pin-Lan Li M.D., Ph.D.

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  1. Fan Zhang M.D., Ph.D.
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Correspondence to Pin-Lan Li M.D., Ph.D. .

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Editors and Affiliations

  1. University of Illinois at Chicago, Chicago, Illinois, USA

    Irena Levitan, PhD

  2. The University of Tennessee, Memphis, Tennessee, USA

    Alex M. Dopico, MD, PhD

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Zhang, F., Li, PL. (2016). Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases. In: Levitan, PhD, I., Dopico, MD, PhD, A. (eds) Vascular Ion Channels in Physiology and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-29635-7_10

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