Abstract
Several toxic agents have an easy access to the peripheral nervous system. These toxic substances belong to different classes, including therapeutic drugs, recreational abuse substances, and environmental and industrial contaminants.
Establishment of a real causal relationship between peripheral nervous system damage and toxic agents exposure is obvious in some condition (e. g., in the course of anticancer chemotherapy), but it can be very difficult or even misleading in other contexts, when potential exposure is not easy to be proven or is not reported by the affected subjects.
Not all the reports describing the peripheral toxicity of substances causing rare events are convincing, and the list of putative neurotoxic agents is probably overestimated. Nevertheless, relationship even with agents with only occasional neurotoxicity has been clearly established.
The clinical effects of the exposure to neurotoxic agents are highly variable, depending on the mechanism of their action and on the intracellular target. In most cases sensory impairment is exclusive or largely predominant over motor or autonomic damage. Similarly, the clinical course may be acute, subacute, or chronic, and recovery after withdrawal from toxic exposure is not always guaranteed. Moreover, worsening lasting months after the suspension of toxic exposure (the “coasting effect”) has also been reported.
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Weimer LH, Sachdev N (2009) Update on medication-induced peripheral neuropathy. Curr Neurol Neurosci Rep 9:69–75
Arezzo JC, Litwak MS, Zotova EG (2011) Correlation and dissociation of electrophysiology and histopathology in the assessment of toxic neuropathy. Toxicol Pathol 39:46–51
DeGrandchamp RL, Lowndes HE (1990) Early degeneration and sprouting at the rat neuromuscular junction following acrylamide administration. Neuropathol Appl Neurobiol 16:239–254
Marmiroli P, Nicolini G, Miloso M, Scuteri A, Cavaletti G (2012) The fundamental role of morphology in experimental neurotoxicology: the example of chemotherapy-induced peripheral neurotoxicity. Ital J Anat Embryol 117:75–97
Grisold W, Cavaletti G, Windebank AJ (2012) Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol 14(Suppl 4):iv45–iv54
Cavaletti G, Alberti P, Marmiroli P (2011) Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics. Lancet Oncol 12:1151–1161
Cavaletti G, Marmiroli P (2010) Chemotherapy-induced peripheral neurotoxicity. Nat Rev Neurol 6:657–666
Carozzi VA, Chiorazzi A, Canta A, Meregalli C, Oggioni N, Cavaletti G, Marmiroli P (2015) Chemotherapy-induced peripheral neurotoxicity in immune-deficient mice: new useful ready-to-use animal models. Exp Neurol 264:92–102
Carozzi VA, Canta A, Oggioni N, Sala B, Chiorazzi A, Meregalli C, Bossi M, Marmiroli P, Cavaletti G (2010) Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies. Exp Neurol 226:301–309
Bennett GJ, Doyle T, Salvemini D (2014) Mitotoxicity in distal symmetrical sensory peripheral neuropathies. Nat Rev Neurol 10:326–336
Meregalli C, Chiorazzi A, Carozzi VA, Canta A, Sala B, Colombo M, Oggioni N, Ceresa C, Foudah D, La Russa F, Miloso M, Nicolini G, Marmiroli P, Bennett DL, Cavaletti G (2014) Evaluation of tubulin polymerization and chronic inhibition of proteasome as cytotoxicity mechanisms in bortezomib-induced peripheral neuropathy. Cell Cycle 13:612–621
Cavaletti G, Ceresa C, Nicolini G, Marmiroli P (2014) Neuronal drug transporters in platinum drugs-induced peripheral neurotoxicity. Anticancer Res 34:483–486
Sprowl JA, Ciarimboli G, Lancaster CS, Giovinazzo H, Gibson AA, Du G, Janke LJ, Cavaletti G, Shields AF, Sparreboom A (2013) Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter oct2. Proc Natl Acad Sci U S A 110:11199–11204
Sprowl JA, Lancaster CS, Pabla N, Hermann E, Kosloske AM, Gibson AA, Li L, Zeeh D, Schlatter E, Janke LJ, Ciarimboli G, Sparreboom A (2014) Cisplatin-induced renal injury is independently mediated by oct2 and p53. Clin Cancer Res 20:4026–4035
Abbi KK, Rizvi SM, Sivik J, Thyagarajan S, Loughran T, Drabick JJ (2010) Guillain-Barré syndrome after use of alemtuzumab (Campath) in a patient with t-cell prolymphocytic leukemia: a case report and review of the literature. Leuk Res 34:e154–e156
Pastorelli F, Derenzini E, Plasmati R, Pellegrini C, Broccoli A, Casadei B, Argnani L, Salvi F, Pileri S, Zinzani PL (2013) Severe peripheral motor neuropathy in a patient with hodgkin lymphoma treated with brentuximab vedotin. Leuk Lymphoma 54:2318–2321
Orr CF, Ahlskog JE (2009) Frequency, characteristics, and risk factors for amiodarone neurotoxicity. Arch Neurol 66:865–869
Hao S (2013) The molecular and pharmacological mechanisms of HIV-related neuropathic pain. Curr Neuropharmacol 11:499–512
Manji H (2011) Toxic neuropathy. Curr Opin Neurol 24:484–490
Mellion M, Gilchrist JM, de la Monte S (2011) Alcohol-related peripheral neuropathy: nutritional, toxic, or both? Muscle Nerve 43:309–316
Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G (2003) Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54:19–29
Ramcharan K, Ramesar A, Ramdath M, Teelucksingh J, Gosein M (2014) Encephalopathy and neuropathy due to glue, paint thinner, and gasoline sniffing in trinidad and tobago-MRI findings. Case Rep Neurol Med 2014:850109
Sills RC, Harry GJ, Morgan DL, Valentine WM, Graham DG (1998) Carbon disulfide neurotoxicity in rats: V. Morphology of axonal swelling in the muscular branch of the posterior tibial nerve and spinal cord. Neurotoxicology 19:117–127
Ghosh A (2013) Evaluation of chronic arsenic poisoning due to consumption of contaminated ground water in west Bengal, India. Int J Prev Med 4:976–979
Kim S, Takeuchi A, Kawasumi Y, Endo Y, Lee H, Kim Y (2012) A Guillain-Barré syndrome-like neuropathy associated with arsenic exposure. J Occup Health 54:344–347
Rice KM, Walker EM, Wu M, Gillette C, Blough ER (2014) Environmental mercury and its toxic effects. J Prev Med Public Health 47:74–83
Kingman A, Albers JW, Arezzo JC, Garabrant DH, Michalek JE (2005) Amalgam exposure and neurological function. Neurotoxicology 26:241–255
Thomson RM, Parry GJ (2006) Neuropathies associated with excessive exposure to lead. Muscle Nerve 33:732–741
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Cavaletti, G., Marmiroli, P. (2016). Toxic Neuropathies. In: Angelini, C. (eds) Acquired Neuromuscular Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-29514-5_20
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DOI: https://doi.org/10.1007/978-3-319-29514-5_20
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