Abstract
Confusion is among the most common neurological complaints in hospitalized patients. It is characterized principally by the loss of the normal coherent stream of thought or action, and may manifest as agitated delirium or somnolence. Examination of a confused patient should focus on assessment of attention. Fluent aphasias, neglect, transient global amnesia, psychosis, and the Charles Bonnet syndrome are important conditions that may be misdiagnosed as confusion. The right-hemispheric syndrome is a multimodal disorder of directed attention. Toxic-metabolic disturbances are the most common causes of confusion, and encephalopathies related to alcohol and hepatic dysfunction have characteristic presentations. Meningitis and encephalitis are important causes of confusion and can be overlooked if directed evaluation is not performed. Lumbar puncture is an important diagnostic tool in the evaluation of a confused patient, and can be performed easily if anatomic landmarks are identified and proper positioning is achieved. Structural lesions of the brain are uncommon causes of confusion. Most disorders that produce confusion are treatable if recognized in a timely fashion.
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References
Bromberg JE, Breems DA, Kraan J, et al. CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies. Neurology. 2007;68:1674–9.
Caplan LR, Schmahmann JD, Kase CS, et al. Caudate infarcts. Arch Neurol. 1990;47:133–43.
Chaidir L, Rizal Ganiem A, vander Zander A, et al. Comparison of real time IS6110-PCR, microscopy, and culture for diagnosis of tuberculous meningitis in a cohort of adult patients in Indonesia. PLoS One. 2012;7:e52001.
Charness ME, Simon RP, Greenberg DA. Ethanol and the nervous system. N Engl J Med. 1989;321:442–54.
Clarke J, Perez H, Jacks L, Panageas KS, Deangelis LM. Leptomeningeal metastases in the MRI era. Neurology. 2010;74:1449–54.
Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10:63–74.
Day JN, Chau TTH, Wolbers M, et al. Combination antifungal therapy for cryptococcal meningitis. N Engl J Med. 2013;368:1291–302.
Devinsky O, Bear D, Volpe BT. Confusional states following posterior cerebral artery infarction. Arch Neurol. 1988;45:160–3.
Gomori JM, Heching N, Siegal T. Leptomeningeal metastases: evaluation by gadolinium enhanced spinal magnetic resonance imaging. J Neurooncol. 1998;36:55–60.
Graus F, Saiz A, Lai M, et al. Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations. Neurology. 2008;71:930–6.
Gultekin SH, Rosenfeld MR, Voltz R, et al. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain. 2000;123:1481–94.
Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry. 1986;49:341–5.
Hasbun R, Abrahams J, Jekel J, Quagliarello VJ. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med. 2001;345:1727–33.
Herrlinger U, Forschler H, Kuker W, et al. Leptomeningeal metastasis: survival and prognostic factors in 155 patients. J Neurol Sci. 2004;223:167–78.
Hodges JR, Warlow CP. The aetiology of transient global amnesia. Brain. 1990;113:639–57.
Hoftberger R, Titulaer MJ, Sabater L, et al. Encephalitis and GABAB receptor antibodies. Novel findings in a new case series of 20 patients. Neurology. 2013;81:1500–6.
Inouye SK. Delirium in hospitalized older patients. Clin Geriatr Med. 1998;14:745–64.
Kaplan HI, Sadock BJ. Kaplan and Sadock’s synopsis of psychiatry. Baltimore: Williams & Wilkins; 1998.
Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis after synaptic receptor location. Ann Neurol. 2009;65:424–34.
Lai M, Huijbers MGM, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010;9:776–85.
Lancaster E, Martinez-Hernandez E, Dalmau J. Encephalitis and antibodies to synaptic and neuronal cell surface proteins. Neurology. 2011;77:179–89.
Leavitt S, Tyler HR. Studies in asterixis. Arch Neurol. 1964;10:360–8.
Lee VH, Wijdicks EFM, Manno EM, Rabinstein AA. Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol. 2008;65:205–10.
Mayo-Smith MF. Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. JAMA. 1997;278:144–51.
McKeon A, Pittock SJ, Lennon VA. CSF complements serum for evaluating paraneoplastic antibodies and NMO-IgG. Neurology. 2011;76:1108–9.
Mesulam M. Attentional networks, confusional states, and neglect syndromes. In: Mesulam M, editor. Principles of behavioral and cognitive neurology. Oxford: Oxford University Press; 2000. p. 174–256.
Mesulam M, Waxman SG, Geschwind N, Sabin TD. Acute confusional states with right middle cerebral artery infarctions. J Neurol Neurosurg Psychiatry. 1976;39:84–9.
Ong JP, Aggarwal A, Krieger D, et al. Correlation between ammonia levels and the severity of hepatic encephalopathy. Am J Med. 2003;114:188–93.
Patel RR, Subramaniam RM, Mandrekar JN, et al. Occult malignancy in patients with suspected paraneoplastic neurologic syndromes: value of positron emission tomography in diagnosis. Mayo Clin Proc. 2008;83:917–22.
Petit-Pedrol M, Armangue T, Peng X, et al. Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies. Lancet Neurol. 2014;13:276–86.
Ronthal M. Confusional states and metabolic encephalopathy. In: Samuels MA, Feske SK, editors. Office practice of neurology. 2nd ed. Philadelphia: Churchill Livingstone; 2003. p. 886–90.
Sedlaczek O, Hirsch JG, Grips E, et al. Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia. Neurology. 2004;62:2165–70.
Thomas KE, Hasbun R, Jekel J, Quagliarello VJ. The diagnostic accuracy of Kernig’s sign, Brudzkinski’s sign, and nuchal rigidity in adults with suspected meningitis. Clin Infect Dis. 2002;35:46–52.
Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39:1267–84.
van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351:1849–59.
Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982;49:759–72.
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Tarulli, A. (2016). Confusion. In: Neurology. Springer, Cham. https://doi.org/10.1007/978-3-319-29632-6_1
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DOI: https://doi.org/10.1007/978-3-319-29632-6_1
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