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Psychosis in the Elderly

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Abstract

Psychosis is a particularly distressing psychiatric illness for sufferers and their carers, and it can feel especially difficult for practitioners dealing with its uncertain course and instilling hope in sufferers. Although assessing and managing a patient with psychosis in primary care can be daunting, the majority of patients should also receive input from mental health services. Psychotic symptoms are found in a wide range of medical and psychiatric conditions. Patients with psychosis in later life can be divided into three groups: those with pre-existing schizophrenia, new diagnoses of schizophrenia (‘late-life schizophrenia’, also known as ‘late paraphrenia’) and other conditions producing hallucinations or delusions (dementia, delirium, mood disorders, delusional disorder, paranoid personality disorders). As the population ages and treatments improve, the first group is getting significantly larger and making up a greater proportion of mental illness in older people. The prevalence of all psychotic disorders over 65 years of age is 4–6 %, rising to 10 % over 85 years. However, a large proportion of these cases are related to dementia. True schizophrenia or delusional disorder in the over 65 has a prevalence of 0.5–1.0 %. There is a female preponderance, with a ratio of female to males of 5:1, which is partly because the onset of schizophrenia tends to be later in females. Sixty per cent of older people with psychosis have paranoid schizophrenia, 30 % delusional disorder and only 10 % all other forms of psychosis.

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References

  1. Geddes P. McKnight psychiatry, 4th ed. Oxford: Oxford University Press; 2012. ISBN 978-0-19-923396-0.

    Google Scholar 

  2. Cowen P, Harrison P. The shorter Oxford textbook of psychiatry, 6th ed. Oxford: Oxford University Press; ISBN 9780199605613.

    Google Scholar 

  3. The World Health Organization. The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva: World Health Organization; 1992.

    Google Scholar 

  4. Howard, et al. Late-onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am J Psychiatry. 2000;157:172–8.

    Article  CAS  PubMed  Google Scholar 

  5. Meesters, et al. Schizophrenia spectrum disorders in later life: prevalence and distribution of age at onset and sex in a Dutch catchment area. Am J Geriatr Psychiatry. 2012;20(1):18–28.

    Article  PubMed  Google Scholar 

  6. Karim S, Byrne E. Treatment of psychosis in elderly people. Adv Psychiatr Treat. 2005;11:286–96.

    Article  Google Scholar 

  7. Palmer, et al. Schizophrenia in late life: findings challenge traditional concepts. Harv Rev Psychiatry. 2001;9:51–8.

    Article  CAS  PubMed  Google Scholar 

  8. Targum SD. Treating psychotic symptoms in elderly patients. Prim Care Companion J Clin Psychiatry. 2001;3:156–63.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Targum SD, Abbott JL. Treating psychotic symptoms in the elderly: a spectrum of disorders. J Clin Psychiatry. 1999;60 Suppl 8:4–10.

    PubMed  Google Scholar 

  10. National Institute for Health and Care Excellence, Guidelines (CG178), psychosis and schizophrenia in adults: treatment and management, February 2014.

    Google Scholar 

  11. Gaebel W, Weinmann S, Sartorius N. Schizophrenia practice guidelines: international survey and comparison. Br J Psychiatry. 2005;187:248–55.

    Article  PubMed  Google Scholar 

  12. Taylor et al. The Maudsley, prescribing guidelines in psychiatry, 11th ed. West Sussex, UK: Wiley-Blackwell; 2012. 978-0-470-97948-8.

    Google Scholar 

  13. Douglas, et al. exposure to antipsychotics and risk of stroke: self controlled case series study. Br Med J. 2008;337:a1227.

    Article  Google Scholar 

  14. Munro, et al. Active monitoring of 12,760 clozapine recipients in the UK and Ireland. Beyond Pharmacovigilance. Br J Psychiatry. 1999;175:576–80.

    Article  CAS  PubMed  Google Scholar 

  15. O’Connor, et al. The safety and tolerability of Clozapine in aged patients: a retrospective clinical file review. World J Biol Psychiatry. 2010;11:788–91.

    Article  PubMed  Google Scholar 

  16. Mayersohn M. Special pharmacokinetic considerations in the elderly. In: Evans WE, Schentag JJ, Jusko WJ, editors. Applied pharmacokinetics principles of therapeutic drug monitoring. Spokane: Applied Therapeutics; 1986. p. 229–93.

    Google Scholar 

  17. Morris R, et al. Lithium and eGFR: a new routinely available tool for the prevention of chronic kidney disease. Br J Psychiatry. 2008;193:93–5.

    Article  Google Scholar 

  18. Gurwitz JH. Start low and go slow: dosing of antipsychotic medications in elderly patients with dementia. Arch Intern Med. 1995;155(18):2017–8.

    Article  CAS  PubMed  Google Scholar 

  19. Davis JM, Chen N, Glick ID. A meta-analysis of the efficacy of second-generation antipsychotics. Arch Gen Psychiatry. 2003;60:553–64.

    Article  CAS  PubMed  Google Scholar 

  20. Ucok, Gaebel. Side effects of atypical antipsychotics: a brief overview. World Psychiatry. 2008;7(1):58–62.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Medicines & Healthcare products Regulatory Agency, atypical antipsychotic drugs and stoke, 9th Mar 2004, mhra.gov.uk.

  22. Herman, et al. Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry. 2004;161:1113–5.

    Article  Google Scholar 

  23. Lawlor B. Managing behavioural and psychological symptoms in dementia. Br J Psychiatry. 2002;181:463–5.

    Article  PubMed  Google Scholar 

  24. Lyketsos, et al. Mental and behavioural disturbances in dementia: findings from Cache County Study on Memory and Aging. Am J Psychiatry. 2000;157:708–14.

    Article  CAS  PubMed  Google Scholar 

  25. Margallo-Lana, et al. Prevalence and pharmacological management of behavioural and psychological symptoms amongst dementia suffers living in care environments. Int J Geriatr Psychiatry. 2001;16:39–44.

    Article  CAS  PubMed  Google Scholar 

  26. Coen, et al. Behaviour disturbance and other predictors of carer burden in Alzheimer’s disease. Int J Geriatr Psychiatry. 1997;12:331–6.

    Article  CAS  PubMed  Google Scholar 

  27. O’Donnell, et al. Incontinence and troublesome behaviours predict institutionalisation in dementia. J Geriatr Psychiatry Neurol. 1992;5:45–52.

    Article  PubMed  Google Scholar 

  28. Steele, et al. Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am J Psychiatry. 1990;147:1049–51.

    Article  CAS  PubMed  Google Scholar 

  29. Finkel SI. Effects of rivastigmine on behavioural and psychological symptoms of dementia in Alzheimer’s disease. Clin Ther. 2004;26:980–90.

    Article  CAS  PubMed  Google Scholar 

  30. Wynn ZJ, Cummings JL. Cholinesterase inhibitor therapies and Neuropsychiatric manifestations of Alzheimer’s disease. Dement Geriatr Cogn Disord. 2004;17:100–1008.

    Article  CAS  PubMed  Google Scholar 

  31. Ballard, et al. A 3 month randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cut off is a predictor of clinical outcome. J Clin Psychiatry. 2004;65:114–9.

    Article  PubMed  Google Scholar 

  32. Haw, et al. Guidelines on antipsychotics for dementia—are we losing our minds? Psychiatry Bull. 2009;33:57–60.

    Article  Google Scholar 

  33. Wood KA, Harris MJ, Morreale A, Rizos AL. Drug-induced psychosis and depression in the elderly. Psychiatry Clin North Am. 1988;11(1):167–93.

    CAS  Google Scholar 

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Correspondence to Kimberley Harrison MBBS, BSc, MRCPsych .

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Karim, S., Harrison, K. (2016). Psychosis in the Elderly. In: Chew-Graham, C., Ray, M. (eds) Mental Health and Older People. Springer, Cham. https://doi.org/10.1007/978-3-319-29492-6_15

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  • DOI: https://doi.org/10.1007/978-3-319-29492-6_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29490-2

  • Online ISBN: 978-3-319-29492-6

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