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Biochip Architecture Model

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Microfluidic Very Large Scale Integration (VLSI)

Abstract

This chapter presents the biochip architecture models used throughout the book. We first present the microfluidic valve, which is the basic building block of continuous-flow biochips. Microfluidic valves, together with microfluidic channels, are used to build microfluidic components. The chapter presents a microfluidic component model and how we capture the details of the components in a component library. Then, we propose a topology graph model, also called a netlist, which models the components and their interconnections. The chapter also discusses the control of microfluidic biochips using off-chip pressure. In this context, we present recent advances that move the off-chip control on-chip, using microfluidic valves to build logic circuits based on pneumatics.

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Notes

  1. 1.

    An equally large pressure is not necessary. Similar valve have withstood 75 kPa of fluid pressure with 45 kPa pressure applied to the input channel [6].

  2. 2.

    The upper and lower bound for actuation have been shown to be \(-\)20 and \(-\)32 pKa [9], respectively.

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Pop, P., Minhass, W.H., Madsen, J. (2016). Biochip Architecture Model. In: Microfluidic Very Large Scale Integration (VLSI). Springer, Cham. https://doi.org/10.1007/978-3-319-29599-2_3

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  • DOI: https://doi.org/10.1007/978-3-319-29599-2_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29597-8

  • Online ISBN: 978-3-319-29599-2

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