Abstract
In the recent years, muscle imaging has become a very useful tool for studying patients with neuromuscular diseases.
Especially, MRI is a noninvasive method that allows a detailed and defined visualization of the muscle tissue and pathological aspects of the disease and identification of suggestive and, sometimes, specific patterns of muscle involvement and helps in staging and monitoring the extent of muscle damage.
Muscle MRI is greatly used in studying inherited myopathies, while it has not yet been extensively applied in acquired muscle diseases except for the autoimmune inflammatory forms in which it has been often considered prior to obtaining a muscle biopsy.
In this chapter, we summarize the current knowledge on muscle imaging techniques and their usefulness and briefly discuss the radiological pictures in the main acquired myopathies, as dermatomyositis, polymyositis, and inclusion body myositis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Halford H, Graves A, Bertorinie T (2000) Muscle and nerve imaging techniques in neuromuscular diseases. J Clin Neuromusc Dis 2:41–51
Marden FA, Connolly AM, Siegel MJ, Rubin DA (2005) Compositional analysis of muscle in boys with Duchenne muscular dystrophy using MR imaging. Skeletal Radiol 34:140–148
Walker FO, Cartwright MS, Wiesler ER, Caress J (2004) Ultrasound of nerve and muscle. Clin Neurophysiol 115:495–507
Fleckenstein JL (2000) MRI of neuromuscular disease: the basics. Semin Musculoskelet Radiol 4:393–419
Mercuri E, Pichiecchio A, Allsop J et al (2007) Muscle MRI in inherited neuromuscular disorders: past, present and future. J Magn Reson Imaging 25:433–440
Wattjes MP, Kley RA, Fischer D (2010) Neuromuscular imaging in inherited muscle diseases. Eur Radiol 20:2447–2460
Scott DL, Kingsley GH (2004) Use of imaging to assess patients with muscle disease. Curr Opin Rheumatol 16:678–683
Ortolan P, Zanato R, Coran A et al (2015) Eur J Transl Myol Basic Appl Myol 25:121–127
Chan WP, Liu GC (2002) MR imaging of primary skeletal muscle diseases in children. AJR Am J Roentgenol 179:989–997
Hollingsworth KG, de Sousa PL, Straub V et al (2012) Towards harmonization of protocols for MRI outcome measures in skeletal muscle studies: consensus recommendations from two TREAT-NMD NMR workshops, 2 May 2010, Stockholm, Sweden, 1–2 October 2009, Paris, France. Neuromuscul Disord 22(Suppl 2):S54–S67
Wattjes MP (2013) Conventional magnetic resonance imaging. In: Wattjes MP, Fischer D (eds) Neuromuscular imaging. New York: Springer-Verlag, pp 27–34
Morrow JM, Matthews E, Raja Rayan DL et al (2013) Muscle MRI reveals distinct abnormalities in genetically proven non-dystrophic myotonias. Neuromuscul Disord 23:637–646
Quijano-Roy S, Avila-Smirnow D, Carlier RY (2012) Whole body muscle MRI protocol: pattern recognition in early onset NM disorders. Neuromuscul Disord 22:S68–S84
Klein A, Jungbluth H, Clement E et al (2011) Muscle MRI in congenital myopathies due to ryanodine receptor type 1 gene mutations. Arch Neurol 68:1171–1179
Mercuri E, Clements E, Offiah A et al (2009) Muscle magnetic resonance involvement muscular dystrophies with rigidity of the spine. Ann Neurol 67:201–208
Lamminen AE (1990) Magnetic resonance imaging of primary skeletal muscle diseases: patterns of distribution and severity of involvement. Br J Radiol 63:946–950
Mercuri E, Pichiecchio A, Counsell S et al (2002) A short protocol for muscle MRI in children with muscular dystrophies. Eur J Paediatr Neurol 6:305–307
Borsato C, Padoan R, Stramare R, Fanin M, Angelini C (2006) Limb-girdle muscular dystrophies type 2a and 2b: clinical and radiological aspects. Basic Appl Myol 16:17–25
Poliachik SL, Friedman SD, Carter GT et al (2012) Skeletal muscle edema in muscular dystrophy: clinical and diagnostic implications. Phys Med Rehabil Clin Am 23:107–122
Termote JL, Baert A, Crolla D et al (1980) Computed tomography of the normal and pathologic muscular system. Radiology 137:439–444
Alanen AM, Falck B, Kalimo H et al (1994) Ultrasound, computed tomography and magnetic resonance imaging in myopathies: correlations with electromyography and histopathology. Acta Neurol Scand 89:336–346
Pillen S, Arts IM, Zwarts MJ (2008) Muscle ultrasound in neuromuscular disorders. Muscle Nerve 37:679–693
Pillen S, van Alfen N (2011) Skeletal muscle ultrasound. Neurol Res 33:1016–1024
Amato AA, Barohn RJ (2009) Evaluation and treatment of inflammatory myopathies. J Neurol Neurosurg Psychiatry 80:1060–1068
Dalakas MC (1991) Polymyositis, dermatomyositis, and inclusion-body myositis. N Engl J Med 325:1487–1498
Lian C, Needham M (2011) Necrotizing autoimmune myopathy. Curr Opin Rheumatol 23:612–619
Van de Vlekkert J, Maas M, Hoogendijk JE et al (2015) Combining MRI and muscle biopsy improves diagnostic accuracy in subacute-onset idiopathic inflammatory myopathy. Muscle Nerve 51:253–258
Plotz PH, Dalakas M, Leff RL et al (1989) Current concepts in the idiopathic inflammatory myopathies: polymyositis, dermatomyositis, and related disorders. Ann Intern Med 111:143–157
Pitt AM, Fleckenstein JL, Greenlee RG et al (1993) MRI-guided biopsy in inflammatory myopathy: initial results. Magn Reson Imaging 11:1093–1099
Tomasová Studynková J, Charvát F, Jarosová K et al (2007) The role of MRI in the assessment of polymyositis and dermatomyositis. Rheumatology 46:1174–1179
Fraser DD, Frank JA, Dalakas M et al (1991) Magnetic resonance imaging in the idiopathic inflammatory myopathies. J Rheumatol 18:1693–1700
Ladd PE, Emery KH, Salisbury SR et al (2011) Juvenile dermatomyositis: correlation of MRI at presentation with clinical outcome. AJR Am J Roentgenol 197:W153–W158
Davis WR, Halls JE, Offiah AC (2011) Assessment of active inflammation in juvenile dermatomyositis: a novel magnetic resonance imaging-based scoring system. Rheumatology 50:2237–2244
Alvarengab D, Rodriguesb JC et al (2014) Aspectos distintos de ressonância magnética de músculos entre dermatomiosite e polimiosite. Rev Bras Reumatol 54:295–300
Malattia C, Damasio MB, Madeo A et al (2014) Whole-body MRI in the assessment of disease activity in juvenile dermatomyositis. Ann Rheum Dis 73:1083–1090
Qi J, Olsen NJ, Price RR et al (2008) Diffusion-weighted imaging of inflammatory myopathies: polymyositis and dermatomyositis. J Magn Reson Imaging 27:212–217
Ai T, Yu K, Gao L et al (2014) Diffusion tensor imaging in evaluation of thigh muscles in patients with polymyositis and dermatomyositis. Br J Radiol 87(1043):20140261
Li K, Dortch RD, Kroop SF et al (2015) A rapid approach for quantitative magnetization transfer imaging in thigh muscles using the pulsed saturation method. Magn Reson Imaging 33:709–717
Bryant ND, Li K, Does MD et al (2014) Multi-parametric MRI characterization of inflammation in murine skeletal muscle. NMR Biomed 27:716–725
Sciorati C, Esposito A, Campana L et al (2014) 7-tesla magnetic resonance imaging precisely and noninvasively reflects inflammation and remodeling of the skeletal muscle in a mouse model of antisynthetase syndrome. Biomed Res Int 2014:879703. doi:10.1155/2014/879703
Weber MA, Jappe U, Essig M et al (2006) Contrast-enhanced ultrasound in dermatomyositis and polymyositis. J Neurol 253:1625–1632
Tanaka S, Ikeda K, Uchiyama K et al (2013) [18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis. Rheumatology 52:1271–1278
Tateyama M, Fujihara K, Misu T et al (2015) Clinical values of FDG PET in polymyositis and dermatomyositis syndromes: imaging of skeletal muscle inflammation. BMJ Open 5:e006763. doi:10.1136/bmjopen-2014-006763
Tasca G, Monforte M, De Fino C et al (2015) MRI pattern recognition in sporadic inclusion body myositis. Muscle Nerve. doi:10.1002/mus.24661
Farrugia ME, Robson MD, Clover L et al (2006) MRI and clinical studies of facial and bulbar muscle involvement in MuSK antibody-associated myasthenia gravis. Brain 129:1481–1492
Zouvelou V, Rentzos M, Toulas P, Evdokimidis I (2011) MRI evidence of early muscle atrophy in MuSK positive myasthenia gravis. J Neuroimaging 21:303–305
Zouvelou V, Rentzos M, Toulas P, Evdokimidis I (2012) AchR-positive myasthenia gravis with MRI evidence of early muscle atrophy. J Clin Neurosci 19:918–919
Peters SA, Kley R, Tegenthoff M (2010) MRI in lipid-lowering agent-associated myopathy: a retrospective review of 21 cases. AJR Am J Roentgenol 194:W323–W328
Kishi T, Kitani M, Uegaki J, Naganuma R (1997) Alcoholic myopathy: evaluation with magnetic resonance imaging–a case study. Alcohol Clin Exp Res 21:1730–1731
Bigliocchi M, Lo Mele L, Stasolla A et al (2004) MRI and muscle signal intensities in alcoholics compared with control subjects. Alcohol Clin Exp Res 28:1875–1880
Huang BK, Monu JU, Doumanian J (2010) Diabetic myopathy: MRI patterns and current trends. AJR Am J Roentgenol 195:198–204
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Filosto, M., Pichiecchio, A., Padovani, A., Gasparotti, R. (2016). Imaging of the Muscle. In: Angelini, C. (eds) Acquired Neuromuscular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-29514-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-29514-5_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-29512-1
Online ISBN: 978-3-319-29514-5
eBook Packages: MedicineMedicine (R0)